2-Piperidinoethanol supplier

Name
2-Piperidinoethanol
EINECS 221-244-6
CAS No. 3040-44-6
Article Data54
CAS DataBase
Density 0.974 g/cm³
Solubility
Melting Point 16 °C
Formula C₇H₁₅NO
Boiling Point 200.5 °C at 760 mmHg
Molecular Weight 129.202
Flash Point 91.2 °C
Transport Information UN 2735
Appearance clear colourless liquid
Safety 36/37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 1-(2-Hydroxyethyl)piperidine;2-(1-Piperidino)ethanol;2-(1-Piperidinyl)ethanol;2-(N-Piperidino)ethanol;2-(Piperid-1-yl)ethanol;1-Piperidineethanol;N-(2-Hydroxyethyl)piperidine;N-(b-Hydroxyethyl)piperidine;N-Piperidineethanol;N-Piperidinoethanol;NSC 3460;b-Piperidinoethanol;
PSA 23.47000
LogP 0.40250

Synthetic route

: 110-89-4
piperidine

: 540-51-2
2-bromoethanol

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 16h;	99%
at 80℃; for 72h;	85%
With sodium carbonate In acetonitrile at 20℃; for 48h; Reflux;	36.8%

: 23853-10-3
piperidin-1-yl-acetic acid ethyl ester

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 5h; Glovebox; Autoclave;	96%
With ethanol; ruthenium(bis[2‐(ethylsulfanyl)ethyl]amine)(dichloro)(triphenylphosphine); potassium tert-butylate In toluene at 80℃; for 16h;	95%
With ethanol; nickel at 50℃; under 110326 - 147102 Torr; Hydrogenation;

: 58583-90-7
methyl 2-piperidylacetate

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); hydrogen; sodium methylate In methanol at 100℃; under 37503.8 Torr; for 16h; Autoclave; Inert atmosphere;	86%

: 136616-35-8
1-(2-(2-methoxy-4-nitrophenoxy)ethyl)piperidine

A: 110-89-4
piperidine

B: 766-09-6
1-ethyl-piperidine

C: 3040-44-6
1-piperidinoethanol

D: 3251-56-7
2-methoxy-4-nitrophenol

E: 3-Azonia-spiro[2.5]octane

F: 3-methoxy-4-(2-(piperidin-1-yl)ethoxy)aniline

Conditions

Conditions	Yield
In acetonitrile Rate constant; Product distribution; Mechanism; Ambient temperature; Irradiation;	A n/a B n/a C n/a D 83% E n/a F n/a

...Expand

: 110-89-4
piperidine

: 67-56-1
methanol

: 50-00-0
formaldehyd

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; titanium(III) chloride at 20℃; for 0.5h; Acidic aq. solution; Inert atmosphere;	80%

...Expand

: 110-89-4
piperidine

: 107-07-3
2-chloro-ethanol

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
at 70℃; for 5h;	75%
With acetone
With benzene

: 6052-80-8
4-(2,6-dioxacyclohexyl)phenol

: 1391906-41-4
2-(dimethylamino)ethyl ethyl carbonate

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
Stage #1: 4-(2,6-dioxacyclohexyl)phenol; 2-(dimethylamino)ethyl ethyl carbonate In acetonitrile at 200℃; under 12001.2 Torr; for 8h; Autoclave; Stage #2: With trifluoroacetic acid In acetonitrile at 20℃; for 20h;	69%

: 75-21-8
oxirane

: 110-89-4
piperidine

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
at 100℃;
at 100℃;
With water Im Rohr bei Raumtemperatur;

: 111-24-0
1,5-dibromo-pentane

: 141-43-5
ethanolamine

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With potassium hydroxide

: 110-89-4
piperidine

: 107-21-1
ethylene glycol

A: 3040-44-6
1-piperidinoethanol

B: 1932-04-3
1,2-dipiperidinoethane

Conditions

Conditions	Yield
With triphenylphosphine; ruthenium trichloride at 120℃; for 15h; Product distribution; other catalyst, also with THF, other phosphine, also at 220 degC;
With triphenylphosphine; ruthenium trichloride at 220℃; for 15h;

...Expand

: 50594-06-4
IR 1

A: 3040-44-6
1-piperidinoethanol

B: 62-53-3
aniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 55792-10-4
(4-ethoxy-phenyl)-carbamic acid-(2-piperidino-ethyl ester); hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 52205-61-5
(3-Propoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 4469-79-8
3-propoxyaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117855-67-1
p-Tolyl-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 106-49-0
p-toluidine

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 104654-03-7
(4-Ethyl-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 589-16-2
4-aminoethylbenzene

