4-Bromo-2-fluorophenol supplier

Name
4-Bromo-2-fluorophenol
EINECS 218-284-1
CAS No. 2105-94-4
Article Data31
CAS DataBase
Density 1.764 g/cm³
Solubility
Melting Point
Formula C₆H₄BrFO
Boiling Point 206.1 °C at 760 mmHg
Molecular Weight 191
Flash Point 98.9 °C
Transport Information
Appearance clear colorless to brownish liquid
Safety 26-37/39-36/37/39
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 4-bromo-2-fluoro-phenol;Phenol, 4-bromo-2-fluoro-;
PSA 20.23000
LogP 2.29380

Synthetic route

: 367-12-4
2-fluorophenol

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With bromine In dichloromethane; water	90%
With bromine In dichloromethane; water	90%
With bromine In dichloromethane; water	90%

: 2-(2-fluoro-4-bromophenoxy)pyridine

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
Stage #1: 2-(2-fluoro-4-bromophenoxy)pyridine With methyl trifluoromethanesulfonate In toluene at 100℃; for 2h; Inert atmosphere; Stage #2: With sodium ethanolate for 1h; Reflux; Inert atmosphere;	82%
Stage #1: 2-(2-fluoro-4-bromophenoxy)pyridine With methyl trifluoromethanesulfonate In toluene at 100℃; Stage #2: With methanol; sodium at 90℃;	76%

: 106-41-2
4-bromo-phenol

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With acetic acid; Selectfluor; eosin y In water at 20℃; for 6h; Irradiation; Green chemistry;	68%

: 367-12-4
2-fluorophenol

A: 2105-94-4
4-bromo-2-fluorophenol

B: 576-86-3
2,4-dibromo-6-fluorophenol

C: 2040-89-3
2-bromo-6-fluorophenol

Conditions

Conditions	Yield
With 4-morpholineethanesulfonic acid; VBrPO(AnI) bromoperoxidase; dihydrogen peroxide; sodium bromide In water; tert-butyl alcohol at 23℃; pH=6.2; Overall yield = 37 %;	A n/a B 18% C n/a

...Expand

: 2357-52-0
3-fluoro-4-methoxyphenyl bromide

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With hydrogen bromide at 190℃;

: 399-96-2
4-amino-2-fluorophenol

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
2., HBr, CuBr; Yield given. Multistep reaction;

: 1073-06-9
3-fluorobromobenzene

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With microsomal protein; NADPH In phosphate buffer at 37℃; for 0.166667h; pH=7.6; Enzyme kinetics; Oxidation;

: 106-41-2
4-bromo-phenol

A: 2105-94-4
4-bromo-2-fluorophenol

B: 104197-13-9
4-bromo-2,6-difluorophenol

Conditions

Conditions	Yield
With formic acid; fluorine at 10℃; for 1.75h; Fluorination; Title compound not separated from byproducts;	A 22 % Spectr. B 4 % Spectr.

: 403-19-0
2-fluoro-4-nitrophenol

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 2: 2., HBr, CuBr View Scheme

: 366-99-4
3-fluoro-4-methoxyaniline

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuric acid; aqueous sodium nitrite solution / Behandeln des Reaktionsgemisches mit Kupfer(I)-bromid und wss. Bromwasserstoffsaeure 2: aqueous hydrobromic acid / 190 °C View Scheme

: sodium metabisulfite

: 367-12-4
2-fluorophenol

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With bromine In carbon disulfide
With bromine In carbon disulfide

: 367-12-4
2-fluorophenol

: sodium thiosulfate

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
With bromine In carbon disulfide

: 348-61-8
1-bromo-3,4-difluorobenzene

A: 2105-94-4
4-bromo-2-fluorophenol

B: 112204-58-7
5-Bromo-2-fluorophenol

Conditions

Conditions	Yield
Stage #1: 1-bromo-3,4-difluorobenzene With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere; Stage #2: With hydrogenchloride In diethylene glycol dimethyl ether; water at 20℃; Inert atmosphere;

: 367-12-4
2-fluorophenol

A: 2105-94-4
4-bromo-2-fluorophenol

B: 576-86-3
2,4-dibromo-6-fluorophenol

Conditions

Conditions	Yield
With vanadate(V)-dependent bromoperoxidase I from Ascophyllum nodosum; dihydrogen peroxide; sodium bromide In water; tert-butyl alcohol at 23℃; for 72h; pH=6.2; Enzymatic reaction; Overall yield = 106 mg;
Stage #1: 2-fluorophenol In acetonitrile at 20℃; for 0.0833333h; Stage #2: With N-Bromosuccinimide In acetonitrile at 20℃; for 24h;

