• Name

  Aminoacetonitrile hydrochloride

• EINECS 227-865-9
• CAS No. 6011-14-9
• Article Data3
• CAS DataBase
• Density
• Solubility Soluble in water 20°C, 1000g/L.
• Melting Point 172-174 °C
• Formula C₂H₅ClN₂
• Boiling Point 164.2 °C at 760 mmHg
• Molecular Weight 92.5281
• Flash Point 53.1 °C
• Transport Information UN 3439
• Appearance White to off-white crystalline powder
• Safety 22-36/37
• Risk Codes 20/21/22
• Molecular Structure
• Hazard Symbols R22:Harmful if swallowed.; R36/37/38:Irritating to eyes, respiratory system and skin.;
• Synonyms Acetonitrile,amino-, monohydrochloride (9CI);Glycinonitrile, monohydrochloride (8CI);2-Aminoacetonitrile hydrochloride;Aminoacetonitrile monohydrochloride;Glycinonitrile hydrochloride;a-Aminoacetonitrilehydrochloride;
• PSA 49.81000
• LogP 0.97098

Synthetic route

540-61-4

2-aminoacetonitrile

6011-14-9

2-aminoacetonitrile hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 20 - 30℃; for 2h; Temperature;	82.8%

773837-37-9

sodium cyanide

50-00-0

formaldehyd

6011-14-9

2-aminoacetonitrile hydrochloride

Conditions

Conditions	Yield
Stage #1: sodium cyanide; formaldehyd With ammonium hydroxide Stage #2: With hydrogenchloride

85-44-9

phthalic anhydride

6011-14-9

2-aminoacetonitrile hydrochloride

3842-20-4

N-(cyanomethyl)phthalimide

Conditions

Conditions	Yield
With triethylamine In chloroform for 6h; Heating;	100%
With triethylamine In chloroform at 10℃; for 12.5h; Temperature; Reflux;	98.6%
With triethylamine In chloroform for 18h; Reflux;	75%

13139-16-7

N-(t-butoxycarbonyl)-isoleucine

6011-14-9

2-aminoacetonitrile hydrochloride

2-tert-Butyloxycarbonylamino-3-methyl-pentanoic acid cyanomethyl-amide

Conditions

Conditions	Yield
With benzotriazol-1-ol In DMF (N,N-dimethyl-formamide); water at 20℃; for 1h;	100%

55-22-1

pyridine-4-carboxylic acid

6011-14-9

2-aminoacetonitrile hydrochloride

1184796-18-6

N-(cyanomethyl)isonicotinamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h;

6011-14-9

2-aminoacetonitrile hydrochloride

148-53-8

3-methoxy-2-hydroxybenzaldehyde

1279019-01-0

(2-hydroxy-3-methoxybenzylideneamino)acetonitrile

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 2h;	99%

1679-18-1

4-Chlorophenylboronic acid

6011-14-9

2-aminoacetonitrile hydrochloride

140-53-4

p-chlorobenzyl cyanide

Conditions

Conditions	Yield
With sodium nitrite In water; toluene at 50℃; for 24h; Schlenk technique;	99%

15224-05-2

ethyl 2-(allylthio)acetate

6011-14-9

2-aminoacetonitrile hydrochloride

ethyl 2-((1-cyanobut-3-en-1-yl)thio)acetate

Conditions

Conditions	Yield
With meso-tetraphenylporphyrin iron(III) chloride; sodium nitrite In dichloromethane; water at 20℃; for 15h; Inert atmosphere; diastereoselective reaction;	99%

5405-15-2

N-benzyl-N-(4-methylphenyl)amine

6011-14-9

2-aminoacetonitrile hydrochloride

[N-benzyl-(4-methylphenyl)amino]acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With FeCl(tiprp); sodium nitrite In toluene at 55℃; Inert atmosphere; Flow reactor; Stage #2: N-benzyl-N-(4-methylphenyl)amine In toluene at 20℃; Inert atmosphere;	99%

5405-17-4

N-benzyl-3-methylaniline

6011-14-9

2-aminoacetonitrile hydrochloride

3-(benzyl(m-tolyl)amino)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With FeCl(tiprp); sodium nitrite In toluene at 55℃; Inert atmosphere; Flow reactor; Stage #2: N-benzyl-3-methylaniline In toluene at 20℃; Inert atmosphere;	99%

2557-78-0

2-fluorothiophenol

6011-14-9

2-aminoacetonitrile hydrochloride

61081-27-4

2-((2-fluorophenyl)thio)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With FeCl(tiprp); sodium nitrite In toluene at 55℃; Inert atmosphere; Flow reactor; Stage #2: 2-fluorothiophenol In toluene at 20℃; for 3h; Inert atmosphere;	99%

