Amoxapine supplier | CasNO.14028-44-5

Name
Amoxapine
EINECS 237-867-1
CAS No. 14028-44-5
Density 1.37 g/cm³
Solubility
Melting Point 175-176 °C
Formula C₁₇H₁₆ClN₃O
Boiling Point 469.9 °C at 760 mmHg
Molecular Weight 313.787
Flash Point 238 °C
Transport Information
Appearance Crystalline solid
Safety 36
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine;
PSA 36.86000
LogP 3.13150

Synthetic route

: 110-85-0
piperazine

: 3455-14-9
2,11-dichloro-dibenzo[b,f][1,4]oxazepine

: 14028-44-5
amoxapine

Conditions

Conditions	Yield
In xylene for 5h; Heating;

: 1977-10-2
loxapine

: 14028-44-5
amoxapine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. HCl / 16 h / Heating 2: POCl3, PhNMe2 / 5 h / Heating 3: xylene / 5 h / Heating View Scheme

: 3158-91-6
2-chlorodibenzo[b,f][1,4]oxazepin-11(10H)-one

: 14028-44-5
amoxapine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: POCl3, PhNMe2 / 5 h / Heating 2: xylene / 5 h / Heating View Scheme

: 148550-51-0
ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

: 14028-44-5
amoxapine

: 1024010-80-7
ethyl 2-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)pyrimidine-5-carboxylate

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 20℃; for 1h;	100%
In 1,2-dimethoxyethane at 20℃; for 1h;	100%

: 677-25-8
ethylenesulfonyl fluoride

: 14028-44-5
amoxapine

: 2-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)ethanesulfonyl fluoride

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%

: (4-ethynylphenyl)sulfurimidoyl difluoride

: 14028-44-5
amoxapine

: 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)-N-(4-ethynylphenyl)piperazine-1-sulfonimidoyl fluoride

Conditions

Conditions	Yield
With triethylamine In dimethyl sulfoxide at 20℃; for 2h;	99%

: 14028-44-5
amoxapine

: 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazine-1-sulfonyl fluoride

Conditions

Conditions	Yield
With dmap; potassium fluoride; N-ethyl-N,N-diisopropylamine; N,N`-sulfuryldiimidazole; trifluoroacetic acid In dichloromethane at 20℃; for 16h;	99%
With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In dichloromethane at 20℃; for 1h;	95%
With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In dichloromethane at 20℃; for 1h;	95%
With [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 0.166667h;	93%
With [(4-acetamidophenyl)(fluorosulfonyl)amino]sulfonyl fluoride; potassium carbonate In dimethyl sulfoxide at 20℃; for 1h;	89%

: 811-68-7
silver(I) trifluoromethanethiolate

: 14028-44-5
amoxapine

: 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazine-1-carbothioyl fluoride

Conditions

Conditions	Yield
With potassium bromide In acetonitrile at 20℃; for 1h; Inert atmosphere;	98%
With potassium bromide In acetonitrile at 25℃; for 1h;	89%

: 3582-05-6
trifluoromethyl trifluoromethanesulfonate

: 14028-44-5
amoxapine

: 4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazine-1-carbonyl fluoride

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.0833333h; Sealed tube;	97%

: 67-56-1
methanol

: 14028-44-5
amoxapine

: 1977-10-2
loxapine

Conditions

Conditions	Yield
With aluminum (III) chloride; water In acetonitrile at 20℃; Irradiation;	95%
With [(Cp*IrCl)2(4,4′,6,6′-tetrahydroxy-2,2′-bipyrimidine)][Cl]2; potassium hydroxide In water at 130℃; for 12h; Schlenk technique;	73%

: 1455-13-6
deuteromethanol

: 14028-44-5
amoxapine

: C18H15(2)H3ClN3O

Conditions

Conditions	Yield
With aluminum (III) chloride; water-d2 In acetonitrile at 20℃; for 24h; Inert atmosphere; Irradiation;	94%

: 107-18-6
allyl alcohol

: 14028-44-5
amoxapine

: 3-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)propan-1-ol

Conditions

Conditions	Yield
With potassium phosphate; [(bis(2-dicyclohexylphosphinoethyl)amine)Fe(CO)Br2]; sodium triethylborohydride In cyclohexane at 80℃; for 24h; Inert atmosphere; Sealed tube;	91%

: 58824-56-9
1-(p-bromophenyl)prop-2-en-1-ol

: 14028-44-5
amoxapine

: (S)-1-(4-bromophenyl)-3-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)propan-1-ol

