Product Name

  • Name

    2-Methylresorcinol

  • EINECS 210-155-8
  • CAS No. 608-25-3
  • Article Data35
  • CAS DataBase
  • Density 1.21 g/cm3
  • Solubility Soluble in water and methanol.
  • Melting Point 114-120 °C(lit.)
  • Formula C7H8O2
  • Boiling Point 282.1 °C at 760 mmHg
  • Molecular Weight 124.139
  • Flash Point 142.9 °C
  • Transport Information UN 2811 6.1/PG 3
  • Appearance White to off-white crystal powder
  • Safety 26-36-45-37/39-28A-36/37/39-27
  • Risk Codes 25-36/37/38-34-20/21/22
  • Molecular Structure Molecular Structure of 608-25-3 (2-Methylresorcinol)
  • Hazard Symbols ToxicT, CorrosiveC
  • Synonyms Resorcinol,2-methyl- (7CI,8CI);1,3-Dihydroxy-2-methylbenzene;2,6-Dihydroxytoluene;2-Methyl-1,3-benzenediol;2-Methyl-1,3-dihydroxybenzene;2-Methylresorcin;1,3-Benzenediol,2-methyl-;Toluene-2,6-diol;
  • PSA 40.46000
  • LogP 1.40620

Synthetic route

3,5-diamino-4-methylbenzoic acid
6633-36-9

3,5-diamino-4-methylbenzoic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Stage #1: 3,5-diamino-4-methylbenzoic acid With sulfuric acid; zinc(II) chloride; sodium nitrite In water at 2℃; for 5h;
Stage #2: With sulfuric acid; sodium hydroxide In water for 1.75h; Reflux;
98.9%
2-methylcyclohexane-1,3-dione
1193-55-1

2-methylcyclohexane-1,3-dione

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With 5 mol% Pd/C; hydrogen; potassium carbonate In N,N-dimethyl acetamide at 150℃; under 532.036 Torr; for 20h;92%
palladium-carbon In 1,3,5-trimethyl-benzene71%
69.9%
methanol
67-56-1

methanol

recorcinol
108-46-3

recorcinol

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With SO42-/ZrO2-TiO2 at 350℃; Reagent/catalyst;66.1%
2,6-dimethoxytoluene
5673-07-4

2,6-dimethoxytoluene

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With pyridinium hydrobromide perbromide In xylene for 2h; Heating;65%
2-methylcyclohexane-1,3-dione
1193-55-1

2-methylcyclohexane-1,3-dione

A

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

B

3-hydroxy-2-methyl-1-cyclohexanone
102547-88-6

3-hydroxy-2-methyl-1-cyclohexanone

Conditions
ConditionsYield
With bis(η5-cyclopentadienyl)hafnium dihydride In isopropyl alcohol at 80℃; for 8h;A 39%
B 52%
ortho-cresol
95-48-7

ortho-cresol

A

4-methyl resorcinol
496-73-1

4-methyl resorcinol

B

2-methylbenzene-1,4-diol
95-71-6

2-methylbenzene-1,4-diol

C

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

D

3-methylbenzene-1,2-diol
488-17-5

3-methylbenzene-1,2-diol

Conditions
ConditionsYield
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -40℃; for 0.5h; Product distribution;A 3%
B 17%
C 3%
D 4%
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -40℃; for 0.5h;A 3%
B 17%
C 3%
D 4%
3-methoxy-2-methylphenol
6971-52-4

3-methoxy-2-methylphenol

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With hydrogen iodide
2,6-dihydroxybenzaldehyde
387-46-2

2,6-dihydroxybenzaldehyde

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With hydrogenchloride; amalgamated zinc at 100℃;
2,4-dihydroxy-3-methylbenzoic acid
4707-49-7

2,4-dihydroxy-3-methylbenzoic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
at 220℃;
methyl 2,4-dihydroxy-3-methylbenzoate
33662-58-7

methyl 2,4-dihydroxy-3-methylbenzoate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With potassium hydroxide unter Wasserstoff;
2-hydroxy-4-methoxy-3-methylbenzoic acid
116371-82-5

