Ciprofibrate supplier | CasNO.52214-84-3

Name
Ciprofibrate
EINECS 257-744-6
CAS No. 52214-84-3
Article Data13
CAS DataBase
Density 1.37 g/cm³
Solubility
Melting Point 114 - 118oC
Formula C₁₃H₁₄Cl₂O₃
Boiling Point 424.9 °C at 760 mmHg
Molecular Weight 289.158
Flash Point 210.7 °C
Transport Information
Appearance White or almost white powder
Safety 53-22-36/37/39-45
Risk Codes 45
Molecular Structure
Hazard Symbols T
Synonyms 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic acid;Propanoicacid, 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methyl-;Ciprol;Lipanor;Modalim;Win 35833;
PSA 46.53000
LogP 3.58980

Synthetic route

: 130232-51-8, 130233-23-7, 130233-24-8
methyl 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoate

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 0.5h;	92%
With sodium hydroxide In ethanol; water at 20℃; for 0.5h; pH=3 - 4; Solvent; Large scale;	91%

: 52179-28-9, 144940-19-2, 144940-25-0
ethyl 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionate

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water at 20℃; for 0.5h;	90%

: 52179-26-7, 135133-52-7, 135133-54-9
(-)-4-(2,2-dichlorocyclopropyl)phenol

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide In chloroform; acetone
With sodium hydroxide

: 2628-17-3
4-Vinylphenol

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / acetonitrile / 48 h / 20 °C 2: trimethyldodecylammonium chloride; sodium hydroxide / 24 h / 20 °C 3: sodium hydroxide / methanol; water / 0.5 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: caesium carbonate / acetonitrile / 24 h / 20 °C 2: sodium hydroxide; tetrabutylammomium bromide / 12 h / 0 - 20 °C 3: sodium hydroxide / ethanol / 0.5 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: caesium carbonate / acetonitrile / 12 h / 20 °C 2: sodium hydroxide; tetrabutylammomium bromide / chloroform / 12 h / 0 - 20 °C / Autoclave; Large scale 3: sodium hydroxide / ethanol; water / 0.5 h / 20 °C / pH 3 - 4 / Large scale View Scheme

: 7400-08-0
p-Coumaric Acid

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium acetate / N,N-dimethyl-formamide / 150 °C 2: caesium carbonate / acetonitrile / 24 h / 20 °C 3: sodium hydroxide; tetrabutylammomium bromide / 12 h / 0 - 20 °C 4: sodium hydroxide / ethanol / 0.5 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1: potassium acetate / N,N-dimethyl-formamide / 150 °C 2: potassium carbonate / acetonitrile / 48 h / 20 °C 3: trimethyldodecylammonium chloride; sodium hydroxide / 24 h / 20 °C 4: sodium hydroxide / methanol; water / 0.5 h / 20 °C View Scheme

: C13H16O3

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; tetrabutylammomium bromide / 12 h / 0 - 20 °C 2: sodium hydroxide / ethanol / 0.5 h / 20 °C View Scheme

: 123-08-0
4-hydroxy-benzaldehyde

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: ethylenediamine / N,N-dimethyl-formamide / 6 h / 150 °C / Large scale 2: caesium carbonate / acetonitrile / 12 h / 20 °C 3: sodium hydroxide; tetrabutylammomium bromide / chloroform / 12 h / 0 - 20 °C / Autoclave; Large scale 4: sodium hydroxide / ethanol; water / 0.5 h / 20 °C / pH 3 - 4 / Large scale View Scheme
Multi-step reaction with 3 steps 1: diethylamine / toluene / 2 h / 150 °C / Green chemistry 2: sodium hydroxide; tetrabutylammomium bromide / 40 °C / Green chemistry 3: magnesium; titanium tetrachloride / dichloromethane; tetrahydrofuran / 2 h / 0 - 120 °C / Green chemistry View Scheme

: 56-23-5
tetrachloromethane

: 2-methyl-2-(4-vinylphenoxy)propionic acid

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
With titanium tetrachloride; magnesium In tetrahydrofuran; dichloromethane at 0 - 120℃; for 2h; Green chemistry;	98.6 %Chromat.

: 84443-44-7
bromoethyl isobutyrate

: 4-(2,2-dichlorocyclopropyl)phenyl acetate

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

Conditions

Conditions	Yield
Stage #1: 4-(2,2-dichlorocyclopropyl)phenyl acetate With potassium carbonate In methanol at 20℃; for 10h; Stage #2: bromoethyl isobutyrate In methanol for 24h; Reflux; Stage #3: With water Temperature; Alkaline conditions;	240 g

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 538-75-0
dicyclohexyl-carbodiimide

A: (2S)-2-({2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}amino)-3-phenylpropansaeure-methylester

B: N-Cyclohexyl-N-(cyclohexylcarbamoyl)-2-[4-(2,2-dichlorcyclopropyl)phenoxy]-2-methylpropanamid

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 20h;	A 95% B n/a

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: ethyl (R)-2-((mesitylsulfinyl)imino)acetate