6011-14-9

2-aminoacetonitrile hydrochloride

210162-61-1

1-(2-methylphenyl)-1H-indole

2-(1-(2-methylphenyl)-1H-indol-3-yl)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With sodium nitrite In water at 55℃; Stage #2: 1-(2-methylphenyl)-1H-indole With meso-tetraphenylporphyrin iron(III) chloride In dichloromethane; water at 20℃; for 2.16h; Inert atmosphere;	99%

6011-14-9

2-aminoacetonitrile hydrochloride

167283-32-1

N-(p-tolyl)indole

1632196-77-0

2-(1-(p-tolyl)-1H-indol-3-yl)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With sodium nitrite In water at 55℃; Stage #2: N-(p-tolyl)indole With meso-tetraphenylporphyrin iron(III) chloride In dichloromethane; water at 20℃; for 2.16h; Inert atmosphere;	99%

6011-14-9

2-aminoacetonitrile hydrochloride

210162-62-2

1-(3-methylphenyl)-1H-indole

2-(1-(3-methylphenyl)-1H-indol-3-yl)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With sodium nitrite In water at 55℃; Stage #2: 1-(3-methylphenyl)-1H-indole With meso-tetraphenylporphyrin iron(III) chloride In dichloromethane; water at 20℃; for 2.16h; Inert atmosphere;	99%

6011-14-9

2-aminoacetonitrile hydrochloride

97-72-3

2-Methylpropionic anhydride

N-(cyanomethyl)isobutyramide

Conditions

Conditions	Yield
With pyridine at 20℃; for 12h;	99%

5271-67-0

2-Thiophenecarbonyl chloride

6011-14-9

2-aminoacetonitrile hydrochloride

349097-56-9

N-(cyanomethyl)thiophe ne-2-carboxamide

Conditions

Conditions	Yield
With pyridine at 0℃; for 12h;	99%
With pyridine at 0℃; for 12h;	90%

6011-14-9

2-aminoacetonitrile hydrochloride

104-88-1

4-chlorobenzaldehyde

95730-58-8

2-(4-chlorobenzylideneamino)acetonitrile

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 2h;	98%
Stage #1: 2-aminoacetonitrile hydrochloride With triethylamine In ethanol at 20℃; for 0.5h; Inert atmosphere; Stage #2: 4-chlorobenzaldehyde In ethanol Inert atmosphere;

10365-98-7

3-methoxyphenylboronic acid

6011-14-9

2-aminoacetonitrile hydrochloride

19924-43-7

3-methoxyphenylacetonitrile

Conditions

Conditions	Yield
With sodium nitrite In water; toluene at 50℃; for 24h; Schlenk technique;	98%

24309-31-7

1-methyl-2-prop-2-enylsulfanylbenzene

6011-14-9

2-aminoacetonitrile hydrochloride

2-((2-methylphenyl)thio)pent-4-enenitrile

Conditions

Conditions	Yield
With meso-tetraphenylporphyrin iron(III) chloride; sodium nitrite In dichloromethane; water at 20℃; for 15h; Inert atmosphere;	98%

1173006-79-5

(S)-(α,α-dimethylallyl)-p-chlorothiophenol

6011-14-9

2-aminoacetonitrile hydrochloride

2-((4-chlorophenyl)thio)-3,3-dimethylpent-4-enenitrile

Conditions

Conditions	Yield
With meso-tetraphenylporphyrin iron(III) chloride; sodium nitrite In dichloromethane; water at 20℃; for 15h; Inert atmosphere;	98%

33597-89-6

4-methylphenyl prop-2'-ynyl sulfide

6011-14-9

2-aminoacetonitrile hydrochloride

2-((4-methylphenyl)thio)-4λ5-penta-3,4-dienenitrile

Conditions

Conditions	Yield
With meso-tetraphenylporphyrin iron(III) chloride; sodium nitrite In dichloromethane; water at 20℃; for 15h; Inert atmosphere;	98%

758640-21-0

N-Benzylaniline

6011-14-9

2-aminoacetonitrile hydrochloride

36271-19-9

2-(benzyl(phenyl)amino)acetonitrile

Conditions

Conditions	Yield
Stage #1: 2-aminoacetonitrile hydrochloride With FeCl(tiprp); sodium nitrite In toluene at 55℃; Inert atmosphere; Flow reactor; Stage #2: N-Benzylaniline In toluene at 20℃; for 1h; Catalytic behavior; Solvent; Inert atmosphere;	98%

