7-Methoxy-2-tetralone supplier

Name
7-Methoxy-2-tetralone
EINECS 223-954-1
CAS No. 4133-34-0
Article Data27
CAS DataBase
Density 1.124 g/cm³
Solubility 1.151g/L at 25℃
Melting Point 27 - 28oC
Formula C₁₁H₁₂O₂
Boiling Point 306.8 °C at 760 mmHg
Molecular Weight 176.215
Flash Point 150.8 °C
Transport Information
Appearance Clear yellow to orange liquid after melting
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-one;7-methoxytetralin-2-one;7-Methoxy-3,4-dihydronaphthalen-2(1H)-one;7-methoxy-3,4-dihydronaphthalen-2-one;
PSA 26.30000
LogP 1.75300

Synthetic route

: 75804-69-2
(1S,2R)-7-Methoxy-1,2,3,4-tetrahydro-naphthalene-1,2-diol

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 0.25h; Heating;	98%

: 73780-78-6
1-(but-3-yn-1-yl)-4-methoxybenzene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With 2,6-dichloropyridine N-oxide; C33H54AuClP; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In 1,2-dichloro-ethane at 50℃; for 6h;	98%

: 1048330-08-0
7-methoxy-3,4-dihydronaphthalen-2(1H)-one sodium hydrogencarbonate

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With hydrogenchloride In water; toluene at 20℃; for 3h;	92%

: 1190847-93-8
C15H24O4

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With titanium tetrachloride In dichloromethane at 0 - 20℃; for 2h; Friedel Crafts reaction;	85%

: 63320-02-5
6-methoxy-1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With zinc(II) iodide In benzene for 3h; Heating;	74%
With zinc(II) iodide In benzene

: 1160858-16-1
C13H16O5

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With titanium tetrachloride In dichloromethane at -78 - 20℃; for 4h;	73%

: 153993-00-1
tert-Butyl-[3-(4-methoxy-phenyl)-1-methylene-propoxy]-dimethyl-silane

A: 104-20-1
4-(4-methoxyphenyl)-2-butanone

B: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With naphthalene-1,4-dicarbonitrile In water; acetonitrile for 3h; Irradiation;	A 10% B 72%
With naphthalene-1,4-dicarbonitrile In water; acetonitrile for 4h; Cyclization; desilylation; Irradiation;	A 10% B 72%

: 6-Methoxy-2,3-dihydro-1aH-1-oxa-cyclopropa[a]naphthalene-7b-carboxylic acid amide

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With hydrogenchloride Heating;	70%

: 3469-26-9
2,7-Dimethoxynaphthalene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With ethanol; sodium und anschlissend mit wss.HCl;
With hydrogenchloride; ammonia; sodium 1) EtOH, Et2O, THF, -78 deg C; Yield given. Multistep reaction;
With hydrogenchloride; ethanol; sodium 1.) reflux, 1 h, 2.) EtOH, reflux, 30 min; Multistep reaction;

: 60683-71-8
1,4-dihydro-2,7-dimethoxynaphthalene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride In acetone for 0.5h; Heating;	8.2 g
With hydrogenchloride In water; acetone at 25 - 30℃; for 0.25h;	0.42 g

: 90266-06-1
3,8a-dihydro-6-methoxy-1(2H)-azulenone

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 0.5h; Ambient temperature; Yield given;
With trifluoroacetic acid Yield given;

: 582-17-2
2,7-Dihydroxynaphthalene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / sodium hydroxide 2: sodium; liquid ammonia / ethanol 3: 8.2 g / hydrochloric acid / acetone / 0.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 2N aq. NaOH / 1.) 55 deg C, 2 h, 2.) reflux 2 h 2: 1.) Na, EtOH, 2.) 2N aq. HCl / 1.) reflux, 1 h, 2.) EtOH, reflux, 30 min View Scheme

: 104-20-1
4-(4-methoxyphenyl)-2-butanone

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 1.2: tetrahydrofuran / 3 h / -78 - 20 °C 2.1: 72 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme
Multi-step reaction with 2 steps 1: 98 percent / LDA / tetrahydrofuran / 3 h / -78 °C 2: 72 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 3 h / Irradiation View Scheme