: 95-56-7
2-hydroxybromobenzene

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: copper(l) iodide; 2-Picolinic acid; potassium phosphate / dimethyl sulfoxide / 24 h / 80 °C / Inert atmosphere 2.1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 5 h / 80 °C 3.1: methyl trifluoromethanesulfonate / toluene / 2 h / 100 °C / Inert atmosphere 3.2: 1 h / Reflux; Inert atmosphere View Scheme

: 4783-82-8
2-(4-bromophenyloxy)pyridine

: 2105-94-4
4-bromo-2-fluorophenol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide / ethyl acetate / 5 h / 80 °C 2.1: methyl trifluoromethanesulfonate / toluene / 2 h / 100 °C / Inert atmosphere 2.2: 1 h / Reflux; Inert atmosphere View Scheme

: 2105-94-4
4-bromo-2-fluorophenol

: 100-39-0
benzyl bromide

: 133057-82-6
1-benzyloxy-4-bromo-2-fluorobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;	100%
With potassium carbonate In acetonitrile at 20℃; for 15h;	93%

: 2105-94-4
4-bromo-2-fluorophenol

: 541-41-3
chloroformic acid ethyl ester

: 661463-10-1
4-bromo-2-fluorophenyl ethyl carbonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h;	100%
With triethylamine In dichloromethane at 0℃; for 1h;	100%
With triethylamine In dichloromethane at 0℃; for 1h;	93%
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	93%

: 2105-94-4
4-bromo-2-fluorophenol

: 109-70-6
1,3-chlorobromopropane

: 181807-91-0
4-bromo-1-(3-chloro-propoxy)-2-fluoro-benzene

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 3h; Product distribution / selectivity; Heating / reflux;	100%

: 2105-94-4
4-bromo-2-fluorophenol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 203926-74-3
(4-bromo-2-fluorophenoxy)(tert-butyl)dimethylsilane

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 25℃; for 18h;	85.4%
With 1H-imidazole In N,N-dimethyl-formamide

: 2105-94-4
4-bromo-2-fluorophenol

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: tert-butyl 4-((4-bromo-2-fluorophenoxy)methyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile for 12h; Reflux;	100%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;	86%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;	86%
With potassium carbonate In dimethyl sulfoxide at 110℃; for 16h;	83.1%
With potassium carbonate In dimethyl sulfoxide at 110℃; for 16h;	83.1%

: 74-96-4
ethyl bromide

: 2105-94-4
4-bromo-2-fluorophenol

: 115467-08-8
3-fluoro-4-ethoxy bromobenzene

Conditions

Conditions	Yield
With potassium carbonate In butanone for 24h; Heating / reflux;	99%
With tetrabutylammomium bromide; sodium hydroxide In water at 80℃; for 6h; Inert atmosphere;	90%
With potassium carbonate In acetone at 20℃;

: 2105-94-4
4-bromo-2-fluorophenol

: 7051-34-5
cyclopropylcarbinyl bromide

: 622386-52-1
4-Bromo-1-cyclopropylmethoxy-2-fluoro-benzene

Conditions

Conditions	Yield
With caesium carbonate; tetra-(n-butyl)ammonium iodide In 1-methyl-pyrrolidin-2-one at 50 - 80℃; for 2.16667h;	99%

: 2105-94-4
4-bromo-2-fluorophenol

: 75-03-6
ethyl iodide

: 115467-08-8
3-fluoro-4-ethoxy bromobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	99%
With potassium carbonate In acetone for 6h; Inert atmosphere; Reflux;	98%

: 2105-94-4
4-bromo-2-fluorophenol

: 67-63-0
isopropyl alcohol

: 202865-80-3
4-bromo-2-fluoro-1-isopropoxybenzene

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 1h; Reflux;	99%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 1h; Reflux;	99%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 1h; Reflux;	99%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 1h; Reflux;
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 1h; Reflux;

: 13154-24-0
triisopropylsilyl chloride

: 2105-94-4
4-bromo-2-fluorophenol

: 1-bromo-3-fluoro-4-triisopropylsilyloxybenzene

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 25℃; for 3h;	99%
With 1H-imidazole In dichloromethane at 20℃; for 12h;	94%
With 1H-imidazole In dichloromethane at 20℃; for 1h;

