6-Chlorouracil supplier | CasNO.4270-27-3

Name
6-Chlorouracil
EINECS 224-258-0
CAS No. 4270-27-3
Article Data34
CAS DataBase
Density 1.61 g/cm³
Solubility 4.885g/L(25 oC)
Melting Point 290-295 °C
Formula C₄H₃ClN₂O₂
Boiling Point 300 °C
Molecular Weight 146.533
Flash Point 182°C
Transport Information
Appearance White powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 6-chloro-1H-pyrimidine-2,4-dione;4-Chlorouracil;
PSA 65.72000
LogP -0.28340

Synthetic route

: 3764-01-0
2,4,6-trichloropyrimidine

: 4270-27-3
6-chlorouracil

Conditions

Conditions	Yield
With sodium hydroxide In water for 3.5h; Reflux;	98%
With sodium hydroxide In water for 2h; Reflux;	98%
Stage #1: 2,4,6-trichloropyrimidine With sodium hydroxide In water for 1h; Reflux; Stage #2: With hydrogenchloride In water pH=2 - 3;	97%

: 4270-27-3
6-chloro-2,4-dihydroxypyrimidine

: 4270-27-3
6-chlorouracil

Conditions

Conditions	Yield
With sodium hydroxide Reflux; Schlenk technique; Inert atmosphere;	92%

: 6320-15-6
6-chloro-2,4-dimethoxypyrimidine

: 4270-27-3
6-chlorouracil

Conditions

Conditions	Yield
	43%
With hydrogen bromide
With hydrogenchloride

: 67-52-7
6-hydroxyuracil

: 4270-27-3
6-chlorouracil

Conditions

Conditions	Yield
With trichlorophosphate In acetonitrile at 120℃; for 0.166667h; Microwave irradiation;

: 4270-27-3
6-chlorouracil

: 646-25-3
diaminodecane

: 87624-99-5
C18H28N6O4

Conditions

Conditions	Yield
In butan-1-ol for 8h; Heating;	100%

: 4270-27-3
6-chlorouracil

: 108-42-9
3-chloro-aniline

: 7269-03-6
6-(3-chlorophenylamino)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
at 170℃; for 0.333333h;	99%
for 2h; Reflux;	95%
In melt at 180 - 200℃;

: 4270-27-3
6-chlorouracil

: 107-30-2
chloromethyl methyl ether

: 228396-40-5
1-methoxymethyl-6-chlorouracil

Conditions

Conditions	Yield
With lithium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h;	98.8%
Stage #1: 6-chlorouracil With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 0.166667h; Stage #2: chloromethyl methyl ether at 0℃; for 0.333333h;	90%

: 616-47-7
1-methyl-1H-imidazole

: 4270-27-3
6-chlorouracil

: 3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-1-methyl-1H-imidazolium chloride

Conditions

Conditions	Yield
In chlorobenzene for 8h; Reflux;	98%
In chlorobenzene for 7h; Substitution; Heating;	59%

: 4270-27-3
6-chlorouracil

: 930-69-8
sodium thiophenolate

: 15422-05-6
6-(phenylthio)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 90℃; for 0.05h; microwave irradiation;	98%

: 4270-27-3
6-chlorouracil

: 62-53-3
aniline

: 7269-15-0
6-anilinouracil

Conditions

Conditions	Yield
at 150℃; for 1h; Inert atmosphere;	98%
at 160℃; for 0.333333h; microwave irradiation;	95%
at 180℃; for 0.5h;	91%

: 4270-27-3
6-chlorouracil

: 4269-94-7
6-iodo-2,4-dioxopyrimidine

Conditions

Conditions	Yield
With hydrogen iodide; sodium iodide at 20℃; for 24h;	98%
With sodium iodide In N,N-dimethyl-formamide for 1.5h; Heating / reflux;
With potassium iodide In N,N-dimethyl-formamide for 1.5h; Heating / reflux;

