Cyclohexanemethylamine supplier

Name
(Aminomethyl)cyclohexane
EINECS 221-741-8
CAS No. 3218-02-8
Article Data103
CAS DataBase
Density 0.863 g/cm³
Solubility Slightly soluble in water.
Melting Point -8 °C
Formula C₇H₁₅N
Boiling Point 146 °C at 760 mmHg
Molecular Weight 113.203
Flash Point 43.3 °C
Transport Information UN 2734 8/PG 2
Appearance Clear colorless to slightly yellow liquid
Safety 16-26-36/37/39-45
Risk Codes 10-34
Molecular Structure
Hazard Symbols C
Synonyms (Aminomethyl)cyclohexane;Hexahydrobenzylamine;
PSA 26.02000
LogP 2.22570

Synthetic route

: 766-05-2
cyclohexane carbonitrile

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With [Ru(H)(BH4)(CO)(PPh3)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2 yl)methyl)propylamine)]; hydrogen In isopropyl alcohol at 70℃; for 3h; Inert atmosphere; Autoclave;	99%
With ammonia; hydrogen In toluene at 120℃; under 22502.3 Torr; for 16h; Autoclave;	92%
With hydrogen In ethanol at 88℃; under 37503.8 Torr; for 0.5h;	91%

: 86328-85-0
N-(cyclohexylmethyl)-4-methylbenzenesulfonamide

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
Stage #1: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide With n-butyllithium In tetrahydrofuran at 0℃; Stage #2: With naphthalene; lithium In tetrahydrofuran at -78 - 20℃;	94%
Stage #1: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide With n-butyllithium In tetrahydrofuran at 0℃; for 0.166667h; Inert atmosphere; Stage #2: With naphthalene; lithium In tetrahydrofuran at -78 - 25℃; Stage #3: With water In tetrahydrofuran	94%

: 2043-61-0
cyclohexanecarbaldehyde

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In ethanol at 130℃; under 7500.75 Torr; for 18h; Autoclave;	92.8%
With ammonium formate In toluene at 80℃; for 3h; Inert atmosphere; chemoselective reaction;	90%
With ammonium formate In toluene at 80℃; for 3h; Inert atmosphere; chemoselective reaction;	90%

: 1122-56-1
cyclohexylcarboxamide

A: 3218-02-8
cyclohexylmethylamine

B: 100-49-2
cyclohexylmethyl alcohol

Conditions

Conditions	Yield
With hydrogen at 160℃; under 75007.5 Torr;	A 91% B 8%
With dodecacarbonyl-triangulo-triruthenium; hydrogen; molybdenum hexacarbonyl In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 16h; Inert atmosphere;
With hydrogen In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 16h;
With 5 wt% ruthenium/carbon; water; hydrogen at 59.84℃; under 60006 Torr; for 4h; Reagent/catalyst; Autoclave; Sealed tube;

: 1122-56-1
cyclohexylcarboxamide

A: 3309-27-1
N,N-dicyclohexylmethylamine

B: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
at 160℃; under 75007.5 Torr;	A 7% B 89%
With ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6h; Catalytic behavior;	A 18 %Chromat. B 80 %Chromat.

: 766-05-2
cyclohexane carbonitrile

A: 3309-27-1
N,N-dicyclohexylmethylamine

B: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With 10% rhodium on carbon; hydrogen In cyclohexane at 25℃; under 760.051 Torr; for 24h;	A 89% B n/a

: 81917-06-8
(azidomethyl)cyclohexane

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonium formate; zinc In methanol at 20℃; for 0.166667h;	88%
With hydrogen; 25% palladium on carbon In methanol under 2585.81 Torr; for 2h;

: 108-91-8
cyclohexylamine

: 100-47-0
benzonitrile

A: 2211-66-7
N-phenyl(methylidene)cyclohexanamine

B: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In hexane at 100℃; under 3750.38 Torr; for 36h; Autoclave; Green chemistry;	A 78.2% B 10.6%

...Expand

: 65-85-0
benzoic acid

A: 110-82-7
cyclohexane

B: 3218-00-6
N-(cyclohexylmethyl)cyclohexanecarboxamide

C: 3309-27-1
N,N-dicyclohexylmethylamine

D: 1122-56-1
cyclohexylcarboxamide

E: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
Stage #1: benzoic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 5% B 2% C 7% D 4% E 78%

