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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Pharmaceutical Materials 5- (4′-Bromomethyl-biphenyl-2-yl) -1-Trityl-1h-Tetrazole 124750-51-2

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality N-(Triphenylmethyl)-5-(4'-Bromomethylbiphenyl-2-Yl-)Tetrazole supplier in China

Cas:124750-51-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole CAS NO.124750-51-2

Cas:124750-51-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

TTBB CAS 124750-51-2 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the p

TTBB CAS 124750-51-2

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (TTBB)) CAS NO.:124750-51-2 Name 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Synonyms N-

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-[4'-(Bromomethyl)biphenyl-2-yl]-1-trityl-1H-tetrazole

Cas:124750-51-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

SARTAN INTERMEDIATES BBTT powder

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $500.0 / 5000.0

Type:Trading Company

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% Appearan

TTBB

Cas:124750-51-2

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

CHemwill -- 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole CAS NO: 124750-51-2 Grade:Medical scientific research and export Molecular formula:C33H25BrN4 Molecular weight:557.48 Product Quality 12 years of chemical raw

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 124750-51-2 with best quality

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole CAS: 124750-51-2 Molecular formula: C33H25BrN4 Molecular weight: 557.48 Appearance:White

n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to off-white crystalline powder Storage:ln stock Package:25kg/Carton Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

BBTT

Cas:124750-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

ProductName:5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Synonyms:N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole; N-(TRIPHENYLMETHYL)-5-(4'-BROMOMETHYLBIPHENYL-2-YL) TETRAZOLE; 5-(4'-B

High quality BBTT/5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:100 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole CAS: 124750-51-2 MF: C33H25BrN4 MW: 557.48 EINECS: 603-010-9 Mol File: 124750-51-2.mol 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-trip

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 99%

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $86.0 / 98.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 5-(4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole CAS 124750-51-2 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support

5-(4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole CAS 124750-51-2

Cas:124750-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo

5- (4-Bromomethyl-1, 1-biphenyl-2-yl) -1-Triphenylmethyl-1h-Tetrazole CAS 124750-51-2

Cas:124750-51-2

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole;TTBB CAS:124750-51-2, Please contact us by email freely. We a

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

N-(Triphenylmethyl)-5-(4'-Bromomethylbiphenyl-2-Yl-)Tetrazole

Cas:124750-51-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)tetrazole

Cas:124750-51-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Cas:124750-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
124750-53-4

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
With bromine In hexane; water at 69℃; for 0.433333h; Temperature; Solvent; Irradiation; Flow reactor;95.2%
With sodium bromate; sodium hydrogensulfite In water; 1,2-dichloro-ethane at 20℃; Product distribution / selectivity;90%
With N-Bromosuccinimide; dihydrogen peroxide In dichloromethane Reflux;88%
4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl
154709-18-9

4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
With phosphorus tribromide In dichloromethane at 10 - 20℃; for 1h;95.07%
With sulfuric acid; potassium bromide In N,N-dimethyl acetamide at 10 - 25℃; for 7h; Reagent/catalyst; Solvent;81.4%
N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
124750-53-4

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole

A

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

B

5-(4'-Dibromomethyl-biphenyl-2-yl)-1-trityl-1H-tetrazole

5-(4'-Dibromomethyl-biphenyl-2-yl)-1-trityl-1H-tetrazole

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid In dichloromethane for 16h; Heating;A 76%
B 7%
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; Overall yield = 78.6 %;
salicylonitrile
611-20-1

salicylonitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / pyridine / 1.) 0 deg C, 5 min, 2.) r.t., 25 h
2: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h
3: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
4: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
4-tolyl iodide
624-31-7

4-tolyl iodide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h
2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
3: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
o-cyanobromobenzene
2042-37-7

o-cyanobromobenzene

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h
2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
3: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere
2: sodium azide; tributyltin chloride / toluene / Reflux
3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
View Scheme
Multi-step reaction with 4 steps
1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 12 h / 110 °C / Inert atmosphere
2.1: zinc(II) chloride; sodium azide / N,N-dimethyl-formamide / 48 h / 120 °C
3.1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux
4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux
View Scheme
2-Cyano-4'-methylbiphenyl
114772-53-1

