2,5-Dichloropyrimidine supplier

Name
2,5-Dichloropyrimidine
EINECS 639-415-2
CAS No. 22536-67-0
Article Data15
CAS DataBase
Density 1.493 g/cm³
Solubility Slightly soluble in water.
Melting Point 57.0-57.5 °C
Formula C₄H₂Cl₂N₂
Boiling Point 265.3 °C at 760 mmHg
Molecular Weight 148.979
Flash Point 139.8 °C
Transport Information
Appearance
Safety 26-39-61
Risk Codes 22-41-50
Molecular Structure
Hazard Symbols C
Synonyms 2,5-Dichlorpyrimidin;
PSA 25.78000
LogP 1.78340

Synthetic route

: 1003845-06-4
(2-chloropyrimidin-5-yl)boronic acid

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
With N-chloro-succinimide; copper(l) chloride In acetonitrile at 80℃; for 16h;	75%

: 5428-89-7
5-chloropyrimidin-2-amine

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite

: 54326-16-8
5-chloropyrimidin-2-one

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
With trichlorophosphate

: 38353-09-2
2-hydroxypyrimidine hydrochloride

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
With chlorine; N,N-dimethyl-aniline; trichlorophosphate Yield given. Multistep reaction;

: 54326-16-8
2-hydroxy-5-chloropyrimidine

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: 5-chloro-2-hydroxypyrimidine With N,N-dimethyl-aniline; trichlorophosphate at 120℃; for 1h; Stage #2: With water at 0℃;
Stage #1: 5-chloro-2-hydroxypyrimidine With N,N-dimethyl-aniline; trichlorophosphate at 120℃; for 1h; Stage #2: With water
With trichlorophosphate In N,N-dimethyl-aniline at 120℃; for 1h; Inert atmosphere;	6 g

: 5750-76-5
2,4,5-trichloropyrimidine

: 22536-67-0
2,5-dichloropyrimidine

Conditions

Conditions	Yield
Stage #1: 2,4,5-trichloropyrimidine With hydrogen; palladium 10% on activated carbon In methanol at 50℃; for 2h; Stage #2: With sodium hydrogencarbonate In methanol; water at 20℃;
With acetic acid; zinc In tetrahydrofuran at 20℃; for 2h; Heating; Reflux;
With acetic acid; zinc In tetrahydrofuran for 2h; Reflux;
Stage #1: 2,4,5-trichloropyrimidine With acetic acid; zinc In tetrahydrofuran for 2h; Reflux; Stage #2: With sodium hydrogencarbonate; sodium hydroxide In dichloromethane; water pH=10;
With acetic acid; zinc In tetrahydrofuran at 20℃; Reflux;

: 22536-67-0
2,5-dichloropyrimidine

: sodium salt of ethyl cyanoacetate

: 65364-65-0
(5-Chloro-pyrimidin-2-yl)-cyano-acetic acid ethyl ester

Conditions

Conditions	Yield
at 70℃; for 3h;	100%

: 22536-67-0
2,5-dichloropyrimidine

: C26H28N2O3S

: C30H29ClN4O3S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol Reflux;	100%

: 22536-67-0
2,5-dichloropyrimidine

: 1-((1r,4r)-4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)cyclohexyl)piperazine dihydrochloride

: 5-chloro-2-(4-((1r,4r)-4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)cyclohexyl)piperazin-1-yl)pyrimidine

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 80℃; for 3h;	97%

: 22536-67-0
2,5-dichloropyrimidine

: 5-bromo-1-(4,4,4-trifluorobutyl)indazol-7-ol

: 5-bromo-7-(5-chloropyrimidin-2-yl)oxy-1-(4,4,4-trifluorobutyl)indazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	97%

: 22536-67-0
2,5-dichloropyrimidine

: 111-26-2
hexan-1-amine

: 5-chloro-N-hexylpyrimidin-2-amine

Conditions

Conditions	Yield
With potassium phosphate; (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; copper(II) acetate monohydrate In water at 30℃; for 22h; Schlenk technique; Inert atmosphere;	97%

: 22536-67-0
2,5-dichloropyrimidine

: 7486-35-3
tri-n-butyl(vinyl)tin

: 131467-02-2
2-chloro-4-vinylpyrimidine

Conditions

Conditions	Yield
With 2-chloro-4-pyrimidine In 1,2-dichloro-ethane at 70℃; for 2h;	94%