6011-14-9

2-aminoacetonitrile hydrochloride

123-62-6

propionic acid anhydride

36801-37-3

N-(cyanomethyl)propionamide

Conditions

Conditions	Yield
With pyridine at 20℃; for 12h;	98%

6011-14-9

2-aminoacetonitrile hydrochloride

1711-02-0

4-iodobenzoic acid chloride

177724-09-3

N-(cyanomethyl)-4-iodobenzamide

Conditions

Conditions	Yield
With pyridine at 0℃; for 12h;	98%
With pyridine at 0℃; for 12h;	97%

6011-14-9

2-aminoacetonitrile hydrochloride

108-24-7

acetic anhydride

4814-80-6

acetylaminoacetonitrile

Conditions

Conditions	Yield
With triethylamine In dichloromethane; water at 5 - 20℃; for 3h;	97.94%
With pyridine at 20℃; for 12h;	70%
With pyridine for 48h; Ambient temperature;	60%

6011-14-9

2-aminoacetonitrile hydrochloride

513246-79-2

(2R)-2-(3-bromophenyl)-4-methylpentanoic acid

513246-85-0

(2R)-2-(3-bromophenyl)-N-(cyanomethyl)-4-methylpentanamide

Conditions

Conditions	Yield
Stage #1: (2R)-2-(3-bromophenyl)-4-methylpentanoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 2-aminoacetonitrile hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2.5h;	97.5%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;

24424-99-5

di-tert-butyl dicarbonate

6011-14-9

2-aminoacetonitrile hydrochloride

85363-04-8

tert-butyl cyanomethylcarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane; water at 20℃; for 15h; Cooling with ice;	97.1%
With sodium hydroxide In 1,4-dioxane; water for 24h; Ambient temperature;	96%
With triethylamine In dichloromethane for 16h; Ambient temperature;	95%

672-13-9

2-hydroxy-5-methoxybenzaldehyde

6011-14-9

2-aminoacetonitrile hydrochloride

1279019-07-6

(2-hydroxy-5-methoxybenzylideneamino)acetonitrile

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 2h;	97%

6011-14-9

2-aminoacetonitrile hydrochloride

90-02-8

salicylaldehyde

122373-28-8

(2-hydroxy-benzylideneamino)acetonitrile

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 2h;	97%

6011-14-9

2-aminoacetonitrile hydrochloride

635-93-8

5-chlorosalicyclaldehyde

1279019-02-1

(2-hydroxy-5-chlorobenzylideneamino)acetonitrile

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 2h;	97%

6011-14-9

2-aminoacetonitrile hydrochloride

123324-71-0

4-tert-butylphenylboronic acid

3288-99-1

4-tert-butylbenzyl cyanide

Conditions

Conditions	Yield
With sodium nitrite In water; toluene at 50℃; for 24h; Schlenk technique;	97%

5651-88-7

phenyl propargyl sulfide

6011-14-9

2-aminoacetonitrile hydrochloride

2-(phenylthio)-4λ5-penta-3,4-dienenitrile

Conditions

Conditions	Yield
With meso-tetraphenylporphyrin iron(III) chloride; sodium nitrite In dichloromethane; water at 20℃; for 15h; Inert atmosphere;	97%

Aminoacetonitrile hydrochloride Chemical Properties

IUPAC Name: 2-aminoacetonitrile hydrochloride
The MF of GLYCINONITRILE HYDROCHLORIDE(6011-14-9): C₂H₅ClN₂
The MW of GLYCINONITRILE HYDROCHLORIDE(6011-14-9): 92.53
EINECS: 227-865-9
mp: 172-174°C
Sensitive: Hygroscopic
Flash Point: 53.1 °C 
Enthalpy of Vaporization: 40.07 kJ/mol 
Boiling Point: 164.2 °C at 760 mmHg 
Vapour Pressure: 1.99 mmHg at 25°C 
Categories: Pharmaceutical Intermediates;straight chain compounds
Synonyms: AMINO ACETONITRILE HCL;AMINOACETONITRILE HYDROCHLORIDE;Glycinonitrile hydrochloride;alpha-aminoacetonitrilehydrochloride;aminoacetonitrilemonohydrochloride;amino-acetonitrilmonohydrochloride;glycinonitrile,monohydrochloride;2-AminoacetonitrileHydrochloride
The Structure of GLYCINONITRILE HYDROCHLORIDE(6011-14-9):

Aminoacetonitrile hydrochloride Uses

Aminoacetonitrile hydrochloride Consensus Reports

Aminoacetonitrile hydrochloride Safety Profile

Aminoacetonitrile hydrochloride Specification