4-Methoxyphenylacetyl chloride supplier

Name
4-Methoxyphenylacetyl chloride
EINECS -0
CAS No. 4693-91-8
Article Data119
CAS DataBase
Density 1.192 g/cm³
Solubility
Melting Point
Formula C₉H₉ClO₂
Boiling Point 280.1 °C at 760 mmHg
Molecular Weight 184.622
Flash Point 100 °C
Transport Information UN 3265
Appearance colorless liquid
Safety 26-36/37/39-45
Risk Codes 14-34-37
Molecular Structure
Hazard Symbols C
Synonyms Acetylchloride, (p-methoxyphenyl)- (6CI,7CI,8CI);(4-Methoxyphenyl)acetyl chloride;(p-Methoxyphenyl)acetyl chloride;2-(4-Methoxyphenyl)acetyl chloride;4-Methoxybenzeneacetyl chloride;p-Anisylacetyl chloride;p-Methoxyphenacetylchloride;
PSA 26.30000
LogP 2.00310

Synthetic route

: 104-01-8
4-Methoxyphenylacetic acid

: 4693-91-8
4-methoxyphenyl-acetic chloride

Conditions

Conditions	Yield
With thionyl chloride In toluene Heating;	100%
With thionyl chloride In dichloromethane	100%
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 23℃;	100%

: 2746-25-0
p-Methoxybenzyl bromide

A: 4693-91-8
4-methoxyphenyl-acetic chloride

B di-p-tolyl cadmium: di-p-tolyl cadmium

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: AcOH; aq. NaOH 2: thionyl chloride View Scheme

: 104-47-2
p-methoxybenzylnitrile

A: 4693-91-8
4-methoxyphenyl-acetic chloride

B di-p-tolyl cadmium: di-p-tolyl cadmium

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: AcOH; aq. NaOH 2: thionyl chloride View Scheme

: 105-13-5
4-Methoxybenzyl alcohol

A: 4693-91-8
4-methoxyphenyl-acetic chloride

B di-p-tolyl cadmium: di-p-tolyl cadmium

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: PBr3 / CH2Cl2 2: AcOH; aq. NaOH 3: thionyl chloride View Scheme

: 872-50-4
1-methyl-pyrrolidin-2-one

: 104-01-8
4-Methoxyphenylacetic acid

: 4693-91-8
4-methoxyphenyl-acetic chloride

Conditions

Conditions	Yield
With thionyl chloride

: 156-38-7
4-hydroxyphenylacetate

: 4693-91-8
4-methoxyphenyl-acetic chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 12 h / 40 - 45 °C 2: thionyl chloride / 5 h / 60 °C View Scheme

: 104-01-8
4-Methoxyphenylacetic acid

: 79-04-9
chloroacetyl chloride

: 4693-91-8
4-methoxyphenyl-acetic chloride

Conditions

Conditions	Yield
In dichloromethane; N,N-dimethyl-formamide at 30℃; for 2h; Inert atmosphere;

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 267884-96-8
N-methoxy-2-(4-methoxyphenyl)-N-methylethanamide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 1h;	100%
With pyridine In dichloromethane at 20℃; for 1h;	88%
With pyridine; dmap; sodium hydrogencarbonate In diethyl ether
With pyridine In dichloromethane at 0℃; for 1h;

: 401788-86-1
(S)-9-Trityloxy-nonan-4-ol

: 4693-91-8
4-methoxyphenyl-acetic chloride

: (4-Methoxy-phenyl)-acetic acid (S)-1-propyl-6-trityloxy-hexyl ester

Conditions

Conditions	Yield
With potassium tert-butylate; tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide	100%

: 99-57-0
2-hydroxy-5-nitroaniline

: 4693-91-8
4-methoxyphenyl-acetic chloride

: N-(2-hydroxy-5-nitro-phenyl)-2-(4-methoxy-phenyl)-acetamide

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran at 0 - 20℃; for 2h;	100%

: 66584-32-5
3-bromo-N-methylaniline

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 1268826-67-0
N-(3-bromophenyl)-2-(4-methoxyphenyl)-N-methylacetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	100%

: 100-66-3
methoxybenzene

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 120-44-5
1,4-di(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminum (III) chloride at 25℃; for 0.75h; Friedel-Crafts Acylation; Cooling;	99%
With aluminum (III) chloride In dichloromethane at 20℃; for 1h; Friedel-Crafts Acylation;	70%
With aluminium trichloride In 1,2-dichloro-ethane for 2h; Heating;	67%

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 112403-98-2
O-methyl (p-methoxyphenyl)acetohydroxamate

