Cytidine supplier | CasNO.65-46-3

Name
Cytidine
EINECS 200-610-9
CAS No. 65-46-3
Article Data134
CAS DataBase
Density 1.89 g/cm³
Solubility 50 mg/mL in water
Melting Point 210-217 °C
Formula C₉H₁₃N₃O₅
Boiling Point 545.7 °C at 760 mmHg
Molecular Weight 243.219
Flash Point 283.8 °C
Transport Information
Appearance White crystalline powder
Safety 24/25
Risk Codes 68
Molecular Structure
Hazard Symbols
Synonyms Cytosine riboside;1-.beta.-D-Ribofuranosylcytosine;4-Amino-1.beta.-D-ribofuranosyl-2(1H)-pyrimidinone;beta-D-Ribofuranoside, cytosine-1;2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-;Cytosine, 1-beta-D-ribofuranosyl-;2(1H)-Pyrimidinone, 4-amino-1-.beta.-D-ribofuranosyl-;1.beta.-Ribofuranosylcytosine;1-beta-D-ribosyl- (6CI);1beta-2-Ribofuranosylcytosine, d-;4-Amino-1-beta-D-ribofuranosyl-2(1H)-pyrimidinone;cytosine-1;CP-C;1-(beta-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine;Cytidine(CR);Cytosine nucleoside(Cytidine);
PSA 130.83000
LogP -1.98180

Synthetic route

: 4N-dimethylaminomethylene cytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In methanol; water at 50℃; for 36h; Hydrolysis;	99%

: 4N-dibenzylaminomethylene cytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In methanol; water at 50℃; for 26h; Hydrolysis;	99%

: 5040-18-6
4-N-2',3',5'-O-tetraacetylcytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With sodium methylate; guanidine nitrate In methanol; dichloromethane at 0℃; for 0.166667h;	95%
With methanol; water; triethylamine at 71℃; for 0.75h;	92%

: 56787-28-1
2',3',5'-tri-O-acetylcytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With ammonia In dichloromethane at 25℃;	93%
With ammonia In methanol at 25℃; for 24h; Yield given;
In ammonium hydroxide Yield given;

: 6-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6H-tetrazolo[1,5-c]pyrimidin-5-one

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 10h;	89%

: 473910-24-6
[1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid 2-nitro-benzyl ester

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In 1,4-dioxane; water for 1.16667h; UV-irradiation;	89%

: 10578-79-7
4-methylamino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With manganese(IV) oxide; C17H20N4O9P(1-)*Na(1+); oxygen In water; acetonitrile at 20℃; under 760.051 Torr; for 7h; Irradiation; chemoselective reaction;	89%

: 2,2'-anhydrocytidine hydrochloride

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 105℃; for 3h;	80.9%

: 800379-05-9
1-(3,4-dihydroxy-5-hydroxymethyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-(O-benzyloxime)

A: 3258-02-4
uridine 4-oxime

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol at 60℃; for 1h;	A 22% B 77%

: 4-Amino-1-((4aR,6R,7R,7aR)-7-hydroxy-2-oxo-tetrahydro-2λ4-furo[3,2-d][1,3,2]dioxathiin-6-yl)-1H-pyrimidin-2-one

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With sodium hydrogencarbonate In N,N-dimethyl-formamide	76.5%

: 3530-56-1
1-(β-D-xylo-pentofuranosyl)cytosine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
Stage #1: 1-(β-D-xylo-pentofuranosyl)cytosine With thionyl chloride In acetonitrile at 25℃; for 5h; Stage #2: With sodium hydrogencarbonate In N,N-dimethyl-formamide at 105℃; for 3h;	76.5%
Multi-step reaction with 2 steps 1: SOCl2 / acetonitrile 2: 76.5 percent / NaHCO3 / dimethylformamide View Scheme

: 97627-00-4
Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(4-octanoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With sodium hydroxide In ethanol Ambient temperature;	74%

: 13233-20-0, 13239-97-9
2-thiocytidine

A: 156-81-0
2,4-diaminopyrimidine

B: 50574-59-9
cytidine 2′,3′-cyclic monophosphate

C: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With dihydrogen phosphate; formamide Heating;	A 21% B 24% C 48%