2-Cyano-4'-methylbiphenyl

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
2: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: sodium azide; triethylamine hydrochloride / toluene / 18 h / 105 - 110 °C
2: toluene / 3 h / 20 °C
3: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sodium azide; tributyltin chloride / toluene / Reflux
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
View Scheme
trityl chloride
76-83-5

trityl chloride

DL-lysine methyl ester dihydrochloride

DL-lysine methyl ester dihydrochloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
2: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
2-<(trifluoromethanesulfonyl)oxy>benzonitrile
138313-23-2

2-<(trifluoromethanesulfonyl)oxy>benzonitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h
2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h
3: NBS, AIBN / CCl4 / 3 h / Heating
View Scheme
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl
120568-11-8

2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / 3 h / 20 °C
2: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux
2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / methanol
2: bromine; acetic acid
View Scheme
tributyl(p-tolyl)stannane
31614-66-1

tributyl(p-tolyl)stannane

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere
2: sodium azide; tributyltin chloride / toluene / Reflux
3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane
View Scheme
4-methylphenylboronic acid
5720-05-8

4-methylphenylboronic acid

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere
1.2: 12 h / 110 °C / Inert atmosphere
2.1: zinc(II) chloride; sodium azide / N,N-dimethyl-formamide / 48 h / 120 °C
3.1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux
4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: palladium diacetate; triethylamine; triphenylphosphine / acetonitrile
2: sodium azide / N,N-dimethyl-formamide
3: potassium hydroxide / methanol
4: bromine; acetic acid
View Scheme
Multi-step reaction with 4 steps
1: palladium diacetate; triphenylphosphine / acetonitrile
2: sodium azide / N,N-dimethyl-formamide
3: potassium hydroxide / methanol
4: bromine; acetic acid
View Scheme
o-tolylbenzoic acid
7148-03-0

o-tolylbenzoic acid

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: thionyl chloride
2: sodium hydroxide
3: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
4: sodium hydroxide / tetrahydrofuran; methanol
5: N-ethyl-N,N-diisopropylamine
6: N-Bromosuccinimide / tetrachloromethane
View Scheme
4'-methylbiphenyl-2-carboxylic acid chloride
114772-35-9

4'-methylbiphenyl-2-carboxylic acid chloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium hydroxide
2: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
3: sodium hydroxide / tetrahydrofuran; methanol
4: N-ethyl-N,N-diisopropylamine
5: N-Bromosuccinimide / tetrachloromethane
View Scheme
N-(2-cyanoethyl)-4'-methyl[1,1']biphenyl-2-carboxamide
120568-15-2

N-(2-cyanoethyl)-4'-methyl[1,1']biphenyl-2-carboxamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
2: sodium hydroxide / tetrahydrofuran; methanol
3: N-ethyl-N,N-diisopropylamine
4: N-Bromosuccinimide / tetrachloromethane
View Scheme
5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole-1-propanenitrile
120568-17-4

5-<4'-Methyl-1,1'-biphenyl-2-yl>-1H-tetrazole-1-propanenitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / tetrahydrofuran; methanol
2: N-ethyl-N,N-diisopropylamine
3: N-Bromosuccinimide / tetrachloromethane
View Scheme
C17H20N4Si

C17H20N4Si

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: N-Bromosuccinimide / tetrachloromethane
View Scheme
C26H22Zn

C26H22Zn

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: nickel
2: toluene
4: N-Bromosuccinimide / tetrachloromethane
View Scheme
para-bromotoluene
106-38-7

para-bromotoluene

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: magnesium / tetrahydrofuran / 2 h / 20 °C
2: tetrahydrofuran / 3 h / 20 °C
3: pyridine; trichlorophosphate / 3 h / 10 - 100 °C
4: toluene
6: N-Bromosuccinimide / tetrachloromethane
View Scheme
Multi-step reaction with 9 steps
1: magnesium / tetrahydrofuran / 2 h / 20 °C
2: tetrahydrofuran / 3 h / 20 °C
3: hydrogenchloride / water
4: thionyl chloride
5: sodium hydroxide
6: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
7: sodium hydroxide / tetrahydrofuran; methanol
8: N-ethyl-N,N-diisopropylamine
9: N-Bromosuccinimide / tetrachloromethane
View Scheme
para-methylphenylmagnesium bromide
4294-57-9

para-methylphenylmagnesium bromide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tetrahydrofuran / 3 h / 20 °C
2: pyridine; trichlorophosphate / 3 h / 10 - 100 °C
3: toluene
5: N-Bromosuccinimide / tetrachloromethane
View Scheme
Multi-step reaction with 8 steps
1: tetrahydrofuran / 3 h / 20 °C
2: hydrogenchloride / water
3: thionyl chloride
4: sodium hydroxide
5: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
6: sodium hydroxide / tetrahydrofuran; methanol
7: N-ethyl-N,N-diisopropylamine
8: N-Bromosuccinimide / tetrachloromethane
View Scheme
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole
84392-32-5

