3-Amino-5-hydroxypyrazole supplier

Name
3-Amino-5-hydroxypyrazole
EINECS 228-095-6
CAS No. 6126-22-3
Article Data8
CAS DataBase
Density 1.79 g/cm³
Solubility
Melting Point 214 °C (dec.)(lit.)
Formula C₃H₅N₃O
Boiling Point 185.55°C (rough estimate)
Molecular Weight 99.0922
Flash Point
Transport Information
Appearance yellow-beige to beige-brown crystalline powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Pyrazolidinone, 5-imino- (7CI);3-Amino-2-pyrazolin-5-one;3-Aminopyrazolone;NSC 30480;NSC 34806;NSC 50565;2-Pyrazolin-5-one,3-amino- (6CI,8CI);
PSA 74.93000
LogP 0.27870

Synthetic route

: 140-87-4
Cyanoacetohydrazide

: 6126-22-3
3-amino-2-pyrazolin-5-one

Conditions

Conditions	Yield
With potassium hydroxide In methanol for 2h; Reflux;	95%
With sodium methylate In methanol for 2h; Heating;	80%
With sodium In methanol for 2h; Heating;	80%

: 105-56-6
ethyl 2-cyanoacetate

: 6126-22-3
3-amino-2-pyrazolin-5-one

Conditions

Conditions	Yield
With hydrazine hydrate at 80℃; for 0.0833333h; Microwave irradiation; Green chemistry;	82%

: 2318-25-4
ethyl 3-ethoxy-3-iminopropanoate hydrochloride

: 6126-22-3
3-amino-2-pyrazolin-5-one

Conditions

Conditions	Yield
With hydrazine hydrate; triethylamine In ethanol for 6h; Reflux;	82%

: 67449-75-6, 23973-22-0
ethyl (E)-2-cyano-3-(2-furyl)-2-propenoate

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 3-Amino-4-furan-2-yl-6-hydroxy-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	90%

: 13450-77-6
4-chlorohippuric acid

: 108-24-7
acetic anhydride

: 122-51-0
orthoformic acid triethyl ester

: 6126-22-3
3-amino-2-pyrazolin-5-one

: N-(1-acetyl-3-amino-6-oxo-1,6-dihydro-pyrano[2,3-c]pyrazol-5-yl)-4-chloro-benzamide

Conditions

Conditions	Yield
Heating;	90%

...Expand

: 79-04-9
chloroacetyl chloride

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 2-chloro-N-(5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 5h;	86%

: 57031-90-0
ethyl (Z)-3-hydroxy-2-butenoate

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 4-Hydroxy-6-methyl-2,7-dihydro-pyrazolo[3,4-b]pyridin-3-one

Conditions

Conditions	Yield
In acetic acid for 0.5h; Ambient temperature;	85.8%

: 10511-51-0
1-Benzylindole-3-carboxaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: C19H16N4O

Conditions

Conditions	Yield
With acetic acid In ethanol for 3h; Reflux;	85%

: 3237-22-7
2-cyano-3-(2-furanyl)acrylonitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 3,6-Diamino-4-furan-2-yl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	82%

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 18440-58-9
1-(N-phenylhydrazono)-1-chloropropanone

: 93585-28-5
2-Methyl-3-phenylazo-1H-imidazo[1,2-b]pyrazol-6-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 3h; Heating;	82%

: 618098-67-2
1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 1422538-44-0
(4E)-3-amino-4-[(1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl)methylene]-1H-pyrazol-5(4H)-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 1h; Reflux;	82%

: 2-(1,3 benzothiazol-2-yl)-2-(5-oxo-3-phenyl(1,3)thiazolidin-2-ylidene)acetonitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 4-[2-(1H-pyrazol-5(4H)-one-3-yl)diazen-1-yl]-5-oxo-3-phenylthiazolidin-2-ylidene-2-1,3-benzothiazol-2-yl-acetonitrile

Conditions

Conditions	Yield
Stage #1: 3-amino-2-pyrazolin-5-one With hydrogenchloride; sodium nitrite In water at -5℃; Stage #2: 2-(1,3 benzothiazol-2-yl)-2-(5-oxo-3-phenyl(1,3)thiazolidin-2-ylidene)acetonitrile With sodium hydroxide In water at -5℃; for 0.5h;	81.18%

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 6-Amino-4-methylsulfanyl-3-oxo-3,3a-dihydro-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h; Heating;	81%

: 31330-51-5
ethyl (E)-2-cyano-3-(2-thienyl)-2-propenoate

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 3-Amino-6-hydroxy-4-thiophen-2-yl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	80%

: 123-11-5
4-methoxy-benzaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 109-77-3
malononitrile

: 3-cyano-2,5-diamino-4,7-dihydro-4-(4-methoxyphenyl)pyrano<2,3-c>pyrazole

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Ambient temperature;	80%

...Expand

: 108-24-7
acetic anhydride

: 122-51-0
orthoformic acid triethyl ester

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 13214-64-7
N-(4-methoxybenzoyl)glycine

: N-(1-acetyl-3-amino-6-oxo-1,6-dihydro-pyrano[2,3-c]pyrazol-5-yl)-4-methoxy-benzamide

