With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $3.0 / 10.0
Type:Trading Company
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:124750-51-2
Min.Order:0 Metric Ton
Negotiable
Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:124750-51-2
Min.Order:1 Metric Ton
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiryTTBB CAS 124750-51-2 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the p
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Trading Company
inquiry5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (TTBB)) CAS NO.:124750-51-2 Name 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Synonyms N-
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:124750-51-2
Min.Order:1
Negotiable
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:124750-51-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryWhy is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $500.0 / 5000.0
Type:Trading Company
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan
Cas:124750-51-2
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiryName:5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole CAS NO: 124750-51-2 Grade:Medical scientific research and export Molecular formula:C33H25BrN4 Molecular weight:557.48 Product Quality 12 years of chemical raw
Cas:124750-51-2
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:124750-51-2
Min.Order:1 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryName: n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole CAS: 124750-51-2 Molecular formula: C33H25BrN4 Molecular weight: 557.48 Appearance:White
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiryAppearance:White to off-white crystalline powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china
ProductName:5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Synonyms:N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole; N-(TRIPHENYLMETHYL)-5-(4'-BROMOMETHYLBIPHENYL-2-YL) TETRAZOLE; 5-(4'-B
Cas:124750-51-2
Min.Order:100 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryHangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac
Cas:124750-51-2
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryProduct Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole CAS: 124750-51-2 MF: C33H25BrN4 MW: 557.48 EINECS: 603-010-9 Mol File: 124750-51-2.mol 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-trip
Cas:124750-51-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:124750-51-2
Min.Order:1 Metric Ton
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $86.0 / 98.0
Type:Trading Company
inquiryBeluga chemical professional supply 5-(4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole CAS 124750-51-2 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support
Cas:124750-51-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:124750-51-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryCompany information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:124750-51-2
Min.Order:1 Kilogram
FOB Price: $8.0 / 10.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:124750-51-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole;TTBB CAS:124750-51-2, Please contact us by email freely. We a
Cas:124750-51-2
Min.Order:1 Metric Ton
Negotiable
Type:Other
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Cas:124750-51-2
Min.Order:0
Negotiable
Type:Manufacturers
inquiry1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E
Cas:124750-51-2
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Cas:124750-51-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryN-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With bromine In hexane; water at 69℃; for 0.433333h; Temperature; Solvent; Irradiation; Flow reactor; | 95.2% |
With sodium bromate; sodium hydrogensulfite In water; 1,2-dichloro-ethane at 20℃; Product distribution / selectivity; | 90% |
With N-Bromosuccinimide; dihydrogen peroxide In dichloromethane Reflux; | 88% |
4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With phosphorus tribromide In dichloromethane at 10 - 20℃; for 1h; | 95.07% |
With sulfuric acid; potassium bromide In N,N-dimethyl acetamide at 10 - 25℃; for 7h; Reagent/catalyst; Solvent; | 81.4% |
N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
A
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid In dichloromethane for 16h; Heating; | A 76% B 7% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; Overall yield = 78.6 %; |
salicylonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 98 percent / pyridine / 1.) 0 deg C, 5 min, 2.) r.t., 25 h 2: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 3: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 4: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
4-tolyl iodide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
o-cyanobromobenzene
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere 2: sodium azide; tributyltin chloride / toluene / Reflux 3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme | |
Multi-step reaction with 4 steps 1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere 1.2: 12 h / 110 °C / Inert atmosphere 2.1: zinc(II) chloride; sodium azide / N,N-dimethyl-formamide / 48 h / 120 °C 3.1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux 4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux View Scheme |
2-Cyano-4'-methylbiphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 2: NBS, AIBN / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: sodium azide; triethylamine hydrochloride / toluene / 18 h / 105 - 110 °C 2: toluene / 3 h / 20 °C 3: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium azide; tributyltin chloride / toluene / Reflux 2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme |
trityl chloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 2: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
2-<(trifluoromethanesulfonyl)oxy>benzonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 3 h / 20 °C 2: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux 2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide / methanol 2: bromine; acetic acid View Scheme |
tributyl(p-tolyl)stannane
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere 2: sodium azide; tributyltin chloride / toluene / Reflux 3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme |
4-methylphenylboronic acid