Conditions

Conditions	Yield
With potassium phosphate; chloro{(R)-(+)-2,2'-bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl}[(2R)-(-)-1-(4-methoxyphenyl)-1'-(4-methoxyphenyl-kC)-3-methyl-1,2-butanediamine]ruthenium(II) In toluene at 30℃; for 72h; Inert atmosphere; Sealed tube; enantioselective reaction;	89%

: 1455-13-6
deuteromethanol

: 14028-44-5
amoxapine

: C18H16(2)H2ClN3O

Conditions

Conditions	Yield
With aluminum (III) chloride In acetonitrile at 20℃; for 24h; Inert atmosphere; Irradiation;	87%

: 603-76-9
1-methylindole

: 14028-44-5
amoxapine

: 2-chloro-11-(4-(3-iodo-1-methyl-1H-indol-2-yl)piperazin-1-yl)dibenzo[b,f][1,4]oxazepine

Conditions

Conditions	Yield
With ammonium iodide In dimethyl sulfoxide; acetonitrile at 20℃; Electrochemical reaction; Green chemistry;	87%

: 100-47-0
benzonitrile

: 14028-44-5
amoxapine

: C24H22ClN3O

Conditions

Conditions	Yield
With borane-ammonia complex; C16H29Cl2CoN2P at 20℃; for 13h; Schlenk technique; Inert atmosphere; chemoselective reaction;	86%

: 402-43-7
p-trifluoromethylphenyl bromide

: 14028-44-5
amoxapine

: 2-chloro-11-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)dibenzo[b,f][1,4]oxazepine

Conditions

Conditions	Yield
With nickel(II) bromide dimethoxyethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; 4,4'-di-tert-butyl-2,2'-bipyridine; lithium bromide In 1,2-dimethoxyethane; N,N-dimethyl acetamide at 20℃; for 7h; Buchwald-Hartwig Coupling; Inert atmosphere; Electrochemical reaction;	86%

: 1455-13-6
deuteromethanol

: 14028-44-5
amoxapine

: C18H17(2)HClN3O

Conditions

Conditions	Yield
With aluminum (III) chloride; water-d2 In acetonitrile at 20℃; for 24h; Inert atmosphere; Irradiation;	86%

: 710-11-2
2-oxo-4-phenylbutyric acid

: 14028-44-5
amoxapine

: 1-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)-3-phenylpropane-1-thione

Conditions

Conditions	Yield
With sulfur; 1-dodecylthiol In tetrahydrofuran at 20℃; for 2h; Sealed tube; chemoselective reaction;	84%

: N-(pivaloyloxy)pent-4-enamide

: 14028-44-5
amoxapine

: 5-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)piperidin-2-one

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium hydrogencarbonate In 2,2,2-trifluoroethanol; water at 21℃; for 16h; regioselective reaction;	79%

: 1224597-90-3
quinolin-2-yl N,N,N’,N’-tetramethyldiamidophosphate

: 14028-44-5
amoxapine

: 2-(amoxapin-N-yl)quinoline

Conditions

Conditions	Yield
With TurboGrignard In tetrahydrofuran at 0 - 25℃; for 8h; Inert atmosphere;	78%

: 109-85-3
2-methoxyethylamine

: 14028-44-5
amoxapine

: N-(2-methoxyethyl)-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepin-2-amine

Conditions

Conditions	Yield
With C47H70BrO4PPdSi; sodium t-butanolate In tetrahydrofuran at 20℃; Sealed tube; Inert atmosphere;	74%

: (1-methyl-1H-indol-5-yl)boronic acid

: 14028-44-5
amoxapine

: 2-chloro-11-(4-((1-methyl-1H-indol-5-yl)sulfonyl)piperazin-1-yl)dibenzo[b,f][1,4]oxazepine

Conditions

Conditions	Yield
With 4,4'-Dimethoxy-2,2'-bipyridin; 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; copper(II) bis(trifluoromethanesulfonate); caesium carbonate; dimethyl sulfoxide at 130℃; for 16h; Inert atmosphere; Sealed tube;	71%

: 50986-83-9
4-fluorobenzenesulfinyl chloride

: 14028-44-5
amoxapine

: 2-chloro-11-(4-((4-fluorophenyl)sulfinyl)piperazin-1-yl)dibenzo-[b,f ][1,4]oxazepine

Conditions

Conditions	Yield
With triethylamine at 20℃; for 0.5h; Inert atmosphere;	69%

: 912896-78-7
4-(tert-butyl)-N-(quinolin-8-yl)benzamide

: 14028-44-5
amoxapine

: 4-(tert-butyl)-2-(8-chloro-piperazin-1-yl)dibenzo[b,f][1,4]-oxazepine-N-(quinolin-8-yl)benzamide

Conditions

Conditions	Yield
With copper diacetate; sodium acetate In acetonitrile for 12h; Electrochemical reaction;	63%

