4-Methoxyphenacyl chloride supplier

Name
4-Methoxyphenacyl chloride
EINECS
CAS No. 2196-99-8
Article Data80
CAS DataBase
Density 1.18 g/cm³
Solubility
Melting Point 98-100 °C
Formula C₉H₉ClO₂
Boiling Point 302.7 °C at 760 mmHg
Molecular Weight 184.622
Flash Point 134.2 °C
Transport Information UN 1759
Appearance Pale yellow to beige crystalline powder
Safety 45-36/37/39-26
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Acetophenone,2-chloro-4'-methoxy- (6CI,7CI,8CI);2-Chloro-1-(4-methoxyphenyl)ethanone;2-Chloro-1-(4'-methoxyphenyl)ethanone;2-Chloro-4'-methoxyacetophenone;4'-Methoxy-2-chloroacetophenone;Chloromethyl4-methoxyphenyl ketone;NSC 41670;p-Methoxyphenacyl chloride;a-Chloro-4-methoxyacetophenone;a-Chloro-4'-methoxyacetophenone;
PSA 26.30000
LogP 2.11670

Synthetic route

: 80-11-5
N-methyl-N-nitrosotoluene-p-sulfonamide

: 100-07-2
4-methoxy-benzoyl chloride

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: N-methyl-N-nitrosotoluene-p-sulfonamide With potassium hydroxide In methanol; water; N,N-dimethyl-formamide Flow reactor; Stage #2: 4-methoxy-benzoyl chloride In methanol; diethyl ether; water; N,N-dimethyl-formamide at 0 - 30℃; for 1.5h; Sonication; Stage #3: With hydrogenchloride In methanol; diethyl ether; water; N,N-dimethyl-formamide for 1h;	99%

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogenchloride; ammonium nitrate; iodine; oxygen In water; acetonitrile at 60℃; for 72h; Solvent; Green chemistry; Large scale; chemoselective reaction;	98%
With N,N,N-trimethylbenzenemethanaminium dichloroiodate In methanol; 1,2-dichloro-ethane for 5h; Heating;	97%
With 1,3-dichloro-5,5-dimethylhydantoin; toluene-4-sulfonic acid In methanol at 30 - 35℃; for 8h;	94%

: 33491-06-4
4-(2-chloroethynyl)anisole

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With tetrafluoroboric acid; water In 2,2,2-trifluoroethanol at 80℃; for 10h;	95%

: 14337-31-6
2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-ol

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With [2,2]bipyridinyl; copper(l) chloride In 1,2-dichloro-ethane for 3h; Heating;	90%
Multi-step reaction with 4 steps 1: 90 percent / NaH / tetrahydrofuran / 1 h / 0 °C 2: 0.2M ammonium nitrate / methanol; H2O / cathodic reduction 3: 5M KOH / ethanol / Heating 4: cond. H2SO4 / H2O; dioxane / 3 h / Ambient temperature View Scheme

: 5720-07-0
4-methoxyphenylboronic acid

: 79-04-9
chloroacetyl chloride

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With potassium carbonate In toluene at 20℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere;	88%
With mono(1-benzyl-3-(1-benzyl-1-methylpyrrolidin-1-ium-2-yl)pyridin-1-ium)monopalladium(II) tetrachloride; potassium carbonate In chloroform at 20℃; for 0.75h;	91 %Chromat.

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With tris(triphenylphosphine)ruthenium(II) chloride; trifluoromethane sulfonyl chloride In benzene at 120℃; for 7h;	85%

: 2547-61-7
Trichloromethanesulfonyl chloride

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With ruthenium(II) In benzene at 120℃; for 7h; sealed;	80%

: 100-66-3
methoxybenzene

: 79-04-9
chloroacetyl chloride

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminium trichloride In dichloromethane for 2h; Ambient temperature;	78.5%
With carbon disulfide; aluminium trichloride
With carbon disulfide; aluminium trichloride

: 768-60-5
4-methoxyphenylacetylen

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogenchloride; iodine In dimethyl sulfoxide at 20℃; for 16h;	76%

: 637-69-4
4-Methoxystyrene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With magnesium(II) chloride hexahydrate; oxygen; lithium perchlorate; manganese(ll) chloride In dichloromethane; acetone at 40℃; for 40h; Electrochemical reaction;	71%
With magnesium(II) chloride hexahydrate; cobalt(II) chloride hexahydrate; sulfuric acid; oxygen; lithium perchlorate In dichloromethane; acetone at 40℃; for 12h; Electrolysis; Sealed tube; chemoselective reaction;	65%
With iron(III) chloride; potassium chloride; oxygen; toluene-4-sulfonic acid In tert-butyl methyl ether at 20℃; Irradiation; Green chemistry;	43%
Multi-step reaction with 3 steps 1: thionyl chloride / chloroform / 20 °C 2: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 24 h / 70 °C 3: iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen / 1,2-dichloro-ethane / 16 h / 75 °C / 760.05 Torr / Green chemistry View Scheme