...Expand

: 13233-20-0, 13239-97-9
2-thiocytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With water In aq. phosphate buffer at 60℃; for 2016h; pH=7;	41%

: 97626-95-4
N4-benzoyl-1-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)-cytosine

A: 13089-48-0
N4-benzoylcytidine

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With N,N,N',N'-tetramethylguanidine In methanol; dichloromethane at 20℃; for 0.333333h;	A 40% B n/a

: 13233-20-0, 13239-97-9
2-thiocytidine

A: 20235-78-3
2-thiouridine

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With water In aq. phosphate buffer at 60℃; for 2016h; pH=5;	A 8% B 33%

: 532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7
D-Ribose

: 71-30-7
Cytosine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In ethanol; water; acetonitrile at 60 - 70℃; for 192h;	12%

: 65523-07-1
5-(chloromercuri)cytidine

: 118042-46-9
N,N'-Bis(trifluoroacetyl)cystamine

A: 135638-75-4
N-{2-[4-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-5-ylsulfanyl]-ethyl}-2,2,2-trifluoro-acetamide

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With lithium tetrachloropalladate(II) In methanol Ambient temperature;	A 10.1% B n/a

...Expand

: 36468-53-8
β-D-ribofuranose

: 71-30-7
Cytosine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With phosphoric acid; magnesium sulfate In water at 20℃; under 760.051 Torr;	0.7%

: 27391-03-3
N4-acetyl-O2',O3',O5'-tribenzoyl-cytidine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With ethanol; ammonia

: 15049-50-0
1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-thiouracil

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With ethanol; ammonia

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 33304-87-9
N4-octanoylcytosine

: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
With methanol; sodium; tin(IV) chloride 1.) 1,2-dichloroethane, 20 h room temperature; 2.) MeOH, reflux 1 h; Yield given. Multistep reaction;

: 53337-88-5
2-methoxy-1-β-D-ribofuranosyl-pyrimidine-4-one

A: 65-46-3
CYTIDINE

B: 489-59-8
2-amino-1-(β-D-ribofuranosyl)pyrimidin-4(1H)-one

Conditions

Conditions	Yield
With ammonia at 20℃; Product distribution; half-time;

: 73-97-2
orotate anion

: C9H13N3O5(1-)

A: 73-97-2
2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid anion

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.5;

...Expand

: 5746-18-9
1-methyl-4-carboxypyridinium chloride

: C9H13N3O5(1-)

A: 36455-39-7
C7H8NO2

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.5-8.8;

...Expand

: 50574-59-9
cytidine 2′,3′-cyclic monophosphate

A: 47136-83-4
3'-monophosphate of cytidine

B: 2'-monophosphate of cytidine

C: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
alpha cyclodextrin In water at 20℃; Rate constant; Mechanism; pH=11.08 (hydrogen bicarbonate buffer); cleavage selectivity; without catalyst, other chemically modified cyclodextrins, other temperature, other additives;

...Expand

: 2301-80-6
N-methyl-4-methylpyridinium iodide

: C9H13N3O5(1-)

A: 1,4-dimethylpyridinyl radical

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In water at 20℃; Rate constant; pH 8.5-8.8;

...Expand

: 26467-87-8
4-[2-(4-cyanophenyl)ethenyl]-1-methylpyridinium iodide

: C9H13N3O5(1-)

A: C15H13N2

B: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
In water at 20℃; Rate constant; Equilibrium constant; pH 8.5-8.8;

...Expand

: C19H24N8O11P(1-)

A: 2'-monophosphate of adenosine

B: 135245-29-3
3'-monophosphate of adenosine

C: 65-46-3
CYTIDINE

Conditions

Conditions	Yield
alpha cyclodextrin at 50℃; Rate constant; pH=11.08;	A 21 % Chromat. B 79 % Chromat. C n/a
β‐cyclodextrin at 50℃; Rate constant; pH=11.08;	A 88 % Chromat. B 12 % Chromat. C n/a
cyclomaltooctaose at 50℃; Rate constant; pH=11.08;	A 70 % Chromat. B 30 % Chromat. C n/a
at 50℃; Rate constant; pH=11.08;	A 52 % Chromat. B 48 % Chromat. C n/a

