Boc-L-Valine supplier | CasNO.13734-41-3

Name
(S)-2-(Boc-amino)-3-methylbutyric acid
EINECS 237-307-6
CAS No. 13734-41-3
Article Data160
CAS DataBase
Density 1.079 g/cm³
Solubility insoluble
Melting Point 77-80 °C(lit.)
Formula C₁₀H₁₉NO₄
Boiling Point 341.8 °C at 760 mmHg
Molecular Weight 217.265
Flash Point 160.5 °C
Transport Information
Appearance white fine crystalline powder
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms N-BOC-valine;N-a-tert-Butoxycarbonyl-L-valine;NSC 197197;tert-Butoxycarbonyl-L-valine;Boc-Val-OH;Valine,N-carboxy-, N-tert-butyl ester, L- (6CI,8CI);(S)-2-(tert-Butoxycarbonylamino)-3-methylbutanoic acid;(S)-N-tert-Butoxycarbonylvaline;BOC-valine;
PSA 75.63000
LogP 2.01120

Synthetic route

: 72-18-4
L-valine

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 16h;	100%

: 95499-91-5
Boc-Val-NHNHPh

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With oxygen In acetonitrile for 16h; tyrosinase, phosphate buffer pH 7;	99%
With phosphate buffer; oxygen; tyrosinase In water; acetonitrile at 20℃; for 16h; pH=7.0;	99%

: 128359-98-8
Boc-Val-O-t-Bu

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 6h; Heating;	99%
With water; iodine In acetonitrile for 5h; Heating;	89%

: 72-18-4
L-valine

: 104272-92-6
2-t-butoxycarbonyloxy-3,6-diisopropylpyrazine

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile for 24h; Ambient temperature;	98%

: (S)-(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

A: 13734-41-3
t-Boc-L-valine

B: 1033736-87-6
C16H10O3S

Conditions

Conditions	Yield
In chloroform-d1 for 0.233333h; Photolysis; Inert atmosphere;	A 97% B n/a

: 72-18-4
L-valine

: 89985-91-1
tert-butyl pyridin-2-yl carbonate

A: 142-08-5
2-hydroxypyridin

B: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 9h; Ambient temperature;	A n/a B 92%

...Expand

: 72-18-4
L-valine

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
Stage #1: L-valine With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; Stage #2: 2,2-dimethylpropanoic anhydride In tetrahydrofuran; water at 0 - 20℃; for 12h;	90%

: 66447-55-0
((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With formic acid; potassium hydroxide In ethanol at 70℃; for 1h;	89%
With hydrogen; palladium on activated charcoal

: 58561-04-9
N-tert-butoxycarbonyl-L-valine methyl ester

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With lithium hydroxide In methanol for 8h;	85%
With water; lithium hydroxide In methanol for 4h;

: 72-18-4
L-valine

: 75844-68-7
tert-butyl 2-oxo-1,3-oxazole-3(2H)-carboxylate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With dmap; triethylamine In 1,4-dioxane; water for 15h; Ambient temperature;	84%

: 851714-00-6
N-(tert-butoxycarbonyl)valine 1,1-dimethylallyl ester

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃;	84%

: 72-18-4
L-valine

: 98015-52-2
1,2,2,2-Tetrachloroethyl tert-Butyl Carbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 20℃; pH=9.2;	80%

: 72-18-4
L-valine

: 105678-24-8
O-(tert-butyl) S-(pyridin-2-yl)carbonothioate

A: 2637-34-5
2-Mercaptopyridine

B: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; N,N-dimethyl-formamide for 12h; Ambient temperature;	A n/a B 80%

...Expand

: 640-68-6
D-Val-OH

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In water; acetone at 25℃; for 4.5h;	70%

: 72-18-4
L-valine

: 104272-95-9
t-butyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With dmap; triethylamine In water; acetonitrile for 24h; Ambient temperature;	63%

: 72-18-4
L-valine

: 13303-10-1
tert-Butyl 4-nitrophenyl carbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sodium carbonate; tert-butyl alcohol

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 72-18-4
L-valine

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water
With triethylamine In water; N,N-dimethyl-formamide

: 18595-55-6
tert-butyl (quinolin-8-yl)carbonate

: 72-18-4
L-valine

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide

: 72-18-4
L-valine

: 18595-34-1
tert-butyl fluoroformate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sodium hydroxide In N,N-dimethyl-formamide

: 72-18-4
L-valine

: 16965-08-5
1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate

: 13734-41-3
t-Boc-L-valine

: 18942-25-1
t-butylpentachlorophenyl carbonate

: 34241-42-4, 58485-27-1, 110579-73-2
sodium (S)-valinate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In chloroform; N,N-dimethyl-formamide

