7-Fluoroisatin supplier | CasNO.317-20-4

Name
7-Fluoroisatin
EINECS 31-720-4
CAS No. 317-20-4
Article Data23
CAS DataBase
Density 1.477 g/cm³
Solubility Sparingly Soluble in water (0.022 g/L)
Melting Point 192-196 °C
Formula C₈H₄FNO₂
Boiling Point
Molecular Weight 165.124
Flash Point
Transport Information
Appearance
Safety 37/39
Risk Codes 22-43
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 7-Fluoroindole-1H-2,3-dione;7-fluoroindoline-2,3-dione;
PSA 46.17000
LogP 1.09850

Synthetic route

: 349-24-6
N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 65 - 80℃; for 0.666667h;	98.6%
With sulfuric acid at 65℃; for 3h;	58%
With sulfuric acid In water at 65 - 80℃; for 0.75h;	57%

: 349-24-6
N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 80℃; for 2h;	90%
With sulfuric acid at 70℃; for 0.75h;	55%
With sulfuric acid

: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-oxo-acetic acid ethyl ester

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran Heating;	87%

: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 55 - 80℃;	65%
With sulfuric acid at 55 - 80℃;	65%
In sulfuric acid	46%
With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene
With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene

: 71294-06-9
7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multistep reaction;

: 348-54-9
2-Fluoroaniline

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 71 percent / hydroxylamine hydrochloride; sodium sulfate; aq. HCl / H2O / 55 °C 2: 65 percent / conc. sulfuric acid / 55 - 80 °C View Scheme
Multi-step reaction with 2 steps 1: 71 percent / NH2OH*HCl; Na2SO4; aq. HCl / 55 °C 2: 65 percent / H2SO4 / 55 - 80 °C View Scheme
Multi-step reaction with 2 steps 1: Na2SO4; NH2OH*HCl; aq. HCl / 2 h / 80 - 90 °C 2: H2SO4 / 0.25 h / 80 °C View Scheme

: 98968-72-0
tert-butyl 2-fluorophenylcarbamate

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / t-BuLi / tetrahydrofuran / 2 h / -40 °C 2: 87 percent / 3N HCl / tetrahydrofuran / Heating View Scheme

: 349-24-6
N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

A: 317-20-4
7-fluoro-1H-indole-2,3-dione

B: 143884-84-8
7-fluoro-1H-indole-2,3-dione 3-oxime

Conditions

Conditions	Yield
Stage #1: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide With sulfuric acid at 74 - 76℃; for 1.5h; Stage #2: With sodium sulfate; acetone In water; toluene at 20℃; for 15h; Product distribution / selectivity;
With sulfuric acid at 73 - 76℃; for 1.5h; Product distribution / selectivity;
Stage #1: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide With sulfuric acid Stage #2: With Glyoxal; sodium sulfate In Isopropyl acetate; water at 20℃; for 1 - 37h; Product distribution / selectivity;

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: sodium 7-fluoroisatin-5-sulfonate

Conditions

Conditions	Yield
Stage #1: 7-fluoro-1H-indole-2,3-dione With fuming sulphuric acid at -20 - 70℃; for 1.91667h; Inert atmosphere; Stage #2: With sodium hydroxide In water pH=7.5; Inert atmosphere;	100%

: 120-72-9
indole

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: C24H16FN3O

Conditions

Conditions	Yield
With 60 wtpercent phosphotungstic acid supported on MCM-41 In tetrahydrofuran at 20℃; for 2.5h; Friedel-Crafts Acylation;	99%

: 1123-49-5
3,5-dimethyl-4-nitroisoxazole

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In water at 20℃; for 2h; Henry Nitro Aldol Condensation;	98%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 42348-86-7
5-chloro-1-indanone

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 7-chloro-7'-fluoro-2-phenyl-1,2,5,10-tetrahydro-3H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',3-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	98%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 2,2-difluoro-2-(3-methyl-4-nitro-1,2-oxazol-5-yl)-1-phenylethan-1-one

: 3-(difluoro(3-methyl-4-nitroisoxazol-5-yl)methyl)-7-fluoro-3-hydroxyindolin-2-one

Conditions

Conditions	Yield
With methanol; triethylamine at 20℃; for 24h;	98%

: 6025-60-1
2-(1H-pyrrol-1-yl)aniline

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-5'H-spiro[indoline-3,4'-pyrrolo[1,2-a]quinoxalin]-2-one

Conditions

Conditions	Yield
In ethanol at 80℃; for 8.5h; Solvent;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 83-33-0
inden-1-one

: 7'-fluoro-2-phenyl-1,2,5,10-tetrahydro-3H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',3-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	97%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 7'-fluoro-3-methoxy-9-phenyl-6,9,10,11-tetrahydrospiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3'-indoline]-2',8(5H)-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	97%