: 5460-32-2
1-iodo-3,4-dimethoxybenzene

: 14028-44-5
amoxapine

: 2-chloro-11-(4-((3,4-dimethoxyphenyl)sulfonyl)piperazin-1-yl)dibenzo[b,f][1,4]oxazepine

Conditions

Conditions	Yield
With dmap; 1-ethenyl-4-methylbenzene; palladium(II) acetylacetonate; 2,3,4,5-tetrabromothiophene 1,1-dioxide In dimethyl sulfoxide at 95℃; for 24h; Sealed tube; Inert atmosphere;	62%

: (E)-N-([1,1'-biphenyl]-4-yl)-2,2,2-trifluoroacetimidoyl cyanide

: 14028-44-5
amoxapine

: N-(1-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)-2,2,2-trifluoroethylidene)-[1,1'-biphenyl]-4-amine

Conditions

Conditions	Yield
With triethylamine In toluene at 120℃; for 12h; Inert atmosphere; Schlenk technique;	61%

: 623-00-7
4-bromobenzenecarbonitrile

: 14028-44-5
amoxapine

: C24H19ClN4O

Conditions

Conditions	Yield
With Pd(PAd3)(4-FC6H4)Br; triethylamine In water; toluene at 80℃; for 48h; Inert atmosphere; Glovebox; chemoselective reaction;	61%

: 1246765-49-0
3,3-difluorocyclobutane-1-carbaldehyde

: C16H19NO4

: 14028-44-5
amoxapine

: C38H41ClF2N4O5

Conditions

Conditions	Yield
With tris[2-phenylpyridinato-C2,N]iridium(III); diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; propionic acid In dichloromethane at 20℃; for 2h; Molecular sieve; Irradiation;	55%

...Expand

: 4-methoxy-N-tritylbenzenesulfonimidoyl fluoride

: 14028-44-5
amoxapine

: 2-chloro-11-(4-(4-methoxy-N-tritylphenylsulfonimidoyl)piperazin-1-yl)dibenzo[b,f][1,4]oxazepane

Conditions

Conditions	Yield
Stage #1: 4-methoxy-N-tritylbenzenesulfonimidoyl fluoride With aluminum (III) chloride In acetonitrile at 0℃; for 0.5h; Inert atmosphere; Sealed tube; Stage #2: amoxapine With triethylamine In acetonitrile at 0 - 20℃; for 16h; Inert atmosphere; Sealed tube;	53%

: cyclobutanone O-perfluorobenzoyl oxime

: 14028-44-5
amoxapine

: 4-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)butanenitrile

Conditions

Conditions	Yield
With 2,6-bis[(4S)-4-methyl-4,5-dihydrooxazol-2-yl]pyridine; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Sealed tube; Inert atmosphere; Irradiation;	45%

: tert-butyl (fluoro(methyl)(oxo)-λ6-sulfaneylidene)carbamate

: 14028-44-5
amoxapine

: tert-butyl ((4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)(methyl)(oxo)-λ6-sulfaneylidene)carbamate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;	45%

: 201230-82-2
carbon monoxide

: 116199-39-4
(S)-4-phenylbutan-2-yl 4-methylbenzenesulfonate

: 14028-44-5
amoxapine

: (R)-1-(4-(2-chlorodibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-yl)-2-methyl-4-phenylbutan-1-one

Conditions

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; dicobalt octacarbonyl In tert-Amyl alcohol at 70℃; under 30402 Torr; for 24h; Inert atmosphere; Sealed tube;	43%

...Expand

Amoxapine Consensus Reports

AMOXAPINE is reported in EPA TSCA Inventory.

Amoxapine Specification

The Amoxapine, with the CAS registry number 14028-44-5 and EINECS registry number 237-867-1, has the systematic name of 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine. It is a kind of crystalline solid, and belongs to the following product categories: Intermediates & Fine Chemicals; Pharmaceuticals; Adrenoceptor. It is a strong norepinephrine reuptake inhibitor and weak serotonin reuptake inhibitor. It also possesses antiadrenergic, anticholinergic, antidopaminergic, antihistamine, and antiserotonergic actions. The molecular formula of this chemical is C₁₇H₁₆ClN₃O.

The physical properties of Amoxapine are as following: (1)ACD/LogP: 2.35; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.06; (4)ACD/LogD (pH 7.4): 1.76; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 9.32; (7)ACD/KOC (pH 5.5): 2.32; (8)ACD/KOC (pH 7.4): 117.52; (9)#H bond acceptors: 4; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 28.07 Å²; (13)Index of Refraction: 1.685; (14)Molar Refractivity: 86.74 cm³; (15)Molar Volume: 228.2 cm³; (16)Polarizability: 34.39×10^-24cm³; (17)Surface Tension: 52.1 dyne/cm; (18)Density: 1.37 g/cm³; (19)Flash Point: 238 °C; (20)Enthalpy of Vaporization: 73.23 kJ/mol; (21)Boiling Point: 469.9 °C at 760 mmHg; (22)Vapour Pressure: 5.32E-09 mmHg at 25°C.