: 72-18-4
L-valine

: 24608-52-4
tert-butyl chloroformate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sodium hydroxide
With sodium hydroxide In 1,4-dioxane for 16h; Ambient temperature;
With magnesium oxide In diethyl ether; water

: 75-44-5
phosgene

: 72-18-4
L-valine

: 1907-33-1
lithium tert-butoxide

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 72-18-4
L-valine

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water for 4h; Ambient temperature;

: 72-18-4
L-valine

: 50739-44-1
1-(t-butoxycarbonyl)-1,2,4-triazolo<4,3-a>pyridinium-3-olate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With pyridine; sodium hydroxide In acetone for 3h; Ambient temperature;

: 72-18-4
L-valine

: 81616-10-6
tert-butyl α-methoxyvinyl carbonate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With triethylamine 1.) dioxane, water, room temp., 30 min, 2.) 20 deg C, 5 h; Yield given. Multistep reaction;

: 72-18-4
L-valine

: 13734-41-3
t-Boc-L-valine

: 16948-40-6
(S)-4-nitrophenyl 2-(tert-butoxycarbonylamino)-3-methylbutanoate

A: 100-02-7
4-nitro-phenol

B: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With N+C5AlaHis2C16; phosphate buffer pH=7.47; In water at 15 - 40℃; Rate constant; Kinetics; Mechanism; enantioselectivity in ester hydrolysis; other micelle- and vesicle- catalysts; ΔH (excit.); ΔS (excit.); ΔG (excit.);;

: 16944-17-5, 61315-58-0, 102213-00-3
dicyclohexylammonium Boc-L-valinate

: 13734-41-3
t-Boc-L-valine

Conditions

Conditions	Yield
With sulfonic acid In ethyl acetate

: 13734-41-3
t-Boc-L-valine

: 74-88-4
methyl iodide

: 45170-31-8
Boc-N-Me-Val-OH

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran at 0 - 23℃; Inert atmosphere;	100%
With sodium hydride In tetrahydrofuran at 20℃; for 24h;	99%
With sodium hydride In tetrahydrofuran at 0 - 20℃;	98%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 13734-41-3
t-Boc-L-valine

: 3392-12-9
Boc-Val-ONSu

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 72h; Inert atmosphere; Sealed tube;	100%
In tetrahydrofuran at 0 - 20℃; for 16h;	72%
With dicyclohexyl-carbodiimide In 1,2-dimethoxyethane at 5℃; for 6h;	69.5%

: 49715-04-0
chlorosulfuric acid chloromethyl ester

: 13734-41-3
t-Boc-L-valine

: 40224-39-3
N-tert-butyloxycarbonyl-L-valine chloromethyl ester

Conditions

Conditions	Yield
Stage #1: t-Boc-L-valine With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.166667h; Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 0 - 20℃; for 19.3333h;	100%
With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate In dichloromethane; water at 0 - 20℃; for 19.33h;	100%
Stage #1: t-Boc-L-valine With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 20℃; for 0.0833333h; Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 0 - 20℃; for 2h;	99%

: 13734-41-3
t-Boc-L-valine

: 5680-79-5
glycine ethyl ester hydrochloride

: 51803-69-1
methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)acetate

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	100%
With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 2h; optical yield given as %de;	95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	91%

: 13734-41-3
t-Boc-L-valine

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 20902-47-0
N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 24h;	100%
Stage #1: t-Boc-L-valine With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole In dichloromethane; N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: methyl (2S)-2-amino-3-phenylpropanoate hydrochloride With 2,6-dimethylpyridine In dichloromethane; N,N-dimethyl-formamide	97%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; acetonitrile at 20℃; for 3h;	89%

: 13734-41-3
t-Boc-L-valine

: 16652-75-8
L-isoleucine benzyl ester tosylate

: (2S,3S)-benzyl-2-{(S)-2-[(tert-butoxycarbonyl)amino]-3-methyl-butanamido}-3-methylpentanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In water; N,N-dimethyl-formamide for 16h; molar ratio: HOBt:Boc-Val-OH=1:10;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,2-dichloro-ethane for 1h; Product distribution; Ambient temperature; other additives, other solvents;	82%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 12h;	74%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 2h;

: 13734-41-3
t-Boc-L-valine

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 87694-52-8
tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 4℃;	100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃;	100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	100%

: 13734-41-3
t-Boc-L-valine

: 24601-74-9
(S)-4-isopropyloxazolidine-2,5-dione

Conditions

Conditions	Yield
With phosphorus trichloride In dichloromethane at 0℃; for 2h;	100%
With bis(trichloromethyl) carbonate; triethylamine In ethyl acetate for 3h; Ambient temperature;	75%
Multi-step reaction with 2 steps 1: 50 percent / N-ethyl,N'-(γ-dimethylaminopropyl)-carbodiimideHCl, triethylamineHCl / CH2Cl2 2: 90 percent / HCl / CH2Cl2 / 0 °C View Scheme