: 123-11-5
4-methoxy-benzaldehyde

solid phase-bound -CH2OC(O)NH2: solid phase-bound -CH2OC(O)NH2

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: aq. NaOH 2.1: 90 percent / H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 3.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 3.2: tetrahydrofuran / 3 h / -78 - 20 °C 4.1: 72 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme

: 3815-30-3
4-(4-methoxyphenyl)-3-buten-2-one

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 90 percent / H2 / Pd/C / ethanol / 20 °C / 3102.89 Torr 2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C 2.2: tetrahydrofuran / 3 h / -78 - 20 °C 3.1: 72 percent / 1,4-dicyanonaphthalene / acetonitrile; H2O / 4 h / Irradiation View Scheme

: 60573-58-2
7-methoxy-3,4-dihydronaphthalene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / 10percent aq. NaHCO3, 3-chloroperbenzoic acid / toluene / 2 h / Ambient temperature 2: 74 percent / ZnI2 / benzene / 3 h / Heating View Scheme
Multi-step reaction with 2 steps 1: m-chloroperoxybenzoic acid 2: ZnI2 / benzene View Scheme
Multi-step reaction with 2 steps 1: 77 percent / N-methylmorpholine N-oxide, osmium tetroxide / H2O; acetone; 2-methyl-propan-2-ol; CCl4 2: 98 percent / p-toluenesulfonic acid / benzene / 0.25 h / Heating View Scheme

: 32820-10-3
7-methoxy-1,2,3,4-tetrahydro-1-naphthol

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridinium p-toluenesulfonate / toluene / 3 h / Heating 2: 95 percent / 10percent aq. NaHCO3, 3-chloroperbenzoic acid / toluene / 2 h / Ambient temperature 3: 74 percent / ZnI2 / benzene / 3 h / Heating View Scheme

: 6836-19-7
7-Methoxy-1-tetralone

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 51.1 g / NaBH4 / methanol; tetrahydrofuran / 2 h / Ambient temperature 2: pyridinium p-toluenesulfonate / toluene / 3 h / Heating 3: 95 percent / 10percent aq. NaHCO3, 3-chloroperbenzoic acid / toluene / 2 h / Ambient temperature 4: 74 percent / ZnI2 / benzene / 3 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 1.) ZnI2; 2.) POCl3 / 2.) pyridine 2: 80 percent / n-Bu4NHSO4, NaOH, H2O2 3: 70 percent / 3N HCl / Heating View Scheme
Multi-step reaction with 3 steps 1: 1) NaBH4, 2) p-TsOH / 2) benzene 2: m-chloroperoxybenzoic acid 3: ZnI2 / benzene View Scheme
Multi-step reaction with 3 steps 1: 1.) sodium borohydride, ethanol, 15 min., reflux 2.) p-toluenesulfonic acid, benzene, reflux 2: 77 percent / N-methylmorpholine N-oxide, osmium tetroxide / H2O; acetone; 2-methyl-propan-2-ol; CCl4 3: 98 percent / p-toluenesulfonic acid / benzene / 0.25 h / Heating View Scheme

: 158365-53-8
7-methoxy-3,4-dihydronaphthalene-1-carbonitrile

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / n-Bu4NHSO4, NaOH, H2O2 2: 70 percent / 3N HCl / Heating View Scheme

: 60-29-7
diethyl ether

: 3469-26-9
2,7-Dimethoxynaphthalene

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water; sodium carbonate

: 123-11-5
4-methoxy-benzaldehyde

: 4133-34-0
7-methoxyl-2-tetralone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aluminium; mercury(I) chloride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: -78 °C / Inert atmosphere 2.1: 2,6-dichloropyridine N-oxide; C33H54AuClP; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / 1,2-dichloro-ethane / 6 h / 50 °C View Scheme