: 4270-27-3
6-chlorouracil

: 337917-66-5
N,N'-diethyl-N-(3-methyluracil-6-yl)-p-phenylenediamine

: 337917-67-6
N,N'-diethyl-N-(3-methyluracil-6-yl)-N'-(uracil-6-yl)-p-phenylenediamine

Conditions

Conditions	Yield
With N,N-diethylaniline at 180℃; for 1h;	96%

: 110-89-4
piperidine

: 4270-27-3
6-chlorouracil

: 73823-06-0
6-piperidyluracil

Conditions

Conditions	Yield
at 100℃; for 0.25h; microwave irradiation;	96%

: 4270-27-3
6-chlorouracil

: 39905-45-8
4-octyloxyaniline

: 6-(4-octyloxy-phenylamino)-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
at 200℃; for 3h;	95%

: 4270-27-3
6-chlorouracil

: 39905-57-2
4-(n-hexyloxy)aniline

: 6-(4-hexyloxy-phenylamino)-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
at 200℃; for 3h;	95%

: 4270-27-3
6-chlorouracil

: N-(8-phenylnaphthalene-1-yl)acetamide

: 6-[(8-phenylnaphthalen-1-yl)amino]uracil

Conditions

Conditions	Yield
at 180℃; for 0.666667h; Inert atmosphere;	95%

: 4270-27-3
6-chlorouracil

: 1666-13-3
diphenyl diselenide

: 6-chloro-5-(phenylselanyl)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃; for 3h; Schlenk technique;	95%
With potassium iodide In dimethyl sulfoxide at 20℃; for 15h; Electrolysis; Green chemistry;	90%
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 50℃;	87%
With ammonium iodide In N,N-dimethyl-formamide at 50℃; for 2h; Electrochemical reaction; Green chemistry;	80%

: 4270-27-3
6-chlorouracil

: 104-94-9
4-methoxy-aniline

: 72255-57-3
6-(4-methoxyphenylamino)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether Heating;	94%
for 2h; Reflux;	90%
at 180 - 200℃; for 0.166667 - 0.25h;
In propan-1-ol at 150℃; Microwave irradiation;

: 4270-27-3
6-chlorouracil

: 60-34-4
methylhydrazine

: 68558-26-9
6-(1-methylhydrazino)uracil

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	94%
In ethanol at 100℃; for 0.166667h; Microwave irradiation; regioselective reaction;
In ethanol at 100℃; for 0.166667h; Microwave irradiation;

: 4270-27-3
6-chlorouracil

: 587-02-0
m-ethylaniline

: 72255-48-2
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether Heating;	94%

: 4270-27-3
6-chlorouracil

: 100-46-9
benzylamine

: 5759-80-8
6-benzylaminouracil

Conditions

Conditions	Yield
at 130℃; for 0.25h; microwave irradiation;	94%
In butan-1-ol for 9h; Heating;	90%
Heating;

: 4270-27-3
6-chlorouracil

: 189748-84-3
N-(6'-hydroxyhexyl)-3,4-dimethylaniline

: 189748-85-4
6-[N-(6'-hydroxyhexyl)-3,4-xylidino]uracil

Conditions

Conditions	Yield
In 1,4-dioxane; water for 15h; Reflux;	94%
In 1,4-dioxane; water for 15h; Heating;	63%
In 1,4-dioxane; water for 15h; Inert atmosphere; Reflux;

: 110-91-8
morpholine

: 4270-27-3
6-chlorouracil

: 15783-46-7
6-morpholin-4-yl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
at 100℃; for 0.25h; microwave irradiation;	94%

: 4270-27-3
6-chlorouracil

: 22115-41-9
2-(bromomethyl)benzonitrile

: 865758-95-8
2-[(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)methyl]benzonitrile

Conditions

Conditions	Yield
With sodium hydride; lithium bromide In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃; for 12h;	93.5%
Stage #1: 6-chlorouracil With triethylamine In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 2-(bromomethyl)benzonitrile In N,N-dimethyl-formamide at 25℃; for 8h; Reagent/catalyst; Solvent; Temperature;	79.7%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	58%