...Expand

: 1122-56-1
cyclohexylcarboxamide

A: 3309-27-1
N,N-dicyclohexylmethylamine

B: 3218-02-8
cyclohexylmethylamine

C: 100-49-2
cyclohexylmethyl alcohol

Conditions

Conditions	Yield
With hydrogen at 150℃; under 75007.5 Torr;	A 9% B 77% C 13%
With tris(2,4-pentanedionato)ruthenium(III); hydrogen; molybdenum hexacarbonyl In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 16h; Inert atmosphere;
With hydrogen; lithium hydroxide In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 16h;

...Expand

: benzyliminoethyl ether hydrochloride

A: 3309-27-1
N,N-dicyclohexylmethylamine

B: 3218-02-8
cyclohexylmethylamine

C: 100-46-9
benzylamine

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In ethanol at 30℃; under 30003 Torr; for 12h; Autoclave;	A 77% B 21% C 2%

...Expand

: 100-49-2
cyclohexylmethyl alcohol

A: 3218-02-8
cyclohexylmethylamine

B: 1-cyclohexyl-N-(cyclohexylmethylene)methanamine

Conditions

Conditions	Yield
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia In toluene under 5700.38 Torr; for 25h; Inert atmosphere; Reflux;	A 73% B n/a
With ammonia; carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II) In toluene under 5700.38 Torr; for 25h; Product distribution / selectivity; Reflux;

: 773-82-0
Pentafluorobenzonitrile

A: 3218-02-8
cyclohexylmethylamine

B: 100-49-2
cyclohexylmethyl alcohol

Conditions

Conditions	Yield
With water In aq. phosphate buffer at 25℃; for 18h; pH=2.7 - 3.2; Electrochemical reaction;	A 33% B 65%

: 2043-61-0
cyclohexanecarbaldehyde

A: 3218-02-8
cyclohexylmethylamine

B: 1-cyclohexyl-N-(cyclohexylmethylene)methanamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In ethanol at 130℃; under 7500.75 Torr; for 12h; Autoclave;	A 64.8% B 16.9%

: 1194-02-1
4-fluorobenzonitrile

A: 3218-02-8
cyclohexylmethylamine

B: 100-49-2
cyclohexylmethyl alcohol

Conditions

Conditions	Yield
With water In aq. phosphate buffer at 25℃; for 6h; pH=2.7 - 3.2; Electrochemical reaction;	A 35% B 63%

: 121-91-5
isophthalic acid

A: 280-70-6
3-azabicyclo<3.3.1>nonane

B: 2555-12-6
3-azabicyclo[3.3.1]nonan-2-one

C: 34147-55-2
(3-methylcyclohexyl)methanamine

D: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
Stage #1: isophthalic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 57% B 21% C 11% D 3%

...Expand

: 69-72-7
salicylic acid

A: 7003-32-9
2-METHYLCYCLOHEXYLAMINE

B: 108-91-8
cyclohexylamine

C: 1122-56-1
cyclohexylcarboxamide

D: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
Stage #1: salicylic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A 11% B 50% C 11% D 10%

...Expand

: 586-38-9
3-Methoxybenzoic acid

: trans-(3-methoxycyclohexyl)methanamine

: cis-(3-methoxycyclohexyl)methanamine

C: 1122-56-1
cyclohexylcarboxamide

D: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
Stage #1: 3-Methoxybenzoic acid With cyclopentyl methyl ether; ammonia at 200℃; under 4500.45 Torr; Sealed tube; Green chemistry; Stage #2: With cyclopentyl methyl ether; ammonia; hydrogen at 200℃; under 42004.2 Torr; for 6.5h; Cooling with ice; Green chemistry;	A n/a B n/a C 6% D 44%

...Expand

: C18H23NO

A: 1096-84-0
bis(2-hydroxy-1-naphthyl)methane

B: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
In ethanol for 2h; Inert atmosphere; Schlenk technique; Reflux;	A 36% B n/a

