4-Amino-2,6-dichloropyridine supplier

Name
4-Amino-2,6-dichloropyridine
EINECS -0
CAS No. 2587-02-2
Article Data22
CAS DataBase
Density 1.497 g/cm³
Solubility
Melting Point 169-173 °C(lit.)
Formula C₅H₄Cl₂N₂
Boiling Point 336.7 °C at 760 mmHg
Molecular Weight 163.006
Flash Point 157.4 °C
Transport Information
Appearance white crystals
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Pyridine,4-amino-2,6-dichloro- (6CI,7CI,8CI);(2,6-Dichloropyridin-4-yl)amine;2,6-Dichloro-4-aminopyridine;2,6-Dichloropyridin-4-amine;NSC 136573;
PSA 38.91000
LogP 2.55180

Synthetic route

: 25194-01-8
2,6-dichloro-4-nitro-pyridine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
With hydrogenchloride; iron In ethanol; water at 95℃; for 16h;	95.1%
With hydrogenchloride; water; iron In ethanol at 95℃; for 16h;	95.1%
With ammonium hydroxide In tetrahydrofuran at 95℃; for 4h;	82%

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Stage #1: 2,6-dichloropyridine-4-carboxylic acid; trifluoroacetic acid With sodium azide; oxalyl dichloride In dichloromethane Curtius Rearrangement; Heating / reflux; Stage #2: With potassium carbonate In methanol	78%

: 16063-69-7
2,4,6-trichloropyridine

A: 2587-02-2
2,6-dichloro-[4]pyridylamine

B: 116632-24-7
2-amino-4,6-dichloropyridine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 130℃; for 4h;	A n/a B 67%
With ammonium hydroxide at 160℃;

: 2402-78-0
2,6-dichloropyridine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Stage #1: 2,6-dichloropyridine With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex Inert atmosphere; Stage #2: With C10H17NO In tetrahydrofuran; toluene at -25℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water; toluene Inert atmosphere;	64%
Multi-step reaction with 3 steps 1: CF3COOH; aq. H2O2 / 6.5 h / Heating 2: HNO3; H2SO4 / 160 °C 3: AcOH; Fe / Heating View Scheme
Multi-step reaction with 3 steps 1: potassium carbonate; trifluoroacetic acid; dihydrogen peroxide / chloroform; water 2: nitric acid; sulfuric acid 3: hydrogenchloride / ethanol; water View Scheme

: 2402-78-0
2,6-dichloropyridine

A: 2587-02-2
2,6-dichloro-[4]pyridylamine

B: 53344-76-6
2,2',6,6'-tetrachloro-4,4'-bipyridine

Conditions

Conditions	Yield
With potassium permanganate; ammonia; potassium amide 1.) DME, -70 deg C, 2.) DME, -70 deg C; Yield given. Multistep reaction. Yields of byproduct given;

2.6-dichloro-4-ethoxycarbonylamino-pyridine: 2.6-dichloro-4-ethoxycarbonylamino-pyridine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
With potassium hydroxide

: 2,6-Dichloro-N-(2,2,2-trifluoro-acetyl)-isonicotinamide

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
With potassium carbonate In methanol for 8h;	5.93 g

: 42521-08-4
2,6-dichloroisonicotinoyl chloride

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Stage #1: 2,6-dichloroisonicotinoyl chloride With sodium azide In water; acetone Stage #2: With trifluoroacetic acid In benzene for 16h; Heating; Stage #3: With potassium carbonate In methanol for 8h;	5.93 g
Multi-step reaction with 3 steps 1: sodium azide / water; acetone / 0.03 h / 25 °C 2: trifluoroacetic acid / benzene / 21 h / 90 °C 3: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme

: 2587-00-0
2,6-dichloropyridine N-oxide

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HNO3; H2SO4 / 160 °C 2: AcOH; Fe / Heating View Scheme
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid 2: hydrogenchloride / ethanol; water View Scheme
Multi-step reaction with 2 steps 1.1: nitric acid; sulfuric acid / water / 1 h / 148 - 156 °C 1.2: pH 6 2.1: hydrogenchloride; iron / ethanol; water / 16 h / 95 °C View Scheme
Multi-step reaction with 2 steps 1.1: nitric acid; sulfuric acid / 1 h / 148 - 156 °C 1.2: 20 °C / pH 6 2.1: hydrogenchloride; water; iron / ethanol / 16 h / 95 °C View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid; potassium nitrate / 7 h / 20 - 100 °C 2: acetic acid; iron / 3 h / 45 °C View Scheme