: 110-53-2
1-Bromopentane

: 2105-94-4
4-bromo-2-fluorophenol

: 127326-78-7
4-bromo-2-fluoro-1-(pentyloxy)benzene

Conditions

Conditions	Yield
Stage #1: 4-bromo-2-fluorophenol With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.5h; Inert atmosphere; Stage #2: 1-Bromopentane In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	99%
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 100℃; for 9h; Inert atmosphere;

: 2105-94-4
4-bromo-2-fluorophenol

: 6482-24-2
2-Bromoethyl methyl ether

: 944279-01-0
4-bromo-2-fluoro-1-(2-methoxyethoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	99%

: 111-83-1
1-bromo-octane

: 2105-94-4
4-bromo-2-fluorophenol

: 119259-26-6
1-Bromo-3-fluoro-4-octyloxybenzene

Conditions

Conditions	Yield
With potassium carbonate	98%
With potassium carbonate In N,N-dimethyl-formamide; benzene for 4h; Reflux; Dean-Stark;	96%
With potassium carbonate; potassium iodide In acetone for 24h; Reflux; Inert atmosphere;	60.5%
With tetrabutylammomium bromide; potassium carbonate In butanone for 4h; Heating / reflux;

: 2105-94-4
4-bromo-2-fluorophenol

: 320-76-3
2-fluoro-4-bromo-6-nitro-phenol

Conditions

Conditions	Yield
With Nitrogen dioxide In pentane 35 min, 0 deg C then 20 min, room temperature;	98%

: 109-65-9
1-bromo-butane

: 2105-94-4
4-bromo-2-fluorophenol

: 54509-63-6
4-bromo-1-butoxy-2-fluorobenzene

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In water at 80℃; for 6h; Inert atmosphere;	98%
With caesium carbonate; tetra-(n-butyl)ammonium iodide In 1-methyl-pyrrolidin-2-one at 85℃; for 2h;	96%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	85%

: 79670-17-0
methyl 2-bromomethyl-5-bromobenzoate

: 2105-94-4
4-bromo-2-fluorophenol

: 1427423-10-6
methyl 5-bromo-2-((4-bromo-2-fluorophenoxy)methyl)benzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	98%
With potassium carbonate In N,N-dimethyl-formamide at 50℃;	98%

: 557-21-1
zinc(II) cyanide

: 2105-94-4
4-bromo-2-fluorophenol

: 405-04-9
3-fluoro-4-hydroxybenzonitrile

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 120℃; for 2h;	98%

: 542-69-8
1-iodo-butane

: 2105-94-4
4-bromo-2-fluorophenol

: 54509-63-6
4-bromo-1-butoxy-2-fluorobenzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;	98%

: 2105-94-4
4-bromo-2-fluorophenol

: 274692-06-7
(S)-tert-butyl 3-{[(methylsulfonyl)oxy]methyl}pyrrolidine-1-carboxylate

: tert-butyl (S)-3-((4-bromo-2-fluorophenoxy)methyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; Solvent; Reagent/catalyst; Temperature;	98%
With potassium carbonate In N,N-dimethyl-formamide at 100℃; Reagent/catalyst; Temperature;	98%

: 2105-94-4
4-bromo-2-fluorophenol

: 164025-54-1
tert-butyl-(5-iodo-pentyloxy)-diphenyl-silane

: 831223-27-9
2-fluoro-4-[5-(tert-butyldiphenylsilanyloxy)-pentylselanyl]-phenol

Conditions

Conditions	Yield
Stage #1: 4-bromo-2-fluorophenol With tert.-butyl lithium In tetrahydrofuran at -78℃; for 0.333333h; Stage #2: With selenium In tetrahydrofuran at 20℃; for 1h; Stage #3: tert-butyl-(5-iodo-pentyloxy)-diphenyl-silane In tetrahydrofuran at 0 - 20℃;	97%

: 2105-94-4
4-bromo-2-fluorophenol

: 540-51-2
2-bromoethanol

: 944278-92-6
4-bromo-1-(2-bromoethoxy)-2-fluorobenzene

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 20℃; for 2h;	97%

: 2105-94-4
4-bromo-2-fluorophenol

: 107-30-2
chloromethyl methyl ether

: 4-bromo-2-fluoro-1-methoxymethoxybenzene

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;	97%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Cooling with ice;	97%
With potassium carbonate In acetone at 20℃; for 2h;	82%
With triethylamine In dichloromethane at 0 - 20℃; for 25h; Inert atmosphere;	57%

