• Name

  Azaconazole

• EINECS 262-102-3
• CAS No. 60207-31-0
• Article Data15
• CAS DataBase
• Density 1.51 g/cm³
• Solubility 0.3g/l (20°C), In water
• Melting Point 112.6°C
• Formula C12H11 Cl2 N3 O2
• Boiling Point 460.7 °C at 760 mmHg
• Molecular Weight 300.144
• Flash Point 232.4 °C
• Transport Information
• Appearance
• Safety 46
• Risk Codes 22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms 1-[[2-(2,4-Dichlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole;Azaconazole; Azoconazole; Madurox; R 28644; Rodewod
• PSA 49.17000
• LogP 2.48470

Synthetic route

288-88-0

1,2,4-Triazole

2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane

60207-31-0

azaconazole

Conditions

Conditions	Yield
Stage #1: 1,2,4-Triazole With sodium In methanol at 20℃; for 0.5h; Stage #2: 2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane With potassium iodide for 3h; Reflux;	59.98%
Stage #1: 1,2,4-Triazole With sodium In methanol at 20℃; for 0.5h; Stage #2: 2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane With potassium iodide In N,N-dimethyl-formamide at 130℃; for 3h;	59.98%
With sodium In N-methyl-acetamide; methanol

107-21-1

ethylene glycol

58905-16-1

1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

60207-31-0

azaconazole

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In pentan-1-ol for 20h; Reflux;	56.7%
With toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene; pentan-1-ol for 20h; Reflux;	56.7%

1-(2,4-dichlorophenyl)-2-(4-amino-4H-1,2,4-triazolyl)ethanone hydrochloride

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C 2: toluene-4-sulfonic acid / pentan-1-ol / 20 h / Reflux View Scheme

2234-16-4

1-(2,4-dichlorophenyl)ethan-1-one

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine / butan-1-ol / 2 h / 20 °C 1.2: 4 h / Reflux 2.1: sodium / methanol / 0.5 h / 20 °C 2.2: 3 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; bromine / diethyl ether / Cooling with ice 2.1: toluene-4-sulfonic acid / butan-1-ol; benzene / 6 h / Reflux 3.1: sodium / methanol / 0.5 h / 20 °C 3.2: 3 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride; chlorine / diethyl ether / Cooling with ice 2: isopropyl alcohol / 4 h / Reflux 3: toluene-4-sulfonic acid / pentan-1-ol / 20 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / benzene; butan-1-ol / 6 h / 86 - 87 °C 2.1: bromine / 20 °C 3.1: sodium / methanol / 0.5 h / 20 °C 3.2: 3 h / 130 °C View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; bromine / diethyl ether / Cooling with ice 2.1: toluene-4-sulfonic acid / benzene; butan-1-ol / 5 h / 87 - 88.5 °C 3.1: sodium / methanol / 0.5 h / 20 °C 3.2: 3 h / 130 °C View Scheme

2631-72-3

2,4-dichlorophenacyl bromide

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid / butan-1-ol; benzene / 6 h / Reflux 2.1: sodium / methanol / 0.5 h / 20 °C 2.2: 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: toluene-4-sulfonic acid / benzene; butan-1-ol / 5 h / 87 - 88.5 °C 2.1: sodium / methanol / 0.5 h / 20 °C 2.2: 3 h / 130 °C View Scheme

4252-78-2

2,2',4'-trichloroacetophenone

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: isopropyl alcohol / 4 h / Reflux 2: toluene-4-sulfonic acid / pentan-1-ol / 20 h / Reflux View Scheme

541-73-1

1,3-Dichlorobenzene

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 0.33 h 1.2: Cooling with ice 2.1: bromine / butan-1-ol / 2 h / 20 °C 2.2: 4 h / Reflux 3.1: sodium / methanol / 0.5 h / 20 °C 3.2: 3 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 0.33 h 1.2: Cooling with ice 2.1: aluminum (III) chloride; chlorine / diethyl ether / Cooling with ice 3.1: isopropyl alcohol / 4 h / Reflux 4.1: toluene-4-sulfonic acid / pentan-1-ol / 20 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / 1,2-dichloro-benzene / 0.33 h 1.2: Cooling with ice 2.1: aluminum (III) chloride; bromine / diethyl ether / Cooling with ice 3.1: toluene-4-sulfonic acid / butan-1-ol; benzene / 6 h / Reflux 4.1: sodium / methanol / 0.5 h / 20 °C 4.2: 3 h / Reflux View Scheme

C10H10Cl2O2

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: bromine / 20 °C 2.1: sodium / methanol / 0.5 h / 20 °C 2.2: 3 h / 130 °C View Scheme

118227-30-8

1-(2,4-dichlorophenyl)-2-(4-amino-4H-1,2,4-triazoliumyl)ethanone chloride

60207-31-0

azaconazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C 2: toluene-4-sulfonic acid / pentan-1-ol; 5,5-dimethyl-1,3-cyclohexadiene / 20 h / Reflux View Scheme

60207-31-0

azaconazole

1-[[2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole nitrate

Conditions

Conditions	Yield
With nitric acid In di-isopropyl ether	3.0 g
With nitric acid In di-isopropyl ether Cooling;	3 g

60207-31-0

azaconazole

1-[[2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole sulfate

Conditions

Conditions	Yield
With sulfuric acid In di-isopropyl ether	6.4 g
With sulfuric acid In di-isopropyl ether	6.4 g

Azaconazole Chemical Properties

Azaconazole Uses

Azaconazole Toxicity Data With Reference

Azaconazole Safety Profile

Azaconazole Specification