...Expand

: 18395-90-9
Di-tert-butyldichlorosilane

: 65-46-3
CYTIDINE

: 126628-28-2
3',5'-O-(Di-tert-butylsilanediyl)cytidine

Conditions

Conditions	Yield
With silver nitrate In N,N-dimethyl-formamide at 0℃; for 0.5h;	100%
With silver nitrate DMF; Yield given. Multistep reaction;

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 65-46-3
CYTIDINE

: 51432-41-8
O2',O3',O5'-tris-trimethylsilanyl-cytidine

Conditions

Conditions	Yield
With pyridine In acetonitrile for 2h; Heating;	100%
With chloro-trimethyl-silane In acetonitrile at 20℃; for 1h;
With ammonium sulfate In 1,4-dioxane Heating;

: 58479-61-1
tert-butylchlorodiphenylsilane

: 65-46-3
CYTIDINE

: 58479-65-5
5'-O-(tert-butyldiphenylsilyl)cytidine

Conditions

Conditions	Yield
With pyridine; dmap at 20℃; for 18h; Inert atmosphere;	100%
With 1H-imidazole In N,N-dimethyl-formamide Ambient temperature;	65.2%
With 1H-imidazole In N,N-dimethyl-formamide for 20h; Ambient temperature;

: 65-46-3
CYTIDINE

: 3768-18-1
N-acetylcytidine

Conditions

Conditions	Yield
With tiolacetic acid In pyridine at 50℃; for 4h;	100%
Multi-step reaction with 2 steps 1: 98 percent / sodium acetate / 1 h / 120 °C 2: 77 percent / Aspergillus niger lipase Amano A; phosphate buffer / H2O / 15.5 h / 37 °C / pH 7.0 View Scheme
Multi-step reaction with 2 steps 1: pyridine 2: 1-hydroxybenzotriazole / acetonitrile / 17 h / Ambient temperature View Scheme
With acetic anhydride In N,N-dimethyl-formamide

: 108-24-7
acetic anhydride

: 65-46-3
CYTIDINE

: 5040-18-6
4-N-2',3',5'-O-tetraacetylcytidine

Conditions

Conditions	Yield
With pyridine at 80℃; for 1h;	100%
With pyridine at 20℃; Cooling with ice;	99%
With sodium acetate at 120℃; for 1h; Acetylation;	98%
molecular sieve; potassium chloride at 100℃; for 3h;	86%
With pyridine at 80℃; for 2h;

: 18162-48-6
tert-butyldimethylsilyl chloride

: 65-46-3
CYTIDINE

: 72409-19-9
4-amino-1-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

Conditions

Conditions	Yield
With pyridine; 1H-imidazole at 20℃;	100%
With pyridine; silver nitrate; triethylamine In tetrahydrofuran	96%
With 1H-imidazole; triethylsilyl chloride at 20℃; for 48h; Inert atmosphere;	80%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 72h; Inert atmosphere;
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 20h;

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 65-46-3
CYTIDINE

: 800379-05-9
N4-(O-(benzyloxy))cytidine

Conditions

Conditions	Yield
With pyridine at 100℃;	100%
With pyridine at 110℃;
With pyridine at 80℃; for 12h;

: 18395-90-9
Di-tert-butyldichlorosilane

: 18162-48-6
tert-butyldimethylsilyl chloride

: 65-46-3
CYTIDINE

: 438582-96-8
2'-O-(tert-butyldimethylsilyl)-3',5'-O-(di-tert-butylsilylene)cytidine

Conditions

Conditions	Yield
Stage #1: Di-tert-butyldichlorosilane; CYTIDINE With silver nitrate In N,N-dimethyl-formamide at 4 - 20℃; for 4h; Inert atmosphere; Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole In N,N-dimethyl-formamide at 60℃; for 15h; Inert atmosphere;	100%

...Expand

: 65-46-3
CYTIDINE

: 58-96-8
uridine

Conditions

Conditions	Yield
With cytidine deaminase enzyme In aq. phosphate buffer at 37℃; for 0.0833333h; pH=7; Enzymatic reaction;	99%
With oxygen; nitrogen(II) oxide In dimethyl sulfoxide for 1h; Ambient temperature;	47%
With sodium hydroxide at 90.1℃; Rate constant; Mechanism; various reagent concentration, decomposition to nonchromophoric products;

: 865-50-9
iodomethane-d3

: 65-46-3
CYTIDINE

: C10H13(2)H3N3O5(1+)*I(1-)