...Expand

: 865350-17-0
4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-3-hydroxy-3-(prop-2-yn-1-yl)indolin-2-one

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 25℃; for 0.416667h; regioselective reaction;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 5-chloro-7-fluoroindoline-2,3-dione

Conditions

Conditions	Yield
With methanesulfonic acid; trichloroisocyanuric acid; sulfuric acid at 0 - 20℃; for 4h;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 825-22-9
3-fluoroanthranilic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In water at 30 - 40℃; for 2.25h;	96%
With hydrogenchloride; dihydrogen peroxide In sodium hydroxide	59%
With sodium hydroxide; dihydrogen peroxide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 68-11-1
mercaptoacetic acid

: 108-42-9
3-chloro-aniline

: 1373763-24-6
C16H10ClFN2O2S

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate at 140℃; for 0.0333333h; Microwave irradiation; Ionic liquid;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 108-42-9
3-chloro-aniline

: 107-96-0
3-mercaptopropionic acid

: 1373763-18-8
C17H12ClFN2O2S

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate at 140℃; for 0.0666667h; Microwave irradiation; Ionic liquid;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6829-40-9
aminomalonic acid diethyl ester

: 118659-23-7
(1-methyl-2-oxo-indolin-3-yliden)-acetonitrile

: C26H23FN4O6

Conditions

Conditions	Yield
With C42H28O9P2 In chloroform at 50℃; for 36h; Molecular sieve; stereoselective reaction;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 1225387-53-0
3(5)-aminopyrazole

: 7-fluoro-6',8'-dimethyl-1',9'-dihydrospiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: (vinylselenonyl)benzene

: 147-85-3
L-proline

: 7-fluoro-5′,6′,7′,7a′-tetrahydrospiro[indole-3,3′-pyrrolizin]-2(1H)-one

Conditions

Conditions	Yield
In 1,4-dioxane Reflux; diastereoselective reaction;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 68014-21-1
triphenyl(t-butoxycarbonylimino)phosphorane

: 1373943-22-6
tert-butyl 7-fluoro-1-methyl-2-oxoindolin-3-ylidenecarbamate

Conditions

Conditions	Yield
In 1,4-dioxane Aza-Wittig reaction; Inert atmosphere; Reflux;	95%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 109-77-3
malononitrile

: 1370462-99-9
2-(7-fluoro-2-oxoindolin-3-ylidene)malononitrile

Conditions

Conditions	Yield
With piperdinium acetate In water at 100℃; Knoevenagel Condensation;	95%
With piperidine In ethanol at 20℃; for 3h;

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluorospiro[indoline-3,7'-pyrano[5,6-c:5,6-c']dichromene]-2,6',8'-trione

Conditions

Conditions	Yield
With sodium tetrachloroaurate(III) dihydrate In ethanol at 40℃; for 0.25h; Microwave irradiation;	95%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 31230-17-8
3-amino-5-methylpyrazole

: 7-fluoro-3',6',8'-trimethyl-1',9'-dihydrospiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	95%

...Expand

: 349-24-6
N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 65 - 80℃; for 0.666667h;	98.6%
With sulfuric acid at 65℃; for 3h;	58%
With sulfuric acid In water at 65 - 80℃; for 0.75h;	57%

: 349-24-6
N-(2-Fluorophenyl)-2-hydroxyiminoacetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 80℃; for 2h;	90%
With sulfuric acid at 70℃; for 0.75h;	55%
With sulfuric acid

: (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-oxo-acetic acid ethyl ester

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran Heating;	87%

: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
With sulfuric acid at 55 - 80℃;	65%
With sulfuric acid at 55 - 80℃;	65%
In sulfuric acid	46%
With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene
With sulfuric acid In 5,5-dimethyl-1,3-cyclohexadiene

: 71294-06-9
7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multistep reaction;

: 348-54-9
2-Fluoroaniline

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 71 percent / hydroxylamine hydrochloride; sodium sulfate; aq. HCl / H2O / 55 °C 2: 65 percent / conc. sulfuric acid / 55 - 80 °C View Scheme
Multi-step reaction with 2 steps 1: 71 percent / NH2OH*HCl; Na2SO4; aq. HCl / 55 °C 2: 65 percent / H2SO4 / 55 - 80 °C View Scheme
Multi-step reaction with 2 steps 1: Na2SO4; NH2OH*HCl; aq. HCl / 2 h / 80 - 90 °C 2: H2SO4 / 0.25 h / 80 °C View Scheme

: 98968-72-0
tert-butyl 2-fluorophenylcarbamate

: 317-20-4
7-fluoro-1H-indole-2,3-dione

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / t-BuLi / tetrahydrofuran / 2 h / -40 °C 2: 87 percent / 3N HCl / tetrahydrofuran / Heating View Scheme