: 4133-34-0
7-methoxyl-2-tetralone

: 616-38-6
carbonic acid dimethyl ester

: 34865-33-3
methyl 7-methoxy-2-oxotetralin-1-carboxylate

Conditions

Conditions	Yield
With sodium hydride In benzene for 2h; Heating;	100%

: 4133-34-0
7-methoxyl-2-tetralone

: 100-46-9
benzylamine

: 83343-23-1
N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Conditions

Conditions	Yield
Stage #1: 7-methoxyl-2-tetralone; benzylamine In dichloromethane for 0.25h; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 15h; Inert atmosphere;	100%
Stage #1: 7-methoxyl-2-tetralone; benzylamine In dichloromethane for 0.25h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃; for 15h; Inert atmosphere;	100%
Stage #1: 7-methoxyl-2-tetralone; benzylamine With acetic acid In methanol at 20℃; for 0.5h; Stage #2: With sodium cyanoborohydride In methanol at 0 - 20℃;	97%
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;

: 60-35-5
acetamide

: 4133-34-0
7-methoxyl-2-tetralone

: N-(7-methoxy-3,4-dihydronaphthalen-2-yl)acetamide

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Inert atmosphere; Reflux;	98%
With toluene-4-sulfonic acid In toluene for 20h; Inert atmosphere; Reflux; Dean-Stark;	75%
With toluene-4-sulfonic acid In water; toluene Inert atmosphere;
With toluene-4-sulfonic acid In toluene for 20h; Inert atmosphere; Dean-Stark; Reflux;
With toluene-4-sulfonic acid In toluene for 20h; Reflux; Dean-Stark; Inert atmosphere;

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 4133-34-0
7-methoxyl-2-tetralone

: ethyl 2-(7-methoxy-3,4-dihydronaphthalen-2(1H)-ylidene)acetate

Conditions

Conditions	Yield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In 1,2-dimethoxyethane; mineral oil at 20℃; for 1h; Stage #2: 7-methoxyl-2-tetralone In 1,2-dimethoxyethane; mineral oil at 20℃; for 3h;	97%

: 4133-34-0
7-methoxyl-2-tetralone

: (R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ol

Conditions

Conditions	Yield
With isopropyl alcohol; NADH; magnesium chloride In methanol at 30℃; for 1h; pH=8; aq. buffer; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	97%
With formic acid; (S)-chloro[(1,2,3,4,5-η)-pentamethyl-2,4-cyclopentadien-1-yl](2-pyrrolidinecarboxamidato-kN1,kN2)iridium (III); triethylamine In methanol at -10℃; for 48h;	480 mg
With dichloro(benzene)ruthenium(II) dimer; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine Noyori Asymmetric Hydrogenation;

: 4133-34-0
7-methoxyl-2-tetralone

: 616-38-6
carbonic acid dimethyl ester

: 63491-51-0
2-hydroxy-7-methoxy-3,4-dihydronaphthalene-1-carboxylic acid methyl ester

Conditions

Conditions	Yield
Stage #1: 7-methoxyl-2-tetralone With sodium hydride In benzene for 0.5h; Reflux; Stage #2: carbonic acid dimethyl ester In benzene for 3h; Reflux;	96%
Stage #1: 7-methoxyl-2-tetralone; carbonic acid dimethyl ester With sodium hydride Reflux; Inert atmosphere; Stage #2: With water; ammonium chloride	91%

: 4133-34-0
7-methoxyl-2-tetralone

: 17356-08-0
thiourea

: 8-methoxynaphtho[2,1-d]thiazol-2-amine

Conditions

Conditions	Yield
With iodine; oxygen; toluene-4-sulfonic acid In dimethyl sulfoxide at 75℃; under 760.051 Torr; for 24h;	95%

: 4133-34-0
7-methoxyl-2-tetralone

: 100-39-0
benzyl bromide

: 263714-29-0
1-benzyl-7-methoxy-3,4-dihydronaphthalen-2(1H)-one

Conditions

Conditions	Yield
Stage #1: 7-methoxyl-2-tetralone With pyrrolidine In methanol for 2h; Stage #2: benzyl bromide In acetonitrile at -5 - 20℃;	95%
Stage #1: 7-methoxyl-2-tetralone With pyrrolidine In methanol at 20℃; for 1h; Inert atmosphere; Stage #2: benzyl bromide In acetonitrile at 20℃; Inert atmosphere; Stage #3: With acetic acid In methanol; dichloromethane; water