: 22536-67-0
2,5-dichloropyrimidine

: 20194-18-7
sodium phenyl-methanolate

: 2-benzyloxy-5-chloropyrimidine

Conditions

Conditions	Yield
In benzyl alcohol Ambient temperature;	94%

: 22536-67-0
2,5-dichloropyrimidine

: 3-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyloxy)pyrazine-2-carbonitrile hydrochloride

: 3-((1r,4r)-4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)cyclohexyloxy)pyrazine-2-carbonitrile

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol at 120℃; for 3h; Microwave irradiation;	93.1%

: 680-31-9
N,N,N,N,N,N-hexamethylphosphoric triamide

: 22536-67-0
2,5-dichloropyrimidine

: 5-chloro-2-N,N-dimethylaminopyrimidine

Conditions

Conditions	Yield
Heating;	92%

: 22536-67-0
2,5-dichloropyrimidine

: 927-74-2
1-butyn-4-ol

: 1356542-25-0
2-(but-3-ynyloxy)-5-chloropyrimidine

Conditions

Conditions	Yield
Stage #1: 3-Butyn-1-ol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,5-dichloropyrimidine In tetrahydrofuran at 20℃; for 17h; Inert atmosphere;	92%
Stage #1: 3-Butyn-1-ol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,5-dichloropyrimidine In tetrahydrofuran at 20℃; for 17h; Inert atmosphere;	92%
Stage #1: 3-Butyn-1-ol With sodium hydride In tetrahydrofuran at 0℃; for 1h; Stage #2: 2,5-dichloropyrimidine In tetrahydrofuran at 20℃;	57%

: 22536-67-0
2,5-dichloropyrimidine

: 1-(4,4,4-trifluorobutyl)indazol-7-ol

: 7-(5-chloropyrimidin-2-yl)oxy-1-(4,4,4-trifluorobutyl)indazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	91%

: 22536-67-0
2,5-dichloropyrimidine

: 3-(4,4,4-trifluorobutyl)benzotriazol-4-ol

: 7-(5-chloropyrimidin-2-yl)oxy-1-(4,4,4-trifluorobutyl)benzotriazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	91%

: 22536-67-0
2,5-dichloropyrimidine

: 1-(4,4,4-trifluorobutyl)-3-(trifluoromethyl)indazol-7-ol

: 7-(5-chloropyrimidin-2-yl)oxy-1-(4,4,4-trifluorobutyl)-3-(trifluoromethyl)indazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	90%

: 7774-74-5
Thiophene-2-thiol

: 22536-67-0
2,5-dichloropyrimidine

: 2-(thien-2-yl)thio-5-chloropyrimidine

Conditions

Conditions	Yield
With NaOEt	89%

: 123-75-1
pyrrolidine

: 22536-67-0
2,5-dichloropyrimidine

: 5-chloro-2-(pyrrolidin-1-yl)pyrimidine

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; 4-phenyl-N-methylpyridinium iodide; 4,4'-di-tert-butyl-2,2'-bipyridine; zinc In dimethyl sulfoxide at 80℃; for 8h; Reagent/catalyst; Inert atmosphere;	89%

: 22536-67-0
2,5-dichloropyrimidine

: (S)-3-((4-bromo-2-fluorophenoxy)methyl)pyrrolidine hydrochloride

: (S)-2-(3-((4-bromo-2-fluorophenoxy)methyl)pyrrolidin-1-yl)-5-chloropyrimidine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 150℃; for 3h; Solvent; Microwave irradiation;	88.2%
With triethylamine In N,N-dimethyl acetamide at 150℃; for 3h; Microwave irradiation;	88%

: 22536-67-0
2,5-dichloropyrimidine

: 64099-82-7
1-propynyltributylstannane

: 5-chloro-2-(prop-1-yn-1-yl)pyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride In 1,4-dioxane at 80℃;	88%

: 22536-67-0
2,5-dichloropyrimidine

: 4-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile dihydrochloride

: 1415818-51-7
4-((1r,4r)-4-(1-(5-chloropyrimidin-2-yl)piperidin-4-yloxy)cyclohexyloxy)nicotinonitrile

Conditions

Conditions	Yield
With potassium carbonate In isopropyl alcohol at 100℃; for 4h; Microwave irradiation;	87.7%

: 110-91-8
morpholine

: 22536-67-0
2,5-dichloropyrimidine

: 124595-95-5
4-(5-chloropyrimidin-2-yl)morpholine

Conditions

Conditions	Yield
With potassium phosphate; (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; copper(II) acetate monohydrate In water at 30℃; for 22h; Schlenk technique; Inert atmosphere; chemoselective reaction;	87%

