Benzaldehyde,3,5-dichloro-4-hydroxy- supplier

Name
3,5-DICHLORO-4-HYDROXYBENZALDEHYDE
EINECS
CAS No. 2314-36-5
Article Data45
CAS DataBase
Density 1.547 g/cm³
Solubility
Melting Point 154 °C
Formula C₇H₄Cl₂O₂
Boiling Point 256.7 °C at 760 mmHg
Molecular Weight 191.014
Flash Point 109 °C
Transport Information
Appearance
Safety 26
Risk Codes 36
Molecular Structure
Hazard Symbols Xi
Synonyms AKOS B029235;
PSA 37.30000
LogP 2.51150

Synthetic route

: 123-08-0
4-hydroxy-benzaldehyde

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With N-chloro-N-(benzenesulfonyl)benzenesulfonamide In acetonitrile at 20 - 25℃; for 0.666667h; Green chemistry;	97.4%
Stage #1: 4-hydroxy-benzaldehyde With 3-aminopropyltriethoxysilane In acetonitrile for 0.166667h; Stage #2: With N-chloro-succinimide In acetonitrile at 20℃;	75%
With sulfuryl dichloride In chloroform Inert atmosphere; Reflux;	55%
With chloroform; chlorine unter Kuehlung;
With chlorine; acetic acid unter Erwaermen;

: 22002-17-1
3,5-dichloro-4-hydroxybenzyl alcohol

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane for 16h; Ambient temperature;	92%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 20℃;	22%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,4-dioxane at 20℃;	22%

: 2432-12-4
2,6-dichloro-4-methylophenol

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With oxygen; cobalt(II) diacetate tetrahydrate; sodium hydroxide In ethylene glycol at 80℃; under 760.051 Torr; for 8h;	91%
With oxygen; cobalt(II) diacetate tetrahydrate; sodium hydroxide In ethylene glycol at 80℃; under 760.051 Torr; for 9h;	91%
With copper diacetate; ethylene glycol at 100℃; for 12h; Green chemistry; chemoselective reaction;	18%

: 910635-08-4
[2-(2,6-dichloro-4-iodo-phenoxymethoxy)-ethyl]-trimethylsilane

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: [2-(2,6-dichloro-4-iodo-phenoxymethoxy)-ethyl]-trimethylsilane With isopropylmagnesium chloride In tetrahydrofuran at -20 - -10℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -10 - 20℃; Stage #3: With hydrogenchloride; water In tetrahydrofuran at 20℃;	88%

: 87-65-0
2,6-Dichlorophenol

: 100-97-0
hexamethylenetetramine

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Stage #1: 2,6-Dichlorophenol; hexamethylenetetramine With acetic acid for 3h; Duff Reaction; Reflux; Stage #2: With sulfuric acid; water at 100℃;	84%

: 2432-12-4
2,6-dichloro-4-methylophenol

: 124-41-4
sodium methylate

A: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

B: 79817-03-1
3,5-dichloro-4-hydroxybenzyl methyl ether

C: 2-chloro-6-(2,6-dichloro-4-methyl-phenoxy)-4-methoxy-4-methyl-cyclohexa-2,5-dienone

D: 2-chloro-6-(2,6-dichloro-4-methoxymethyl-phenoxy)-4-methoxy-4-methyl-cyclohexa-2,5-dienone

Conditions

Conditions	Yield
In methanol Product distribution; Mechanism; electrolysis at 0.13 mA/cm2, 1.4 F/mol, C.C.E. 906 --> 1111 mV vs SCE; electrolyte LiClO4; acidic conditions;	A 5% B 8% C 61% D 13%

...Expand

: 79-46-9
2-nitropropane

: 22002-17-1
3,5-dichloro-4-hydroxybenzyl alcohol

A: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

B: 85628-45-1
2,6-Dichlor-4-(2-methyl-2-nitropropyl)phenol

Conditions

Conditions	Yield
potassium fluoride; tetrabutyl-ammonium chloride for 30h; Heating;	A 15% B 26%

...Expand

: 79-46-9
2-nitropropane

: 56733-60-9
2,6-dichloro-4-dimethylaminomethyl-phenol

A: 87-65-0
2,6-Dichlorophenol

B: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

C: 85628-45-1
2,6-Dichlor-4-(2-methyl-2-nitropropyl)phenol

Conditions

Conditions	Yield
potassium fluoride; tetrabutyl-ammonium chloride for 30h; Heating;	A n/a B n/a C 12%

...Expand

: 87-65-0
2,6-Dichlorophenol

: 67-66-3
chloroform

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With calcium hydroxide; sodium carbonate In water for 2h; Heating;	8%
With sodium hydroxide