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere 1.2: 12 h / 110 °C / Inert atmosphere 2.1: zinc(II) chloride; sodium azide / N,N-dimethyl-formamide / 48 h / 120 °C 3.1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux 4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1: palladium diacetate; triethylamine; triphenylphosphine / acetonitrile 2: sodium azide / N,N-dimethyl-formamide 3: potassium hydroxide / methanol 4: bromine; acetic acid View Scheme | |
Multi-step reaction with 4 steps 1: palladium diacetate; triphenylphosphine / acetonitrile 2: sodium azide / N,N-dimethyl-formamide 3: potassium hydroxide / methanol 4: bromine; acetic acid View Scheme |
o-tolylbenzoic acid
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: thionyl chloride 2: sodium hydroxide 3: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 4: sodium hydroxide / tetrahydrofuran; methanol 5: N-ethyl-N,N-diisopropylamine 6: N-Bromosuccinimide / tetrachloromethane View Scheme |
4'-methylbiphenyl-2-carboxylic acid chloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydroxide 2: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 3: sodium hydroxide / tetrahydrofuran; methanol 4: N-ethyl-N,N-diisopropylamine 5: N-Bromosuccinimide / tetrachloromethane View Scheme |
N-(2-cyanoethyl)-4'-methyl[1,1']biphenyl-2-carboxamide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 2: sodium hydroxide / tetrahydrofuran; methanol 3: N-ethyl-N,N-diisopropylamine 4: N-Bromosuccinimide / tetrachloromethane View Scheme |
5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole-1-propanenitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / tetrahydrofuran; methanol 2: N-ethyl-N,N-diisopropylamine 3: N-Bromosuccinimide / tetrachloromethane View Scheme |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: N-Bromosuccinimide / tetrachloromethane View Scheme |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: nickel 2: toluene 4: N-Bromosuccinimide / tetrachloromethane View Scheme |
para-bromotoluene
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: magnesium / tetrahydrofuran / 2 h / 20 °C 2: tetrahydrofuran / 3 h / 20 °C 3: pyridine; trichlorophosphate / 3 h / 10 - 100 °C 4: toluene 6: N-Bromosuccinimide / tetrachloromethane View Scheme | |
Multi-step reaction with 9 steps 1: magnesium / tetrahydrofuran / 2 h / 20 °C 2: tetrahydrofuran / 3 h / 20 °C 3: hydrogenchloride / water 4: thionyl chloride 5: sodium hydroxide 6: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 7: sodium hydroxide / tetrahydrofuran; methanol 8: N-ethyl-N,N-diisopropylamine 9: N-Bromosuccinimide / tetrachloromethane View Scheme |
para-methylphenylmagnesium bromide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: tetrahydrofuran / 3 h / 20 °C 2: pyridine; trichlorophosphate / 3 h / 10 - 100 °C 3: toluene 5: N-Bromosuccinimide / tetrachloromethane View Scheme | |
Multi-step reaction with 8 steps 1: tetrahydrofuran / 3 h / 20 °C 2: hydrogenchloride / water 3: thionyl chloride 4: sodium hydroxide 5: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 6: sodium hydroxide / tetrahydrofuran; methanol 7: N-ethyl-N,N-diisopropylamine 8: N-Bromosuccinimide / tetrachloromethane View Scheme |
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine; trichlorophosphate / 3 h / 10 - 100 °C 2: toluene 4: N-Bromosuccinimide / tetrachloromethane View Scheme | |
Multi-step reaction with 7 steps 1: hydrogenchloride / water 2: thionyl chloride 3: sodium hydroxide 4: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine 5: sodium hydroxide / tetrahydrofuran; methanol 6: N-ethyl-N,N-diisopropylamine 7: N-Bromosuccinimide / tetrachloromethane View Scheme |
4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: zinc(II) chloride; sodium azide / butan-1-ol / 20 h / 100 - 105 °C 2.1: triethylamine / dichloromethane / 10 - 15 °C 2.2: 10 °C / Reflux 3.1: potassium bromide; sulfuric acid / N,N-dimethyl acetamide / 7 h / 10 - 25 °C View Scheme |
biphenyl-2-carbonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: zinc(II) chloride; hydrogenchloride / 1,2-dimethoxyethane; water / 0 - 5 °C 2.1: zinc(II) chloride; sodium azide / butan-1-ol / 20 h / 100 - 105 °C 3.1: triethylamine / dichloromethane / 10 - 15 °C 3.2: 10 °C / Reflux 4.1: potassium bromide; sulfuric acid / N,N-dimethyl acetamide / 7 h / 10 - 25 °C View Scheme |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C 2.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C 2.2: 0.25 h / 0 °C 3.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C View Scheme |
5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C 1.2: 0.25 h / 0 °C 2.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C View Scheme |
2-(4-chlorophenyl)-1,3-dioxolane
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: magnesium; iodine / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux 2.1: tributyltin chloride; sodium azide / toluene; N,N-dimethyl-formamide / 48 h / Reflux 3.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C 4.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C 4.2: 0.25 h / 0 °C 5.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C View Scheme |
2-Chlorobenzonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: magnesium; iodine / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux 2.1: tributyltin chloride; sodium azide / toluene; N,N-dimethyl-formamide / 48 h / Reflux 3.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C 4.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C 4.2: 0.25 h / 0 °C 5.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C View Scheme |
2-propyl-4,5-bis(methoxycarbonyl)-imidazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid dimethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl acetamide; acetone Reflux; Large scale reaction; | 99% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide
Conditions | Yield |
---|---|
In N-methyl-acetamide | 96% |
With sodium azide In N,N-dimethyl-formamide at 70℃; for 0.333333h; | 96% |
In dimethyl sulfoxide | |
With sodium azide In water; N,N-dimethyl-formamide at 20℃; for 22h; |
[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide
5-butyl-2,4-dihydro-4-[[2-(1-triphenylmethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4'-yl]methyl]-3H-1,2,4-triazol-3-one
dichloromethane
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
In methanol | 96% |
L-valine benzyl ester hydrochloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water; ethyl acetate for 0.333333h; pH=10 - 12; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃; Stage #3: With phosphonic Acid In ethyl acetate for 1h; | 95% |
