2，3，4，5，6-Pentafluorobenzyl bromide supplier

Name
PENTAFLUOROBENZYL BROMIDE
EINECS 217-182-4
CAS No. 1765-40-8
Article Data10
CAS DataBase
Density 1.864 g/cm³
Solubility Hydrolyzes in water.
Melting Point 19-20 °C(lit.)
Formula C₇H₂BrF₅
Boiling Point 173.2 °C at 760 mmHg
Molecular Weight 260.989
Flash Point 82.8 °C
Transport Information UN 3265 8/PG 2
Appearance Clear colourless to yellowish liquid
Safety 26-36/37/39-45-23-27
Risk Codes 34-36/37/38-36/37
Molecular Structure
Hazard Symbols Xi, C
Synonyms 1-(Bromomethyl)pentafluorobenzene;2,3,4,5,6-Pentafluoro-a-bromotoluene;NSC 96888;Pentafluorobenzyl bromide;a-Bromo-2,3,4,5,6-pentafluorotoluene;Benzene,(bromomethyl)pentafluoro- (9CI);Toluene, a-bromo-2,3,4,5,6-pentafluoro- (6CI,7CI,8CI);(Bromomethyl)pentafluorobenzene;(Pentafluorophenyl)methyl bromide;1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene;
PSA 0.00000
LogP 3.27700

Synthetic route

: 440-60-8
(2,3,4,5,6-pentafluorophenyl)methanol

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide; potassium hexamethylsilazane; (1,3,4)-triphenyl-4,5-dihydro-1H-1,2,4-triazol-5-ylidene In dichloromethane at 20℃; for 6h; Appel Halogenation; Inert atmosphere;	53%
With sulfuric acid; hydrogen bromide
With hydrogen bromide

: 118096-88-1
2,3,4,5,6-pentafluorobenzyl(dimethyl)sulphonium bromide

A: 118096-90-5
3,4,5,6-tetrafluoro-2-methylthiomethylbenzyl bromide

B: 118096-91-6
(E)-1-pentafluorophenyl-2-(3,4,5,6-tetrafluoro-2-methylthiomethyl)phenylethene

C: 118096-92-7
1,2-bis(3,4,5,6-tetrafluoro-2-methylthiomethylphenyl)ethene

D: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -70 - 20℃; for 19h; Mechanism; Product distribution;	A 2.5% B 5% C 11% D 32%

...Expand

: 771-56-2
2,3,4,5,6-pentafluorotoluene

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
With bromine In tetrachloromethane
With bromine Irradiation;
Multi-step reaction with 3 steps 1: Cl2 / Irradiation 2: aq. K2CO3 / Heating 3: aq. HBr, H2SO4 View Scheme
With bromine at 36℃; for 18h; Irradiation; neat (no solvent);
With N-Bromosuccinimide at 36℃; for 18.3333h; Reactivity; Time; Irradiation; neat (no solvent);

: 344-04-7
bromopentafluorobenzene

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Mg, (ii) /BRN= 636496/ 2: LiAlH4 3: aq. HBr, H2SO4 View Scheme

: 653-37-2
perfluorobenzaldehyde

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: LiAlH4 2: aq. HBr, H2SO4 View Scheme

: 827-15-6
1,2,3,4,5-pentafluoro-6-iodobenzene

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Mg, (ii) /BRN= 906769/ 2: LiAlH4 3: aq. HBr, H2SO4 View Scheme

: 653-35-0
2,3,4,5,6-pentafluorobenzyl chloride

: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. K2CO3 / Heating 2: aq. HBr, H2SO4 View Scheme

: 771-56-2
2,3,4,5,6-pentafluorotoluene

A: 887266-89-9
C7HBr2F5

B: 1765-40-8
(bromomethyl)pentafluorobenzene

Conditions

Conditions	Yield
With N-Bromosuccinimide at 36℃; for 18h; Irradiation; neat (no solvent);

: 603-35-0
triphenylphosphine

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 13509-91-6
(2,3,4,5,6-pentafluorobenzyl)triphenylphosphonium bromide