: C25H31Cl2NO4S

Conditions

Conditions	Yield
With 9-mesityl-2,7-dimethyl-10-phenylacridin-10-ium tetrafluoroborate; potassium carbonate at 20℃; Inert atmosphere; Irradiation; diastereoselective reaction;	91%

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 5680-79-5
glycine ethyl ester hydrochloride

: 538-75-0
dicyclohexyl-carbodiimide

A: N-{2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}glycin-methylester

B: N-Cyclohexyl-N-(cyclohexylcarbamoyl)-2-[4-(2,2-dichlorcyclopropyl)phenoxy]-2-methylpropanamid

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 20h;	A 87.5% B n/a

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 538-75-0
dicyclohexyl-carbodiimide

A: 3-({2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}amino)propansaeure-methylester

B: N-Cyclohexyl-N-(cyclohexylcarbamoyl)-2-[4-(2,2-dichlorcyclopropyl)phenoxy]-2-methylpropanamid

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 20h;	A 84.2% B n/a

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 13031-60-2
methyl γ-aminobutyrate hydrochloride

: 538-75-0
dicyclohexyl-carbodiimide

A: 4-({2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}amino)butansaeure-methylester

B: N-Cyclohexyl-N-(cyclohexylcarbamoyl)-2-[4-(2,2-dichlorcyclopropyl)phenoxy]-2-methylpropanamid

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 20h;	A 83.4% B n/a

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 538-75-0
dicyclohexyl-carbodiimide

A: N-{2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}-L-glutaminsaeure-dimethylester

B: N-Cyclohexyl-N-(cyclohexylcarbamoyl)-2-[4-(2,2-dichlorcyclopropyl)phenoxy]-2-methylpropanamid

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 20h;	A 80% B n/a

...Expand

: 67-56-1
methanol

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 130232-51-8, 130233-23-7, 130233-24-8
methyl 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoate

Conditions

Conditions	Yield
With tert.-butylnitrite at 40℃; for 48h;	79%
With tert.-butylnitrite at 40℃; for 48h; Green chemistry;	79%

: 574-66-3
Benzophenone oxime

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: diphenylmethanone O-(2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoyl)oxime

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Schlenk technique; Inert atmosphere;	78%

: 623-13-2
4-methylphenyl methylsulfide

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: (p-tolylthio)methyl 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoate

Conditions

Conditions	Yield
With tetrabutylammonium tetrafluoroborate In methanol; acetonitrile at 20℃; for 6h; Inert atmosphere; Electrochemical reaction;	66%

: 100-02-7
4-nitro-phenol

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropansaeure-(4-nitrophenyl)-ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 20h;	59.9%

: 392-56-3
Hexafluorobenzene

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: C18H13Cl2F5O

Conditions

Conditions	Yield
With Ir(dFFppy)2(dtbbpy)PF6; lithium carbonate In dimethyl sulfoxide at 35℃; for 48h; Inert atmosphere; Irradiation; Sealed tube;	54%

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

A: 52179-07-4
2-(p-acetylphenoxy)-2-methylpropionic acid

B: 2-(4-ethynylphenoxy)-2-methylpropanoic acid

C: 2-<4-(3-hydroxypropynyl)phenoxy>-2-methylpropanoic acid

D: 2-<4-(2-carboxyethyl)phenoxy>-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 56h; Heating; Further byproducts given;	A n/a B 7% C 42% D 4%

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

A: 42019-57-8
4-(1-carboxy-1-methyl-ethoxy)-benzoic acid

B: 2-(4-ethynylphenoxy)-2-methylpropanoic acid

C: 2-<4-(3-hydroxypropynyl)phenoxy>-2-methylpropanoic acid

D: 2-<4-(2-carboxyethyl)phenoxy>-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 56h; Heating; Further byproducts given;	A n/a B 7% C 42% D 4%

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

A: 2-(4-ethynylphenoxy)-2-methylpropanoic acid

B: 85212-83-5
2-(4-formylphenoxy)-2-methylpropanoic acid

C: 2-<4-(3-hydroxypropynyl)phenoxy>-2-methylpropanoic acid

D: 2-<4-(2-carboxyethyl)phenoxy>-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 56h; Heating; Further byproducts given;	A 7% B n/a C 42% D 4%

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

A: 52179-07-4
2-(p-acetylphenoxy)-2-methylpropionic acid

B: 42019-57-8
4-(1-carboxy-1-methyl-ethoxy)-benzoic acid

C: 2-(4-ethynylphenoxy)-2-methylpropanoic acid

D: 85212-83-5
2-(4-formylphenoxy)-2-methylpropanoic acid

E: 2-<4-(3-hydroxypropynyl)phenoxy>-2-methylpropanoic acid

F: 2-<4-(2-carboxyethyl)phenoxy>-2-methylpropanoic acid

G 2-<4-(2-chloro-1-hydroxyprop-2-enyl)- and (2-chloro-3-hydroxyprop-1-enyl)phenoxy>-2-methylpropanoic acid: 2-<4-(2-chloro-1-hydroxyprop-2-enyl)- and (2-chloro-3-hydroxyprop-1-enyl)phenoxy>-2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 56h; Mechanism; Heating;	A n/a B n/a C 7% D n/a E 42% F 4% G n/a