: 64847-82-1
cyclohexylmethylene diacetate

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With methanol; ammonia; nickel at 100℃; under 106400 Torr; Hydrogenation;

: 5292-21-7
Cyclohexylacetic acid

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With sodium azide; sulfuric acid

: 22155-44-8
cyclohexylmethylcarbamic acid methyl ester

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With calcium hydroxide

: 3287-99-8, 39110-74-2
benzylamine hydrochloride

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With platinum(IV) oxide; ethanol at 50 - 60℃; under 1520 - 2280 Torr; Hydrogenation;

: 1855-63-6
cyclohex-1-enecarbonitrile

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonia; nickel at 100 - 110℃; under 91938.4 Torr; Hydrogenation;
With i-Amyl alcohol; sodium
(i) H2, Raney-Ni, (ii) aq. HCl; Multistep reaction;

: 75-04-7
ethylamine

: 100-47-0
benzonitrile

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With lithium

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 2043-61-0
cyclohexanecarbaldehyde

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonium sulfate anschliessend mit wss.HCl;

: 1122-56-1
cyclohexylcarboxamide

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride
Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: P2O5 / durch Destillation 2: sodium; alcohol View Scheme

: 100-46-9
benzylamine

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With nickel at 170 - 180℃; Hydrogenation;
With acetic acid; platinum at 50 - 60℃; under 1520 - 2280 Torr; Hydrogenation;
With hydrogen In neat (no solvent) at 80℃; under 7600.51 Torr; for 24h; Autoclave;	54 %Spectr.
With hydrogen In tert-butyl alcohol at 135℃; for 24h; Autoclave;	93 %Chromat.
With hydrogen In 1,4-dioxane at 100℃; under 15001.5 Torr; for 3.33333h; Autoclave;

: 100-49-2
cyclohexylmethyl alcohol

: 3218-02-8
cyclohexylmethylamine

Conditions

Conditions	Yield
With ammonia; nickel at 185℃;
Multi-step reaction with 2 steps 1.1: potassium tert-butylate; copper diacetate / toluene / 120 h / 150 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere 2.2: -78 - 25 °C View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C 2: sodium azide / N,N-dimethyl-formamide / 65 °C 3: hydrogen / 25% palladium on carbon / methanol / 2 h / 2585.81 Torr View Scheme

: 79-04-9
chloroacetyl chloride

: 3218-02-8
cyclohexylmethylamine

: 40914-11-2
2-chloro-N-(cyclohexylmethyl)acetamide

Conditions

Conditions	Yield
In dichloromethane	100%
With potassium carbonate In dichloromethane Heating;	97%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	60%

: 3218-02-8
cyclohexylmethylamine

: 1489-69-6
Cyclopropanecarboxaldehyde

: Cyclohexylmethyl-[1-cyclopropyl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane Heating;	100%

: 351-32-6
N-(4-fluoro-3-nitrophenyl)acetamide

: 3218-02-8
cyclohexylmethylamine

: 809237-74-9
N-{4-[(cyclohexylmethyl)amino]-3-nitrophenyl}acetamide

Conditions

Conditions	Yield
With sodium carbonate In ethanol at 60℃; for 48h; Heating;	100%
With sodium carbonate In ethanol at 20 - 60℃; for 48h;	100%
With sodium carbonate In ethanol at 20 - 60℃; for 48h;	100%

: 1009-35-4
4-fluoro-3-nitrobenzonitrile

: 3218-02-8
cyclohexylmethylamine

: 809273-55-0
4-[(cyclohexylmethyl)amino]-3-nitro-benzonitrile

Conditions

Conditions	Yield
With sodium carbonate In ethanol at 20℃;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 3218-02-8
cyclohexylmethylamine

: 56700-67-5
tert-butyl N-cyclohexylmethylcarbamate

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃;	100%
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;	85%

: 50978-45-5
3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide

: 3218-02-8
cyclohexylmethylamine

: N-(cyclohexylmethyl)formamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.25h; chemoselective reaction;	100%

: 1370008-75-5
tert-butyl-[(1S,2S)-(4R)-4-(4-tert-butylsulfonylthieno[3,2-d]pyrimidin-7-yl)-2-(methoxymethoxymethyl)cyclopentoxy]-dimethyl-silane