4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine; trichlorophosphate / 3 h / 10 - 100 °C
2: toluene
4: N-Bromosuccinimide / tetrachloromethane
View Scheme
Multi-step reaction with 7 steps
1: hydrogenchloride / water
2: thionyl chloride
3: sodium hydroxide
4: trimethylsilylazide; diethylazodicarboxylate; triphenylphosphine
5: sodium hydroxide / tetrahydrofuran; methanol
6: N-ethyl-N,N-diisopropylamine
7: N-Bromosuccinimide / tetrachloromethane
View Scheme
4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile
154709-19-0

4'-(hydroxymethyl)-[1,1'-biphenyl]-2-carbonitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: zinc(II) chloride; sodium azide / butan-1-ol / 20 h / 100 - 105 °C
2.1: triethylamine / dichloromethane / 10 - 15 °C
2.2: 10 °C / Reflux
3.1: potassium bromide; sulfuric acid / N,N-dimethyl acetamide / 7 h / 10 - 25 °C
View Scheme
biphenyl-2-carbonitrile
24973-49-7

biphenyl-2-carbonitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: zinc(II) chloride; hydrogenchloride / 1,2-dimethoxyethane; water / 0 - 5 °C
2.1: zinc(II) chloride; sodium azide / butan-1-ol / 20 h / 100 - 105 °C
3.1: triethylamine / dichloromethane / 10 - 15 °C
3.2: 10 °C / Reflux
4.1: potassium bromide; sulfuric acid / N,N-dimethyl acetamide / 7 h / 10 - 25 °C
View Scheme
C35H28N4O2

C35H28N4O2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C
2.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C
2.2: 0.25 h / 0 °C
3.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C
View Scheme
5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole
155983-56-5

5-<2-(4'-formylbiphenylyl)>-2-(triphenylmethyl)-2H-tetrazole

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C
1.2: 0.25 h / 0 °C
2.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C
View Scheme
2-(4-chlorophenyl)-1,3-dioxolane
2403-54-5

2-(4-chlorophenyl)-1,3-dioxolane

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux
2.1: tributyltin chloride; sodium azide / toluene; N,N-dimethyl-formamide / 48 h / Reflux
3.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C
4.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C
4.2: 0.25 h / 0 °C
5.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C
View Scheme
2-Chlorobenzonitrile
873-32-5

2-Chlorobenzonitrile

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran; toluene / 5 h / Inert atmosphere; Reflux
2.1: tributyltin chloride; sodium azide / toluene; N,N-dimethyl-formamide / 48 h / Reflux
3.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 20 °C
4.1: sodium tetrahydroborate / methanol / 1 h / 5 - 20 °C
4.2: 0.25 h / 0 °C
5.1: phosphorus tribromide / dichloromethane / 1 h / 10 - 20 °C
View Scheme
2-propyl-4,5-bis(methoxycarbonyl)-imidazole
124750-59-0

2-propyl-4,5-bis(methoxycarbonyl)-imidazole

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid dimethyl ester
124750-61-4

2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid dimethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl acetamide; acetone Reflux; Large scale reaction;99%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide
124806-66-2

[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide

Conditions
ConditionsYield
In N-methyl-acetamide96%
With sodium azide In N,N-dimethyl-formamide at 70℃; for 0.333333h;96%
In dimethyl sulfoxide
With sodium azide In water; N,N-dimethyl-formamide at 20℃; for 22h;
[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide
124806-66-2

[2'-(N-Triphenylmethyl-tetrazol-5-yl)-biphenyl-4-yl]methyl azide

5-butyl-2,4-dihydro-4-[[2-(1-triphenylmethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4'-yl]methyl]-3H-1,2,4-triazol-3-one
169598-69-0

5-butyl-2,4-dihydro-4-[[2-(1-triphenylmethyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4'-yl]methyl]-3H-1,2,4-triazol-3-one

dichloromethane
75-09-2

dichloromethane

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2,4-Bis[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