: 100-66-3
methoxybenzene

: 79-11-8
chloroacetic acid

A: 53688-19-0
2-chloro-1-(2-methoxy-phenyl)-ethanone

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With P2O5/silica gel In 1,2-dichloro-ethane for 3h; Friedel Crafts acylation; Reflux;	A 12 %Spectr. B 70%

...Expand

: 40811-01-6
1-(1-chloroethenyl)-4-methoxybenzene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen In 1,2-dichloro-ethane at 75℃; under 760.051 Torr; for 16h; Solvent; Green chemistry; chemoselective reaction;	70%

: 6832-17-3
2-diazo-1-(4-methoxyphenyl)ethanone

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With iron(III) chloride; silica gel In dichloromethane at 20℃; for 0.166667h;	65%

: 107-14-2
chloroacetonitrile

: 100-66-3
methoxybenzene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 264h; Ambient temperature;	63%

: (Z)-2-chloro-1-ethoxy-p-methoxystyrene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogenchloride; ethanol In 1,2-dichloro-ethane at 20℃;	62%

: 162147-95-7
2-chloro-1-(4-methoxyphenyl)-2-(phenylsulfinyl)-1-ethanone

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With ethylmagnesium bromide In tetrahydrofuran at -70 - -40℃; for 2h;	60%

: 36458-91-0
2,2,2-trichloro-1-(4-methoxyphenyl)ethan-1-one

A: (Z)-2,3-dichloro-1,4-bis(4-methoxyphenyl)but-2-ene-1,4-dione

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With [2,2]bipyridinyl; copper(l) chloride In 1,2-dichloro-ethane; benzene for 1h; Inert atmosphere; Schlenk technique; Reflux; diastereoselective reaction;	A 60% B 18%

: 637-69-4
4-Methoxystyrene

: N-chloro-N-fluoro-benzenesulfonamide

A: (Z)-N-(2-chloro-1-(4-methoxyphenyl)vinyl)benzenesulfonamide

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: 4-Methoxystyrene; N-chloro-N-fluoro-benzenesulfonamide In dichloromethane at 35℃; for 12h; Stage #2: With triethylamine In dichloromethane at 35℃; for 1h;	A 48% B 38%

...Expand

: 100-06-1
1-(4-methoxyphenyl)ethanone

A: 79881-25-7
2-chloro-1-(3-chloro-4-methoxyphenyl)-ethanone

B: 37612-52-5
4-acetyl-2-chloroanisole

C: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminum oxide; sodium chlorite; manganese(III) acetylacetonate In dichloromethane at 20℃; for 3.16667h;	A 25% B 22% C 30%
With chlorine In acetic acid for 0.5h; Ambient temperature;	A 14% B 19% C 29%

...Expand

: 100-06-1
1-(4-methoxyphenyl)ethanone

A: 29003-60-9
2,2-dichloro-4'-methoxyacetophenone

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogenchloride; potassium permanganate In acetonitrile at 60℃;	A 16% B 28%
With aluminum (III) chloride; oxygen; vanadium(V) oxytriisopropoxide; tetra-(n-butyl)ammonium iodide In acetonitrile at 80℃; for 24h;	A 13 %Spectr. B 44 %Spectr.

: 710949-40-9
2-chloro-1,3-bis(4′-methoxy-phenyl)-1,3-propanedione

A: 18362-51-1
1,3-bis(4'-methoxyphenyl)propane-1,3-dione

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
Stage #1: 2-chloro-1,3-bis(4′-methoxy-phenyl)-1,3-propanedione With [Cu(tris(2-pyridylmethyl)amine)(CH3CN)](ClO4)2; lithium hexamethyldisilazane In diethyl ether; acetonitrile for 48h; Inert atmosphere; Glovebox; Stage #2: With water In diethyl ether; acetonitrile	A n/a B 28%

: 186581-53-3, 908094-01-9
diazomethane

: 6305-04-0
p-hydroxyphenacyl chloride

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With methanol; diethyl ether

: 186581-53-3, 908094-01-9
diazomethane

: 100-07-2
4-methoxy-benzoyl chloride

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With diethyl ether

: 100-66-3
methoxybenzene

: 79-04-9
chloroacetyl chloride

A: 2132-66-3
2-chloro-1,1-bis-(4-methoxy-phenyl)-ethene

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminium trichloride at 20℃;