: 2105-94-4
4-bromo-2-fluorophenol

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: (2-((4-bromo-2-fluorophenoxy)methoxy)ethyl)trimethylsilane

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	97%

: 2105-94-4
4-bromo-2-fluorophenol

: 82010-31-9
(S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester

: (S)-tert-butyl (1-(4-bromo-2-fluorophenoxy)-4-methylpentan-2-yl)carbamate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h;	97%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h;	97%

: 2105-94-4
4-bromo-2-fluorophenol

: 73789-86-3
4-i-propylbenzyl bromide

: C16H16BrFO

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃;	97%

: 111-25-1
1-bromo-hexane

: 2105-94-4
4-bromo-2-fluorophenol

: 54509-62-5
2-fluoro-4-bromo-1-(hexyloxy)benzene

Conditions

Conditions	Yield
With potassium carbonate	96%

: 2105-94-4
4-bromo-2-fluorophenol

: C18H23ClN4O3

: C24H26BrFN4O4

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 18h; Inert atmosphere;	95%

: 2895-21-8
2-chloro-N-isopropylacetamide

: 2105-94-4
4-bromo-2-fluorophenol

: 2-(4-bromo-2-fluoro-phenoxy)-N-isopropylacetamide

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane at 80℃; for 18h; Inert atmosphere;	95%

: 2105-94-4
4-bromo-2-fluorophenol

: 862876-56-0
(2R)-1-(3-chloropropyl)-2-methylpyrrolidine

: 1152749-38-6
(2R)-1-[3-(4-bromo-2-fluorophenoxy)propyl]-2-methylpyrrolidine

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 100℃; for 4h;	94%

: 2105-94-4
4-bromo-2-fluorophenol

: (S)-tert-butyl 4-isobutyl-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

: (S)-tert-butyl (1-(4-bromo-2-fluorophenoxy)-2,4-dimethylpentan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: 4-bromo-2-fluorophenol With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.666667h; Stage #2: (S)-tert-butyl 4-isobutyl-4-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide In N,N-dimethyl-formamide at 80℃;	94%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	83%

4-Bromo-2-fluorophenol Chemical Properties

Molecular Structure of 2-Fluoro-4-bromophenol(2105-94-4):

IUPAC Name:4-bromo-2-fluorophenol
Molecular Formula:C₆H₄BrFO
Molecular Weight:190.997763 g/mol
Appearance:clear colorless to slightly yellow liquid
Density:1.764 g/cm³
Flash Point:98.9 °C
Enthalpy of Vaporization:46.04 kJ/mol
Boiling Point:206.1 °C at 760 mmHg
Vapour Pressure:0.168 mmHg at 25 °C
Water Solubility:1105 mg/L at 25 °C
Refractive index:n20/D 1.566(lit.)
Synonyms of 2-Fluoro-4-bromophenol(2105-94-4):
4-BROMO-2-FLUOROPHENOL;2-Fluoro-4-Bromophenol;4-Bromo-2-fluorophenol 98%;4-Bromo-2-fluorophenol98%;4-Bromo-2-fluorophenol, 97+%
Categories of 2-Fluoro-4-bromophenol(2105-94-4):
Fluorobenzene Series;Aromatic Phenols;Fluorobenzene;Phenol&Thiophenol&Mercaptan;Bromine Compounds;Fluorine Compounds;Phenols;Building Blocks for Liquid Crystals;Functional Materials;Phenols(Building Blocks for Liquid Crystals);Organic Building Blocks;Oxygen Compounds

4-Bromo-2-fluorophenol Safety Profile

Safety Information of 2-Fluoro-4-bromophenol(2105-94-4):
Hazard Codes:Xi,Xn
Hazard Note:Irritant
Risk Statements:36/37/38-22
36/37/38:Irritating to eyes, respiratory system and skin
22:Harmful if swallowed
Safety Statements:26-37/39-36/37/39
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
37/39:Wear suitable gloves and eye/face protection
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
WGK Germany:3

4-Bromo-2-fluorophenol Specification

First Aid Measures of 2-Fluoro-4-bromophenol(2105-94-4):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Storage of 2-Fluoro-4-bromophenol(2105-94-4):
Store in a cool, dry place. Store in a tightly closed container.

Product Name

4-Bromo-2-fluorophenol

Synthetic route

4-Bromo-2-fluorophenol Chemical Properties

4-Bromo-2-fluorophenol Safety Profile

4-Bromo-2-fluorophenol Specification

Related Products

Hot Products