4-(4-Aminophenyl)butyric acid supplier

Name
4-(4-Aminophenyl)butyric acid
EINECS 628-142-4
CAS No. 15118-60-2
Article Data21
CAS DataBase
Density 1.177 g/cm³
Solubility
Melting Point 121-124 °C(lit.)
Formula C₁₀H₁₃NO₂
Boiling Point 363.7 °C at 760 mmHg
Molecular Weight 179.219
Flash Point 173.7 °C
Transport Information
Appearance
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Butyricacid, 4-(p-aminophenyl)- (6CI,8CI);4-(p-Aminophenyl)butyric acid;4-Aminobenzenebutanoic acid;NSC 27531;p-Aminobenzenebutyric acid;
PSA 63.32000
LogP 2.25730

Synthetic route

: 3-(4-propionylaminobenzoyl)propionic acid

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
With hydrazine hydrate; potassium hydroxide In diethylene glycol at 120℃; for 1.5h;	98%

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
With hydrogen; 10percent Pd/C In methanol under 2068.65 Torr; for 1h;	96%
With sodium methanoate; hydrogen; palladium on activated charcoal In methanol	90%
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 6h; Reduction;	85%

: 5473-15-4
4-(4-acetamidophenyl)-4-oxobutanoic acid

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
With hydrazine hydrate; potassium hydroxide In diethylene glycol for 1.5h; Reflux;	95%
With hydrazine hydrate; potassium hydroxide In diethylene glycol for 8h; Wolff-Kishner Reduction; Reflux;

: 15116-32-2
4-(4-amino-phenyl)-butyric acid ethyl ester

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol Heating;

: 1821-12-1
4-Phenylbutyric acid

γ-phenyl-γ-butyrolactone: γ-phenyl-γ-butyrolactone

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 22 percent / HNO3 / 6 h / Ambient temperature 2: 90 percent / H2, sodium methanoate / Pd/C / methanol View Scheme

: 1821-12-1
4-Phenylbutyric acid

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: nitric acid / -30 - -20 °C 2: Raney nickel; ethanol / Hydrogenation View Scheme
Multi-step reaction with 2 steps 1: nitric acid / -30 - -20 °C 2: zinc; aqueous hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: acetic acid anhydride; aqueous nitric acid / 20 - 40 °C 2: palladium/CaCO3; methanol / Hydrogenation View Scheme

: 14308-34-0
2,2-diethoxy-5-(4-nitro-phenyl)-2,3-dihydro-furan

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: H2 / Pd-C / dioxane 2: KOH / ethanol / Heating View Scheme

: 62-53-3
aniline

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: water / 0.33 h / 45 °C 2: aluminum (III) chloride / dichloromethane / 20 °C / Cooling with ice 3: potassium hydroxide; hydrazine hydrate / diethylene glycol / 1.5 h / Reflux View Scheme

: 103-84-4
Acetanilid

: 15118-60-2
4-(4-aminophenyl)butyric Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 20 °C / Cooling with ice 2: potassium hydroxide; hydrazine hydrate / diethylene glycol / 1.5 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8 h / 20 °C 2: potassium hydroxide; hydrazine hydrate / diethylene glycol / 8 h / Reflux View Scheme

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 91251-45-5
4-(p-aminophenyl)butanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; for 2h;	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃; for 2h;	96%
With lithium aluminium tetrahydride In tetrahydrofuran	95%

: 5672-89-9
N-trifluoroacetoxy succinimide

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: C16H15F3N2O6

Conditions

Conditions	Yield
In pyridine at 20℃;	99%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: (S)-2,5-dichloro-N-((tetrahydrofuran-2-yl)methyl)pyrimidin-4-amine

: (S)-4-(4-(5-chloro-4-((tetrahydrofuran-2-yl)methylamino)pyrimidin-2-ylamino)phenyl)butanoic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile at 150℃; for 2h; Microwave irradiation;	99%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 186320-14-9
4-[4'-(9H-fluoren-9-ylmethoxycarbonylamino)phenyl]butanoic acid

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)butyric Acid; N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide With sodium hydrogencarbonate In tetrahydrofuran at 20℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water	98%
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; for 16h; Inert atmosphere;	68%
With sodium carbonate In N,N-dimethyl-formamide