...Expand

: 100-66-3
methoxybenzene

: 79-04-9
chloroacetyl chloride

A: 53688-19-0
2-chloro-1-(2-methoxy-phenyl)-ethanone

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With carbon disulfide; aluminium trichloride in der Kaelte;
With iron(III) oxide at 20℃; for 0.25h; Friedel Crafts acylation; regioselective reaction;

...Expand

: 595-91-5
triphenylacetic acid

: 100-66-3
methoxybenzene

: 541-88-8
Chloroacetic anhydride

A: 7402-89-3
(4-methoxyphenyl)triphenylmethane

B: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
at 150 - 155℃;

...Expand

: 637-69-4
4-Methoxystyrene

A: 18684-79-2
Z-1-(2-chloroethenyl)phenyl methyl ether

B: 18684-94-1
1-[(E)-2-chlorovinyl]-4-methoxybenzene

C: 123-11-5
4-methoxy-benzaldehyde

D: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With chlorine dioxide In tetrachloromethane at 52 - 54℃; for 1.16667h; Further byproducts given. Title compound not separated from byproducts;	A 4.2 % Chromat. B 14.1 % Chromat. C 1.5 % Chromat. D 33.7 % Chromat.
With chlorine dioxide In tetrachloromethane at 52 - 54℃; for 1.16667h; Further byproducts given;	A 4.2 % Chromat. B 14.1 % Chromat. C 1.5 % Chromat. D 33.7 % Chromat.

...Expand

: 637-69-4
4-Methoxystyrene

A: 18684-79-2
Z-1-(2-chloroethenyl)phenyl methyl ether

B: 18684-94-1
1-[(E)-2-chlorovinyl]-4-methoxybenzene

C: 100-09-4
4-methoxybenzoic acid

D: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With chlorine dioxide In tetrachloromethane at 52 - 54℃; for 1.16667h; Further byproducts given;	A 4.2 % Chromat. B 14.1 % Chromat. C 1.2 % Chromat. D 33.7 % Chromat.

...Expand

: 1-((E)-2-Chloro-1-methoxy-vinyl)-4-methoxy-benzene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane; water for 3h; Ambient temperature; Yield given;

: 552-89-6
2-nitro-benzaldehyde

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 73936-40-0
trans-(4-methoxyphenyl)(3-(2-nitrophenyl)oxiran-2-yl)methanone

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 0.5h; Darzens Condensation; stereoselective reaction;	100%
With methanol; sodium at 20℃; for 0.25h; Darzens Condensation;

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: (S)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; f-amphox; hydrogen; potassium carbonate In ethanol; hexane at 25 - 30℃; under 60804.1 Torr; for 48h; Pressure; Inert atmosphere; Glovebox; Autoclave; enantioselective reaction;	99%
With potassium tert-butylate; isopropyl alcohol; chloro[(1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine] (pentamethylcyclopentadienyl) rhodium at 25℃;	96%
With borane-THF; potassium hydroxide; (S)-Corey-Bakshi-Shibata oxazaborolidine In diethyl ether; water at -30℃;
With (R)-alcohol dehydrogenase from Lactobacillus kefir DSM 20587 In aq. buffer at 30℃; for 12h; pH=7; Enzymatic reaction; stereoselective reaction;	n/a
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In dimethyl sulfoxide at 30℃; for 24h; pH=7.5; Enzymatic reaction; enantioselective reaction;	n/a

: 93378-56-4
5-(4-methylphenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 743477-46-5
1-(4-methoxyphenyl)-2-{[5-(4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 2h; Heating / reflux;	99%

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: (R)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane

Conditions

Conditions	Yield
With formic acid; C31H33N2O3RuS; potassium formate In water; ethyl acetate at 60℃; for 4h; Inert atmosphere; enantioselective reaction;	98%
With sodium perchlorate; hydrogen; chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II) In methanol at 30℃; under 76005.1 Torr; for 24h; Product distribution / selectivity;	93%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In dimethyl sulfoxide at 30℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	90%
With glucose; glucose dehydrogenase from Bacillus subtilis CGMCC 1.1398; medium-chain dehydrogenase from Kuraishia capsulate CBS1993; NAD In aq. phosphate buffer for 16h; pH=7.0; Enzymatic reaction; enantioselective reaction;	n/a

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 1097-25-2
(4-methoxyphenyl)(4-(4-methoxyphenyl)-1H-imidazol-2-yl)methanone