Preparation and uses of Amoxapine: o-(p-chlorophenoxy) benzene Ethyl carbamate react with N-ethyl piperazine-based to give 4-[[o-(p-chlorophenoxy)phenyl]carbamoyl]-1-piperazine carboxylate. Then heat it with phosphorus pentoxide and phosphorus oxychloride to reflux. And you can get the aim product with this cyclization reaction. What's more, Amoxapine is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder.

You should be cautious while dealing with this chemical. It is harmful if swallowed. Therefore, you had better take the wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc2ccc1Oc4c(/N=C(\c1c2)N3CCNCC3)cccc4
(2)InChI: InChI=1/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
(3)InChIKey: QWGDMFLQWFTERH-UHFFFAOYAA

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD	unreported	> 20mg/kg (20mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY	Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 1, 1979.
child	LDLo	oral	25mg/kg (25mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Southern Medical Journal. Vol. 76, Pg. 543, 1983.
child	TDLo	oral	10mg/kg (10mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	JAMA, Journal of the American Medical Association. Vol. 250, Pg. 1069, 1983.
dog	LD	unreported	> 20mg/kg (20mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: IRRITABILITY	Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 1, 1979.
dog	LDLo	intraperitoneal	20mg/kg (20mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 1, 1979.
man	TDLo	oral	4285ug/kg/2D- (4.285mg/kg)	BEHAVIORAL: EXCITEMENT	American Journal of Psychiatry. Vol. 140, Pg. 115, 1983.
man	TDLo	oral	4286ug/kg (4.286mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: REGIDITY	Southern Medical Journal. Vol. 77, Pg. 94, 1984.
man	TDLo	oral	14mg/kg (14mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	JAMA, Journal of the American Medical Association. Vol. 248, Pg. 3141, 1982.
man	TDLo	oral	27mg/kg (27mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Pharmacotherapy Vol. 15, Pg. 528, 1995.
man	TDLo	oral	70mg/kg/3W-I (70mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Clinical Psychiatry. Vol. 45, Pg. 358, 1984.
man	TDLo	unreported	5714ug/kg/2D- (5.714mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Southern Medical Journal. Vol. 76, Pg. 1077, 1983.
monkey	LD	unreported	> 20mg/kg (20mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 1, 1979.
mouse	LD50	intraperitoneal	112mg/kg (112mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: REGIDITY	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 233, Pg. 107, 1978.
mouse	LD50	oral	104mg/kg (104mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 1, 1979.
mouse	LD50	subcutaneous	385mg/kg (385mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1852, 1971.
rat	LD50	intraperitoneal	201mg/kg (201mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 233, Pg. 107, 1978.
rat	LD50	oral	313mg/kg (313mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1852, 1971.
rat	LD50	subcutaneous	> 4500mg/kg (4500mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1852, 1971.
women	LDLo	oral	40mg/kg (40mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: CHANGE IN RATE CARDIAC: OTHER CHANGES	Annals of Emergency Medicine. Vol. 17, Pg. 274, 1988.
women	LDLo	oral	40mg/kg (40mg/kg)	BEHAVIORAL: COMA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	JAMA, Journal of the American Medical Association. Vol. 250, Pg. 1069, 1983.
women	LDLo	oral	75953ug/kg (75.953mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: OTHER CHANGES CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Forensic Science International. Vol. 26, Pg. 33, 1984.
women	TDLo	oral	5mg/kg (5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	JAMA, Journal of the American Medical Association. Vol. 250, Pg. 1069, 1983.
women	TDLo	oral	15mg/kg/5D-I (15mg/kg)	ENDOCRINE: HYPERGLYCEMIA	Journal of Clinical Psychiatry. Vol. 44, Pg. 347, 1983.
women	TDLo	oral	17mg/kg (17mg/kg)	BEHAVIORAL: COMA VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 101, 1983.
women	TDLo	oral	30mg/kg (30mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	JAMA, Journal of the American Medical Association. Vol. 248, Pg. 1092, 1982.
women	TDLo	oral	50mg/kg (50mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA	Ugeskrift for Laeger. Doctor's Weekly. Vol. 146, Pg. 3285, 1984.

Product Name

Amoxapine

Synthetic route

Amoxapine Consensus Reports

Amoxapine Specification

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