: 13734-41-3
t-Boc-L-valine

: 21715-90-2
N-hydroxy-5-norbornene-2,3-dicarboximide

: 66714-48-5, 68967-04-4
N-(t-butoxycarbonyl)-L-valine N-hydroxy-5-norbornene-2,3-dicarboximide ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide; acetonitrile 1.) 0 deg C, 1 h, 2.) RT, 4 h;	100%
With WSCD*HCl In N,N-dimethyl-formamide; acetonitrile at 0℃; for 1h;

: 13734-41-3
t-Boc-L-valine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130529-82-7
C16H33NO4Si

Conditions

Conditions	Yield
With triethylamine In ethyl acetate at 0℃; for 0.5h;	100%

: 13734-41-3
t-Boc-L-valine

: 5619-04-5
methyl 2-amino-3-hydroxypropanoate hydrochloride

: 793727-88-5
2-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-propionic acid methyl ester

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In acetonitrile at 20℃; for 12.0833h;	100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In acetonitrile at 20℃; for 12h;	100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In acetonitrile at 20℃; for 12h;	100%
With triethylamine; isobutyl chloroformate 1) THF, -30 deg C, 30 min; 2) THF, -30 deg C --> rt, 6 h, rt, 12 h; Yield given. Multistep reaction;
Stage #1: t-Boc-L-valine With triethylamine; isobutyl chloroformate In tetrahydrofuran at -30℃; for 1h; Stage #2: methyl 2-amino-3-hydroxypropanoate hydrochloride In tetrahydrofuran at -30 - 20℃; Further stages.;

: 13734-41-3
t-Boc-L-valine

: 3945-69-5
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

: 345911-01-5
2-tert-butoxycarbonylamino-3-methyl-butyric acid 4,6-dimethoxy-[1,3,5]triazin-2-yl ester

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 0℃; for 3h; Condensation;	100%

: 13734-41-3
t-Boc-L-valine

: 100-46-9
benzylamine

: 67106-22-3
tert-butyl (S)-1-(benzylamino)-3-methyl-1-oxobutan-2-ylcarbamate

Conditions

Conditions	Yield
	100%
Stage #1: t-Boc-L-valine With chloroformic acid ethyl ester; triethylamine at 0℃; for 1h; Inert atmosphere; Stage #2: benzylamine at 0 - 20℃; for 2h; Inert atmosphere;	92%
Stage #1: t-Boc-L-valine With chloroformic acid ethyl ester; triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere; Stage #2: benzylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	90%

: 13734-41-3
t-Boc-L-valine

: (3aR,6aS)-1-(cyclopropylcarbonyl)-3,3-dimethylhexahydropyrrolo[3,2-b]pyrrol-2(1H)-one hydrochloride

: 488748-91-0
tert-butyl (1S)-{[(3aS,6aR)-4-(cyclopropylcarbonyl)-6,6-dimethyl-5-oxohexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]carbonyl}-2-methylpropylcarbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In acetonitrile at 20℃;	100%

: 13734-41-3
t-Boc-L-valine

: C13H20N2O2

: C23H37N3O5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In acetonitrile	100%

: 123-75-1
pyrrolidine

: 13734-41-3
t-Boc-L-valine

: 130013-62-6
(S)-tert-butyl 3-methyl-1-oxo-1-(pyrrolidin-1-yl)butan-2-ylcarbamate

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃;	100%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃;	82%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 24.4167h; Inert atmosphere;	82%

: 13734-41-3
t-Boc-L-valine

: 2450-71-7
Propargylamine

: 810671-37-5
(S)-2-methyl-1-(prop-2-ynylcarbamoyl)-propylcarbamic acid t-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane for 2h; Inert atmosphere; Reflux;	100%
Stage #1: t-Boc-L-valine With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 1h; Stage #2: Propargylamine In dichloromethane at 20℃; for 16h; Further stages.;	99%
With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane at 0 - 20℃; for 16h; Inert atmosphere;	97%

: 13734-41-3
t-Boc-L-valine

: 16652-76-9
L-valine benzyl ester p-toluenesulfonate salt

: 77443-49-3
(S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine	100%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃;	99%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 12h;	87%
With triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 5h;	26%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;

: H-Asp(TMSE)-OBn

: 13734-41-3
t-Boc-L-valine

: Boc-Val-Asp(TMSE)-OBn

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.75h;	100%
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 2h;	99%