...Expand

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

A: (Z)-2-<4-(2-chloro-3-hydroxyprop-1-enyl)phenoxy>-2-methylpropanoic acid

B: 2-<4-(2-chloro-1-hydroxyprop-2-enyl)phenoxy>2-methylpropanoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 96h; Heating; pH 7;

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: (+)-2-<4-(2,2-dichlorocyclopropyl)phenoxy>-2-methylpropanoic acid

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: (-)-2-<4-(2,2-dichlorocyclopropyl)phenoxy>-2-methylpropanoic acid

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 640772-36-7
N-{2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}glycin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87.5 percent / Et3N; DMAP / CH2Cl2 / 20 h / 20 °C 2: 94.9 percent / NaOH / methanol; H2O / 4 h / 20 °C View Scheme

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 3-({2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}amino)propansaeure

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 84.2 percent / Et3N; DMAP / CH2Cl2 / 20 h / 20 °C 2: 95 percent / NaOH / methanol; H2O / 4 h / 20 °C View Scheme

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 2-({2-[4-(2,2-Dichlorcyclopropyl)phenoxy]-2-methylpropanoyl}amino)ethansulfonsaeure

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 59.9 percent / DCC; DMAP / CH2Cl2 / 20 h / 20 °C 2: 27.9 percent / pyridine / H2O / 24 h / 20 °C View Scheme

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 7664-93-9
sulfuric acid

: 130232-51-8, 130233-23-7, 130233-24-8
methyl 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methylpropanoate

Conditions

Conditions	Yield
In methanol; diethyl ether

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 77369-38-1
2-amino-1-(4-hydroxyphenyl)ethyl ketone

: 1416548-75-8
2-(4-(2,2-dichlorocyclopropyl)phenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2-methylpropanamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;	760 mg

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 77369-38-1
2-amino-1-(4-hydroxyphenyl)ethyl ketone

: 1416548-76-9
C34H33Cl4NO6

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;	1.15 g

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 17194-82-0
2-(4-hydroxyphenyl)acetamide

: 1416548-75-8
2-(4-(2,2-dichlorocyclopropyl)phenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2-methylpropanamide

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;	760 mg

: 52214-84-3
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

: 17194-82-0
2-(4-hydroxyphenyl)acetamide

: 1416548-76-9
C34H33Cl4NO6

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h;	1.15 g

Ciprofibrate Chemical Properties

The molecular structure of Ciprofibrate (CAS NO.52214-84-3):

IUPAC Name: 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Molecular Weight: 289.15446 g/mol
Molecular Formula: C₁₃H₁₄Cl₂O₃
Density: 1.37 g/cm³
Boiling Point: 424.9 °C at 760 mmHg
Flash Point: 210.7 °C
Index of Refraction: 1.579
Molar Refractivity: 70.16 cm³
Molar Volume: 211 cm³
Surface Tension: 50.8 dyne/cm
Enthalpy of Vaporization: 71.62 kJ/mol
Vapour Pressure: 5.63E-08 mmHg at 25 °C
Storage Temp.: 2-8 °C
XLogP3-AA: 3.4
H-Bond Donor: 1
H-Bond Acceptor: 3
Rotatable Bond Count: 4
Exact Mass: 288.032
MonoIsotopic Mass: 288.032
Topological Polar Surface Area: 46.5
Heavy Atom Count: 18
Canonical SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl
InChI: InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
InChIKey: KPSRODZRAIWAKH-UHFFFAOYSA-N
EINECS: 257-744-6
Product Categories: Intracellular receptor

Ciprofibrate Uses

Ciprofibrate (CAS NO.52214-84-3) is a kind of lipid-lowering drugs. It has anti-platelet aggregation and the role of soluble fibrin.

Ciprofibrate Toxicity Data With Reference

otr-rat-orl 3650 mg/kg/1Y C

CNREA8 Cancer Research. 46 (1986),4601.

Ciprofibrate Safety Profile

Hazard Codes: Toxic T
Risk Statements: 45
R45:May cause cancer.
Safety Statements: 53-22-36/37/39-45
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: UF0880000
Questionable carcinogen with experimental tumorigenic data. Experimental reproductive data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl⁻.

Ciprofibrate Specification

Ciprofibrate (CAS NO.52214-84-3) is also named as 2-(p-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropionic acid ; BRN 1984981 ; CCRIS 173 ; Ciprofibrato ; Ciprofibrato [INN-Spanish] ; Ciprofibratum ; Ciprofibratum [INN-Latin] ; UNII-F8252JGO9S ; WIN 35833 . Ciprofibrate (CAS NO.52214-84-3) is white or almost white crystalline powder.

Product Name

Ciprofibrate

Synthetic route

Ciprofibrate Chemical Properties

Ciprofibrate Uses

Ciprofibrate Toxicity Data With Reference

Ciprofibrate Safety Profile

Ciprofibrate Specification

Related Products

Hot Products