Conditions

Conditions	Yield
In xylene at 115℃; for 18h;	100%
In toluene Reflux;	74%
In toluene for 1.5h; Heating;	61%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 594-09-2
trimethylphosphane

: 80431-31-8
Trimethyl<(pentafluorphenyl)methyl>phosphoniumbromid

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 1h;	100%

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1207604-26-9
(S)-tert-butyl 2-(diphenylmethyleneamino)-3-(perfluorophenyl)propanoate

Conditions

Conditions	Yield
With 2,7-bis[O(9)-allylhydrocinchonidinium-N-methyl]naphthalene dibromide; potassium hydroxide In chloroform; water; toluene at -20℃; for 84h; Inert atmosphere; optical yield given as %ee;	100%

: 109-06-8
α-picoline

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1229616-85-6
N-(pentafluorobenzyl)-2-methylpyridinium bromide

Conditions

Conditions	Yield
In chloroform at 20℃; for 24h;	100%

: 121-44-8
triethylamine

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 149183-44-8
triethyl(pentafluorobenzyl)ammonium bromide

Conditions

Conditions	Yield
at 20℃; for 24h;	100%

: 1428628-97-0
C48H38O18

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1428628-89-0
2,2',2'',2''',2'''',2'''''-[[1,1':4',1'':4'',1''':4''',1'''':4'''',1'''''-sexiphenyl]-2'',2'''',3,3',3''',3'''''-sexiylhexakis(oxy)]hexakis[acetic acid] 01, 01',01'',01''',01'''',01'''''-hexa(2,3,4,5,6-pentafluorobenzyl)ester

Conditions

Conditions	Yield
Stage #1: C48H38O18 With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere; Stage #2: (bromomethyl)pentafluorobenzene In N,N-dimethyl-formamide at 120℃; for 3h; Microwave irradiation;	100%

: C16H14O6

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1428628-87-8
C30H16F10O6

Conditions

Conditions	Yield
Stage #1: C16H14O6 With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Inert atmosphere; Stage #2: (bromomethyl)pentafluorobenzene In N,N-dimethyl-formamide at -10℃; for 1h;	100%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 122-52-1
triethyl phosphite

: 125138-11-6
diethyl 2,3,4,5,6-pentafluorobenzylphosphonate

Conditions

Conditions	Yield
at 140℃; for 12h;	100%
With triethylamine at 140℃; for 0.0833333h; Microwave irradiation;	99%
Arbuzov Reaction;

: 110-86-1
pyridine

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 164655-83-8
1-(2,3,4,5,6-pentafluoro-benzyl)pyridinium bromide

Conditions

Conditions	Yield
In neat (no solvent) at 50℃;	100%
In methanol for 12h; Inert atmosphere; Reflux;	94%
In acetonitrile at 88℃; for 12h;	92%
at 20℃;

: 7164-98-9
1-phenylimidazole

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1-(2,3,4,5,6-pentafluorobenzyl)-3-phenylimidazolium bromide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h;	100%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 213015-69-1
tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate

: C19H17F6NO4S

Conditions

Conditions	Yield
Stage #1: tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate With caesium carbonate In acetonitrile at 20℃; for 0.333333h; Inert atmosphere; Stage #2: (bromomethyl)pentafluorobenzene In acetonitrile at 20℃; for 16h; Inert atmosphere;	100%
Stage #1: tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate With caesium carbonate In acetonitrile Stage #2: (bromomethyl)pentafluorobenzene In acetonitrile at 20℃; for 16h;	96%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 887150-20-1
tert–butyl (2-(((perfluorophenyl)methyl)amino)ethyl)carbamate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 22℃; for 25h;	100%

: 32812-89-8
bis(benzenethiolato)lead(II)

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1,2,4,5-Tetrafluoro-3-phenylsulfanyl-6-phenylsulfanylmethyl-benzene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 23h; Heating;	99%

: 1765-40-8
(bromomethyl)pentafluorobenzene

Pb(SPh)2: Pb(SPh)2

: 1,2,4,5-Tetrafluoro-3-phenylsulfanyl-6-phenylsulfanylmethyl-benzene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 23h; Heating;	99%