: 42521-09-5
methyl 2,6-dichloroisonicotinate

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.33 h / 25 °C 2: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 3: sodium azide / water; acetone / 0.03 h / 25 °C 4: trifluoroacetic acid / benzene / 21 h / 90 °C 5: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme
Multi-step reaction with 4 steps 1: hydrazine hydrate / ethanol / 50 - 55 °C 2: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 3: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 4: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 4 steps 1: hydrazine hydrate / ethanol / 50 - 55 °C 2: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 3: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 4: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme

: 99-11-6
citrazinic acid

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: trichlorophosphate / 24 h / 130 °C 2: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.33 h / 25 °C 3: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 4: sodium azide / water; acetone / 0.03 h / 25 °C 5: trifluoroacetic acid / benzene / 21 h / 90 °C 6: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 40 - 105 °C 1.2: 20 - 60 °C 2.1: hydrazine hydrate / ethanol / 50 - 55 °C 3.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 4.1: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 5.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 40 - 105 °C 1.2: 20 - 60 °C 2.1: hydrazine hydrate / ethanol / 50 - 55 °C 3.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 4.1: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 5.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 40 - 105 °C 2.1: thionyl chloride / dichloromethane / 0 - 45 °C 2.2: 0 - 10 °C 3.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 4.1: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 5.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 40 - 105 °C 2.1: thionyl chloride / dichloromethane / 0 - 45 °C 2.2: 0 - 10 °C 3.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 4.1: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 5.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: oxalyl dichloride / dichloromethane; tetrahydrofuran / 4 h / 25 °C 2: sodium azide / water; acetone / 0.03 h / 25 °C 3: trifluoroacetic acid / benzene / 21 h / 90 °C 4: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme
Multi-step reaction with 4 steps 1.1: thionyl chloride / dichloromethane / 0 - 45 °C 1.2: 0 - 10 °C 2.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 3.1: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 4.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 4 steps 1.1: thionyl chloride / dichloromethane / 0 - 45 °C 1.2: 0 - 10 °C 2.1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 3.1: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 4.1: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme

: 81001-09-4
2,6-dichloropyridine-4-carbonylazide

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trifluoroacetic acid / benzene / 21 h / 90 °C 2: potassium carbonate / methanol / 7.5 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 2: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 2: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme

: 159178-03-7
2,6-dichloro-4-isocyanatopyridine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Stage #1: 2,6-dichloro-4-isocyanatopyridine With potassium carbonate In methanol at 25℃; for 7.5h; Stage #2: With water	4.11 g
With hydrogenchloride In water; toluene at 40 - 45℃;

: 2587-01-1
2,6-dichloro-4-nitropyridine-1-oxide

: 25194-01-8
2,6-dichloro-4-nitro-pyridine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
With iron; acetic acid at 45℃; for 3h;	1.3 g

: 501907-61-5
tert-butyl (2,6-dichloropyridin-4-yl)carbamate

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
With hydrogenchloride In water; toluene at 40 - 45℃;

: 57803-51-7
2,6-dichloro-isonicotinic acid hydrazide

: 2587-02-2
2,6-dichloro-[4]pyridylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 2: sodium hydroxide / toluene; water / 60 - 70 °C / pH 7 - 8 3: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme
Multi-step reaction with 3 steps 1: hydrogenchloride; sodium nitrite / toluene; water / 0 - 10 °C 2: sodium hydroxide / toluene; water / 90 - 100 °C / pH 7 - 8 3: hydrogenchloride / toluene; water / 40 - 45 °C View Scheme

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 2587-03-3
2,6-dichloro-N-nitro-4-pyridinamine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0℃; for 2h;	100%
With sulfuric acid; nitric acid In water at -5 - 10℃; for 2.66667h;	100%
With sulfuric acid; nitric acid at -5℃;	100%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 79-04-9
chloroacetyl chloride

: 1352830-49-9
2-chloro-N-(2,6-dichloro-pyridin-4-yl)-acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane; N,N-dimethyl acetamide at 100℃; for 7h;	97%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 39716-58-0
pent-4-enoyl chloride

: C10H10Cl2N2O

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine	97%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 1044148-88-0
tert-butyl N-tert-butoxycarbonyl-N-(2,6-dichloro-4-pyridyl)carbamate

Conditions

Conditions	Yield
With sodium hexamethyldisilazane In tetrahydrofuran at 25℃; for 16h;	96%
Stage #1: 2,6-dichloro-[4]pyridylamine With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Cooling with ice; Stage #2: di-tert-butyl dicarbonate In tetrahydrofuran at 20℃; for 16h;	96%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 2897-43-0
2,6-dichloro-3-nitropyridin-4-amine