: 349-24-6
N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

A: 317-20-4
7-fluoro-1H-indole-2,3-dione

B: 143884-84-8
7-fluoro-1H-indole-2,3-dione 3-oxime

Conditions

Conditions	Yield
Stage #1: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide With sulfuric acid at 74 - 76℃; for 1.5h; Stage #2: With sodium sulfate; acetone In water; toluene at 20℃; for 15h; Product distribution / selectivity;
With sulfuric acid at 73 - 76℃; for 1.5h; Product distribution / selectivity;
Stage #1: N-(2-fluorophenyl)-2-(hydroxyimino)acetamide With sulfuric acid Stage #2: With Glyoxal; sodium sulfate In Isopropyl acetate; water at 20℃; for 1 - 37h; Product distribution / selectivity;

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: sodium 7-fluoroisatin-5-sulfonate

Conditions

Conditions	Yield
Stage #1: 7-fluoro-1H-indole-2,3-dione With fuming sulphuric acid at -20 - 70℃; for 1.91667h; Inert atmosphere; Stage #2: With sodium hydroxide In water pH=7.5; Inert atmosphere;	100%

: 120-72-9
indole

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: C24H16FN3O

Conditions

Conditions	Yield
With 60 wtpercent phosphotungstic acid supported on MCM-41 In tetrahydrofuran at 20℃; for 2.5h; Friedel-Crafts Acylation;	99%

: 1123-49-5
3,5-dimethyl-4-nitroisoxazole

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane In water at 20℃; for 2h; Henry Nitro Aldol Condensation;	98%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 42348-86-7
5-chloro-1-indanone

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 7-chloro-7'-fluoro-2-phenyl-1,2,5,10-tetrahydro-3H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',3-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	98%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 2,2-difluoro-2-(3-methyl-4-nitro-1,2-oxazol-5-yl)-1-phenylethan-1-one

: 3-(difluoro(3-methyl-4-nitroisoxazol-5-yl)methyl)-7-fluoro-3-hydroxyindolin-2-one

Conditions

Conditions	Yield
With methanol; triethylamine at 20℃; for 24h;	98%

: 6025-60-1
2-(1H-pyrrol-1-yl)aniline

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-5'H-spiro[indoline-3,4'-pyrrolo[1,2-a]quinoxalin]-2-one

Conditions

Conditions	Yield
In ethanol at 80℃; for 8.5h; Solvent;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 83-33-0
inden-1-one

: 7'-fluoro-2-phenyl-1,2,5,10-tetrahydro-3H-spiro[indeno[1,2-b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2',3-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	97%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 4149-06-8
3-amino-1-phenyl-2-pyrazolin-5-one

: 1078-19-9
6-methoxy-3,4-dihydro-1(2H)-naphthalenone

: 7'-fluoro-3-methoxy-9-phenyl-6,9,10,11-tetrahydrospiro[benzo[h]pyrazolo[3,4-b]quinoline-7,3'-indoline]-2',8(5H)-dione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 5h; Green chemistry;	97%

...Expand

: 865350-17-0
4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluoro-3-hydroxy-3-(prop-2-yn-1-yl)indolin-2-one

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate) In water at 25℃; for 0.416667h; regioselective reaction;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 5-chloro-7-fluoroindoline-2,3-dione

Conditions

Conditions	Yield
With methanesulfonic acid; trichloroisocyanuric acid; sulfuric acid at 0 - 20℃; for 4h;	97%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 825-22-9
3-fluoroanthranilic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In water at 30 - 40℃; for 2.25h;	96%
With hydrogenchloride; dihydrogen peroxide In sodium hydroxide	59%
With sodium hydroxide; dihydrogen peroxide

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 68-11-1
mercaptoacetic acid

: 108-42-9
3-chloro-aniline

: 1373763-24-6
C16H10ClFN2O2S

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate at 140℃; for 0.0333333h; Microwave irradiation; Ionic liquid;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 108-42-9
3-chloro-aniline

: 107-96-0
3-mercaptopropionic acid

: 1373763-18-8
C17H12ClFN2O2S

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate at 140℃; for 0.0666667h; Microwave irradiation; Ionic liquid;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6829-40-9
aminomalonic acid diethyl ester

: 118659-23-7
(1-methyl-2-oxo-indolin-3-yliden)-acetonitrile

: C26H23FN4O6

Conditions

Conditions	Yield
With C42H28O9P2 In chloroform at 50℃; for 36h; Molecular sieve; stereoselective reaction;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 1225387-53-0
3(5)-aminopyrazole

: 7-fluoro-6',8'-dimethyl-1',9'-dihydrospiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: (vinylselenonyl)benzene