: 4133-34-0
7-methoxyl-2-tetralone

: 74-88-4
methyl iodide

: 1865-83-4
7-methoxy-1,1-dimethyl-3,4-dihydronaphthalene-2-(1H)-one

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran at -78 - 20℃; Inert atmosphere;	93%
With tetrabutylammonium sulfate; potassium hydroxide In tetrahydrofuran; water at 20℃; for 2h;	91%
Stage #1: 7-methoxyl-2-tetralone With potassium tert-butylate In tetrahydrofuran; tert-butyl alcohol at 0℃; for 0.333333h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; tert-butyl alcohol at 20℃; for 2h; Inert atmosphere;	79%

: 21091-61-2
2-(4-phenyl-piperazin-1-yl)-ethylamine

: 4133-34-0
7-methoxyl-2-tetralone

: 744209-08-3, 744209-09-4, 444145-80-6
(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-[2-(4-phenyl-piperazin-1-yl)-ethyl]-amine

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;	93%
Stage #1: 2-(4-phenyl-piperazin-1-yl)-ethylamine; 7-methoxyl-2-tetralone With acetic acid In 1,2-dichloro-ethane at 20℃; for 0.333333h; Stage #2: With sodium cyanoborohydride In methanol; 1,2-dichloro-ethane at 20℃; for 12h; Further stages.;	69.44%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane

: 4133-34-0
7-methoxyl-2-tetralone

: 13511-60-9
1,2,3,4-tetrahydro-7-methoxy-naphthalen-2-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol at -20 - 20℃; for 4h; Inert atmosphere;	93%
With sodium tetrahydroborate; ethanol at 20℃; Cooling with ice;	93%
With sodium tetrahydroborate In ethanol at 20℃; for 4h;

: 4133-34-0
7-methoxyl-2-tetralone

: 99-61-6
3-nitro-benzaldehyde

: 109-77-3
malononitrile

: 3-amino-9-methoxy-1-(3-nitrophenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In ethanol for 2h; Heating;	92%

...Expand

: 4133-34-0
7-methoxyl-2-tetralone

: 1122-91-4
4-bromo-benzaldehyde

: 109-77-3
malononitrile

: 3-amino-1-(4-bromo-phenyl)-9-methoxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In ethanol for 3h; Heating;	92%

...Expand

: 2826-22-4
4-fluorobenzylidenemalononitrile

: 4133-34-0
7-methoxyl-2-tetralone

: 3-amino-9-methoxy-1-(4-fluorophenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 17h;	92%

: 4133-34-0
7-methoxyl-2-tetralone

: 2826-32-6
3-nitrobenzylidenemalononitrile

: 3-amino-9-methoxy-1-(3-nitrophenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	92%

: 2698-41-1
o-chlorobenzylidene malononitrile

: 4133-34-0
7-methoxyl-2-tetralone

: 3-amino-1-(2-chlorophenyl)-9-methoxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	91%

: 6342-56-9
Pyruvic aldehyde dimethyl acetal

: 4133-34-0
7-methoxyl-2-tetralone

: 7-methoxy-3-methylnaphtho[2,3-b]furan

Conditions

Conditions	Yield
Stage #1: 7-methoxyl-2-tetralone With tributyl-amine; titanium tetrachloride In dichloromethane at -35℃; Stage #2: Pyruvic aldehyde dimethyl acetal In dichloromethane at -35 - 20℃;	91%

: 4133-34-0
7-methoxyl-2-tetralone

: 2972-73-8
2-(3-chlorobenzylidene)malononitrile

: 3-amino-9-methoxy-1-(3-chlorophenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 19h;	90%