Conditions

Conditions	Yield
Stage #1: 2,6-dichloro-[4]pyridylamine With sulfuric acid at -5℃; Stage #2: With nitric acid In water at 0 - 80℃; Stage #3: With ammonia In water pH=~ 4; Cooling with acetone-dry ice;	94%
With sulfuric acid; nitric acid at 0 - 20℃; for 1h; Inert atmosphere;	80%
With sulfuric acid; nitric acid at 0 - 80℃; for 2h;	74%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 100-52-7
benzaldehyde

: 868665-68-3
C12H10Cl2N2

Conditions

Conditions	Yield
Stage #1: 2,6-dichloro-[4]pyridylamine; benzaldehyde In toluene for 12h; Heating / reflux; Stage #2: With sodium tetrahydroborate In ethanol at 50 - 75℃; for 2h;	94%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 15568-85-1
5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione

: 863785-65-3
5-[[(2,6-dichloropyridin-4-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

Conditions

Conditions	Yield
In isopropyl alcohol at 70℃; for 4h;	94%
In isopropyl alcohol Heating;	92%
In isopropyl alcohol at 110℃; for 3h;
In isopropyl alcohol at 20 - 75℃; for 0.75h;

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 76-83-5
trityl chloride

: 1352830-73-9
C24H18Cl2N2

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 16h;	93.8%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 24424-99-5
di-tert-butyl dicarbonate

: 501907-61-5
tert-butyl (2,6-dichloropyridin-4-yl)carbamate

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃;	93%
With sodium hexamethyldisilazane In tetrahydrofuran at 29℃; for 3h;
With sodium hexamethyldisilazane In tetrahydrofuran
With dmap In tetrahydrofuran at 60 - 70℃; for 23h;	2.04 g

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 124-41-4
sodium methylate

: 1008304-85-5
2-chloro-6-methoxy-pyridin-4-ylamine

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In methanol at 100℃; for 7h; Reagent/catalyst; Solvent; Autoclave;	91.9%
In 1-methyl-pyrrolidin-2-one at 140℃;	74%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 98-80-6
phenylboronic acid

: 52816-93-0
4-amino-2,6-diphenylpyridine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene at 100℃; for 5h; Inert atmosphere;	89%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 141-52-6
sodium ethanolate

: 904311-14-4
2-chloro-6-ethoxy-pyridin-4-amine

Conditions

Conditions	Yield
In ethanol at 150℃; for 6h;	88%
In ethanol at 150℃; for 6h; Sealed tube;	88%
In ethanol at 150℃; for 2h;

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 2-Ethoxycarbonyl-7-methoxybenzofuran-4-carboxylic acid

: 222297-34-9
ethyl 4-[(3,5-dichloro-pyridin-4-yl)carbamoyl]-7-methoxybenzofuran-2-carboxylate

Conditions

Conditions	Yield
With hydrogenchloride; thionyl chloride In tetrahydrofuran; dichloromethane	88%

: 110-91-8
morpholine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 878809-77-9
2-chloro-6-(morpholin-4-yl)-pyridin-4-ylamine

Conditions

Conditions	Yield
In 1,4-dioxane at 150℃;	87.8%
at 150℃; for 4h; Sealed tube;	85%
at 150℃; for 4h; Sealed tube;	85%

: 67-56-1
methanol

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 124-41-4
sodium methylate

: 1008304-85-5
2-chloro-6-methoxy-pyridin-4-ylamine

Conditions

Conditions	Yield
at 130 - 160℃; Inert atmosphere;	87%

...Expand

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: (N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-4-methyl-1,2,3-thiadiazole-5-formamide)

: N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-N'-(2,6-dichloropyridin-4-yl)-4-methyl-1,2,3-thiadiazole-5-formamidine

Conditions

Conditions	Yield
With thionyl chloride; dicyclohexyl-carbodiimide In sulfolane for 8h; Inert atmosphere; Autoclave; Reflux;	86.4%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 5654-83-1
octahydropyrrolo[1,2-a]pyrazine

: 2-chloro-6-(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)pyridin-4-amine

Conditions

Conditions	Yield
In sulfolane at 150℃;	85%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1-((4,5-dihydro-1H-imidazol-1-yl)sulfonyl)pyrrolidine-3-carbonyl chloride

: N-(2,6-dichloropyridin-4-yl)-1-((4,5-dihydro-1H-imidazol-1-yl)sulfonyl)pyrrolidine-3-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	85%

: 67-56-1
methanol

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1008304-85-5
2-chloro-6-methoxy-pyridin-4-ylamine

Conditions

Conditions	Yield
With sodium methylate for 72h; Reflux;	81.2%
at 150℃; for 0.5h; Microwave irradiation;	79%
With sodium In methanol at 150℃; for 0.5h; Microwave irradiation;	79%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 34160-24-2
2,5-dimethoxytetrahydrofuran