Conditions

Conditions	Yield
With sodium azide; choline chloride; glycerol at 80℃; for 4h; Green chemistry;	98%

: 15570-12-4
3-methoxybenzenethiol

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 63675-73-0
α-(3-methoxyphenyl-thio)-4-methoxyacetophenone

Conditions

Conditions	Yield
Stage #1: 3-methoxybenzenethiol With sodium methylate In methanol at 35℃; Stage #2: 2-chloro-1-(4-methoxyphenyl)ethanone In methanol at 0 - 35℃; for 1.16667h;	97.4%

: 16629-40-6
4-phenyl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 325694-22-2
1-(4-methoxyphenyl)-2-[(4-phenyl-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl)thio]ethanone

Conditions

Conditions	Yield
With potassium carbonate In acetone for 3h; Heating / reflux;	97%

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 4973-18-6
(+/-)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at 2℃;	96.2%
	95.9%
With formic acid; 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; sodium formate In water at 80℃; for 18h; pH=4.5; Inert atmosphere; chemoselective reaction;	92%

: 127-08-2
potassium acetate

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 58518-78-8
p-methoxyphenacyl acetate

Conditions

Conditions	Yield
With [bmim]Br at 20℃; for 0.666667h;	96%

: 6628-86-0
5-chloro-2-nitrobenzaldehyde

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: C16H12ClNO5

Conditions

Conditions	Yield
With sodium methylate In methanol at 15℃; for 0.25h; Darzens Condensation;	96%

: 90-02-8
salicylaldehyde

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 63157-19-7
(1-benzofuran-2-yl)(4-methoxyphenyl)methanone

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In tetrahydrofuran at 20℃; for 0.0666667h; Rap-Stoermer reaction;	95%
With potassium carbonate at 100℃; for 0.416667h; Rapp-Stoermer Benzofuran Synthesis; Inert atmosphere;	86%

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

A: (S)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane

B: (R)-1-chloro-2-hydroxy-2-(p-methoxyphenyl)ethane

Conditions

Conditions	Yield
With formic acid*triethylamine; Ru/(S,S)-DPEN/MCF In dichloromethane at 20℃; for 12h;	A 94% B n/a
With Geotrichum sp. 38 in 5percent glucose In dimethyl sulfoxide at 30℃; for 17h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With dimethylsulfide borane complex; (S)-chiral pyrrolidine-based ionic liquid In toluene Heating; Title compound not separated from byproducts;

: 3290-99-1
4-methoxybenzoic acid hydrazide

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 64327-01-1
3,6-bis(4-methoxyphenyl)-1,2,4-triazine

Conditions

Conditions	Yield
With ammonium propionate; propionic acid In 1-methyl-pyrrolidin-2-one at 190℃; for 36h;	94%

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With bismuth(III) chloride; sodium tetrahydroborate; sodium iodide In acetone Ambient temperature;	93.3%
With triphenyl phosphite; sodium hydrogencarbonate; (BrBu2Te)2O In water; N,N-dimethyl-formamide at 80℃; for 5h;	89%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; acetic acid for 1.5h; Irradiation; Inert atmosphere;	88%
With tris(2,2'-bipyridyl)ruthenium dichloride; 1,5-dimethoxynaphthalene; ascorbic acid In methanol; water for 15h; Inert atmosphere; Irradiation;	81%

: 38205-60-6
5-acetyl-2,4-dimethylthiazole

: 79-19-6
thiosemicarbazide

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 2-(4-(4-methoxyphenyl)thiazol-2-yl)-1-(1-(2,4-dimethylthiazol-5-yl)ethylidene)hydrazine

Conditions

Conditions	Yield
at 20℃; for 0.5h; Solvent;	93%

...Expand

: 7520-94-7
5-acetyl-4-methyl-2-phenylthiazole

: 79-19-6
thiosemicarbazide

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 2-(4-(4-methoxyphenyl)thiazol-2-yl)-1-(1-(4-methyl-2-phenyl thiazol-5-yl)ethylidene)hydrazine

Conditions

Conditions	Yield
at 20℃; for 0.5h; Solvent;	93%

...Expand

: 72824-04-5
2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: (S)-1-chloro-2-(4-methoxyphenyl)pent-4-en-2-ol

Conditions

Conditions	Yield
With methanol; (S)-2-((2-hydroxy-3-(triphenylsilyl)benzyl)amino)-3-methyl-1-(pyrrolidin-1-yl)butan-1-one; zinc dimethoxide In toluene at 22℃; for 4h; Inert atmosphere; enantioselective reaction;	93%

