• Name

  2,3-DIFLUORO-1-PROPOXYBENZENE

• EINECS
• CAS No. 124728-93-4
• Article Data4
• CAS DataBase
• Density 1.111 g/cm³
• Solubility
• Melting Point
• Formula C₉H₁₀F₂O
• Boiling Point 189.5 °C at 760 mmHg
• Molecular Weight 172.175
• Flash Point 74.8 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 1,2-Difluoro-3-propyloxybenzene;2,3-Difluoro-1-propyloxybenzene;2,3-Difluorophenyl propyl ether;3-Propoxy-1,2-difluorobenzene;
• PSA 9.23000
• LogP 2.75360

Synthetic route

6418-38-8

2,3-difluorophenol

107-08-4

1-iodo-propane

124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions

Conditions	Yield
With sodium carbonate In ethanol; water	92%

540-54-5

1-Chloropropane

6418-38-8

2,3-difluorophenol

124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium hydroxide In water; N,N-dimethyl-formamide; toluene at 30℃; Reflux; Industrial scale;	90.6%

890840-88-7

1,2-difluoro-3-(prop-2-yn-1-yloxy)benzene

1029476-86-5

7,8-difluoro-2H-chromene

A

1029476-87-6

7,8-difluoro-3,4-dihydro-1-benzopyran

B

124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions

Conditions	Yield
With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran at 20℃; for 1h;

...Expand

71-23-8

propan-1-ol

1489-53-8

1,2,3-trifluorobenzene

124728-93-4

1,2-difluoro-3-n-propoxybenzene

Conditions

Conditions	Yield
With calcium hydroxide at 100℃; for 20h;

121-43-7

Trimethyl borate

598-30-1

sec.-butyllithium

124728-93-4

1,2-difluoro-3-n-propoxybenzene

2,3-difluoro-4-propyloxyphenyl boric acid

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; hexane	62%

...Expand

68-12-2, 33513-42-7

N,N-dimethyl-formamide

124728-93-4

1,2-difluoro-3-n-propoxybenzene

4-Propoxy-2,3-difluorobenzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃;

124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-propyl-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: p-toluenesulfonic acid / toluene / Heating View Scheme

124728-93-4

1,2-difluoro-3-n-propoxybenzene

5-(4-butyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: p-toluenesulfonic acid / toluene / Heating View Scheme

124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(4-pentyl-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: p-toluenesulfonic acid / toluene / Heating View Scheme

124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxy-phenyl)-5-(2-fluoro-4-pentyl-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: p-toluenesulfonic acid / toluene / Heating View Scheme

124728-93-4

1,2-difluoro-3-n-propoxybenzene

5-(2,3-difluoro-4-pentyl-phenyl)-2-(2,3-difluoro-4-propoxy-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-BuLi / hexane; tetrahydrofuran / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: p-toluenesulfonic acid / toluene / Heating View Scheme

82832-73-3

4-(trans-4-n-propylcyclohexyl)cyclohexanone

124728-93-4

1,2-difluoro-3-n-propoxybenzene

C24H36F2O2

Conditions

Conditions	Yield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75 - -70℃; for 2h; Inert atmosphere; Large scale; Stage #2: 4-(trans-4-n-propylcyclohexyl)cyclohexanone In tetrahydrofuran; hexane at -75 - -30℃; for 2.5h; Inert atmosphere; Large scale;

82832-73-3

4-(trans-4-n-propylcyclohexyl)cyclohexanone

124728-93-4

1,2-difluoro-3-n-propoxybenzene

C24H34F2O

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 - -70 °C / Inert atmosphere; Large scale 1.2: 2.5 h / -75 - -30 °C / Inert atmosphere; Large scale 2.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Large scale View Scheme

84868-02-0

4-(trans-4-n-pentylcyclohexyl)cyclohexanone

124728-93-4

1,2-difluoro-3-n-propoxybenzene

C26H40F2O2

Conditions

Conditions	Yield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75 - -70℃; for 2h; Inert atmosphere; Large scale; Stage #2: 4-(trans-4-n-pentylcyclohexyl)cyclohexanone In tetrahydrofuran; hexane at -75 - -30℃; for 2.5h; Inert atmosphere; Large scale;

84868-02-0

4-(trans-4-n-pentylcyclohexyl)cyclohexanone

124728-93-4

1,2-difluoro-3-n-propoxybenzene

C26H38F2O

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 - -70 °C / Inert atmosphere; Large scale 1.2: 2.5 h / -75 - -30 °C / Inert atmosphere; Large scale 2.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux; Large scale View Scheme

121-43-7

Trimethyl borate

124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium; potassium tert-butylate In tetrahydrofuran; hexane at -78 - -70℃; for 0.5h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane for 0.5h; Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water at 20℃; for 1h;	8.2 g

124728-93-4

1,2-difluoro-3-n-propoxybenzene

2-(2,3-difluoro-4-propoxyphenyl)-4,5-bis(trifluoromethyl)-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 0.5 h / -78 - -70 °C / Inert atmosphere 1.2: 0.5 h 1.3: 1 h / 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; toluene / Reflux; Inert atmosphere View Scheme

124728-93-4

1,2-difluoro-3-n-propoxybenzene

6418-38-8

2,3-difluorophenol

Conditions

Conditions	Yield
With iron(III) chloride In ethanol at 30℃; for 3h;	10.6 g

124728-93-4

1,2-difluoro-3-n-propoxybenzene

6-butoxy-2-(4-propyloxy-2,3-difluorophenyl)-3,4,5-trifluoronaphthalene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 - -3 °C 2: triphenylphosphine; potassium carbonate; palladium diacetate / tetrahydrofuran; water / 5 h / Reflux View Scheme

5419-55-6

Triisopropyl borate

124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions

Conditions	Yield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -10 - -3℃; for 1h;	48 g

688-74-4

boric acid tributyl ester

124728-93-4

1,2-difluoro-3-n-propoxybenzene

(2,3-difluoro-4-propoxyphenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: 1,2-difluoro-3-n-propoxybenzene With n-butyllithium In 2-methyltetrahydrofuran; cyclohexane at -70 - -60℃; for 2h; Inert atmosphere; Stage #2: boric acid tributyl ester In 2-methyltetrahydrofuran; cyclohexane at -70 - -60℃; for 2h;

Benzene,1,2-difluoro-3-propoxy- Specification