2-hydroxy-4-methoxy-3-methylbenzoic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With hydrogen iodide
6-acetoxy-6-methylcyclohexa-2,4-dienone
7577-74-4

6-acetoxy-6-methylcyclohexa-2,4-dienone

acetic acid
64-19-7

acetic acid

A

4-methyl resorcinol
496-73-1

4-methyl resorcinol

B

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

C

3-methylbenzene-1,2-diol
488-17-5

3-methylbenzene-1,2-diol

Conditions
ConditionsYield
at 110℃; beim anschliessenden Erwaermen mit wss.-methanol. HCl;
2-Chlor-2-methyl-cyclohexandion-(1,3)
52956-17-9

2-Chlor-2-methyl-cyclohexandion-(1,3)

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
(i) HCl, DMF, (ii) aq. HCl; Multistep reaction;
6-acetoxy-6-methylcyclohexa-2,4-dienone
7577-74-4

6-acetoxy-6-methylcyclohexa-2,4-dienone

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
(i) Ac2O, H2SO4, (ii) Py, (iii) aq. NaOH, MeOH; Multistep reaction;
2-oxy-6-amino-toluene

2-oxy-6-amino-toluene

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With sulfuric acid Diazotization;
2-hydroxy-4-methoxy-3-methylbenzoic acid
116371-82-5

2-hydroxy-4-methoxy-3-methylbenzoic acid

hydrogen iodide
10034-85-2

hydrogen iodide

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4-hydroxysalicylic acid
89-86-1

4-hydroxysalicylic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium; methanol / dann die Mischung mit Methyljodid versetzen
2: hydriodic acid
View Scheme
methyl 2,4-dihydroxybenzoate
2150-47-2

methyl 2,4-dihydroxybenzoate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: aluminium chloride; diethyl ether / Einleiten von Chlorwasserstoff und anschliessendes Erwaermen mit Wasser
2: aq. NaOH solution
3: 100 - 110 °C
4: amalgamated zinc; aqueous HCl / 100 °C
View Scheme
5-carbomethoxy-6-hydroxysalicylaldehyde
39503-26-9

5-carbomethoxy-6-hydroxysalicylaldehyde

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. NaOH solution
2: 100 - 110 °C
3: amalgamated zinc; aqueous HCl / 100 °C
View Scheme
3-formyl-2, 4-dihydroxybenzoic acid
4435-88-5

3-formyl-2, 4-dihydroxybenzoic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 - 110 °C
2: amalgamated zinc; aqueous HCl / 100 °C
View Scheme
MCPA
94-74-6

MCPA

A

4,6-dichloro-2-methylphenol
1570-65-6

4,6-dichloro-2-methylphenol

B

2-methyl-4-chlorophenol
1570-64-5

2-methyl-4-chlorophenol

C

2-methylbenzene-1,4-diol
95-71-6

2-methylbenzene-1,4-diol

D

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

E

2,5-dihydroxy-3-methylbenzoaldehyde
108372-60-7

2,5-dihydroxy-3-methylbenzoaldehyde

F

2-Methyl-1,4-benzoquinone
553-97-9

2-Methyl-1,4-benzoquinone

G

ortho-cresol
95-48-7

ortho-cresol

H

3-methylbenzene-1,2-diol
488-17-5

3-methylbenzene-1,2-diol

I

2-chloro-6-methylphenol
87-64-9

2-chloro-6-methylphenol

J

5-chloro-7-methyl-3H-benzofuran-2-one

5-chloro-7-methyl-3H-benzofuran-2-one

Conditions
ConditionsYield
With water UV-irradiation;
3-chloro-o-cresol
3260-87-5