Conditions

Conditions	Yield
In N,N-dimethyl acetamide for 2.4h; Ambient temperature;	99%

: 65-46-3
CYTIDINE

: 74-88-4
methyl iodide

: 6-Amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-methyl-2-oxo-2,3-dihydro-pyrimidin-1-ium; iodide

Conditions

Conditions	Yield
In N,N-dimethyl acetamide for 2.4h; Ambient temperature;	99%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 65-46-3
CYTIDINE

: 4N-dimethylaminomethylene cytidine

Conditions

Conditions	Yield
at 20℃; for 5h; Condensation;	99%

: 874-60-2
4-methyl-benzoyl chloride

: 65-46-3
CYTIDINE

: 863592-01-2
4-N-2',3',5'-tri-O-tetra(4-methylbenzoyl)cytidine

Conditions

Conditions	Yield
With pyridine at 20℃;	99%
With pyridine at 20℃; for 3h;

: 108-24-7
acetic anhydride

: 65-46-3
CYTIDINE

: 2,3,5-O-acetyl-N-acetylcytidine

Conditions

Conditions	Yield
With lithium perchlorate for 10h; Heating;	99%

: 93-97-0
benzoic acid anhydride

: 65-46-3
CYTIDINE

: 13089-48-0
N4-benzoylcytidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.0166667h; Irradiation;	98%
In DMF (N,N-dimethyl-formamide) at 20℃; for 20h;	98.3%
In N,N-dimethyl-formamide at 20℃; for 20h;	98.3%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 65-46-3
CYTIDINE

: 72409-16-6, 82976-97-4
5'-O-(tert-butyldimethylsilyl)cytidine

Conditions

Conditions	Yield
With pyridine; dmap	98%
With pyridine; 1H-imidazole at 0 - 20℃; Inert atmosphere;	97%
With pyridine; 1H-imidazole at 0 - 20℃; for 12h; Inert atmosphere;	96%

: 65-46-3
CYTIDINE

: 69260-61-3
5'-chloro-5'-deoxy-2',3'-O-sulphinylcytidine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In acetonitrile for 0.75h; Heating;	98%

: 154068-67-4
dichloro-1,4-diazacycloheptaneplatinum(II)

: silver nitrate

: 65-46-3
CYTIDINE

: [Pt(II)(homopiperazine)(cytidine)2](NO3)2

Conditions

Conditions	Yield
With H2O In N,N-dimethyl-formamide byproducts: AgCl; AgNO3 added to soln. of Pt compd., mixt. stirred in dark for 5 d at 45°C, AgCl filtered, org. compd. added to filtrate and stirred for 96h; soln. filtered, concd. in vac., pptd. with acetone, product filtered, washed with CH2Cl2 and acetone, dried in vac.; elem. anal.;	98%

...Expand

: 138421-23-5
2-acetone-isobutyryl oxime

: 65-46-3
CYTIDINE

: 5'-O-isobutyrylcytidine

Conditions

Conditions	Yield
With Candida antarctica lipase B In 1,4-dioxane at 60℃; for 43h;	98%

: 77-76-9
2,2-dimethoxy-propane

: 65-46-3
CYTIDINE

: C12H17N3O5*H2O4S

Conditions

Conditions	Yield
With sulfuric acid In acetone at 20℃; Inert atmosphere;	98%
With sulfuric acid In acetone at 20℃; for 2h;	95.25%

: 3332-29-4
O-ethylhydroxylamine hydrochloride

: 65-46-3
CYTIDINE

: 1228271-25-7
N4-ethoxycytidine

Conditions

Conditions	Yield
With pyridine at 100℃;	97%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 65-46-3
CYTIDINE

: 69304-42-3
3',5'-O-[(1,1,3,3-tetraisopropyl)-1,3-disiloxanediyl]cytidine

Conditions

Conditions	Yield
With pyridine	96%
With pyridine	92%
With pyridine for 4h; cooling;	92%

: 108-24-7
acetic anhydride

: 65-46-3
CYTIDINE

: 3768-18-1
N-acetylcytidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 0.0111111h; Irradiation;	96%
In acetonitrile for 3h; Reflux;	96%
In N,N-dimethyl-formamide for 0.0111111h; Microwave radiation;	95%

