• Name

  BIS(2-ETHYLHEXYL) PHOSPHITE

• EINECS 222-904-6
• CAS No. 3658-48-8
• Article Data18
• CAS DataBase
• Density g/cm³
• Solubility
• Melting Point
• Formula C16H35 O3 P
• Boiling Point 395.2°Cat760mmHg
• Molecular Weight 306.426
• Flash Point 192.8°C
• Transport Information
• Appearance
• Safety Poison by intravenous route. Moderately toxic by intraperitoneal route. An eye irritant. When heated to decomposition it emits toxic fumes of PO_x. See also ESTERS.
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols
• Synonyms Bis(2-ethylhexyl)hydrogen phosphite;Bis(2-ethylhexyl) phosphite;Bis(2-ethylhexyl) phosphonate;Bis(2-ethylhexyl) phosphonic acid;Chelex H 8;Di-2-Ethylhexyl phosphite;Di-2-ethylhexyl hydrogen phosphite;Diisooctyl phosphite;NSC 2664;Phosphonicacid di(2-ethylhexyl) ester;
• PSA 59.00000
• LogP 5.84210

Synthetic route

104-76-7

2-Ethylhexyl alcohol

3658-48-8

bis(2-ethylhexyl)phosphite

Conditions

Conditions	Yield
With phosphorus trichloride In benzene at 20℃; for 2h; Condensation;	96%
With phosphorus trichloride at 20℃; for 2h;	85.8%
With phosphonic acid; toluene

96-36-6, 868-85-9

methyl phosphite

104-76-7

2-Ethylhexyl alcohol

3658-48-8

bis(2-ethylhexyl)phosphite

Conditions

Conditions	Yield
With sodium at 160℃;

104-76-7

2-Ethylhexyl alcohol

762-04-9

phosphonic acid diethyl ester

3658-48-8

bis(2-ethylhexyl)phosphite

Conditions

Conditions	Yield
With sodium at 160℃;
With sodium hydride In mineral oil at 160℃;

104-76-7

2-Ethylhexyl alcohol

diphenylphosphonate

diphenylphosphonate

3658-48-8

bis(2-ethylhexyl)phosphite

Conditions

Conditions	Yield

104-76-7

2-Ethylhexyl alcohol

mono-2-ethyl-1-hexyl phosphite

3658-48-8

bis(2-ethylhexyl)phosphite

Conditions

Conditions	Yield
Stage #1: mono-2-ethyl-1-hexyl phosphite With phosphorus pentoxide at 54℃; for 3h; Inert atmosphere; Stage #2: 2-Ethylhexyl alcohol at 56℃; for 0.5h; Inert atmosphere;	46.2 %Spectr.

3658-48-8

bis(2-ethylhexyl)phosphite

63449-80-9

bis(2-ethylhexyl) phosphorochloridate

Conditions

Conditions	Yield
With N-chloro-succinimide at -78 - 20℃; Inert atmosphere; neat (no solvent);	97%
With chlorine
With sulfuryl dichloride

119-61-9

benzophenone

3658-48-8

bis(2-ethylhexyl)phosphite

C29H45O4P

Conditions

Conditions	Yield
Stage #1: benzophenone; bis(2-ethylhexyl)phosphite With calcium fluoride for 0.0833333h; Stage #2: With potassium hydroxide at 40 - 50℃; for 2.16667h;	97%

50-00-0

formaldehyd

3658-48-8

bis(2-ethylhexyl)phosphite

100-46-9

benzylamine

O,O-di(2-ethylhexyl) 1-(benzylamino)methylphosphonate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 12h; Heating;	95%

...Expand

3658-48-8

bis(2-ethylhexyl)phosphite

78-93-3

butanone

C20H43O4P

Conditions

Conditions	Yield
Stage #1: bis(2-ethylhexyl)phosphite; butanone With calcium fluoride for 0.0833333h; Stage #2: With potassium hydroxide at 40 - 50℃; for 2.16667h;	92.5%