3-chloro-o-cresol

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Stage #1: 3-chloro-o-cresol With sodium formate; copper(l) chloride; sodium hydroxide; sodium sulfite In water at 195 - 200℃; under 7500.75 - 9000.9 Torr; Autoclave; Large scale;
Stage #2: With hydrogenchloride In water Large scale;
Stage #1: 3-chloro-o-cresol With sodium formate; copper(l) chloride; sodium hydroxide at 195 - 200℃; for 1.5h; Autoclave;
Stage #2: With hydrogenchloride In water at 30℃; pH=2 - 3;
p-Toluic acid
99-94-5

p-Toluic acid

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; nitric acid / methanol / 3 h / 10 - 60 °C
2.1: iron(III) chloride; manganese(IV) oxide; hydrazine hydrate / diethyl ether / 4 h / 80 °C / Reflux
3.1: sulfuric acid; zinc(II) chloride; sodium nitrite / water / 5 h / 2 °C
3.2: 1.75 h / Reflux
View Scheme
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

dicyanozinc
557-21-1

dicyanozinc

2,4-dihydroxy-3-methylbenzaldehyde
6248-20-0

2,4-dihydroxy-3-methylbenzaldehyde

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether at 20℃;100%
With hydrogenchloride; water 1.) ether, 45 min, 2.) 40 deg C; Yield given. Multistep reaction;
With hydrogenchloride
With hydrogenchloride In diethyl ether at 20℃; Gattermann formylation;
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

methyl iodide
74-88-4

methyl iodide

2,6-dimethoxytoluene
5673-07-4

2,6-dimethoxytoluene

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide100%
4-hydroxyphenylacetate
156-38-7

4-hydroxyphenylacetate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2,4,4'-trihydroxy-3-methyldeoxybenzoin
139256-03-4

2,4,4'-trihydroxy-3-methyldeoxybenzoin

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 110℃; for 0.5h; Heating / reflux;99%
With boron trifluoride diethyl etherate at 60 - 70℃; for 5h;97%
With boron trifluoride diethyl etherate at 110℃; for 2h; Inert atmosphere;
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4,6-dibromo-2-methylbenzene-1,3-diol
63992-60-9

4,6-dibromo-2-methylbenzene-1,3-diol

Conditions
ConditionsYield
With benzyltrimethylammonium tribromide In methanol; dichloromethane99%
With benzyltrimethylammonium tribromide In methanol; dichloromethane for 1h; Ambient temperature;93%
With benzyltrimethylammonium tribromide70%
With bromine In acetic acid
With bromine In dichloromethane for 2h;5.54 g
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

acetic anhydride
108-24-7

acetic anhydride

1-(2,4-dihydroxy-3-methylphenyl)ethanone
10139-84-1

1-(2,4-dihydroxy-3-methylphenyl)ethanone

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 80℃; for 6h;99%
Stage #1: 2-methylbenzene-1,3-diol With boron trifluoride diethyl etherate at 70℃; Friedel-Crafts Acylation;
Stage #2: acetic anhydride at 20 - 80℃; for 7h;
95%
Stage #1: 2-methylbenzene-1,3-diol With boron trifluoride diethyl etherate at 70℃;
Stage #2: acetic anhydride at 80℃; for 6h;
85%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ethyl 2-oxocyclohexane carboxylate
1655-07-8

ethyl 2-oxocyclohexane carboxylate

3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one
55047-37-5

3-Hydroxy-4-methyl-7,8,9,10-tetrahydro-6H-dibenzopyran-6-one

Conditions
ConditionsYield
With sulfuric acid at 0℃; for 2.5h;99%
With sulfuric acid In ethanol at 0 - 20℃; Pechmann condensation;84%
With sulfuric acid In water at 20℃; for 15h; Pechmann condensation;71%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

benzyl chloride
100-44-7

benzyl chloride

1,3-bisbenzyloxy-2-methylbenzene
124317-11-9

1,3-bisbenzyloxy-2-methylbenzene

Conditions
ConditionsYield
With potassium phosphate In dimethyl sulfoxide at 60℃; for 1.33333h;99%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