: 13734-41-3
t-Boc-L-valine

: 68754-63-2
Boc-Val-OBt

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;	100%

: 13734-41-3
t-Boc-L-valine

: 913359-77-0
((S)-1-{(S)-4-benzyl-2-[(R)-(1,2,3,4-tetrahydro-naphthalen-1-yl)carbamoyl]-piperazine-1-carbonyl}-2-methyl-propyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: (S)-4-benzyl-piperazine-2-carboxylic acid [(1R)-1,2,3,4-tetrahydro-naphthalen-1-yl]-amide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: t-Boc-L-valine In N,N-dimethyl-formamide for 1h; Stage #3: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	100%

: 903561-50-2
4-N-(tert-butoxycarbonyl)-3'-O-(tert-butyldimethylsilyl)-2'-cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine

: 13734-41-3
t-Boc-L-valine

: 903561-55-7
4-N-(tert-butoxycarbonyl)-5'-O-[N-(tert-butoxycarbonyl)-L-valyl]-3'-O-(tert-butyldimethylsilyl)-2'-cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0℃; for 3h;	100%

: 903561-53-5
4-N-(tert-butoxycarbonyl)-3'-O-(dimethyl-t-hexylsilyl)-2'-cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine

: 13734-41-3
t-Boc-L-valine

: 903561-54-6
4-N-(tert-butoxycarbonyl)-3'-O-(dimethyl-t-hexylsilyl)-5'-O-[N-(tert-butoxycarbonyl)-L-valyl]-2'-cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0℃; for 4h;	100%

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 82732-07-8, 108524-68-1, 142926-43-0, 100564-78-1
Boc-L-homophenylalanine

: 1187223-35-3
H-Hphe-Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-OH

Conditions

Conditions	Yield
Stage #1: Boc-L-homophenylalanine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; N-tert-butoxycarbonyl-L-phenylalanine Further stages;	100%

...Expand

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 82732-07-8, 108524-68-1, 142926-43-0, 100564-78-1
Boc-L-homophenylalanine

: 1187223-36-4
H-Ile-Ile-Leu-Val-Pro-Pro-Hphe-Hphe-Leu-OH

Conditions

Conditions	Yield
Stage #1: N-tert-butoxycarbonyl-L-leucine solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane solid phase reaction; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-phenylalanine; Boc-L-homophenylalanine Further stages;	100%

...Expand

: 13734-41-3
t-Boc-L-valine

: 42854-62-6
L-alanine benzyl ester p-toluenesulfonate

: 77946-33-9
Boc-Val-Ala-OBzl

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine	100%

: 67-56-1
methanol

: 13734-41-3
t-Boc-L-valine

: 6306-52-1
L-valine methylester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0 - 20℃;	100%
With thionyl chloride at 20℃; Cooling;

: 13734-41-3
t-Boc-L-valine

: 1189551-08-3
4-{5-fluoro-2-[(piperidin-4-yl)oxy]phenyl}morpholine hydrochloride

: 1189551-09-4
t-Butyl [(1S)-1-{[4-(4-fluoro-2-morpholin-4-ylphenoxy)piperidin-1-yl]carbonyl}-2-methylpropyl]carbamate

Conditions

Conditions	Yield
	100%

: 13734-41-3
t-Boc-L-valine

: 1189550-98-8
t-butyl 4-[4-fluoro-2-(methoxycarbonyl)phenoxy]piperidine-1-carboxylate

: 1189551-00-5
methyl 2-({1-[N-(t-butoxycarbonyl)-L-valyl]piperidin-4-yl}oxy)-5-fluorobenzoate

Conditions

Conditions	Yield
Product distribution / selectivity;	100%

Boc-L-Valine Chemical Properties

Synonyms: BOC-VALINE;BOC-VALINE-OH;BOC-VAL-OH;BOC-VAL;BOC-L-VAL;BOC-L-VALINE;BOC-L-VAL-OH
Molecular formula: C₁₀H₁₉NO₄
Molar weight: 217.26
Molecular Structure:
Product Categories: Boc-Amino Acids and Derivative;Amino Acids (N-Protected);Biochemistry;Boc-Amino Acids;Boc-Amino acid series;Pharmaceutical intermediate
mp : 77-80 ℃(lit.)
alpha : -6.3 ^o(c=1,CH₃COOH)
refractive index : -6.5 ° (C=1, AcOH)
storage temp.: -20℃

Boc-L-Valine Uses

Uses in the multi-peptide synthesis, serves as the amino acid protection monomer. Patterned SILK past Lu Wei intermediate .

Boc-L-Valine Safety Profile

Hazard Codes :Xn
The Risk Statements information of Boc-L-Valine:
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Boc-L-Valine:
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
24/25: Avoid contact with skin and eyes
WGK Germany : 3

Product Name

(S)-2-(Boc-amino)-3-methylbutyric acid

Synthetic route

Boc-L-Valine Chemical Properties

Boc-L-Valine Uses

Boc-L-Valine Safety Profile

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