L-valine benzyl ester hydrochloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water pH=10 - 12; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃; Stage #3: With phosphorous acid In ethyl acetate for 1h; | 95% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
2-n-butyl-5-(N,N-dimethylaminothioformylmethyl)-6-methyl-3-[[2'-(N-triphenylmethyl-5-tetrazolyl)biphenyl]-4-methyl]pyrimidin-4-one
Conditions | Yield |
---|---|
Stage #1: 2-(2-n-butyl-4-hydroxy-6-methylpyrimidin-5-yl)-N,N-dimethylthioacetamide With lithium hydride In hexane; N,N-dimethyl-formamide at 0℃; for 1h; Inert atmosphere; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In hexane; N,N-dimethyl-formamide at 70℃; for 24h; Inert atmosphere; | 95% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h; Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity; | 94% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetrabutylammomium bromide In xylene at 85℃; for 2h; Stage #2: With hydrogenchloride; water In xylene at 55℃; for 0.75h; Product distribution / selectivity; | 94% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; 18-crown-6 ether In xylene at 85℃; for 2 - 4h; Stage #2: With hydrogenchloride; water In xylene at 55℃; for 0.75h; Product distribution / selectivity; | 94% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
Conditions | Yield |
---|---|
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate In butanone at 60℃; for 2h; Stage #2: With N,N-dimethyl acetamide In butanone at 45℃; for 4h; | 93.8% |
With tetrabutylammomium bromide; potassium carbonate In acetone at 50 - 60℃; for 20h; Green chemistry; | 90.7% |
With potassium carbonate In acetonitrile for 7h; Heating / reflux; | 89% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
Conditions | Yield |
---|---|
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h; Stage #2: With hydrogenchloride; water In acetone at 20℃; Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity; | 92% |
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h; Heating / reflux; | 84.3% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h; Stage #2: With hydrogenchloride; water In acetone at 20℃; Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity; | 84% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With tetrabutylammomium bromide; potassium carbonate In ethyl acetate at 25 - 80℃; for 10h; Stage #2: With hydrogenchloride In methanol at 0 - 30℃; for 3.5h; Stage #3: With sodium hydroxide In water; toluene at 0 - 30℃; for 0.5h; pH=12; |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h; Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity; | 92% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide In toluene at 85℃; for 2h; Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity; | 69% |
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium carbonate In MIBK (methyl isobutyl ketone); water at 85℃; for 2h; Stage #2: With hydrogenchloride; water In MIBK (methyl isobutyl ketone) at 55℃; for 0.75h; Product distribution / selectivity; | 69% |
ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 5h; Reflux; | 92% |
With potassium carbonate In acetonitrile at 80℃; for 7h; |
4-methoxy-aniline
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 92% |
2-(2-thienyl)-1,3-diazaspiro[4.4]non-1-en-4-one
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
2-(2-thienyl)-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Conditions | Yield |
---|---|
Stage #1: 2-(2-thienyl)-1,3-diazaspiro[4.4]non-1-en-4-one With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 20℃; | 91% |
N-(3-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
N-(3-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-(3-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h; | 90.2% |
2,2,2-trifluoroacetamide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
C35H26F3N5O
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium tert-butylate In tetrahydrofuran; diethyl ether at 20℃; for 96h; | 90% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
trityl irbesartan
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 0.0194444h; microwave irradiation; | 90% |
trityl chloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
(S)-4-isopropyl-2-(thiophen-2-yl)-4,5-dihydrooxazole
(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In butanone for 24h; Product distribution / selectivity; Heating / reflux; | 90% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
2-amino-phenol
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 90% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
3-fluoro-4-(morpholinyl)aniline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 90% |
N-benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
N-benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h; | 89.7% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
A
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
B
4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
Conditions | Yield |
---|---|
With potassium phosphate In N,N-dimethyl acetamide at 60 - 65℃; for 6h; Solvent; Reagent/catalyst; | A 89.6% B 0.02% C 0.02% |
p-toluidine
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 89% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
(4-acetyl-5-methyl-1-pentanoylamino-1H-pyrrol-2-yl)-acetic acid ethyl ester
(4-acetyl-5-methyl-1-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-1H-pyrrol-2-yl)-acetic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane at 20℃; Alkylation; | 88.7% |
1H-Naphtho<2,3-d><1,2,3>triazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-naphtho[2,3-d][1,2,3]triazole
Conditions | Yield |
---|---|
With sodium hydride In N,N-dimethyl-formamide at 0℃; 1.) 1h, 2.) 0 deg C, 4 h; r.t., overnight; | 88% |
4-amino-benzoic acid
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide Reflux; | 88% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
N-butylamine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 3h; | 88% |
In tetrahydrofuran at 20℃; for 2h; | 80% |
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With hydrogenchloride In water; ethyl acetate at 80℃; for 15h; Temperature; Solvent; | 88% |
N-(4-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
N-(4-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
Conditions | Yield |
---|---|
Stage #1: N-(4-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h; | 87.7% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View