2,4-Bis[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
In methanol96%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphite

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphite

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water; ethyl acetate for 0.333333h; pH=10 - 12;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃;
Stage #3: With phosphonic Acid In ethyl acetate for 1h;
95%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-[(2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphorous acid salt

N-[(2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphorous acid salt

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water pH=10 - 12;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃;
Stage #3: With phosphorous acid In ethyl acetate for 1h;
95%
2-(2-n-butyl-4-hydroxy-6-methylpyrimidin-5-yl)-N,N-dimethylthioacetamide

2-(2-n-butyl-4-hydroxy-6-methylpyrimidin-5-yl)-N,N-dimethylthioacetamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-n-butyl-5-(N,N-dimethylaminothioformylmethyl)-6-methyl-3-[[2'-(N-triphenylmethyl-5-tetrazolyl)biphenyl]-4-methyl]pyrimidin-4-one
1361024-52-3

2-n-butyl-5-(N,N-dimethylaminothioformylmethyl)-6-methyl-3-[[2'-(N-triphenylmethyl-5-tetrazolyl)biphenyl]-4-methyl]pyrimidin-4-one

Conditions
ConditionsYield
Stage #1: 2-(2-n-butyl-4-hydroxy-6-methylpyrimidin-5-yl)-N,N-dimethylthioacetamide With lithium hydride In hexane; N,N-dimethyl-formamide at 0℃; for 1h; Inert atmosphere;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In hexane; N,N-dimethyl-formamide at 70℃; for 24h; Inert atmosphere;
95%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride sesquihydrate

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride sesquihydrate

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity;
94%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetrabutylammomium bromide In xylene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In xylene at 55℃; for 0.75h; Product distribution / selectivity;
94%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; 18-crown-6 ether In xylene at 85℃; for 2 - 4h;
Stage #2: With hydrogenchloride; water In xylene at 55℃; for 0.75h; Product distribution / selectivity;
94%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
144690-33-5

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With potassium carbonate In butanone at 60℃; for 2h;
Stage #2: With N,N-dimethyl acetamide In butanone at 45℃; for 4h;
93.8%
With tetrabutylammomium bromide; potassium carbonate In acetone at 50 - 60℃; for 20h; Green chemistry;90.7%
With potassium carbonate In acetonitrile for 7h; Heating / reflux;89%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one
138402-11-6

2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In acetone at 20℃;
Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity;
92%
With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h; Heating / reflux;84.3%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 90℃; for 1.5h;
Stage #2: With hydrogenchloride; water In acetone at 20℃;
Stage #3: With potassium hydroxide In water; acetone Product distribution / selectivity;
84%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With tetrabutylammomium bromide; potassium carbonate In ethyl acetate at 25 - 80℃; for 10h;
Stage #2: With hydrogenchloride In methanol at 0 - 30℃; for 3.5h;
Stage #3: With sodium hydroxide In water; toluene at 0 - 30℃; for 0.5h; pH=12;
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride hemihydrate

2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one hydrochloride hemihydrate

Conditions
ConditionsYield
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity;
92%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium hydroxide In toluene at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In toluene at 55℃; for 0.75h; Product distribution / selectivity;
69%
Stage #1: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; 2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride With potassium carbonate In MIBK (methyl isobutyl ketone); water at 85℃; for 2h;
Stage #2: With hydrogenchloride; water In MIBK (methyl isobutyl ketone) at 55℃; for 0.75h; Product distribution / selectivity;
69%
ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate
136285-65-9

ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate
906474-56-4

ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 5h; Reflux;92%
With potassium carbonate In acetonitrile at 80℃; for 7h;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

4-methoxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

4-methoxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;92%
2-(2-thienyl)-1,3-diazaspiro[4.4]non-1-en-4-one
1199814-93-1

2-(2-thienyl)-1,3-diazaspiro[4.4]non-1-en-4-one

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-(2-thienyl)-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diazaspiro[4.4]non-1-en-4-one
1199814-94-2

2-(2-thienyl)-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
Stage #1: 2-(2-thienyl)-1,3-diazaspiro[4.4]non-1-en-4-one With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 20℃;
91%
N-(3-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1239196-62-3

N-(3-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-(3-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1390645-40-5

N-(3-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

Conditions
ConditionsYield
Stage #1: N-(3-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h;
90.2%
2,2,2-trifluoroacetamide
354-38-1