: 3218-02-8
cyclohexylmethylamine

: 1370008-77-7
7-[(1R,3S,4S)-3-[tert-butyl(dimethyl)silyl]oxy-4-(methoxymethoxymethyl)cyclopentyl]-N-(cyclohexylmethyl)thieno[3,2-d]pyrimidin-4-amine

Conditions

Conditions	Yield
In 1,2-dimethoxyethane at 150℃; for 3h; Microwave irradiation;	100%

: 3218-02-8
cyclohexylmethylamine

: 19646-07-2
2,4-dichloro-5-methoxypyrimidine

: (2-chloro-5-methoxy-pyrimidin-4-yl)-cyclohexylmethyl-amine

Conditions

Conditions	Yield
With DIPEA	100%

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 3218-02-8
cyclohexylmethylamine

: 809273-51-6
4-(cyclohexylmethyl-amino)-3-nitro-benzoic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 7021-09-2
rac-methoxyphenylacetic acid

: 3218-02-8
cyclohexylmethylamine

: N-(cyclohexylmethyl)-2-methoxy-2-phenylacetamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine	100%

: 300816-22-2
4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

: 3218-02-8
cyclohexylmethylamine

: N-(cyclohexylmethyl)-6,7-dihydro-5H-cyclopenta[4,5]-thieno[2,3-d]pyrimidin-4-amine

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	100%

: C29H23Cl2FN6O2

: 3218-02-8
cyclohexylmethylamine

: 3-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-piperidin-4-yl}-1-(cyclohexylmethyl)urea

Conditions

Conditions	Yield
In 1,4-dioxane for 20h;	100%

: 103515-22-6
dibenzobarallene

: 3218-02-8
cyclohexylmethylamine

: C25H27NO3

Conditions

Conditions	Yield
In tetrahydrofuran Ambient temperature;	99%

: 3173-53-3
Cyclohexyl isocyanate

: 3218-02-8
cyclohexylmethylamine

: 2222-58-4
1-Cyclohexyl-3-cyclohexylmethyl-urea

Conditions

Conditions	Yield
In hexane at 20℃;	99%

: 3218-02-8
cyclohexylmethylamine

: 543708-58-3
(4-fluoro-3-nitrophenyl)carbamic acid tert butyl ester

: 809237-77-2
N-(4-[(cyclohexylmethyl)amino]-3-nitrophenyl)-2,2-dimethylpropanamide

Conditions

Conditions	Yield
With triethylamine In ethanol at 75℃; for 24h;	99%

: 486436-98-0
4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid

: 3218-02-8
cyclohexylmethylamine

: 486436-51-5
N-(cyclohexylmethyl)-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N-methyl-acetamide	99%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N-methyl-acetamide	99%

: 54120-56-8
2,3,5,6-tetrabromoterephthaloyl dichloride

: 3218-02-8
cyclohexylmethylamine

: 1096061-42-5
C22H28Br4N2O2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 23h; Reflux;	99%

: 1185428-39-0
2-cyclopropyl-5-((2-trimethylsilanyl)ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-carboxylic acid

: 3218-02-8
cyclohexylmethylamine

: 1350712-62-7
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid cyclohexylmethyl-amide

Conditions

Conditions	Yield
Stage #1: 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 0.75h; Stage #2: cyclohexylmethylamine In tetrahydrofuran at 20℃; for 3h;	99%

: 1584725-55-2
dimethyl (S)-2-[N-(chloroacetyl)-N-(naphthalen-1-ylmethyl)amino]butandioate

: 3218-02-8
cyclohexylmethylamine

: 1584725-59-6
methyl (S)-2-[4-(cyclohexylmethyl)-1-(naphthalen-1-ylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 16h; Molecular sieve;	99%
With triethylamine In acetonitrile at 20℃; Inert atmosphere;

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 3218-02-8
cyclohexylmethylamine

: 5472-16-2
1,3-Bis(cyclohexylmethyl)urea

Conditions

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate In 5,5-dimethyl-1,3-cyclohexadiene at 165℃; for 24h; Schlenk technique; Inert atmosphere;	99%