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 55792-06-8
2-piperidinoethyl N-(3-methoxyphenyl)carbamate hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 536-90-3
m-Anisidine

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117872-31-8
(4-Fluoro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 371-40-4
4-fluoroaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117872-32-9
(3-Fluoro-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 372-19-0
meta-fluoroaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 20229-03-2
2-piperidinoethyl N-(4-chlorophenyl)carbamate hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 106-47-8
4-chloro-aniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 55792-09-1
(3-Ethoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 621-33-0
m-phenetidine

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117855-65-9
(4-Isopropoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 7664-66-6
4-(isopropoxy)aniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 55792-12-6
(4-Propoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 4469-80-1
4-propoxyaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117855-66-0
(3-Isopropoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 41406-00-2
3-isopropoxyaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 117855-64-8
(3-Trifluoromethyl-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester; hydrochloride

A: 3040-44-6
1-piperidinoethanol

B: 98-16-8
3-trifluoromethylaniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 55792-07-9
1-(2-(4-methoxyphenylcarbamoyloxy)ethyl)piperidinium chloride

A: 3040-44-6
1-piperidinoethanol

B: 104-94-9
4-methoxy-aniline

Conditions

Conditions	Yield
With water In ethanol at 40 - 70℃; Rate constant; Thermodynamic data; Kinetics;

: 50594-06-4
IR 1

A: 3040-44-6
1-piperidinoethanol

B: 124-38-9
carbon dioxide

C: 62-53-3
aniline

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 40℃; Rate constant; Thermodynamic data; var. temp., EA;

...Expand

diethylene-bis-piperidinium chloride: diethylene-bis-piperidinium chloride

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With potassium hydroxide Destillieren;

N-<β-chloro-ethyl>-piperidine: N-<β-chloro-ethyl>-piperidine

: 3040-44-6
1-piperidinoethanol

Conditions

Conditions	Yield
With sulfuric acid at 160℃;

: 3040-44-6
1-piperidinoethanol

: 221040-07-9
4-benzyloxy-2-fluoro-1-nitrobenzene

: 1-{2-[5-(benzyloxy)-2-nitrophenoxy]ethyl}piperidine

Conditions

Conditions	Yield
Stage #1: 1-piperidinoethanol With sodium hydride In tetrahydrofuran; mineral oil at 20 - 30℃; for 1h; Stage #2: 4-benzyloxy-2-fluoro-1-nitrobenzene In tetrahydrofuran; mineral oil at 20℃; for 1h;	98.3%

: 3040-44-6
1-piperidinoethanol

: 95925-60-3
4-(2-hydroxyethyl)morpholine 4-oxide

Conditions

Conditions	Yield
With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; acetonitrile In tert-butyl alcohol at 20℃; for 18h; Green chemistry; chemoselective reaction;	98%

: 3040-44-6
1-piperidinoethanol

: 243845-88-7
(2-dimethylamino-6-methoxy-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-methanone

: 165742-76-7
[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h; Alkylation;	97%

: 3040-44-6
1-piperidinoethanol

: 85-44-9
phthalic anhydride

: 80673-06-9
phtalate acide de (piperidinyl)-2 ethanol

Conditions

Conditions	Yield
In benzene for 4.5h; Heating;	96.5%
With acetone

: 3040-44-6
1-piperidinoethanol

: 85233-19-8
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid

: C50H76N6O10

Conditions

Conditions	Yield
With 3-nitrobenzoic acid In dimethyl sulfoxide at 60℃; for 6h; Temperature; Reagent/catalyst; Solvent;	96.1%

: 3040-44-6
1-piperidinoethanol

: 1268684-53-2
(3,9-dibenzyloxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorofluorophenyl)methanone

: 1394852-41-5
(3,9-dihydroxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[2-(piperidin-1-yl)ethoxy]phenyl)methanone

Conditions

Conditions	Yield
Stage #1: 1-piperidinoethanol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 30h; Stage #2: (3,9-dibenzyloxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorofluorophenyl)methanone for 6h;	96%

: 3040-44-6
1-piperidinoethanol

: 1-hexadecyl-2-nonyl-6-oxopiperidine-3-carboxylic acid

: C38H72N2O3

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;	96%

: 3040-44-6
1-piperidinoethanol

: 1-dodecyl-2-((8Z,11Z)-heptadecyl-8,11-dien-1-yl)-5-oxopyrrolidine-3-carboxylic acid

: C41H74N2O3

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2h;	96%

: 3040-44-6
1-piperidinoethanol

: 24424-99-5
di-tert-butyl dicarbonate

: 118811-03-3
tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran-water	95%