Conditions

Conditions	Yield
Heating;	80%

...Expand

: 495-69-2
Hippuric Acid

: 108-24-7
acetic anhydride

: 122-51-0
orthoformic acid triethyl ester

: 6126-22-3
3-amino-2-pyrazolin-5-one

: N-(1-acetyl-3-amino-6-oxo-1,6-dihydro-pyrano[2,3-c]pyrazol-5-yl)-benzamide

Conditions

Conditions	Yield
Heating;	78.5%

...Expand

: 141-97-9
ethyl acetoacetate

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 1198299-30-7
N-(pyrazol-2-en-5-one-3-yl)-3-oxobutanamide

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.0666667h; Microwave irradiation;	78%

: 1-[2-(piperidin-1-yl)ethyl]-1H-indole-3-carboxaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: (4E)-3-amino-4-[{1-(2-(piperidin-1-yl)ethyl)-1H-indol-3-yl}methylene]-1H-pyrazol-5(4H)-one

Conditions

Conditions	Yield
With triethylamine In ethanol for 1h; Reflux;	78%

: 618098-67-2
1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 1422538-45-1
(3E)-3-[(1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl)methylene]amino-1H-pyrazol-5(4H)-one

Conditions

Conditions	Yield
With acetic acid In ethanol for 1h; Reflux;	76%

: 28162-32-5
2-(2-thienyl)-1-cyanoacrylonitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 110983-00-1
3,6-Diamino-4-thiophen-2-yl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	75%
With piperidine In ethanol Heating;	60%

: 135-02-4
ortho-anisaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 109-77-3
malononitrile

: 3-cyano-2,5-diamino-4,7-dihydro-4-(2-methoxyphenyl)pyrano<2,3-c>pyrazole

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Ambient temperature;	75%

...Expand

: 2700-22-3
Benzylidenemalononitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 87379-25-7
3,6-Diamino-4-phenyl-3a,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	75%

: 2700-22-3
Benzylidenemalononitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 87379-26-8
3-(3-amino-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)-2-cyano-3-phenylpropanamide

Conditions

Conditions	Yield
With piperidine In ethanol for 20h; Heating;	75%

: 95644-00-1
2-benzoyl-3-(2-thienyl)prop-2-enenitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 3-Amino-6-phenyl-4-thiophen-2-yl-1,4-dihydro-pyrano[2,3-c]pyrazole-5-carbonitrile

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Heating;	75%

: 870-64-4
2-aminocrotononitrile

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 4-Amino-6-methyl-2,7-dihydro-pyrazolo[3,4-b]pyridin-3-one

Conditions

Conditions	Yield
With acetic acid for 0.5h; Heating;	75%
In acetic acid for 0.5h; Heating;	75%

: 27115-50-0
N-(4-methylbenzoyl)glycine

: 108-24-7
acetic anhydride

: 122-51-0
orthoformic acid triethyl ester

: 6126-22-3
3-amino-2-pyrazolin-5-one

: N-(1-acetyl-3-amino-6-oxo-1,6-dihydro-pyrano[2,3-c]pyrazol-5-yl)-4-methyl-benzamide

Conditions

Conditions	Yield
Heating;	75%

...Expand

: 59507-92-5
3-nitro-4H-chromen-4-one

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 3-hydroxy-6-(2-hydroxyphenyl)-5-nitro-1H-pyrazolo[3,4-b]pyridine

Conditions

Conditions	Yield
With triethylamine In ethanol for 1h; Reflux;	75%

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 109-77-3
malononitrile

: 3-cyano-2,5-diamino-4,7-dihydro-4-(2,4-dimethoxyphenyl)pyrano<2,3-c>pyrazole

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Ambient temperature;	73%

...Expand

: 500-22-1
3-pyridinecarboxaldehyde

: 6126-22-3
3-amino-2-pyrazolin-5-one

: 109-77-3
malononitrile

: 128453-21-4
3-cyano-2,5-diamino-4,7-dihydro-4-(3-pyridyl)pyrano<2,3-c>pyrazole

Conditions

Conditions	Yield
With piperidine In ethanol for 3h; Ambient temperature;	72%

...Expand

3-Amino-5-hydroxypyrazole Chemical Properties

Molecular structure of 3-Amino-5-hydroxypyrazole (CAS NO.6126-22-3) is:

Product Name: 3-Amino-5-hydroxypyrazole
CAS Registry Number: 6126-22-3
IUPAC Name: 3-amino-1,4-dihydropyrazol-5-one
Molecular Weight: 99.0913 [g/mol]
Molecular Formula: C₃H₅N₃O
XLogP3-AA: -1.4
H-Bond Donor: 2
H-Bond Acceptor: 3
EINECS: 228-095-6
Melting Point: 214 °C (dec.)(lit.)
Surface Tension: 84.5 dyne/cm
Density: 1.79 g/cm³
Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Amines;Pyrazoles & Triazoles;Pyrazoles & Triazoles;Building Blocks;Heterocyclic Building Blocks;Pyrazoles

3-Amino-5-hydroxypyrazole Safety Profile

Safty information about 3-Amino-5-hydroxypyrazole (CAS NO.6126-22-3) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3

3-Amino-5-hydroxypyrazole Specification

3-Amino-5-hydroxypyrazole , its cas register number is 6126-22-3. It also can be called 3-Amino-1H-pyrazol-5-ol ; 3-Amino-2-pyrazolin-5-one ; 5-Amino-2,3-dihydro-1H-pyrazol-3-one .It is a yellow-beige to beige-brown crystalline powder.

Product Name

3-Amino-5-hydroxypyrazole

Synthetic route

3-Amino-5-hydroxypyrazole Chemical Properties

3-Amino-5-hydroxypyrazole Safety Profile

3-Amino-5-hydroxypyrazole Specification

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