7-N-Fmoc-aminocoumarin-4-acetic acid supplier

Name
[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid
EINECS
CAS No. 378247-75-7
Article Data5
CAS DataBase
Density 1.419 g/cm³
Solubility
Melting Point
Formula C₂₆H₁₉NO₆
Boiling Point 660.549 °C at 760 mmHg
Molecular Weight 441.44
Flash Point 353.288 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 7-N-Fmoc-aminocoumarin-4-acetic acid
PSA 105.84000
LogP 4.85410

Synthetic route

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 85157-21-7
2-(7-amino-2-oxo-2H-chromen-4-yl)acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

Conditions

Conditions	Yield
Stage #1: 2-(7-amino-2-oxo-2H-chromen-4-yl)acetic acid With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Heating; Stage #2: (fluorenylmethoxy)carbonyl chloride In dichloromethane at 20℃; for 11h; Further stages.;	88%
With sodium hydrogencarbonate In water; acetone
With sodium hydrogencarbonate In water; acetone at 0 - 20℃;
Stage #1: 2-(7-amino-2-oxo-2H-chromen-4-yl)acetic acid With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Reflux; Stage #2: (fluorenylmethoxy)carbonyl chloride In dichloromethane at 20℃; Stage #3: With hydrogenchloride In dichloromethane; water pH=2;	1.43 g

: 591-27-5
m-Hydroxyaniline

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: ethyl acetate / 1 h / Reflux 2.1: sulfuric acid / 12 h / 20 °C / Cooling with ice 3.1: sodium hydroxide / water / Reflux 4.1: N-ethyl-N,N-diisopropylamine; chloro-trimethyl-silane / dichloromethane / 3 h / Reflux 4.2: 20 °C 4.3: pH 2 View Scheme

: 7159-96-8
ethyl N-(3-hydroxyphenyl)carbamate

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sulfuric acid / 12 h / 20 °C / Cooling with ice 2.1: sodium hydroxide / water / Reflux 3.1: N-ethyl-N,N-diisopropylamine; chloro-trimethyl-silane / dichloromethane / 3 h / Reflux 3.2: 20 °C 3.3: pH 2 View Scheme

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

Rink Amide AM resin: Rink Amide AM resin

[7-N-(fluorenylmethoxycarbonyl)aminocoumarin-4-CH2CONH]-Rink Amide AM resin: [7-N-(fluorenylmethoxycarbonyl)aminocoumarin-4-CH2CONH]-Rink Amide AM resin

Conditions

Conditions	Yield
With benzotriazol-1-ol; diisopropyl-carbodiimide In N,N-dimethyl-formamide

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-60-0
Fmoc-Leu-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-6-amino-hexanoylamino]-4-methyl-pentanoylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-1-((S)-2-Acetylamino-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-{(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentylcarbamoyl}-ethyl)-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-39-3
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-propionylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-40-6
N-Fmoc L-Phe

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-3-hydroxy-propionylamino]-3-phenyl-propionylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-3-hydroxy-propionylamino]-5-guanidino-pentanoylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-4-((2S,3S)-2-Acetylamino-3-methyl-pentanoylamino)-5-((S)-2-{(S)-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-2-carboxy-ethylcarbamoyl}-pyrrolidin-1-yl)-5-oxo-pentanoic acid

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-3-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-carbamoyl-butyrylamino]-N-{(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-succinamic acid

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-4-[(S)-2-((S)-2-Acetylamino-propionylamino)-5-guanidino-pentanoylamino]-4-{(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentylcarbamoyl}-butyric acid

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-23-6
Fmoc-Ile-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{2-[(2S,3S)-2-((S)-2-Acetylamino-propionylamino)-3-methyl-pentanoylamino]-acetylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-38-3
Fmoc-Tyr(tBu)-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-[(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-methyl-pentanoylamino]-3-(4-hydroxy-phenyl)-propionylamino]-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-1-[2-((S)-2-Acetylamino-4-methyl-pentanoylamino)-acetyl]-pyrrolidine-2-carboxylic acid {(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{[(S)-1-((S)-2-Acetylamino-propionyl)-pyrrolidine-2-carbonyl]-amino}-N1-{(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-succinamide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-methyl-pentanoylamino]-6-amino-hexanoylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(2S,3S)-2-((S)-2-Acetylamino-propionylamino)-3-methyl-pentanoylamino]-6-amino-hexanoylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-[(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-6-amino-hexanoylamino]-3-(3H-imidazol-4-yl)-propionylamino]-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-35-0
Fmoc-Thr(tBu)-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(2S,3R)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-methylsulfanyl-butyrylamino]-3-hydroxy-butyrylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-28-1
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-methylsulfanyl-butyrylamino]-3-methyl-butyrylamino}-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 132388-59-1
L-Asn(Trt)

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-((S)-2-Acetylamino-propionylamino)-N1-((S)-1-{(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentylcarbamoyl}-3-methylsulfanyl-propyl)-succinamide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 132327-80-1
Fmoc-L-Gln(Trt)-OH

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-1-[(S)-2-((S)-2-Acetylamino-propionylamino)-4-carbamoyl-butyryl]-pyrrolidine-2-carboxylic acid {(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 64-19-7
acetic acid