: 147-85-3
L-proline

: 7-fluoro-5′,6′,7′,7a′-tetrahydrospiro[indole-3,3′-pyrrolizin]-2(1H)-one

Conditions

Conditions	Yield
In 1,4-dioxane Reflux; diastereoselective reaction;	96%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 68014-21-1
triphenyl(t-butoxycarbonylimino)phosphorane

: 1373943-22-6
tert-butyl 7-fluoro-1-methyl-2-oxoindolin-3-ylidenecarbamate

Conditions

Conditions	Yield
In 1,4-dioxane Aza-Wittig reaction; Inert atmosphere; Reflux;	95%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 109-77-3
malononitrile

: 1370462-99-9
2-(7-fluoro-2-oxoindolin-3-ylidene)malononitrile

Conditions

Conditions	Yield
With piperdinium acetate In water at 100℃; Knoevenagel Condensation;	95%
With piperidine In ethanol at 20℃; for 3h;

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 7-fluorospiro[indoline-3,7'-pyrano[5,6-c:5,6-c']dichromene]-2,6',8'-trione

Conditions

Conditions	Yield
With sodium tetrachloroaurate(III) dihydrate In ethanol at 40℃; for 0.25h; Microwave irradiation;	95%

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 31230-17-8
3-amino-5-methylpyrazole

: 7-fluoro-3',6',8'-trimethyl-1',9'-dihydrospiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	95%

...Expand

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 1131-18-6
1-Phenyl-3-methyl-5-aminopyrazole

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 7-fluoro-3',6',8'-trimethyl-1'-phenyl-1',9'-dihydrospiro[indoline-3,4'-pyraz olo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H)-trione

Conditions

Conditions	Yield
With acetic acid In water at 90℃; for 7h; Green chemistry;	95%

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: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 109-77-3
malononitrile

: C20H10FN3O4

Conditions

Conditions	Yield
With cesium fluoride In ethanol at 20℃; for 0.0833333h; Knoevenagel Condensation;	95%

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: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 113-24-6
sodium pyruvate

: 8-fluoroquinoline-2,4-dicarboxylic acid

Conditions

Conditions	Yield
With water; sodium hydroxide at 110℃; under 4500.45 Torr; for 0.166667h; Microwave irradiation;	94%
With potassium hydroxide In water at 50℃;
With sodium hydroxide In water at 110℃; for 0.166667h; Pfitzinger Quinoline Synthesis; Microwave irradiation;
With sodium hydroxide In water at 110℃; for 0.166667h; Microwave irradiation;

: 675-10-5
4-hydroxy-6-methyl-2-pyron

: 317-20-4
7-fluoro-1H-indole-2,3-dione

: 109-77-3
malononitrile

: C17H10FN3O4

Conditions

Conditions	Yield
With 6A-{{2-{{2-[(2-aminoethyl)amino]ethyl}amino}ethyl}amino}-6A-deoxy-β-cyclodextrin In water at 20℃; for 7h; chemoselective reaction;	94%

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7-Fluoroisatin Specification

The 7-Fluoroisatin is an organic compound with the formula C₈H₄FNO₂. The IUPAC name of this chemical is 7-fluoro-1H-indole-2,3-dione. With the CAS registry number 317-20-4, it is also named as 1H-Indole-2,3-dione, 7-fluoro-. The product's categories are Indane/Indanone and Derivatives; Indoles; Simple Indoles.

Physical properties about 7-Fluoroisatin are: (1)ACD/LogP: 0.52; (2)ACD/LogD (pH 5.5): 0.52; (3)ACD/LogD (pH 7.4): 0.49; (4)ACD/BCF (pH 5.5): 1.47; (5)ACD/BCF (pH 7.4): 1.35; (6)ACD/KOC (pH 5.5): 45.86; (7)ACD/KOC (pH 7.4): 42.14; (8)#H bond acceptors: 3; (9)#H bond donors: 1; (10)Polar Surface Area: 37.38 Å²; (11)Index of Refraction: 1.584; (12)Molar Refractivity: 37.41 cm³; (13)Molar Volume: 111.7 cm³; (14)Polarizability: 14.83×10^-24cm³; (15)Surface Tension: 50.8 dyne/cm; (16)Density: 1.477 g/cm³.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. Besides, this chemical may cause sensitisation by skin contact. When you are using it, wear suitable gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1cccc2c1NC(=O)C2=O
(2)InChI: InChI=1/C8H4FNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
(3)InChIKey: HGBGVEOXPHGSOS-UHFFFAOYAH
(4)Std. InChI: InChI=1S/C8H4FNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
(5)Std. InChIKey: HGBGVEOXPHGSOS-UHFFFAOYSA-N

Product Name

7-Fluoroisatin

Synthetic route

7-Fluoroisatin Specification

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