2,2,2-trifluoroacetamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

C35H26F3N5O
868742-05-6

C35H26F3N5O

Conditions
ConditionsYield
With 18-crown-6 ether; potassium tert-butylate In tetrahydrofuran; diethyl ether at 20℃; for 96h;90%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride

trityl irbesartan
138402-10-5

trityl irbesartan

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.0194444h; microwave irradiation;90%
trityl chloride
76-83-5

trityl chloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

(S)-4-isopropyl-2-(thiophen-2-yl)-4,5-dihydrooxazole
149065-76-9

(S)-4-isopropyl-2-(thiophen-2-yl)-4,5-dihydrooxazole

(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide
1033772-55-2

(1S)-N-(1-hydroxymethyl-2-methyl-propyl)-N'-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-thiophene-2-carboxamide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In butanone for 24h; Product distribution / selectivity; Heating / reflux;90%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

2-amino-phenol
95-55-6

2-amino-phenol

2-hydroxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

2-hydroxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;90%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

3-fluoro-4-(morpholinyl)aniline
93246-53-8

3-fluoro-4-(morpholinyl)aniline

3-fluoro-4-morpholino-N-((2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl)methyl)aniline

3-fluoro-4-morpholino-N-((2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-yl)methyl)aniline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;90%
N-benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1239196-56-5

N-benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1390645-39-2

N-benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

Conditions
ConditionsYield
Stage #1: N-benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h;
89.7%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
144689-93-0

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

A

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
144690-33-5

ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate

B

4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid
761404-85-7

4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(1-(triphenylmethyl)tetrazol-5-yl)phenyl)phenyl)methylimidazole-5-carboxylic acid

C

C45H42N6O2

C45H42N6O2

Conditions
ConditionsYield
With potassium phosphate In N,N-dimethyl acetamide at 60 - 65℃; for 6h; Solvent; Reagent/catalyst;A 89.6%
B 0.02%
C 0.02%
p-toluidine
106-49-0

p-toluidine

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

4-methyl-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

4-methyl-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;89%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

(4-acetyl-5-methyl-1-pentanoylamino-1H-pyrrol-2-yl)-acetic acid ethyl ester
230627-21-1

(4-acetyl-5-methyl-1-pentanoylamino-1H-pyrrol-2-yl)-acetic acid ethyl ester

(4-acetyl-5-methyl-1-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-1H-pyrrol-2-yl)-acetic acid ethyl ester
230627-26-6

(4-acetyl-5-methyl-1-{pentanoyl-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-1H-pyrrol-2-yl)-acetic acid ethyl ester

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane at 20℃; Alkylation;88.7%
1H-Naphtho<2,3-d><1,2,3>triazole
269-12-5

1H-Naphtho<2,3-d><1,2,3>triazole

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-naphtho[2,3-d][1,2,3]triazole
194417-18-0

1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-naphtho[2,3-d][1,2,3]triazole

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃; 1.) 1h, 2.) 0 deg C, 4 h; r.t., overnight;88%
4-amino-benzoic acid
150-13-0

4-amino-benzoic acid

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

4-carboxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

4-carboxy-N-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)aniline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Reflux;88%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-butylamine
109-73-9

N-butylamine

1-trityl-5-(4'-butylaminomethyl-1,1'-biphenyl-2-yl)-1H-tetrazole

1-trityl-5-(4'-butylaminomethyl-1,1'-biphenyl-2-yl)-1H-tetrazole

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 3h;88%
In tetrahydrofuran at 20℃; for 2h;80%
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

5-(4'-(chloromethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole

5-(4'-(chloromethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole

Conditions
ConditionsYield
With hydrogenchloride In water; ethyl acetate at 80℃; for 15h; Temperature; Solvent;88%
N-(4-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1239196-65-6

N-(4-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-(4-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide
1390645-41-6

N-(4-methoxy)benzyl-1-([2'-(1-triphenylmethyltetrazol-5-yl)-(1,1'-biphenyl)-4-yl]methyl)-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide

Conditions
ConditionsYield
Stage #1: N-(4-methoxy)benzyl-4-methyl-2-n-propyl-1H-benzimidazole-6-carboxamide With potassium tert-butylate In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In N,N-dimethyl-formamide at 0 - 25℃; for 12h;
87.7%
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