: 5824-40-8
Triphenylmethylamin

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1161882-79-6
N-trityl-2,3,4,5,6-pentafluorobenzylamine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	99%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 214694-10-7
4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamino)-benzoic acid ethyl ester

: 1300118-25-5
ethyl 4-[N-pentafluorobenzyl-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalen-2-yl)amino]benzoate

Conditions

Conditions	Yield
Stage #1: 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamino)-benzoic acid ethyl ester With sodium hydride In N,N-dimethyl-formamide for 0.333333h; Inert atmosphere; Stage #2: (bromomethyl)pentafluorobenzene In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	99%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 122-52-1
triethyl phosphite

A: 78-38-6
ethylphosphonic acid diethyl ester

B: 2,3,4,5,6-pentafluorobenzylphosphonic acid ethyl ester

Conditions

Conditions	Yield
at 160℃; for 12h;	A n/a B 99%

...Expand

: 1455006-14-0
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(perfluorophenylsulfonamido)acetamido)benzoate

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1455006-39-9
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-((perfluorophenyl)methyl)phenylsulfonamido)acetamido)benzoate

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	99%

: 1072-63-5
1-vinylimidazole

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 3-(2,3,4,5,6-pentafluorobenzyl)-1-vinylimidazol-1-ium bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 48h; Cooling with ice; Inert atmosphere;	99%
In acetonitrile at 88℃; for 12h;	91%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 133831-28-4
methyl 3-formyl-6-indolecarboxylate

: methyl 3–formyl–1-((perfluorophenyl)methyl)-1H–indole–6–carboxylate

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 18h; Inert atmosphere;	99%

: 561297-18-5
(η5-cyclopentadienyl)(dppe)Ru((N2)-4,5-bis(methoxycarbonyl)-1,2,3-triazolato)

: 1765-40-8
(bromomethyl)pentafluorobenzene

: (η5-C5H5)(1,2-bis(diphenylphosphino)ethane)ruthenium(Br)

Conditions

Conditions	Yield
In dichloromethane byproducts: N3(CH2C6F5)C2(CO2Me)2; under N2; CH2Cl2 added to Ru complex and BrCH2C6F5 (molar ratio 1:5), stirred at 40°C for 48 h; at 50°C and 20-fold excess of BrCH2C6F5 react. completed in 1 d; solvent removed under vac.; cold n-pentane added; filtered; ppt. washed with n-pentane; dried under vac.; elem. anal.;	98%

: 536-74-3
phenylacetylene

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1-((perfluorophenyl)methyl)-4-phenyl-1H-1,2,3-triazole

Conditions

Conditions	Yield
With copper(l) iodide; sodium azide; diethylamine In glycerol at 20℃; for 5h; Schlenk technique; Inert atmosphere; Green chemistry;	98%
With sodium azide; C24H20N62I(1-)2Cu(1+) In water at 25℃; for 12h;	33 %Chromat.

: 3978-81-2
4-tert-butylpyridine

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1609277-94-2
4-tert-butyl-N-((pentafluorophenyl)methyl)pyridinium bromide

Conditions

Conditions	Yield
In neat (no solvent) at 50℃;	98%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 1-methyl-2-[(2,3,4,5,6-pentafluorobenzyl)thio]imidazole

: 3-methyl-1-(2,3,4,5,6-pentafluorobenzyl)-2-[(2,3,4,5,6-pentafluorobenzyl)thio]imidazol-1-ium bromide

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 144h; Inert atmosphere;	98%

: methyl (E)-3-(4-(prop–2–yn–1–ylamino)phenyl)acrylate

: 1765-40-8
(bromomethyl)pentafluorobenzene

: methyl (E)-3-(4-((((perfluorophenyl)methyl)(prop–2–yn–1–yl)amino)methyl)phenyl)acrylate

Conditions

Conditions	Yield
Stage #1: methyl (E)-3-(4-(prop–2–yn–1–ylamino)phenyl)acrylate With potassium carbonate In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: (bromomethyl)pentafluorobenzene In acetonitrile at 20℃; for 14h; Inert atmosphere;	98%