: 3040-44-6
1-piperidinoethanol

: 2622-89-1
diphenylborinic acid

: diphenylhydroxo[2-(1-piperidinium)ethoxy]borate

Conditions

Conditions	Yield
In diethyl ether addn. of slight excess of B-compd. to piperidine derivative; crystn., filtration, drying;	95%

: 3040-44-6
1-piperidinoethanol

: B5H4O10(1-)*C7H15NO*H(1+)

Conditions

Conditions	Yield
With boric acid In methanol; water	95%

: 3040-44-6
1-piperidinoethanol

: 11113-50-1
boric acid

: B5H4O10(1-)*C7H15NO*H(1+)

Conditions

Conditions	Yield
In methanol; water to soln. H3BO3 in aq. MeOH (1:1) amine was added, stirred for 10 min, solvent was removed in vacuo, residue was heated in oven to dry 4 h at 100°C; elem. anal.;	95%

: 3040-44-6
1-piperidinoethanol

: benzyl 4-chloroacetoacetate

: benzyl 3-oxo-4-(2-(piperedine-1-yl)ethoxy)-3-oxobutanoate

Conditions

Conditions	Yield
With sodium hydride; sodium hydrogencarbonate; sodium chloride In tetrahydrofuran at 0 - 20℃;	93.1%

: 3040-44-6
1-piperidinoethanol

: 5,6-bis(benzyloxy)-2-phenylbenzofuran-3-carboxylic acid

: 2-(piperidin-1-yl)ethyl 5,6-bis(benzyloxy)-2-phenylbenzofuran-3-carboxylate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃;	93%

: 3040-44-6
1-piperidinoethanol

: 904678-18-8
{1-[3-(tert-butyldimethylsilyloxy)propyl]benzimidazolidin-2-ylidene}malononitrile

: 904678-19-9
{1-[3-(tert-butyldimethylsilyloxy)propyl]-3-(2-piperidinoethyl)benzimidazolidin-2-ylidene}malononitrile

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃; for 0.166667h;	92.8%

: 3040-44-6
1-piperidinoethanol

: 103-71-9
phenyl isocyanate

: 56269-29-5
1-phenylcarbamoyloxy-2-piperidin-1-yl-ethane

Conditions

Conditions	Yield
In toluene for 7h; Heating;	92%
With diethyl ether
In dichloromethane for 1.5h; Heating;

: 3040-44-6
1-piperidinoethanol

: 67-56-1
methanol

: 2159-40-2
2-(4-bromobenzoyl)benzoic acid

: 54063-52-4
2-methoxycarbonyl-4'-(2-piperidinoethyloxy)benzophenone

Conditions

Conditions	Yield
Stage #1: 1-piperidinoethanol With sodium hydride In tetrahydrofuran for 0.5h; Reflux; Stage #2: methanol; 2-(4-bromobenzoyl)benzoic acid With sodium hydride In tetrahydrofuran at 20℃; Stage #3: With thionyl chloride at 0 - 20℃;	91%

...Expand

: 3040-44-6
1-piperidinoethanol

: 206434-77-7
6-methoxy-2-(4-methoxyphenyl)-3-(4-fluorobenzoyl)benzo[b]thiophene

: 84541-38-8
[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 0.25h; Ambient temperature;	90%
With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h; Addition;	90%

: 3040-44-6
1-piperidinoethanol

: methyl (E)-5-[4-(2,2-dimethylpropanoyloxy)phenyl]-5-(4-hydroxyphenyl)-4-phenyl-pent-4-enoate

: 4-phenyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(4-(pivaloyloxy)phenyl)pent-4-enoate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 0 - 20℃; Mitsunobu Displacement;	90%

: 3040-44-6
1-piperidinoethanol

: 624-83-9
methyl isocyanate

: 123556-14-9
Methyl-carbamic acid 2-piperidin-1-yl-ethyl ester

Conditions

Conditions	Yield
With pyridine at 70 - 80℃; for 7.5h;	89%

: 3040-44-6
1-piperidinoethanol

: 1135317-03-1
3-(4-hydroxyphenyl)-5-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene

: 1261352-32-2
5-methoxy-2-(4-methoxyphenyl)-3-{4-[ 2-(1-piperidinyl)ethoxy]phenyl}benzo[b]thiophene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;	89%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;	87%

: 3040-44-6
1-piperidinoethanol

: 91830-42-1
6-bromo-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid

: 91849-12-6
β-piperidinoethyl 6-bromo-3-methylflavone-8-carboxylate

Conditions

Conditions	Yield
Stage #1: 6-bromo-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid With thionyl chloride In toluene at 0.9℃; for 3h; Stage #2: 1-piperidinoethanol In toluene at 0.9 - 40℃; for 3h;	89%