: 117785-05-4
Fmoc-L-His(Boc)-OH

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-1-[(S)-2-((S)-2-Acetylamino-propionylamino)-3-(3H-imidazol-4-yl)-propionyl]-pyrrolidine-2-carboxylic acid {(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 64-19-7
acetic acid

: 143824-78-6
3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-[(S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-6-amino-hexanoylamino]-3-(1H-indol-3-yl)-propionylamino]-6-amino-hexanoic acid [4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-yl]-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 64-19-7
acetic acid

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-2-[(S)-2-((S)-2-Acetylamino-propionylamino)-5-guanidino-pentanoylamino]-pentanedioic acid 5-amide 1-({(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-amide)

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 228245-16-7
tert-butyl (3-aminopropoxy)carbamate

: Fmoc-Pro-OH

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 64-19-7
acetic acid

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: (S)-1-[(2S,3R)-2-((S)-2-Acetylamino-hexanoylamino)-3-hydroxy-butyryl]-pyrrolidine-2-carboxylic acid {(S)-5-amino-1-[4-({[(3-aminooxy-propylcarbamoyl)-methyl]-carbamoyl}-methyl)-2-oxo-2H-chromen-7-ylcarbamoyl]-pentyl}-amide

Conditions

Conditions	Yield
Multistep reaction.;

...Expand

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: C26H18NO5Pol

Conditions

Conditions	Yield
With benzotriazol-1-ol; diisopropyl-carbodiimide In N,N-dimethyl-formamide Rink Amide AM resin;

: 35661-38-2, 35661-39-3, 79990-15-1
N-(9-fluorenylmethoxycarbonyl)-D-alanine

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: 1558029-19-8
C14H15N3O4

Conditions

Conditions	Yield
Stage #1: 7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.5h; Stage #3: N-(9-fluorenylmethoxycarbonyl)-D-alanine Further stages;

: 35661-60-0, 126727-03-5, 114360-54-2
N-(9-fluorenylmethoxycarbonyl)-D-leucine

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: 1558029-33-6
C17H21N3O4

Conditions

Conditions	Yield
Stage #1: 7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.5h; Stage #3: N-(9-fluorenylmethoxycarbonyl)-D-leucine Further stages;

: 86123-10-6
Fmoc-D-Phe-OH

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: 1558029-39-2
C20H19N3O4

Conditions

Conditions	Yield
Stage #1: 7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.5h; Stage #3: Fmoc-D-Phe-OH Further stages;

: 71989-31-6, 109425-54-9, 144829-96-9, 101555-62-8
(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 378247-75-7
7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid

: 1558029-41-6
C16H17N3O4

Conditions

Conditions	Yield
Stage #1: 7-N-(fluoren-9-ylmethoxycarbonyl)-aminocoumarin-4-acetic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Stage #2: With piperidine In N,N-dimethyl-formamide for 0.5h; Stage #3: (R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester Further stages;

7-N-Fmoc-aminocoumarin-4-acetic acid Specification

The 7-N-Fmoc-aminocoumarin-4-acetic acid is an organic compound with the formula C₂₆H₁₉NO₆. The IUPAC name of this chemical is 2-[7-(9H-fluoren-9-ylmethoxycarbonylamino)-2-oxochromen-4-yl]acetic acid. With the CAS registry number 378247-75-7, it is also named as [7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid.

Physical properties about 7-N-Fmoc-aminocoumarin-4-acetic acid are: (1)ACD/LogP: 4.45; (2)ACD/LogD (pH 5.5): 3; (3)ACD/LogD (pH 7.4): 1; (4)ACD/BCF (pH 5.5): 65; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 289; (7)ACD/KOC (pH 7.4): 5; (8)#H bond acceptors: 7; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 101.93 Å²; (12)Index of Refraction: 1.687; (13)Molar Refractivity: 118.479 cm³; (14)Molar Volume: 311.087 cm³; (15)Polarizability: 46.969×10^-24cm³; (16)Surface Tension: 66.697 dyne/cm; (17)Density: 1.419 g/cm³; (18)Flash Point: 353.288 °C; (19)Enthalpy of Vaporization: 102.126 kJ/mol; (20)Boiling Point: 660.549 °C at 760 mmHg.

You can still convert the following datas into molecular structure:
(1)SMILES: c1ccc2c(c1)-c3ccccc3C2COC(=O)Nc4ccc5c(cc(=O)oc5c4)CC(=O)O
(2)InChI: InChI=1/C26H19NO6/c28-24(29)11-15-12-25(30)33-23-13-16(9-10-17(15)23)27-26(31)32-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22H,11,14H2,(H,27,31)(H,28,29)
(3)InChIKey: RCUKLQDGAASIAX-UHFFFAOYAN
(4)Std. InChI: InChI=1S/C26H19NO6/c28-24(29)11-15-12-25(30)33-23-13-16(9-10-17(15)23)27-26(31)32-14-22-20-7-3-1-5-18(20)19-6-2-4-8-21(19)22/h1-10,12-13,22H,11,14H2,(H,27,31)(H,28,29)
(5)Std. InChIKey: RCUKLQDGAASIAX-UHFFFAOYSA-N

Product Name

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid

Synthetic route

7-N-Fmoc-aminocoumarin-4-acetic acid Specification

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