• Name

  3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE

• EINECS -0
• CAS No. 113770-87-9
• Article Data4
• CAS DataBase
• Density 1.371 g/cm³
• Solubility
• Melting Point
• Formula C₆H₃F₄N
• Boiling Point 139.163 °C at 760 mmHg
• Molecular Weight 165.09
• Flash Point 37.965 °C
• Transport Information UN 1992 3/PG 2
• Appearance Light yellow liquid
• Safety 26-45
• Risk Codes 11-25-36/37/38
• Molecular Structure
• Hazard Symbols F,T,C
• Synonyms 3-Fluoro-4-trifluoromethylpyridine;
• PSA 12.89000
• LogP 2.23950

Synthetic route

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

124-68-5

2-Amino-2-methyl-1-propanol

C10H13F3N2O

Conditions

Conditions	Yield
Stage #1: 2-Amino-2-methyl-1-propanol With sodium hydride In 1,4-dioxane; mineral oil at 0℃; for 0.25h; Stage #2: 3-fluoro-4-(trifluoromethyl)-pyridine In 1,4-dioxane; mineral oil at 100℃; for 1h;	84%
Stage #1: 2-Amino-2-methyl-1-propanol With sodium hydride In 1,4-dioxane; mineral oil at 0℃; for 0.25h; Stage #2: 3-fluoro-4-(trifluoromethyl)-pyridine In 1,4-dioxane; mineral oil at 100℃; for 1h;	84%

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

64318-28-1

N-t-butoxycarbonyl-tyramine

1210071-59-2

{2-[4-(4-trifluoromethylpyridine-3-yloxy)phenyl]ethyl}carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 100℃; for 0.5h;	60%

109-72-8, 29786-93-4

n-butyllithium

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

C6H2F4LiN

Conditions

Conditions	Yield
In tetrahydrofuran; hexane at -78℃; for 1h;

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

3-fluoro-4-(trifluoromethyl)pyridine 1-oxide

Conditions

Conditions	Yield
With dihydrogen peroxide; methyltrioxorhenium(VII) at 0 - 20℃;

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

1338226-04-2

3-(difluoromethyl)-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / 0 - 20 °C 2.1: hydrogen; trifluoroacetic anhydride / 15 h / 85 °C 2.2: pH 9 3.1: potassium carbonate / 1,4-dioxane / 0.08 h 3.2: 2 h / 20 °C 4.1: potassium carbonate / 75 °C View Scheme

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

1227594-89-9

3-fluoro-4-(trifluoromethyl)pyridin-2-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / 0 - 20 °C 2.1: hydrogen; trifluoroacetic anhydride / 15 h / 85 °C 2.2: pH 9 View Scheme

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

1338226-22-4

3-fluoro-1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-4-(trifluoromethyl)pyridin-2(1 H)-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: dihydrogen peroxide / methyltrioxorhenium(VII) / 0 - 20 °C 2.1: hydrogen; trifluoroacetic anhydride / 15 h / 85 °C 2.2: pH 9 3.1: potassium carbonate / 1,4-dioxane / 0.08 h 3.2: 2 h / 20 °C View Scheme

113770-87-9

3-fluoro-4-(trifluoromethyl)-pyridine

91837-43-3

1,3-dioxoisoindolin-2-yl (tert-butoxycarbonyl)glycinate

A

tert-butyl (1-(3-fluoro-4-trifluoromethylpyridin-2-yl)methyl)carbamate

B

tert-butyl (1-(5-fluoro-4-trifluoromethylpyridin-2-yl)methyl)carbamate

Conditions

Conditions	Yield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; trifluoroacetic acid In N,N-dimethyl acetamide at 38℃; for 16h; Minisci Aromatic Substitution; Microwave irradiation; Inert atmosphere; Overall yield = 351 mg; regioselective reaction;

...Expand

3-Fluoro-4-(trifluoromethyl)pyridine Chemical Properties

3-Fluoro-4-(trifluoromethyl)pyridine Safety Profile

3-Fluoro-4-(trifluoromethyl)pyridine Specification