: 67-56-1
methanol

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

Conditions

Conditions	Yield
With sulfuric acid for 1.5h; Reflux;	96%
With sulfuric acid at 20℃; for 12h; Inert atmosphere;	86%
With thionyl chloride In methanol at 0 - 80℃; for 16h;	70%
With sulfuric acid Reflux;	58%
With hydrogenchloride

: 67-56-1
methanol

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 205759-94-0
methyl 4-(p-aminophenyl)butyrate

Conditions

Conditions	Yield
With thionyl chloride at 10 - 20℃; for 2h; Reflux;	96%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 5,5-dichloro-meldrum’s acid

: 4-(4-(2,2-dichloroacetamido)phenyl)butanoic acid

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 16h; Sealed tube;	96%

: 24424-99-5
di-tert-butyl dicarbonate

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 105300-90-1
4-(4-((tert-butoxycarbonyl)amino)phenyl)butanoic acid

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water at 20℃; for 24h;	94%
Stage #1: di-tert-butyl dicarbonate; 4-(4-aminophenyl)butyric Acid With sodium hydroxide In tert-butyl alcohol at 0 - 20℃; for 9h; Stage #2: With potassium hydrogensulfate; water In diethyl ether pH=2 - 3;	94%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 108-24-7
acetic anhydride

: 31815-69-7
4-(acetylamino)benzenebutanoic acid

Conditions

Conditions	Yield
In water; acetonitrile for 4h; Ambient temperature;	93%

CH2Cl2/MeOH: CH2Cl2/MeOH

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

Conditions

Conditions	Yield
With HCl conc.; sodium carbonate In methanol	91%

: 67-56-1
methanol

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 4-(4-aminophenyl)butanoic acid methyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃;	89.2%

: 5862-27-1
3-heptadecylbenzene-1,2-diol (hydrolaccol)

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 3-hepta-1,2-phenylene bis(4-aminophenyl)butanoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	89%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 100-28-7
4-Nitrophenyl isocyanate

: 80258-90-8
4-(4-(3-(4-nitrophenyl)ureido)phenyl)butanoic acid

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one In benzene at 50℃; for 0.166667h;	88%
In N,N-dimethyl-formamide at 20℃; for 1h;	80%

: 85-44-9
phthalic anhydride

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 209961-84-2
4-(4-(1,3-dioxoisoindolin-2-yl)phenyl)butanoic acid

Conditions

Conditions	Yield
With triethylamine In toluene for 12h; Heating;	87%
In acetic acid for 5h; Inert atmosphere; Reflux;	81%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 108-95-2
phenol

: 887764-00-3
4-(4-((4-hydroxyphenyl)diazenyl)phenyl)butanoic acid

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)butyric Acid With hydrogenchloride; ammonium sulphamate; sodium nitrite In water at 5℃; Stage #2: phenol With sodium hydroxide In water at 5℃; for 0.333333h; Stage #3: With hydrogenchloride In water pH=3;	86.7%
Stage #1: 4-(4-aminophenyl)butyric Acid With hydrogenchloride; sodium nitrite at 5℃; Stage #2: phenol With ammonium sulfamate; sodium hydroxide Stage #3: With hydrogenchloride In water pH=3;	61%

: 1191-95-3
cyclobutanone

: 7677-24-9
trimethylsilyl cyanide

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 915086-92-9
4-[4-(1-cyanocyclobutylamino)phenyl]butanoic acid

Conditions

Conditions	Yield
With sodium sulfate In 1,4-dioxane for 15h; Product distribution / selectivity;	86%
With sodium sulfate In 1,4-dioxane for 15h;	86%
With sodium sulfate In 1,4-dioxane for 15h; Strecker reaction; Inert atmosphere;	86%
at 80℃; for 13h; Product distribution / selectivity;	74%

...Expand

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 110-13-4
2,5-hexanedione

: 4-(4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)butanoic acid

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)butyric Acid; 2,5-hexanedione With montmorillonite K10 Clay In dichloromethane at 20℃; for 0.25h; Stage #2: at 90℃; for 0.5h; Microwave irradiation;	85%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