3.5-dichloro-anisaldehyde: 3.5-dichloro-anisaldehyde

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
With hydrogen iodide

: 3337-59-5
methyl 3,5-dichloro-4-hydroxybenzoate

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 4.6 g / LiAlH4 / tetrahydrofuran / 12 h / Heating 2: 4.4 g / DDQ / dioxane / 12 h / Ambient temperature View Scheme

: 87-65-0
2,6-Dichlorophenol

benzenediazonium-sulfate: benzenediazonium-sulfate

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 21.3 percent / NaOH / H2O / 192 h / 70 °C 2: 15 percent / KF*2H2O, tetrabutylammonium chloride / 30 h / Heating View Scheme

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 75-16-1
methylmagnesium bromide

: 154639-00-6
(rac.)-2,6-dichloro-4-(1-hydroxyethyl)phenol

Conditions

Conditions	Yield
In diethyl ether at -78 - 20℃; for 2.3h;	95%
Stage #1: 3,5-dichloro-4-hydroxybenzaldehyde; methylmagnesium bromide In diethyl ether at -78 - 20℃; for 2.3h; Stage #2: With water; ammonium chloride In diethyl ether at 0 - 20℃;	95%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 106-93-4
ethylene dibromide

: 4-(2-bromoethoxy)-3,5-dichlorobenzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	95%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 106-96-7
propargyl bromide

: C10H6Cl2O2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;	82%

: 358-23-6
trifluoromethylsulfonic anhydride

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 188112-57-4
trifluoromethanesulfonic acid 2,6-dichloro-4-formylphenyl ester

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0 - 20℃;	80%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 6921-34-2
benzylmagnesium chloride

: 73049-09-9
1-(3,5-dichloro-4-hydroxyphenyl)-2-phenylethanol

Conditions

Conditions	Yield
	79%

: 7169-34-8
3-oxo-2,3-dihydrobenzo[b]furan

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: (2Z)-2-[(3,5-dichloro-4-hydroxyphenyl)methylidene]benzofuran-3-one

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol at 80℃;	79%

: 20870-78-4
5-bromo-2-indolin-2-one

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 5-bromo-3-(3,5-dichloro-4-hydroxybenzylidene)indolin-2-one

Conditions

Conditions	Yield
With piperidine In ethanol at 80℃; for 16h; Inert atmosphere;	77%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 20103-10-0
2,6-dichloro-1,4-benzenediol

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide In methanol; water at 17 - 80℃; Dakin Reaction;	76%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 108-24-7
acetic anhydride

: 543-24-8
N-acetylglycine

: 1539318-30-3
(Z)-2,6-dichloro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

Conditions

Conditions	Yield
With sodium acetate at 100℃; for 1h;	75%

...Expand

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 2785-06-0
2,3-dimethylbenzothiazolium iodide

: C16H12Cl2NOS(1+)

Conditions

Conditions	Yield
With piperidine In ethanol at 80℃;	75%

: 60-35-5
acetamide

: 201230-82-2
carbon monoxide

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 212067-18-0
(R,S)-N-acetyl-α-(3,5-dichloro-4-hydroxyphenyl)glycine

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; sulfuric acid; lithium bromide; bis(triphenylphosphine)palladium dibromide at 100℃; under 45003.6 Torr; for 48h;	73%

...Expand

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 2-cyano-N-(4-(pyridin-2-yl)thiazol-2-yl)acetamide

: (E)-2-cyano-3-(3,5-dichloro-4-hydroxyphenyl)-N-(4-(pyridin-2-yl)thiazol-2-yl)acrylamide

Conditions

Conditions	Yield
With piperidine In dichloromethane for 16h; Inert atmosphere; Reflux;	70%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: N-(4-(4-(tert-butyl)phenyl)thiazol-2-yl)-2-cyanoacetamide

: (E)-N-(4-(4-(tert-butyl)phenyl)thiazol-2-yl)-2-cyano-3-(3,5-dichloro-4-hydroxyphenyl)acrylamide

Conditions

Conditions	Yield
With piperidine In dichloromethane for 3h; Inert atmosphere; Reflux;	66%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 102359-00-2
2-oxoindoline-5-carboxylic acid

: 3-(3,5-dichloro-4-hydroxybenzylidene)-2-oxoindoline-5-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid In water at 95℃; for 16h; Inert atmosphere;	65%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 57420-88-9
3-(2,6-dimethylphenoxy)propylamine

: 2,6-dichloro-4-((3-(2,6-dimethylphenoxy)propylamino)methyl)phenol

Conditions

Conditions	Yield
Stage #1: 3,5-dichloro-4-hydroxybenzaldehyde; 3-(2,6-dimethylphenoxy)propylamine In methanol Inert atmosphere; Stage #2: With methanol; sodium tetrahydroborate at 20℃; Stage #3: With hydrogenchloride In methanol; water	64%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 57420-88-9
3-(2,6-dimethylphenoxy)propylamine