Conditions

Conditions	Yield
	99%

: 38945-21-0
O-allylhydroxylamine hydrochloride

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 869089-90-7
N-(O-allylhydroxyl)-4-methoxyphenylacetamide

Conditions

Conditions	Yield
With sodium carbonate In water; benzene at 0 - 20℃; for 12h;	99%

: 96-21-9
1,3-dibromo-2-hydroxypropane

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 2-bromo-1-(bromomethyl)ethyl 2-(4-methoxyphenyl)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane Inert atmosphere;	99%

: 593-56-6
N-methoxylamine hydrochloride

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 112403-98-2
O-methyl (p-methoxyphenyl)acetohydroxamate

Conditions

Conditions	Yield
With sodium carbonate In water; benzene for 5h; Ambient temperature;	98%
With sodium carbonate In water; benzene at 23℃; for 12h; Inert atmosphere; Cooling with ice;	67%
With potassium carbonate In water; ethyl acetate at 0 - 20℃;	256.5 mg

: 174905-91-0
3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 221332-90-7
N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Conditions

Conditions	Yield
With sodium carbonate In benzene at 8 - 10℃; for 0.5h;	98%

: N-(4-cyanobenzyl)-6-aminopyrimidine-4-carboxamide hydrochloride

: 4693-91-8
4-methoxyphenyl-acetic chloride

: C22H19N5O3

Conditions

Conditions	Yield
With pyridine at 60℃; for 15h;	98%

: 55511-44-9
(+)404-3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 1205648-10-7
C22H23FN2O4

Conditions

Conditions	Yield
Stage #1: 4-methoxyphenyl-acetic chloride With bis-triphenylphosphine-palladium(II) chloride; O-benzoylquinidine; N-fluorobis(benzenesulfon)imide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 8h; Inert atmosphere; Stage #2: (+)404-3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione With dmap In tetrahydrofuran at -78 - 20℃; Inert atmosphere; optical yield given as %de;	98%

: 3490-06-0
N-methylhomoveratrylamine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: N-(3,4-dimethoxyphenethyl)-2-(4-methoxyphenyl)-N-methylacetamide

Conditions

Conditions	Yield
With sodium hydroxide In chloroform; water	98%

: 108-98-5
thiophenol

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 86211-05-4
S-phenyl 2-(4-methoxyphenyl)ethanethioate

Conditions

Conditions	Yield
With triethylamine In toluene	97%

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 702-23-8
2-(4-Methoxyphenyl)ethanol

Conditions

Conditions	Yield
With (1,3-dimethylimidazol-2-ylidene)borane In chloroform at 20℃; for 2h;	97%

: (1,3-dimethyl-1H-imidazol-3-ium-2-yl)bis(phenylthio)hydroborate

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 86211-05-4
S-phenyl 2-(4-methoxyphenyl)ethanethioate

Conditions

Conditions	Yield
In chloroform at 20℃; for 2h;	97%

: 90-02-8
salicylaldehyde

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 23000-33-1
3-(4-methoxyphenyl)coumarin

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In benzene for 4h; Ambient temperature;	96%
With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate In dichloromethane; water at 20℃;	56%

: 213692-58-1
3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-D-phenylalanine methyl ester

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 213692-59-2
N-<(4-methoxxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-D-phenylalanine methyl ester

Conditions

Conditions	Yield
With sodium carbonate In water; benzene at 8 - 10℃; for 0.5h;	96%
	96%

: 17534-15-5
1,2-benzenedithiole

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 62217-22-5
2-(4-Methoxy-benzylidene)-benzo[1,3]dithiole

Conditions

Conditions	Yield
With tetrafluoroboric acid In diethyl ether at 105 - 110℃; for 0.166667h;	95%

: 725683-06-7
2-(4-bromophenyl)-N-methylethan-1-amine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: N-(4-bromophenethyl)-2-(4-methoxyphenyl)-N-methylacetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	95%

: 3434-04-6
2-(2-bromobenzyloxy)aniline

: 344-25-2
D-Prolin

: 4693-91-8
4-methoxyphenyl-acetic chloride

: (R)-1-[(4-methoxyphenyl)acetyl]pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In water; acetone	95%

...Expand

: 102226-41-5
3,4-dihydro-2H-pyrido[4,3-b][1,4]oxazine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 1198154-13-0
1-(2,3-dihydro-pyrido[4,3-b][1,4]oxazin-4-yl)-2-(4-methoxy-phenyl)-ethanone