: 4270-27-3
6-chlorouracil

: 123-30-8
4-amino-phenol

: 72255-56-2
6-((4-hydroxyphenyl)amino)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether Heating;	93%
In ethanol at 150℃; for 0.5h; Microwave irradiation;	75%
In propan-1-ol at 150℃; Microwave irradiation;
In ethanol at 150℃; for 0.5h; Microwave irradiation;

: 4270-27-3
6-chlorouracil

: 106-45-6
para-thiocresol

: 6-chloro-5-(p-tolylthio)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 100℃; for 18h; Schlenk technique;	93%
With dihydrogen peroxide; sodium iodide In dimethyl sulfoxide at 100℃; for 15h;	83%

: 4270-27-3
6-chlorouracil

: 527-47-9, 5657-44-3, 42015-12-3, 51108-70-4, 54676-23-2, 55700-82-8, 55700-83-9, 60537-18-0, 69686-08-4, 132881-75-5
D-Ribamin

: 33106-48-8
1-deoxy-1-[(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)amino]-D-ribitol

Conditions

Conditions	Yield
With triethylamine In ethylene glycol at 170℃; for 0.5h;	92%
for 12h; Heating;	60%
With potassium hydroxide at 20℃; for 0.5h;	16%
at 128℃;

: 4270-27-3
6-chlorouracil

: 108-98-5
thiophenol

: 15422-05-6
6-(phenylthio)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
In pyridine for 1h; Heating;	92%
With potassium carbonate In ethylene glycol Substitution;
With pyridine for 1.5h; Heating;
With pyridine Heating;

: 4270-27-3
6-chlorouracil

: 103-67-3
benzyl-methyl-amine

: 21333-17-5
6-(benzylmethylamino)uracil

Conditions

Conditions	Yield
at 130℃; for 0.333333h; microwave irradiation;	92%

: 4270-27-3
6-chlorouracil

: 103-69-5
N-ethyl-N-phenylamine

: 27281-43-2
6-(ethyl(phenyl)amino)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
at 175℃; for 0.333333h;	92%

: 4270-27-3
6-chlorouracil

: 124-30-1
1-aminooctadecane

: 127984-96-7
6-Octadecylaminouracil

Conditions

Conditions	Yield
In butan-1-ol for 5h; Heating;	91%

: 4270-27-3
6-chlorouracil

: 622-57-1
N-ethyl-p-tolylamine

: 77778-47-3
6-(N-ethyl-p-toluidino)uracil

Conditions

Conditions	Yield
	91%

6-Chlorouracil Chemical Properties

Molecular Formula: C₄H₃ClN₂O₂
Molecular Weight: 146.53
EINECS: 224-258-0
Polar Surface Area: 40.62 Å²
Index of Refraction: 1.587
Molar Refractivity: 30.56 cm³
Molar Volume: 90.9 cm³
Surface Tension: 57.3 dyne/cm
Density: 1.61 g/cm³
Index of Refraction: 1.587
Melting Point: 290-295°C
IUPAC Name: 6-Chloro-1H-pyrimidine-2,4-dione
Appearance of 6-Chlorouracil (CAS NO.4720-27-3): A white crystalline powder
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines ; Biochemistry ; Nucleobases and their analogs ; Nucleosides, Nucleotides & Related Reagents
Synonyms of 6-Chlorouracil (CAS NO.4720-27-3): 6-Chloro-2,4-(1H,3H)-pyrimidinedione ; 4-Chloro-2,6-dihydroxypyrimidine
Following is the molecular structure of 6-Chlorouracil (CAS NO.4720-27-3):

6-Chlorouracil Safety Profile

Safety Information of 6-Chlorouracil (CAS NO.4720-27-3):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
Hazard Note: Irritant

Product Name

6-Chlorouracil

Synthetic route

6-Chlorouracil Chemical Properties

6-Chlorouracil Safety Profile

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