: 3218-02-8
cyclohexylmethylamine

: 581-96-4
2-naphthylacetic acid

: C19H23NO

Conditions

Conditions	Yield
With pentamethoxy tantalum; 1-(Trimethylsilyl)imidazole In neat (no solvent) at 50℃; for 48h; Inert atmosphere; Sealed tube;	99%

: 598-21-0
2-Bromoacetyl bromide

: 3218-02-8
cyclohexylmethylamine

: 2-bromo-N-(cyclohexylmethyl)acetamide

Conditions

Conditions	Yield
With sodium carbonate In water pH=9 - 10;	99%

: 75-36-5
acetyl chloride

: 3218-02-8
cyclohexylmethylamine

: 51870-99-6
N-cyclohexanemethylacetamide

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 7h;	98%

: 3218-02-8
cyclohexylmethylamine

: 180716-18-1
2-(bromomethyl)-7-(benzyloxy)chroman

: 198986-39-9
(7-Benzyloxy-chroman-2-ylmethyl)-cyclohexylmethyl-amine

Conditions

Conditions	Yield
at 100℃; for 2h;	98%

: 3218-02-8
cyclohexylmethylamine

: 920-46-7
Methacryloyl chloride

: 110613-30-4
N-(cyclohexylmethyl)methacrylamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	98%

: 22280-56-4
2-chloro-3-methyl-5-nitropyridine

: 3218-02-8
cyclohexylmethylamine

: 773147-98-1
N-(cyclohexylmethyl)-3-methyl-5-nitro-2-pyridinamine

Conditions

Conditions	Yield
With triethylamine In ethanol for 12h; Heating / reflux;	98%

: 3218-02-8
cyclohexylmethylamine

: 75-05-8
acetonitrile

: 14002-08-5
N-(cyclohexylmethyl)-N-ethylamine

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 760.051 Torr; for 36h;	98%

: 3218-02-8
cyclohexylmethylamine

: 616-38-6
carbonic acid dimethyl ester

: 22155-44-8
cyclohexylmethylcarbamic acid methyl ester

Conditions

Conditions	Yield
lipase from Candida antarctica In toluene at 70℃; for 15h;	98%

Cyclohexanemethylamine Specification

The CAS register number of Cyclohexanemethanamine is 3218-02-8. It also can be called as Hexahydrobenzylamine and the IUPAC name about this chemical is cyclohexylmethanamine. The molecular formula about this chemical is C₇H₁₅N and the molecular weight is 113.20. It belongs to the following product categories which include Amines and Anilines; API intermediates and so on.

Physical properties about Cyclohexanemethanamine are: (1)ACD/LogP: 1.93; (2)ACD/LogD (pH 5.5): -1.17; (3)ACD/LogD (pH 7.4): -0.83; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 3.24Å²; (12)Index of Refraction: 1.459; (13)Molar Refractivity: 35.89 cm³; (14)Molar Volume: 131.1 cm³; (15)Polarizability: 14.23x10^-24cm³; (16)Surface Tension: 32.6 dyne/cm; (17)Flash Point: 43.3 °C; (18)Enthalpy of Vaporization: 38.3 kJ/mol; (19)Boiling Point: 146 °C at 760 mmHg; (20)Vapour Pressure: 4.73 mmHg at 25°C.

Uses of Cyclohexanemethanamine: it can be used to produce N-cyclohexylmethyl-benzamide with 3-benzoyl-oxazolidin-2-one of 25 ℃. This reaction will need catalyst Cp₂TiCl₂ and solvent tetrahydrofuran with reaction time of 18 hours. The yield is about 86%.

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable. It can also cause burns. If you want to use this chemical, please keep away from sources of ignition. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, please seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure:
(1)SMILES: NCC1CCCCC1
(2)InChI: InChI=1/C7H15N/c8-6-7-4-2-1-3-5-7/h7H,1-6,8H2
(3)InChIKey: AVKNGPAMCBSNSO-UHFFFAOYAS
(4)Std. InChI: InChI=1S/C7H15N/c8-6-7-4-2-1-3-5-7/h7H,1-6,8H2
(5)Std. InChIKey: AVKNGPAMCBSNSO-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#10002,

Product Name

(Aminomethyl)cyclohexane

Synthetic route

Cyclohexanemethylamine Specification

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