: 3040-44-6
1-piperidinoethanol

: 6155-57-3
sodium saccharinate dihydrate

: silver nitrate

: 1130870-85-7
Ag(saccharinate)(N-(2-hydroxyethylethyl)piperidine)

Conditions

Conditions	Yield
In water; acetonitrile 1 equiv. of Na-salt in H2O to aq. AgNO3 soln., MeCN was added until dissoln., 1 equiv. of piperidine-compd. was added; mixt. was allowed to stand at room temp. in the darkness for 2 d, elem. anal.;	87%

...Expand

: 3040-44-6
1-piperidinoethanol

: 1222858-35-6
C22H18O3S

: 1261352-34-4
C29H31NO3S

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; Mitsunobu reaction;	87%

: 3040-44-6
1-piperidinoethanol

: 99-76-3
methyl 4-hydroxylbenzoate

: 89407-97-6
4-[2-(N-piperidine)-ethoxy]benzoic acid methyl ester

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16h; Inert atmosphere;	86.7%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 30℃; for 4h; Inert atmosphere;	76%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 0.5h; Cooling with ice;
Stage #1: 1-piperidinoethanol; methyl 4-hydroxylbenzoate With triphenylphosphine In tetrahydrofuran at 0℃; for 0.166667h; Mitsunobu Displacement; Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu Displacement;	2.1 g
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 0.166667h;	2.1 g

: 3040-44-6
1-piperidinoethanol

: 80-48-8
methyl p-toluene sulfonate

: 1-(2-hydroxyethyl)-1-methylpiperidin-1-ium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
In acetonitrile for 4h; Reflux;	86%
In acetonitrile for 4h; Reflux;	86%
In diethyl ether for 20h; Ambient temperature;	84%
In acetone; acetonitrile	139 g (0.45 mol, 90%)

: 3040-44-6
1-piperidinoethanol

: 202336-25-2
[2-(4-hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl] [4-fluorophenyl]methanone

: 84449-90-1
Raloxifen

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 5h;	86%

2-Piperidinoethanol Consensus Reports

Reported in EPA TSCA Inventory.

2-Piperidinoethanol Specification

The IUPAC name of N-(Hydroxyethyl)piperidine is 2-piperidin-1-ylethanol. With the CAS registry number 3040-44-6, it is also named as 1-(2-Hydroxyethyl)piperidine. The product's categories are Amines; Heterocycles. Besides, it is clear colourless liquid, which should be closed in a cool and dry place. In addition, its molecular formula is C₇H₁₅NO and molecular weight is 129.20.

The other characteristics of this product can be summarized as: (1)EINECS: 221-244-6; (2)ACD/LogP: 1.06; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -1.91; (5)ACD/LogD (pH 7.4): -0.57; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 2.13; (10)#H bond acceptors: 2; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 3; (13)Index of Refraction: 1.477; (14)Molar Refractivity: 37.48 cm³; (15)Molar Volume: 132.5 cm³; (16)Surface Tension: 35.6 dyne/cm; (17)Density: 0.974 g/cm³; (18)Flash Point: 91.2 °C; (19)Melting Point: 16 °C; (20)Enthalpy of Vaporization: 50.81 kJ/mol; (21)Boiling Point: 200.5 °C at 760 mmHg; (22)Vapour Pressure: 0.0802 mmHg at 25 °C.

Preparation of N-(Hydroxyethyl)piperidine: this chemical can be prepared by the reaction of piperidine with 2-bromo-ethanol.

This reaction will occur at temperature of 80 °C for 72 hours. The yield is 85 %.

Uses of N-(Hydroxyethyl)piperidine: it can react with phthalic acid anhydride to get phthalic acid mono-(2-piperidino-ethyl ester).

This reaction needs benzene by heating for 4.5 hours. The yield is 96.5 %.

When you are using this chemical, please be cautious about it as the following: it is harmful if swallowed. And it is irritating to eyes, respiratory system and skin. You should wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)Canonical SMILES: C1CCN(CC1)CCO
(2)InChI: InChI=1S/C7H15NO/c9-7-6-8-4-2-1-3-5-8/h9H,1-7H2
(3)InChIKey: KZTWONRVIPPDKH-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	250mg/kg (250mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacology and Experimental Therapeutics. Vol. 55, Pg. 419, 1935.
rat	LD50	intravenous	166mg/kg (166mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1916, 1975.
rat	LD50	oral	1498mg/kg (1498mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1916, 1975.

Product Name

2-Piperidinoethanol

Synthetic route

2-Piperidinoethanol Consensus Reports

2-Piperidinoethanol Specification

Related Products

Hot Products