: C22H28O6P2

: 1765-40-8
(bromomethyl)pentafluorobenzene

: C36H30F10O6P2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;	98%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 30℃;	98%

: 641571-45-1
3-{[(tert-butyl)dimethylsilyl]oxy}-5-hydroxybenzyl alcohol

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 875051-01-7
3-{[(tert-butyl)dimethylsilyl]oxy}-5-[(2,3,4,5,6-pentafluorobenzyl)oxy]benzyl alcohol

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate In acetone at 20℃; for 72h;	97.5%

: 28177-48-2
2,6-difluorophenol

: 1765-40-8
(bromomethyl)pentafluorobenzene

1-(2,6-Difluoro-phenoxymethyl)-2,3,4,5,6-pentafluoro-benzene: 1-(2,6-Difluoro-phenoxymethyl)-2,3,4,5,6-pentafluoro-benzene

Conditions

Conditions	Yield
With potassium carbonate In acetone	97%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 157460-18-9
C15H17N3O2S2

: C22H19F5N3O2S2(1+)*Br(1-)

Conditions

Conditions	Yield
In dichloromethane for 12h; Heating;	97%

: 1765-40-8
(bromomethyl)pentafluorobenzene

: 6476-36-4
tris(1-methylethyl)phosphine

: 80438-16-0
Triisopropyl<(pentafluorphenyl)methyl>phosphoniumbromid

Conditions

Conditions	Yield
In benzene for 5h; Heating;	97%

2，3，4，5，6-Pentafluorobenzyl bromide Chemical Properties

Chemical Name: PENTAFLUOROBENZYL BROMIDE
IUPAC NAME: 1-(bromomethyl)-2,3,4,5,6-pentafluorobenzene
CAS No.: 1765-40-8
EINECS: 217-182-4
Molecular Formula: C₇H₂BrF₅
Molecular Weight: 260.99 g/mol
Melting Point: 19-20 °C(lit.)
Density: 1.864 g/cm³
Flash Point: 82.8 °C
Boiling Point: 173.2 °C at 760 mmHg
Sensitive: Lachrymatory
Following is the structure of 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):

Product Categories about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8) are Aromatic Halides (substituted) ; Analytical Chemistry ; Boronic Acid, etc. (GC Derivatizing Reagents) ; GC Derivatizing Reagents
The chemical synonymous of 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8) are 1-(Bromomethyl)-2,3,4,5,6-pentafluorobenzene ; 1-Bromomethylpentafluorobenzene ; Toluene, alpha-bromo-2,3,4,5,6-pentafluoro- ; PFBBR ; PENTAFLUOROBENZYL BROMIDE ; PENTAFLUOROBROMOMETHYL BENZENE ; (BROMOMETHYL)PENTAFLUOROBENZENE ; 2,3,4,5,6-PENTAFLUOROBENZYL BROMIDE

2，3，4，5，6-Pentafluorobenzyl bromide Safety Profile

Hazard Note: Irritant/Lachrymatory
Hazard Codes:
    C: Corrosive
    Xi: Irritant
Risk Statements about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):
    R22 Harmful if swallowed.
    R34 Causes burns.
    R36/37: Irritating to eyes and respiratory system.
    R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements about 2，3，4，5，6-Pentafluorobenzyl bromide (1765-40-8):
    S23 Do not breathe vapour.
    S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    S27 Take off immediately all contaminated clothing.
    S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
    S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

2，3，4，5，6-Pentafluorobenzyl bromide Specification

1. Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under an inert atmosphere.
2. Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
3. Personal Protection: Eyes: Wear chemical splash goggles.Skin: Wear chemical splash goggles. Wear appropriate protective gloves to prevent skin exposure.Clothing: Wear appropriate protective clothing to prevent skin exposure.Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
4. Fire Fighting: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustible liquid.Extinguishing Media: Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!

Product Name

PENTAFLUOROBENZYL BROMIDE

Synthetic route

2，3，4，5，6-Pentafluorobenzyl bromide Chemical Properties

2，3，4，5，6-Pentafluorobenzyl bromide Safety Profile

2，3，4，5，6-Pentafluorobenzyl bromide Specification

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