: 4133-34-0
7-methoxyl-2-tetralone

: 2826-30-4
2-(2-nitrobenzylidene)malononitrile

: 3-amino-9-methoxy-1-(2-nitrophenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	89%

: 4133-34-0
7-methoxyl-2-tetralone

: 2972-76-1
2-(2,4-dichlorobenzylidene)malononitrile

: 3-amino-1-(2,4-dichlorophenyl)-9-methoxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 18h;	89%

: 120-57-0
piperonal

: 4133-34-0
7-methoxyl-2-tetralone

: 109-77-3
malononitrile

: 3-amino-9-methoxy-1-(3,4-methylenedioxyphenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In ethanol for 5h; Heating;	88%

...Expand

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 4133-34-0
7-methoxyl-2-tetralone

: 108972-18-5
(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; water	88%

: 2972-82-9
2-benzo[1,3]dioxol-5-ylmethylene-malononitrile

: 4133-34-0
7-methoxyl-2-tetralone

: 3-amino-9-methoxy-1-(3,4-methylenedioxyphenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	87%

: 4133-34-0
7-methoxyl-2-tetralone

: 6287-38-3
3,4-dichlorobenzaldehyde

: 109-77-3
malononitrile

: 3-amino-1-(3,4-dichloro-phenyl)-9-methoxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With aluminum oxide; potassium fluoride In ethanol for 2.5h; Heating;	86%

...Expand

: 2826-26-8
2-(4-methoxyphenylmethylene)malononitrile

: 4133-34-0
7-methoxyl-2-tetralone

: 3-amino-9-methoxy-1-(4-methoxyphenyl)-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	86%

: 4133-34-0
7-methoxyl-2-tetralone

: 2972-80-7
3,4-dimethoxybenzylidenemalononitrile

: 3-amino-1-(3,4-dimethoxyphenyl)-9-methoxy-5,6-dihydro-1H-benzo[f]chromene-2-carbonitrile

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride at 40 - 50℃; for 20h;	86%

: 4133-34-0
7-methoxyl-2-tetralone

: 1060767-14-7
1-chloro-2,2-dimethylcyclopropyl p-tolyl sulfoxide

: 1329042-08-1
C16H20O2

Conditions

Conditions	Yield
Stage #1: 1-chloro-2,2-dimethylcyclopropyl p-tolyl sulfoxide With isopropylmagnesium chloride In tetrahydrofuran at -78℃; Inert atmosphere; Stage #2: 7-methoxyl-2-tetralone With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃;	86%

7-Methoxy-2-tetralone Chemical Properties

Molecular Structure:

Molecular Formula: C₁₁H₁₂O₂
Molecular Weight: 176.2118
IUPAC Name: 7-Methoxy-3,4-dihydro-1H-naphthalen-2-one
Synonyms of 7-Methoxy-2-tetralone (CAS NO.4133-34-0): EINECS 223-954-1 ; 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-one
CAS NO: 4133-34-0
Product Categories: Benzocycles ; Aromatic Ketones (substituted) ; API intermediates ; Fused Ring Systems ; C11 to C12 ; Carbonyl Compounds ; Ketones
Index of Refraction: 1.548
Molar Refractivity: 49.84 cm³
Molar Volume: 156.7 cm³
Surface Tension: 40.8 dyne/cm
Density: 1.124 g/cm³
Flash Point: 150.8 °C
Enthalpy of Vaporization: 54.73 kJ/mol
Boiling Point: 306.8 °C at 760 mmHg
Vapour Pressure: 0.000754 mmHg at 25°C

7-Methoxy-2-tetralone Uses

7-Methoxy-2-tetralone (CAS NO.4133-34-0) is used as pharmaceutical intermediates.

7-Methoxy-2-tetralone Safety Profile

Hazard Codes of 7-Methoxy-2-tetralone (CAS NO.4133-34-0): Irritant Xi,Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

Product Name

7-Methoxy-2-tetralone

Synthetic route

7-Methoxy-2-tetralone Chemical Properties

7-Methoxy-2-tetralone Uses

7-Methoxy-2-tetralone Safety Profile

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