: 22536-67-0
2,5-dichloropyrimidine

: 4-hydroxy-3-(4,4,4-trifluorobutyl)-3H-isobenzofuran-1-one

: 4-[(5-chloro-2-pyrimidinyl)oxy]-3-(4,4,4-trifluorobutyl)-1(3H)-isobenzofuranone

Conditions

Conditions	Yield
With potassium phosphate In toluene at 110℃; for 3h;	86%

: 22536-67-0
2,5-dichloropyrimidine

: 4-chloro-1-(4,4,4-trifluorobutyl)indazol-7-ol

: 4-chloro-7-(5-chloropyrimidin-2-yl)oxy-1-(4,4,4-trifluorobutyl)indazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	85%

: 22536-67-0
2,5-dichloropyrimidine

: 1060735-14-9
9-phenyl-3,3'-bicarbazole

: C34H21ClN4

Conditions

Conditions	Yield
Stage #1: 9-phenyl-3,3'-bicarbazole With sodium hydride In N,N-dimethyl-formamide for 0.5h; Stage #2: 2,5-dichloropyrimidine In N,N-dimethyl-formamide at 20℃; for 4h;	84%

: 6457-49-4
4-piperidinemethanol

: 22536-67-0
2,5-dichloropyrimidine

: (1-(5-chloropyrimidin-2-yl)piperidin-4-yl)methanol

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 16h; Reflux;	82.4%
With triethylamine In acetonitrile for 16h; Reflux;	82.4%

: 22536-67-0
2,5-dichloropyrimidine

: 1-[4-[6-(aminomethyl)-2-methyl-pyrimidin-4-yl]oxyphenyl]-N-methyl-methanesulfonamide

: 1-[4-[6-[[(5-chloropyrimidin-2-yl)amino]methyl]-2-methyl-pyrimidin-4-yl]oxyphenyl]-N-methyl-methanesulfonamide

Conditions

Conditions	Yield
With potassium fluoride In dimethyl sulfoxide at 120℃; for 2h;	82%

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 22536-67-0
2,5-dichloropyrimidine

: 1204310-31-5
3-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)propan-1-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 60℃;	82%

: 22536-67-0
2,5-dichloropyrimidine

: 147081-49-0
(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester

: (R)-tert-butyl 3-((5-chloropyrimidin-2-yl)amino)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 30℃;	81%

: 5308-25-8
4-ethylpiperazine

: 22536-67-0
2,5-dichloropyrimidine

: 5-chloro-2-(4-{2-[(5-chloropyrimidin-2-yl)sulfanyl]ethyl}piperazin-1-yl)pyrimidine

Conditions

Conditions	Yield
With sodium sulfide In toluene at 40℃; for 12h;	80%

: 22536-67-0
2,5-dichloropyrimidine

: 124-41-4
sodium methylate

: 38373-44-3
2-methoxy-5-chloropyrimidine

Conditions

Conditions	Yield
In methanol at 20℃; for 1h; Sealed tube; regioselective reaction;	80%

: 22536-67-0
2,5-dichloropyrimidine

: (R)-3-hydroxy-1-(piperidin-4-yl)pyrrolidin-2-one hydrochloride

: (R)-1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)-3-hydroxypyrrolidin-2-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	80%

: 22536-67-0
2,5-dichloropyrimidine

: 98-80-6
phenylboronic acid

: 29134-16-5
2,5-diphenylpyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃; Suzuki coupling;	79%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 90℃;	79%

2,5-Dichloropyrimidine Chemical Properties

The molecular formula of 2,5-Dichloropyrimidine(22536-67-0) is C₄H₂Cl₂N₂ and its formula weight is 148.98.
The density of 2,5-Dichloropyrimidine(22536-67-0) is 1.493 g/cm³ and it has a melting point of 57.0-57.5°C. The boiling point is 265.3 °C at 760 mmHg. The refractive index is about 1.559 . Its flash point is 139.8 °C .
The chemical synonyms of 2,5-Dichloropyrimidine(22536-67-0) are 2,5-DICHLOROPYRIMIDINE;Pyrimidine, 2,5-dichloro- (7CI,8CI,9CI);2,5-DICHLOROPYRIMIDINE,PURITY:95% MIN(HPLC);Pyrimidine, 2,5-dichloro-
The molecular structure of 2,5-Dichloropyrimidine(22536-67-0):

2,5-Dichloropyrimidine Safety Profile

Hazard Codes C

Product Name

2,5-Dichloropyrimidine

Synthetic route

2,5-Dichloropyrimidine Chemical Properties

2,5-Dichloropyrimidine Safety Profile

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