3658-48-8

bis(2-ethylhexyl)phosphite

111-92-2

dibutylamine

bis(2-ethylhexyl) dibutylphosphoramidate

Conditions

Conditions	Yield
With tetrachloromethane In hexane Todd-Atherton reaction;	88%

3658-48-8

bis(2-ethylhexyl)phosphite

67-64-1

acetone

100-46-9

benzylamine

O,O-di(2-ethylhexyl) 1-(benzylamino)-1-methylethylphosphonate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 80℃; for 12h;	87%

...Expand

3658-48-8

bis(2-ethylhexyl)phosphite

109-89-7

diethylamine

bis(2-ethylhexyl) diethylphosphoramidate

Conditions

Conditions	Yield
With tetrachloromethane at 0 - 20℃; for 1.5h; Todd-Atherton reaction;	87%

3658-48-8

bis(2-ethylhexyl)phosphite

109-73-9

N-butylamine

53796-11-5

bis(2-ethylhexyl) butylphosphoramidate

Conditions

Conditions	Yield
With tetrachloromethane In hexane Todd-Atherton reaction;	86%

3658-48-8

bis(2-ethylhexyl)phosphite

2216-94-6

phenylpropynoic acid ethyl ester

(E)-ethyl 2-(bis(2-ethylhexyloxy)phosphoryl)-3-phenylacrylate

Conditions

Conditions	Yield
With tributylphosphine In acetonitrile at 20℃; for 1.16667h; stereoselective reaction;	84%

1277-43-6

cobaltocene

3658-48-8

bis(2-ethylhexyl)phosphite

bis[cyclopentadienyltris(bis(2-ethylhexyl) phosphito-P)cobalt-O,O',O'']cobalt(II)

Conditions

Conditions	Yield
In neat (no solvent) byproducts: cyclopentadiene; (N2); 140°C, 40 h; removal of cyclopentadiene by distn., stirring with MeOH, filtration, drying (reduced pressure), chromy. (SiO2; hexane, then MeOH), evapn., dissoln. (hexane), membrane filtration, evapn.;	83%

3658-48-8

bis(2-ethylhexyl)phosphite

171058-17-6

1-hexyl-3-methylimidazol-1-ium chloride

1-hexyl-3-methylimidazolium bis(2-ethylhexyl)phosphate

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In dichloromethane for 24h;	82%

3658-48-8

bis(2-ethylhexyl)phosphite

2315-36-8

2-Chloro-N,N-diethylacetamide

66258-31-9

bis(2-ethyl-1-hexyl) (N,N-diethylcarbamoylmethyl)phosphonate

Conditions

Conditions	Yield
With potassium hydroxide; potassium carbonate In benzene for 6h; Product distribution; Ambient temperature; other diarylphosphine oxides and dialkyl hydrogen phosphites, var. alkylating agents, var. reaction times, also in the presence 18-crown-6, and phase transfer catalysis;	80%
With potassium hydroxide; potassium carbonate In benzene for 6h; Ambient temperature;	80%
With sodium hydroxide; Aliquat 336 In dichloromethane at 20 - 25℃; for 5.5h; Yield given;

18409-18-2

(E)-2-decenol

3658-48-8

bis(2-ethylhexyl)phosphite

1542073-82-4

(2E)-dec-2-en-1-yl bis(2-ethylhexyl) phosphate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In tetrachloromethane; dichloromethane; water at 0℃; for 35h; Inert atmosphere;	80%

3658-48-8

bis(2-ethylhexyl)phosphite

107-59-5

tert-Butyl chloroacetate

103717-36-8

[Bis-(2-ethyl-hexyloxy)-phosphoryl]-acetic acid tert-butyl ester

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane at 0 - 5℃; for 5h;	79%

Bis(2-ethylhexyl) phosphite Consensus Reports

Bis(2-ethylhexyl) phosphite Specification