: 1450-76-6
1-(2-hydroxy-5-nitrophenyl)ethanone

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 141645-11-6
2-(4-methoxy benzoyl) 3-methyl 5-nitro benzofuran

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 4h; Solvent; Molecular sieve; Inert atmosphere;	92.15%

: 110-83-8
cyclohexene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

A: 101869-96-9
6-Methoxy-2,3,4,4a,10,10a-hexahydro-1H-phenanthren-9-one

B: 100-06-1
1-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With silver trifluoromethanesulfonate In benzene for 4h; Irradiation;	A 92% B n/a

...Expand

: 917-64-6
methyl magnesium iodide

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 98815-47-5
1-chloro-2-(4-methoxyphenyl)propan-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃; for 1.5h;	92%

: 5334-56-5
1-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 1234320-82-1
5-[2-(4-methoxyphenyl)-2-oxoethyl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile for 7h; Reflux;	92%

: 95-55-6
2-amino-phenol

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 112030-48-5
3-(4-methoxyphenyl)-2H-benzo[b][1,4]oxazine

Conditions

Conditions	Yield
With iodine; potassium carbonate In tetrahydrofuran; water at 20℃; for 7.5h; Inert atmosphere; Green chemistry;	92%

: 6631-37-4
2-(phenylamino)pyridine

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 1310709-07-9
2-(4-methoxyphenyl)-1-(pyridin-2-yl)-1H-indole

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium fluoride In methanol at 90℃; for 24h;	92%

: 1826-67-1
vinyl magnesium bromide

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 1-chloro-2-(4-methoxyphenyl)but-3-en-2-ol

Conditions

Conditions	Yield
In tetrahydrofuran at -78℃; for 2.5h; Inert atmosphere;	91%

: 40307-11-7
1-ethyl-4-ethynylbenzene

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: C19H19N3O2

Conditions

Conditions	Yield
With sodium azide In water at 20℃; for 2h; Green chemistry;	91%

: 118-93-4
o-hydroxyacetophenone

: 2196-99-8
2-chloro-1-(4-methoxyphenyl)ethanone

: 32730-15-7
(4-methoxyphenyl)-(3-methylbenzofuran-2-yl)methanone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 2.5h; Solvent; Molecular sieve; Inert atmosphere;	90.2%

4-Methoxyphenacyl chloride Specification

The IUPAC name of Ethanone,2-chloro-1-(4-methoxyphenyl)- is 2-chloro-1-(4-methoxyphenyl)ethanone. With the CAS registry number 2196-99-8, it is also named as 4-Methoxyphenacyl chloride. The product's categories are Acetylhalide; Ketone; Acetophenone Series. Besides, it is pale yellow to beige crystalline powder, which should be stored in sealed, cool and dry place away from the corrosion area. In addition, its molecular formula is C₉H₉ClO₂ and molecular weight is 184.62.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.92; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 3; (6)Polar Surface Area: 26.3 Å²; (7)Index of Refraction: 1.523; (8)Molar Refractivity: 47.8 cm³; (9)Molar Volume: 156.3 cm³; (10)Polarizability: 18.95×10^-24cm³; (11)Surface Tension: 37.7 dyne/cm; (12)Density: 1.18 g/cm³; (13)Flash Point: 134.2 °C; (14)Melting point: 98-100 °C; (15)Enthalpy of Vaporization: 54.3 kJ/mol; (16)Boiling Point: 302.7 °C at 760 mmHg; (17)Vapour Pressure: 0.000973 mmHg at 25 °C.

Preparation of Ethanone,2-chloro-1-(4-methoxyphenyl)-: this chemical can be prepared by Chloroacetyl chloride and Methoxybenzene.

This reaction needs AlCl₃ and CH₂Cl₂ at ambient temperature. The reaction time is 2 hours. The yield is 78.5 %.

Uses of Ethanone,2-chloro-1-(4-methoxyphenyl)-: it can react with Methylmagnesium iodide to get 1-Chloro-2-(4-methoxyphenyl)propan-2-ol.

This reaction needs Tetrahydrofuran at temperature of -78 °C for 1.5 hours. The yield is 92 %.

When you are using this chemical, please be cautious about it as the following: it may cause burns. You should wear suitable protective clothing, gloves and eye/face protection. Moreover, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES: ClCC(=O)c1ccc(OC)cc1
(2)InChI: InChI=1/C9H9ClO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
(3)InChIKey: MCRINSAETDOKDE-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C9H9ClO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
(5)Std. InChIKey: MCRINSAETDOKDE-UHFFFAOYSA-N

Product Name

4-Methoxyphenacyl chloride

Synthetic route

4-Methoxyphenacyl chloride Specification

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