Conditions | Yield |
---|---|
53.1% | |
With sodium amalgam In water; isopropyl alcohol | 50% |
Conditions | Yield |
---|---|
With ethanol; zinc |
halon-1211
A
bromodifluoromethane
B
Difluoromethane
C
bromofluoromethane
D
dichloromethane
E
Chlorodifluoromethane
F
1,1-dibromomethane
Conditions | Yield |
---|---|
With hydrogen In gas at 400 - 900℃; under 760 Torr; Rate constant; Product distribution; Mechanism; other reagents; Ea; |
methane
Bromotrifluoromethane
A
methyl bromide
B
Vinyl bromide
C
bromofluoromethane
D
trifluoromethan
E
Vinylidene fluoride
F
1,1-dibromomethane
Conditions | Yield |
---|---|
Mn exchaged zeolite ZSM-5 at 599.85℃; Product distribution; other catalysts, temp.; |
silver(I) monofluoroacetate
bromofluoromethane
Conditions | Yield |
---|---|
With bromine at 20 - 80℃; for 1h; Bromination; | |
With bromine at 50 - 120℃; for 6h; Sealed tube; | 1.4 g |
bromofluoromethane
Conditions | Yield |
---|---|
With bromine |
dibromofluoromethane
ethanol
A
Methyl fluoride
B
bromofluoromethane
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
bromofluoromethane
fluticasone furoate
Conditions | Yield |
---|---|
In butanone at 0 - 22℃; | 99.3% |
With sodium hydrogencarbonate In N,N-dimethyl-formamide at -20℃; | 88% |
Stage #1: 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid With sodium carbonate In N,N-dimethyl-formamide at -15 - -5℃; for 0.25h; Stage #2: bromofluoromethane In N,N-dimethyl-formamide at -15 - -5℃; for 3.3h; | 79.08% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 97% |
bromofluoromethane
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-3-methyl-4-(hydroxyimino) pyrrolidine-1-carboxylate
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-3-methyl-4-(fluoromethoxyimino)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 20℃; Cooling; | 96.1% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 96% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 96% |
bromofluoromethane
tert-butyl 3-(tert-butoxycarbonyl)aminomethyl-4-(hydroxyimino)pyrrolidine-1-carboxylate
tert-butyl 3-((tert-butoxycarbonylamino)methyl)-4-(fluoromethoxyimino)pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene at 0 - 20℃; | 95% |
bromofluoromethane
(4-bromophenyl)(phenyl)methanone
(4-(fluoromethyl)phenyl)(phenyl)methanone
Conditions | Yield |
---|---|
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 95% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 95% |
bromofluoromethane
tert-butyl 3-cyanoazetidine-1-carboxylate
tert-butyl 3-cyano-3-(fluoromethyl)azetidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl 3-cyanoazetidine-1-carboxylate With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: bromofluoromethane In tetrahydrofuran at -78 - 25℃; for 16.5h; Stage #3: With ammonium chloride In tetrahydrofuran; water at 0℃; | 94% |
(S)-tert-butyl 1-(7-hydroxy-2,3-dihydro-1H-pyrrolo-[1,2-a]indol-9-yl)propan-2-ylcarbamate
bromofluoromethane
Conditions | Yield |
---|---|
Stage #1: (S)-tert-butyl 1-(7-hydroxy-2,3-dihydro-1H-pyrrolo-[1,2-a]indol-9-yl)propan-2-ylcarbamate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: bromofluoromethane In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h; Inert atmosphere; | 94% |
3-(benzyloxy)phenyl bromide
bromofluoromethane
Conditions | Yield |
---|---|
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere; | 94% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Sealed tube; Glovebox; | 94% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 94% |
9-(3-bromophenyl)carbazole
bromofluoromethane
Conditions | Yield |
---|---|
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With nickel(II) iodide; dmap; manganese; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl acetamide at 40℃; for 24h; Sealed tube; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 93% |
bromofluoromethane
1-[(3-bromopropoxy)methyl]-benzene
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 93% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 93% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 93% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 92% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 92% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 92% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 92% |
Conditions | Yield |
---|---|
With nickel(II) bromide dimethoxyethane; C9H11N3; tetra-(n-butyl)ammonium iodide; potassium carbonate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane In 1-methyl-pyrrolidin-2-one at 60℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 92% |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In N,N-dimethyl-formamide at -10 - 20℃; for 2h; | 91.7% |
With potassium carbonate In acetone at -5 - 0℃; for 2 - 5h; Product distribution / selectivity; | 84.51% |
Stage #1: 17-propionate carbothioic acid With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: bromofluoromethane In acetone at 0 - 5℃; | 80% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at -10 - 0℃; for 16h; Inert atmosphere; | 91.12% |
Conditions | Yield |
---|---|
With dmap; 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); potassium carbonate In 1,4-dioxane at 70℃; for 12h; Reagent/catalyst; Solvent; Concentration; Suzuki Coupling; | 91% |
With dmap; 1,10-Phenanthroline; (1,2-dimethoxyethane)dichloronickel(II); potassium carbonate In 1,4-dioxane; 1,2-dimethoxyethane at 70℃; for 24h; Catalytic behavior; Kinetics; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Inert atmosphere; | 90% |
Conditions | Yield |
---|---|
With pyridine-4-carbonitrile; nickel(II) iodide; manganese; 4,4'-dimethyl-2,2'-bipyridines In N,N-dimethyl acetamide at 40℃; for 24h; Inert atmosphere; Sealed tube; | 91% |
The Methane, bromofluoro-(6CI,7CI,8CI,9CI) is an organic compound with the formula CH2BrF. The IUPAC name of this chemical is bromo(fluoro)methane. With the CAS registry number 373-52-4, it is also named as Bromofluoromethane. The product's category is Fluoro-containing Compounds. Besides, it is clear colourless to light yellow liquid, which is an important reagent in the manufacture of intermediates, pharmaceuticals and other chemicals.
Physical properties about Methane, bromofluoro-(6CI,7CI,8CI,9CI) are: (1)ACD/LogP: 0.94; (2)ACD/LogD (pH 5.5): 0.94; (3)ACD/LogD (pH 7.4): 0.94; (4)ACD/BCF (pH 5.5): 3.03; (5)ACD/BCF (pH 7.4): 3.03; (6)ACD/KOC (pH 5.5): 76.99; (7)ACD/KOC (pH 7.4): 76.99; (8)Index of Refraction: 1.375; (9)Molar Refractivity: 14.57 cm3; (10)Molar Volume: 63.6 cm3; (11)Polarizability: 5.77×10-24cm3; (12)Surface Tension: 19.3 dyne/cm; (13)Density: 1.773 g/cm3; (14)Enthalpy of Vaporization: 25.49 kJ/mol; (15)Boiling Point: 19 °C at 760 mmHg; (16)Vapour Pressure: 940 mmHg at 25°C.
Uses of Methane, bromofluoro-(6CI,7CI,8CI,9CI): it can be used to produce 2-acetylamino-2-fluoromethyl-malonic acid diethyl ester at temperature of -35 °C. This reaction is a kind of Alkylation. It will need reagent (Et2N)3P=NMe and solvent CH2Cl2. The yield is about 49.9%.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: BrCF
(2)InChI: InChI=1/CH2BrF/c2-1-3/h1H2
(3)InChIKey: LHMHCLYDBQOYTO-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/CH2BrF/c2-1-3/h1H2
(5)Std. InChIKey: LHMHCLYDBQOYTO-UHFFFAOYSA-N
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