: 805229-07-6
2,6-dichloro-4-(1H-pyrrol-1-yl)pyridine

Conditions

Conditions	Yield
With acetic acid at 90℃; for 2h;	80%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 108-86-1
bromobenzene

: 929033-63-6
2,6-dichloro-N,N-diphenylpyridin-4-amine

Conditions

Conditions	Yield
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In toluene for 24h; Inert atmosphere; Reflux;	78%
With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In toluene for 24h; Inert atmosphere; Reflux;	15g

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 622-47-9
4-tolylacetic acid

: N-(2,6-dichloropyridin-4-yl)-2-(p-tolyl)acetamide

Conditions

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 5h;	77%

: 110-89-4
piperidine

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 2-chloro-6-(piperidin-1-yl)pyridin-4-amine

Conditions

Conditions	Yield
at 140℃; for 4h;	77%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: C15H11ClN2O

: 1-benzyl-3-(2,6-dichloropyridin-4-yl)-3,4-dihydro-4-iminoquinazolin-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 2,6-dichloro-[4]pyridylamine With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: C15H11ClN2O In tetrahydrofuran at -78 - 20℃; for 2h;	76%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 1380809-63-1
4-chloro-5,6,7,8-tetrahydrobenzo[1,2-b]pyrimidino[5,4-d]selenophene

: 1380808-60-5
(2,6-dichloropyridin-4-yl)-5,6,7,8-tetrahydrobenzo[1,2-b]pyrimidino[5,4-d]selenophen-4-ylamine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 16h;	73%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 3-bromo-1-(4-methoxybenzyl)-1H-[1,2,4]triazole

: (2,6-dichloropyridin-4-yl)-[1-(4-methoxybenzyl)-1H-[1,2,4]triazol-3-yl]amine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In toluene at 20 - 110℃; Inert atmosphere;	72%

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 3282-30-2
pivaloyl chloride

: 1345456-45-2
N-(2,6-dichloro-4-pyridinyl)-2,2-dimethylpropanamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 13h;	70%
With triethylamine In dichloromethane Cooling with ice;
With triethylamine In dichloromethane Cooling with ice;	11.59 g

: 622-40-2
2-(morpholin-4-yl)ethanol

: 2587-02-2
2,6-dichloro-[4]pyridylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 1432740-81-2
2-(morpholin-4-yl)ethyl (2,6-dichloropyridin-4-yl)carbamate

Conditions

Conditions	Yield
Stage #1: 2,6-dichloro-[4]pyridylamine; bis(trichloromethyl) carbonate With triethylamine In benzene for 5h; Reflux; Stage #2: 2-(morpholin-4-yl)ethanol In benzene at 20℃;	70%

...Expand

4-Amino-2,6-dichloropyridine Chemical Properties

IUPAC Name: 2,6-Dichloropyridin-4-amine
Synonyms: 2,6-Dichloropyridin-4-amine ; 4-Pyridinamine, 2,6-dichloro- ; 2,6-Dichloro-4-aminopyridine ; 2,6-Dichloro-4-pyridinamine ; 2,6-Dichloropyridin-4-ylamine
Product Categories: Pyridine;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides
Molecular Structure of 4-Amino-2,6-dichloropyridine (CAS NO.2587-02-2) :
Molecular Formula of 4-Amino-2,6-dichloropyridine (CAS NO.2587-02-2) : C₅H₄Cl₂N₂
Molecular Weight of 4-Amino-2,6-dichloropyridine (CAS NO.2587-02-2) : 163.01
CAS NO: 2587-02-2
Index of Refraction: 1.622
Surface Tension: 56.9 dyne/cm
Density: 1.497 g/cm³
Flash Point: 157.4 °C
Enthalpy of Vaporization: 57.99 kJ/mol
Boiling Point: 336.7 °C at 760 mmHg
Vapour Pressure: 0.00011 mmHg at 25°C
Melting point 167-170 ºC

4-Amino-2,6-dichloropyridine Production

Raw materials :Etanol-->Hydrochloric acid-->Ethyl acetate-->Diethyl ether-->Sulfuric acid -->Acetic acid glacial-->Nitric acid-->Potassium carbonate-->Sodium carbonate-->Chloroform-->Sodium sulfate-->Acetone-->Hydrogen peroxide-->Iron-->Trifluoroacetic acid-->Phosphorus trichloride-->2,6-Dichloropyridine-->Kieserite

4-Amino-2,6-dichloropyridine Safety Profile

Hazard Codes Irritant Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany 3
Hazard Note Irritant

Product Name

4-Amino-2,6-dichloropyridine

Synthetic route

4-Amino-2,6-dichloropyridine Chemical Properties

4-Amino-2,6-dichloropyridine Production

4-Amino-2,6-dichloropyridine Safety Profile

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