1-O-acetyl-2,3,4-tri-O-benzyl-L-fucopyranose
151909-89-6

1-O-acetyl-2,3,4-tri-O-benzyl-L-fucopyranose

1,3-dihydroxy-2-methyl-4,6-bis(2,3,4-tri-O-benzyl-β-L-fucopyranosyl)benzene

1,3-dihydroxy-2-methyl-4,6-bis(2,3,4-tri-O-benzyl-β-L-fucopyranosyl)benzene

Conditions
ConditionsYield
With calcium sulfate; scandium tris(trifluoromethanesulfonate) In 1,2-dichloro-ethane at -30 - 0℃; for 2.5h;99%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ethyl m-toluoylacetate
33166-79-9

ethyl m-toluoylacetate

7-hydroxy-8-methyl-4-(3-methylphenyl)-2H-chromen-2-one

7-hydroxy-8-methyl-4-(3-methylphenyl)-2H-chromen-2-one

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 3h; Pechmann Condensation;99%
With sulfuric acid In water at 20℃; for 3h; Pechmann Condensation;88%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

N-(4,4-diethoxybutyl)-4-methylbenzenesulfonylamide
858005-68-2

N-(4,4-diethoxybutyl)-4-methylbenzenesulfonylamide

N,N',N'',N'''-((14,16,34,36,54,56,74,76-octahydroxy-15,35,55,75-tetramethyl-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-2,4,6,8-tetrayl)tetrakis(propane-3,1-diyl))tetrakis(4-methylbenzenesulfonamide)

N,N',N'',N'''-((14,16,34,36,54,56,74,76-octahydroxy-15,35,55,75-tetramethyl-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-2,4,6,8-tetrayl)tetrakis(propane-3,1-diyl))tetrakis(4-methylbenzenesulfonamide)

Conditions
ConditionsYield
With trifluoroacetic acid In chloroform at 20℃; for 24h;99%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

malononitrile
109-77-3

malononitrile

C17H13BrN2O2

C17H13BrN2O2

Conditions
ConditionsYield
With cholin hydroxide In water at 20℃; for 0.833333h;99%
With choline acetate at 20℃; for 12h;60%
With choline acetate at 20℃; for 12h;60%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ethyl 3-(3,4-dichloroisothiazol-5-yl)-3-oxopropionate

ethyl 3-(3,4-dichloroisothiazol-5-yl)-3-oxopropionate

C13H7Cl2NO3S

C13H7Cl2NO3S

Conditions
ConditionsYield
With trifluoroacetic acid Reflux;99%
dimethylaminoacetaldehyde diethyl acetal
3616-56-6

dimethylaminoacetaldehyde diethyl acetal

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

1-amino-2,2-bis(2,4-dihydroxy-3-methylphenyl)-N,N-dimethylethane hydrochloride
1211322-47-2

1-amino-2,2-bis(2,4-dihydroxy-3-methylphenyl)-N,N-dimethylethane hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 90℃; for 12h;98.5%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2-methyl-4-nitrosobenzene-1,3-diol
65882-00-0

2-methyl-4-nitrosobenzene-1,3-diol

Conditions
ConditionsYield
With sulfuric acid; sodium nitrite In water98%
With sulfuric acid; sodium nitrite In water at 0℃; for 0.5h;
With sulfuric acid; sodium nitrite In water at 20℃; for 0.75h;
With sulfuric acid; sodium nitrite In water at 0℃; for 2h;
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

2,8,14,20-tetrakis(4-bromophenyl)-5,11,17,23-tetramethylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaen-4,6,10,12,16,18,22,24-octol
216759-95-4

2,8,14,20-tetrakis(4-bromophenyl)-5,11,17,23-tetramethylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaen-4,6,10,12,16,18,22,24-octol