: 2,6-dichloro-4-((3-(2,6-dimethylphenoxy)propylamino)methyl)phenol hydrochloride

Conditions

Conditions	Yield
Stage #1: 3,5-dichloro-4-hydroxybenzaldehyde; 3-(2,6-dimethylphenoxy)propylamine In methanol at 20℃; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol at 20℃; Inert atmosphere; Stage #3: With hydrogenchloride In methanol; water	64%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 504-02-9
1,3-cylohexanedione

: 9-(3,5-dichloro-4-hydroxyphenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione

Conditions

Conditions	Yield
With N,N'-bis(3-sulfopropyl)triethylenediaminium bis(hydrogensulfate); ammonium acetate In ethanol at 80℃; for 4h;	63.5%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 113465-84-2
α-(3,5-dichloro-4-hydroxyphenyl)-3-methyl-5-isoxazoleethanol

Conditions

Conditions	Yield
	61%
	61%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 1-(6-(methylthio)benzofuran-2-yl)ethan-1-one

: (E)-3-(3,5-dichloro-4-hydroxyphenyl)-1-(6-(methylthio)benzofuran-2-yl)prop-2-en-1-one

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 85℃; for 3h;	61%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 171082-32-9
2-dicyanomethylidene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran

: 1610355-52-6
C18H11Cl2N3O2

Conditions

Conditions	Yield
With piperidine In ethanol at 100℃; for 0.25h; Knoevenagel Condensation; Microwave irradiation;	60%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 105-36-2
ethyl bromoacetate

: 27445-09-6
ethyl 2-(2,6-dichloro-4-formylphenoxy)acetate

Conditions

Conditions	Yield
With caesium carbonate In acetone for 1h; Reflux;	59%

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: 5-(furan-2-carbonyl)indolin-2-one

: 3-(3,5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one

Conditions

Conditions	Yield
With piperidine In ethanol at 80℃; for 16h; Inert atmosphere;	58%
With toluene-4-sulfonic acid In toluene at 105℃; for 24h; mixed aldol condensation;

: 2314-36-5
3,5-dichloro-4-hydroxybenzaldehyde

: C18H17N5O2

: C26H21Cl2N5O3

Conditions

Conditions	Yield
Stage #1: 3,5-dichloro-4-hydroxybenzaldehyde With piperidine; acetic acid at 20℃; for 0.166667h; Stage #2: C18H17N5O2 Inert atmosphere; Reflux;	57.53%

Benzaldehyde,3,5-dichloro-4-hydroxy- Specification

The Benzaldehyde,3,5-dichloro-4-hydroxy-, with the CAS registry number of 2314-36-5, is also known as AKOS B029235. It belongs to the product categories of Aromatic Aldehydes & Derivatives (substituted); Aldehydes; Phenyls & Phenyl-Het; Phenyls & Phenyl-Het. This chemical's molecular formula is C₇H₄Cl₂O₂ and molecular weight is 191.01. What's more, its IUPAC name is 3,5-Dichloro-4-hydroxybenzaldehyde.

Physical properties about the Benzaldehyde,3,5-dichloro-4-hydroxy- are: (1)ACD/LogP: 2.56; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.82; (4)ACD/LogD (pH 7.4): 0.1; (5)ACD/BCF (pH 5.5): 9.43; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 106.88; (8)ACD/KOC (pH 7.4): 2.05; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 26.3 Å²; (13)Index of Refraction: 1.643; (14)Molar Refractivity: 44.67 cm³; (15)Molar Volume: 123.4 cm³; (16)Surface Tension: 56.9 dyne/cm; (17)Density: 1.547 g/cm³; (18)Flash Point: 109 °C; (19)Enthalpy of Vaporization: 51.41 kJ/mol; (20)Boiling Point: 256.7 °C at 760 mmHg; (21)Vapour Pressure: 0.00945 mmHg at 25 °C.

Preparation: this chemical is prepared by 3,5-Dichloro-4-hydroxy-benzyl alcohol. The reaction needs reagent 2,3-Dichloro-5,6-dicyanobenzoquinone and solvent Dioxane. The reaction time is 16 h. The yield is about 92 %.

Uses: it is used to produce other chemicals. For example, it is used to produce 1-(3,5-Dichloro-4-hydroxyphenyl)-2-phenylethanol. The yield is about 79 %.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1cc(cc(Cl)c1O)C=O
(2) InChI: InChI=1/C7H4Cl2O2/c8-5-1-4(3-10)2-6(9)7(5)11/h1-3,11H
(3) InChIKey: LIYGCLJYTHRBQV-UHFFFAOYAZ

Product Name

3,5-DICHLORO-4-HYDROXYBENZALDEHYDE

Synthetic route

Benzaldehyde,3,5-dichloro-4-hydroxy- Specification

Related Products

Hot Products