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	95%

: 2450-71-7
Propargylamine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 1030779-93-1
2-(4-methoxyphenyl)-N-(prop-2-yn-1-yl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h; Huisgen Cycloaddition;	95%

: 123-75-1
pyrrolidine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 123902-08-9
2-(4-methoxyphenyl)-1-(pyrrolidin-1-yl)ethan-1-one

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 5h; Inert atmosphere;	95%
With triethylamine In dichloromethane at 20℃;	4.18 g

: 107-11-9
1-amino-2-propene

: 4693-91-8
4-methoxyphenyl-acetic chloride

: N-allyl-2-(4-methoxyphenyl)acetamide

Conditions

Conditions	Yield
In dichloromethane for 4h; Cooling with ice;	94%

: 917473-39-3
(5-bromo-2-chloro-pyridin-3-ylmethyl)-methyl-amine

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 917473-40-6
N-(5-bromo-2-chloro-pyridin-3-ylmethyl)-2-(4-methoxy-phenyl)-N-methyl-acetamide

Conditions

Conditions	Yield
With 4-methyl-morpholine In dichloromethane at 0 - 23℃; for 18h;	94%
With 4-methyl-morpholine In dichloromethane at 0 - 20℃; for 18.0667h;	94%

: 102-56-7
2,5-dimethoxyaniline

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 256424-18-7
N-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acetamide

Conditions

Conditions	Yield
In toluene at 20℃; for 1h;	93%
In toluene; Petroleum ether	1.83 g (93%)

: 108-46-3
recorcinol

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 487-49-0
1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With hydrogen fluoride at 20℃; for 12h; Product distribution / selectivity; Friedel-Crafts acylation; autoclave;	92%
With aluminium trichloride; nitrobenzene

: 634-36-6
1,2,3-trimethoxybenzene

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 3606-32-4
1-(2-hydroxy-3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)ethanone

Conditions

Conditions	Yield
With aluminium trichloride In carbon disulfide at 20℃;	92%
With aluminium trichloride

4-Methoxyphenylacetyl chloride Specification

This chemical is called Benzenacetyl chloride, 4-methoxy-, and its systematic name is (4-methoxyphenyl)acetyl chloride. With the molecular formula of C₉H₉ClO₂, its molecular weight is 184.62. The CAS registry number of this chemical is 4693-91-8. Additionally, its product categories are Aromatic Phenylacetic Acids and Derivatives; Acid Halides; Carbonyl Compounds; Organic Building Blocks. It should be stored at the temperature of 2-8°C.

Other characteristics of the Benzenacetyl chloride, 4-methoxy- can be summarised as followings: (1)ACD/LogP: 2.15; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.15; (4)ACD/LogD (pH 7.4): 2.15; (5)ACD/BCF (pH 5.5): 25.31; (6)ACD/BCF (pH 7.4): 25.31; (7)ACD/KOC (pH 5.5): 351.67; (8)ACD/KOC (pH 7.4): 351.67; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 26.3 Å²; (13)Index of Refraction: 1.524; (14)Molar Refractivity: 47.35 cm³; (15)Molar Volume: 154.7 cm³; (16)Polarizability: 18.77×10^-24cm³; (17)Surface Tension: 37.9 dyne/cm; (18)Density: 1.192 g/cm³; (19)Flash Point: 100 °C; (20)Enthalpy of Vaporization: 51.88 kJ/mol; (21)Boiling Point: 280.1 °C at 760 mmHg; (22)Vapour Pressure: 0.00387 mmHg at 25°C.

Production method of this chemical: The Benzenacetyl chloride, 4-methoxy- could be obtained by the reactant of (4-methoxy-phenyl)-acetic acid. This reaction needs the reagent of SOCl₂, and the solvent of CH₂Cl₂. The other condition is heating.

Uses of this chemical: The Benzenacetyl chloride, 4-methoxy- could react with methoxybenzene, and obtain the 4,4'-dimethoxy-deoxybenzoin. This reaction needs the reagent of , and the solvent of AlCl₃. The yield is 67 %. In addition, this reaction should be taken for 2 hours with the heating.

When you are using this chemical, please be cautious about it as the following: This chemical reacts violently with water and causes burns. It's irritating to respiratory system. Wear suitable protective clothing, gloves and eye/face protection if you use it. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1.SMILES: ClC(=O)Cc1ccc(OC)cc1
2.InChI: InChI=1/C9H9ClO2/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H,6H2,1H3
3.InChIKey: CXJOONIFSVSFAD-UHFFFAOYAG

Product Name

4-Methoxyphenylacetyl chloride

Synthetic route

4-Methoxyphenylacetyl chloride Specification

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