Conditions
ConditionsYield
With hydrogenchloride In ethanol Cyclization; Heating;98%
ethyl 4-nitrobenzoylacetate
838-57-3

ethyl 4-nitrobenzoylacetate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

7-hydroxy-8-methyl-4-(4-nitrophenyl)chromen-2-one

7-hydroxy-8-methyl-4-(4-nitrophenyl)chromen-2-one

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 1.5h; Pechmann Condensation;98%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

acetic anhydride
108-24-7

acetic anhydride

2-methyl-1,3-phenylene diacetate
35236-42-1

2-methyl-1,3-phenylene diacetate

Conditions
ConditionsYield
With magnesium In neat (no solvent) at 25℃; for 18h; Temperature;98%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ethyl acetoacetate
141-97-9

ethyl acetoacetate

4,8-dimethyl-7-hydroxycoumarin
4115-76-8

4,8-dimethyl-7-hydroxycoumarin

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; silica gel for 0.05h; Pechmann reaction; microwave irradiation;97%
With bispyridine cobalt(II) chloride for 0.0333333h; Pechmann condensation; Microwave irradiation; neat (no solvent);97%
With silica gel for 0.0416667h; Pechmann condensation; Microwave irradiation;97%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

7-hydroxy-8-methyl-4-phenyl-chromen-2-one
21392-48-3

7-hydroxy-8-methyl-4-phenyl-chromen-2-one

Conditions
ConditionsYield
With sulfuric acid; silica gel at 80℃; for 0.5h; Pechmann condensation reaction;97%
With potassium aluminum sulfate at 80℃; for 2h; Pechmann reaction;95%
With sulfuric acid In water at 20℃; for 3h; Pechmann Condensation;93%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

malononitrile
109-77-3

malononitrile

2-amino-7-hydroxy-8-methyl-4-(4-chlorophenyl)-4H-chromene-3-carbonitrile
753455-99-1

2-amino-7-hydroxy-8-methyl-4-(4-chlorophenyl)-4H-chromene-3-carbonitrile

Conditions
ConditionsYield
With cholin hydroxide In water at 20℃; for 0.666667h;97%
With choline acetate at 20℃; for 9h;70%
With choline acetate at 20℃; for 9h;70%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

malononitrile
109-77-3

malononitrile

C17H13BrN2O2

C17H13BrN2O2

Conditions
ConditionsYield
With cholin hydroxide In water at 20℃; for 0.666667h;97%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2-chloro-benzaldehyde
89-98-5

2-chloro-benzaldehyde

malononitrile
109-77-3

malononitrile

C17H13ClN2O2

C17H13ClN2O2

Conditions
ConditionsYield
With cholin hydroxide In water at 20℃; for 0.666667h;97%
ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one
163684-50-2

4-(chloromethyl)-7-hydroxy-8-methyl-2H-chromen-2-one

Conditions
ConditionsYield
zirconium(IV) chloride at 20℃; for 0.0833333h;96%
With ammonium cerium(IV) nitrate; silica gel for 0.05h; Pechmann reaction; microwave irradiation;94%
Stage #1: ethyl (2-chloroaceto)acetate With sulfuric acid at 0℃;
Stage #2: 2-methylbenzene-1,3-diol at 20℃;
91%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

malononitrile
109-77-3

malononitrile

C17H13N3O4

C17H13N3O4

Conditions
ConditionsYield
With cholin hydroxide In water at 20℃; for 4.5h;96%
carbon dioxide
124-38-9

carbon dioxide

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2,4-dihydroxy-3-methylbenzoic acid
4707-49-7

2,4-dihydroxy-3-methylbenzoic acid

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 30℃; under 15001.5 Torr; for 24h; Kolbe-Schmidt Synthesis; Autoclave;95%
With potassium hydrogencarbonate In water for 5h; Heating;42%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

4,6-diiodo-2-methyl-1,3-benzenediol
114971-54-9

4,6-diiodo-2-methyl-1,3-benzenediol

Conditions
ConditionsYield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; dichloromethane for 4h; Ambient temperature;95%
ethyl 3,3-diethoxypropanoate
10601-80-6

ethyl 3,3-diethoxypropanoate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