: 98-88-4
benzoyl chloride

: 65-46-3
CYTIDINE

: 13089-48-0
N4-benzoylcytidine

Conditions

Conditions	Yield
With ammonium hydroxide; chloro-trimethyl-silane In pyridine; water; acetone	96%
With ammonium hydroxide; chloro-trimethyl-silane In pyridine; water; acetone	96%
Stage #1: CYTIDINE With pyridine; chloro-trimethyl-silane at 20℃; for 1.5h; Cooling with ice; Stage #2: benzoyl chloride at 20℃; Cooling with ice;	95%

: 586-75-4
4-chlorobenzoyl chloride

: 65-46-3
CYTIDINE

: 1386977-58-7
N4-p-bromobenzoylcytidine

Conditions

Conditions	Yield
Stage #1: CYTIDINE With pyridine; chloro-trimethyl-silane at 20℃; for 2h; Stage #2: 4-chlorobenzoyl chloride for 2h; Stage #3: With ammonia In water at 0℃; for 0.5h;	96%

: 67-64-1
acetone

: 65-46-3
CYTIDINE

: 362-42-5
2',3'-O-isopropylidenecytidine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃; for 6h; Cooling with ice;	95%
With sulfuric acid at 0 - 20℃; for 12h;	93%
Stage #1: acetone; CYTIDINE With perchloric acid at 20℃; for 1.5h; Stage #2: With ammonia In water at 20℃; for 3h;	74%

: 104-15-4
toluene-4-sulfonic acid

: 65-46-3
CYTIDINE

: 362-42-5
2',3'-O-isopropylidenecytidine

Conditions

Conditions	Yield
In acetone for 6h; Inert atmosphere;	95%

Cytidine Consensus Reports

Reported in EPA TSCA Inventory.

Cytidine Specification

The IUPAC name of Cytidine is 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one. With the CAS registry number 65-46-3, it is also named as 1-beta-D-Ribofuranosylcytosine. The product's categories are Pharmaceutical Intermediates; Fine Chemical & Intermediates; Pyridines, Pyrimidines, Purines and Pteredines; Biochemistry; Nucleosides and their Analogs; Nucleosides, Nucleotides & Related Reagents; Nucleic Acids, and the other registry numbers are 4395-95-3; 494210-74-1; 873077-03-3. Besides, it is white crystalline powder, which should be stored in dark, dry and sealed place at room temperature. It is a component of RNA which is attached to a deoxyribose ring. In addition, this chemical is stable and incompatible with strong oxidizing agents.

Physical properties about Cytidine are: (1)ACD/LogP: -1.808; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -1.82; (4)ACD/LogD (pH 7.4): -1.81; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 2.39; (8)ACD/KOC (pH 7.4): 2.47; (9)#H bond acceptors: 8; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.756; (13)Molar Refractivity: 52.643 cm³; (14)Molar Volume: 128.433 cm³; (15)Polarizability: 20.869 10-24cm³; (16)Surface Tension: 89.588996887207 dyne/cm; (17)Density: 1.894 g/cm³; (18)Flash Point: 283.816 °C; (19)Enthalpy of Vaporization: 94.8 kJ/mol; (20)Boiling Point: 545.678 °C at 760 mmHg

Preparation of Cytidine: this chemical can be prepared by 1-(2',3',4'-Tri-O-benzoyl-a-D-xylofuranosyl)-4-thiouracil.

Preparation of Cytidine

This reaction needs Ammonia and Methanol at temperature of 100 °C. The reaction time is 18 hours. The yield is 76 %.

Uses of Cytidine: it is used for biochemical research and organic synthesis. It is also used for producing cytarabine, ring cell, and CTP, cytidine diphosphate choline, etc.

When you are using this chemical, please be cautious about it as the following: it is possible risk of irreversible effects. You should avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1;
(2)InChIKey=UHDGCWIWMRVCDJ-XVFCMESISA-N;
(3)Smilesn1([C@@H]2O[C@H](CO)[C@H]([C@H]2O)O)c(nc(N)cc1)=O

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	2700mg/kg (2700mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Russian Pharmacology and Toxicology Vol. 40, Pg. 66, 1977.

Product Name

Cytidine

Synthetic route

Cytidine Consensus Reports

Cytidine Specification

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