Conditions

Conditions	Yield
With Oxone; sodium hydroxide In water; acetone at 8℃; buffer (NaHCO3);	84%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 2746-19-2
(1R,2R,6S,7S)-4-oxa-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

: 1365657-66-4
C19H19NO4

Conditions

Conditions	Yield
With acetic acid In 1-methyl-pyrrolidin-2-one at 100℃; for 12h; Inert atmosphere;	83%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

Conditions

Conditions	Yield
With sulfuric acid; sodium carbonate In methanol	82%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: (R)-2,5-dichloro-N-((tetrahydrofuran-2-yl)methyl)pyrimidin-4-amine

: (R)-4-(4-(5-chloro-4-((tetrahydrofuran-2-yl)methylamino)pyrimidin-2-ylamino)phenyl)butanoic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile at 150℃; for 2h; Microwave irradiation;	80%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 121-69-7
N,N-dimethyl-aniline

: C18H21N3O2

Conditions

Conditions	Yield
Stage #1: 4-(4-aminophenyl)butyric Acid With nitrosonium tetrafluoroborate In dimethyl sulfoxide; acetonitrile for 0.25h; Cooling with ice; Stage #2: N,N-dimethyl-aniline In dimethyl sulfoxide; acetonitrile at 20℃; for 0.75h; Cooling with ice;	79%

: 4300-97-4
3-Chloropivaloyl chloride

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 4-butyric acid

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane for 1h; Heating;	78%

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 2,5-dichloro-N-((tetrahydrofuran-2-yl)methyl)pyrimidin-4-amine

: 4-(4-(5-chloro-4-((tetrahydrofuran-2-yl)methylamino)pyrimidin-2-ylamino)phenyl)butanoic acid

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile at 150℃; for 2h; Microwave irradiation;	78%
With hydrogenchloride In water; acetonitrile at 150℃; for 2h; Microwave irradiation;	78%

: 1943-83-5
2-chloroethyl isothiocyanate

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 13908-55-9
4-phenyl>butyric acid

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 24h;	77%
In ethanol Ambient temperature;

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 129-64-6
3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

: 1365657-65-3
C19H19NO4

Conditions

Conditions	Yield
With acetic acid In 1-methyl-pyrrolidin-2-one at 100℃; for 12h; Inert atmosphere;	76%

: 1191-95-3
cyclobutanone

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 915086-92-9
4-[4-(1-cyanocyclobutylamino)phenyl]butanoic acid

Conditions

Conditions	Yield
With trimethylsilyl cyanide at 80℃; for 13h;	74%

4-(4-Aminophenyl)butyric acid Chemical Properties

Molecular Weight:179.22
Molecular Formula: C₁₀H₁₃NO₂
Density: 1.177 g/cm³
Flash Point: 173.7 °C
Melting point: 121-124 ºC
Index of Refraction: 1.583
IUPAC: 4-(4-Aminophenyl)butanoic acid
Product Name: 4-(4-Aminophenyl)butyric acid
Enthalpy of Vaporization: 64.34 kJ/mol
Vapour Pressure: 6.3E-06 mmHg at 25°C
Boiling Point of 4-(4-Aminophenyl)butyric acid (15118-60-2): 363.7 °C at 760 mmHg
Synonyms: 4-(4-Aminophenyl)butanoicacid ; P-aminophenylbutyricacid ; Akos BB-8810 ; 4-(4-Aminophenyl)butyric acid ; 4-Aminophenylbutyric Acid ; 4-Aminobenzenebutanoic acid ; 4-Amino-benzenebutanoic
Product Categories: Others ; Peptide Synthesis ; Unnatural Amino Acid Derivatives
Following is the molecular structure of 4-(4-Aminophenyl)butyric acid (15118-60-2):

4-(4-Aminophenyl)butyric acid Safety Profile

Safety Information of 4-(4-Aminophenyl)butyric acid (15118-60-2):
Hazard Codes: Xi
Xi: Irritant
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3

Product Name

4-(4-Aminophenyl)butyric acid

Synthetic route

4-(4-Aminophenyl)butyric acid Chemical Properties

4-(4-Aminophenyl)butyric acid Safety Profile

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