7-hydroxy-8-methyl-2H-chromen-2-one
2732-17-4

7-hydroxy-8-methyl-2H-chromen-2-one

Conditions
ConditionsYield
Stage #1: ethyl 3,3-diethoxypropanoate; 2-methylbenzene-1,3-diol at 120℃;
Stage #2: With sulfuric acid; trifluoroacetic acid at 20℃; for 0.5h;
95%
2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

acetoacetic acid methyl ester
105-45-3

acetoacetic acid methyl ester

4,8-dimethyl-7-hydroxycoumarin
4115-76-8

4,8-dimethyl-7-hydroxycoumarin

Conditions
ConditionsYield
With Fe3O4-SiO2-HMTA nanomaterial In neat (no solvent) at 100℃; for 0.25h; Green chemistry;95%
With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate at 80℃; for 1.5h; Pechmann condensation;92%
With potassium hydrogensulfate at 90℃; for 4h; Pechmann condensation;92%
With poly(4-vinylpyridine)-supported copper iodide In neat (no solvent) at 80℃; for 0.25h; Pechmann Condensation; Green chemistry;87%
(η6-chlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate

(η6-chlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate

2-methylbenzene-1,3-diol
608-25-3

2-methylbenzene-1,3-diol

2-methyl-1,3-bis((η6-phenoxy-η5-cyclopentadienyl)iron)benzene hexafluorophosphate

2-methyl-1,3-bis((η6-phenoxy-η5-cyclopentadienyl)iron)benzene hexafluorophosphate

Conditions
ConditionsYield
With ammonium hexafluorophosphate; potassium carbonate In water; N,N-dimethyl-formamide addn. of the Fe-complex and ligand to K2CO3 and DMF, stirring for 12 h at room temp. under N2, filtn. into aq. HCl, pptn., addn. of acetone, evapn. (vac.) and addn. of a aq. soln. of NH4PF6; filtn., washing with cold water, drying for several hours under vacuum, washing (Et2O), further drying, elem. anal.;95%

2-Methylresorcinol Chemical Properties


IUPAC Name: 2-Methylbenzene-1,3-diol
Molecular Formula: C7H8O2
Molecular Weight: 124.14 g/mol
SMILES: Oc1cccc(O)c1C Copy 
InChI: InChI=1/C7H8O2/c1-5-6(8)3-2-4-7(5)9/h2-4,8-9H,1H3
EINECS: 210-155-8
Product Categories: Intermediates of Dyes and Pigments; Aromatic Hydrocarbons (substituted) & Derivatives; Benzene derivates; Organic Chemicals; Dye Intermediate
Melting Point: 114-120 °C(lit.)
Index of Refraction: 1.594
Molar Refractivity: 34.84 cm3 
Molar Volume: 102.5 cm3
Surface Tension: 51.6 dyne/cm
Density: 1.21 g/cm3 
Flash Point: 142.9 °C 
Enthalpy of Vaporization:  54.18 kJ/mol 
Boiling Point: 282.1 °C at 760 mmHg 
Vapour Pressure of 2-Methylresorcinol (CAS NO.608-25-3): 0.00201 mmHg at 25 °C

2-Methylresorcinol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 200mg/kg (200mg/kg)   Journal of the American College of Toxicology. Vol. 5(3), Pg. 167, 1986.

2-Methylresorcinol Consensus Reports

Reported in EPA TSCA Inventory.

2-Methylresorcinol Safety Profile

A poison by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors.
Hazard Codes: ToxicT, CorrosiveC
Risk Statements: 25-36/37/38-34-20/21/22 
R25 :Toxic if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R34:Causes burns. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36-45-37/39-28A-36/37/39-27 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S37/39:Wear suitable gloves and eye/face protection. 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S27:Take off immediately all contaminated clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: VH2009500
HazardClass: 6.1
PackingGroup of 2-Methylresorcinol (CAS NO.608-25-3): III

2-Methylresorcinol Specification

  2-Methylresorcinol (CAS NO.608-25-3), its Synonyms are 1,3-Benzenediol, 2-methyl- ; 2-Methyl-1,3-benzenediol ; 1,3-Dihydroxy-2-methylbenzene ; 2,6-Dihydroxytoluene ; 2-Methyl-1,3-dihydroxybenzene ; 2-Methylresorcin . It is white to off-white crystal powder.

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