Diethyl (2-oxopropyl)phosphonate supplier

Name
Diethyl (2-oxopropyl)phosphonate
EINECS 682-094-9
CAS No. 1067-71-6
Article Data87
CAS DataBase
Density 1.09 g/cm³
Solubility
Melting Point
Formula C₇H₁₅O₄P
Boiling Point 263.1 °C at 760 mmHg
Molecular Weight 194.167
Flash Point 126.9 °C
Transport Information
Appearance CLEAR COLORLESS TO LIGHT YELLOW LIQUID
Safety 24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phosphonicacid, (2-oxopropyl)-, diethyl ester (9CI);Phosphonic acid, acetonyl-, diethylester (6CI,7CI,8CI);1-Diethoxyphosphinyl-2-propanone;2-Oxopropylphosphonicacid diethyl ester;Diethyl(acetylmethyl)phosphonate;Diethyl 2-oxopropanephosphonate;Diethylacetonylphosphonate;Diethyl phosphonoacetone;NSC 408852;
PSA 62.41000
LogP 1.84150

Synthetic route

: 598-31-2
1-bromoacetone

: 122-52-1
triethyl phosphite

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
for 2h; Reflux;	100%
at 90℃; for 10h;	68%
at 90 - 160℃;

: 389827-60-5
[2-(Methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With hydrogenchloride; acetone for 3h; Ambient temperature;	94%

: 762-04-9
phosphonic acid diethyl ester

: 598-31-2
1-bromoacetone

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With C30H36B10CuO4P2; potassium carbonate at 20℃; for 7h; Time; Reagent/catalyst;	93%

: diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	91%

: 51533-70-1
diethyl (2-methylallyl)phosphonate

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dimethylsulfide; ozone In dichloromethane Oxidation;	88%

: 79-20-9
acetic acid methyl ester

: 683-08-9
Diethyl methylphosphonate

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 4.5h;	87%
With n-butyllithium In tetrahydrofuran at -78 - 20℃;

: 78-95-5
chloroacetone

: 122-52-1
triethyl phosphite

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
Stage #1: chloroacetone With potassium iodide In acetone at 20℃; for 2h; Stage #2: triethyl phosphite In diethyl ether; acetone for 2h; Reflux;	85%
With potassium iodide In acetone; acetonitrile at 20 - 50℃; for 10h;	83%
With sodium iodide In acetonitrile at 20℃;	51%

: 151026-96-9
diethyl 1-methylthio-2-oxo-n-propylphosphonate

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene for 1h; Heating;	81%

: ((E)-2-Pyrrolidin-1-yl-propenyl)-phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With oxalic acid; silica gel In dichloromethane for 1h; Ambient temperature;	80%

: 5954-65-4
diethyl ester of 2-methylvinylphosphonic acid

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With hydrogenchloride; water; oxygen; palladium dichloride at 85℃; for 20h;	80%

: 683-08-9
Diethyl methylphosphonate

XC(O)CH3: XC(O)CH3

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With n-butyllithium; lithium diisopropyl amide In tetrahydrofuran; hexane at -60℃;	78%

: 2466-76-4
N-Acetylimidazole

: 3095-95-2
diethylphosphonoacetic acid

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With triethylamine; magnesium chloride In acetonitrile at 20℃; for 24h; Acylation;	77%

: 762-04-9
phosphonic acid diethyl ester

: 123-54-6
acetylacetone

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique; chemoselective reaction;	76%

: 3019-04-3
iodoacetone

: 122-52-1
triethyl phosphite

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
In diethyl ether Arbuzov reaction;	75%

: 98732-76-4
E-1-Methyl-3-oxo-1-pentenylphosphonsaeurediethylester

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: phosphonsaeure-diethylester

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium carbonate In methanol; water for 30h; Ambient temperature;	A 6.9% B 74%

: 98732-74-2
E-1-Methyl-3-oxo-1-butenylphosphonsaeurediethylester

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: (trans-3-Acetyl-2-methyl-2-oxiranyl)phosphonsaeure-diethylester

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium carbonate In methanol; water at 20℃; for 48h;	A 8.2% B 72%

: 762-04-9
phosphonic acid diethyl ester

: 67-64-1
acetone

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water at 85℃; Inert atmosphere; Schlenk technique; chemoselective reaction;	72%

: 78-95-5
chloroacetone

: 122-52-1
triethyl phosphite

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

B: 5954-28-9
phosphoric acid diethyl ester isopropenyl ester

Conditions

Conditions	Yield
With potassium iodide In acetone; acetonitrile at 0℃; for 12h; Michaelis-Arbuzov reaction;	A 70% B n/a

...Expand

: 148599-29-5
2-methyl-2-phenylsulphonyloxirane

: 762-04-9
phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
other substituted arylsulfonyl epoxides; multistep reaction: synthesis of β-keto phosphonates;	70%
With sodium hydride 1) THF, mineral oil, rt, 10 min, 2) THF, rt, 30 min; Yield given. Multistep reaction;

: 111-34-2
-butyl vinyl ether

: 151026-96-9
diethyl 1-methylthio-2-oxo-n-propylphosphonate

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

B: [1-(2-Butoxy-ethyl)-2-oxo-propyl]-phosphonic acid diethyl ester

C: (1-Acetyl-3,5-dibutoxy-pentyl)-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With n-butyl tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 1h; Heating; Yields of byproduct given;	A n/a B 70% C n/a
With n-butyl tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 1h; Heating; Yields of byproduct given;	A n/a B n/a C 37%

...Expand

: 141-97-9
ethyl acetoacetate

: 762-04-9
phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	70%

: 762-04-9
phosphonic acid diethyl ester

: 2235-46-3
N,N-diethyl-3-oxobutanamide

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	66%

: 917-54-4
methyllithium

: 146036-63-7, 124050-38-0
2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

B: 124050-39-1
diethyl (1-fluoro-2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With copper(l) iodide; dimethylsulfide In tetrahydrofuran; diethyl ether 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;	A 20% B 62%

...Expand

: 146036-63-7, 124050-38-0
2-(diethoxyphosphinyl)-2-fluoro-acetic acid chloride

MeCu*LiMe: MeCu*LiMe

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

B: 124050-39-1
diethyl (1-fluoro-2-oxopropyl)phosphonate

Conditions

Conditions	Yield
at -78 - -45℃; for 3h;	A 20% B 62%

...Expand

: 2044-64-6
N,N-Dimethylacetoacetamid

: 762-04-9
phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	62%

: 5396-89-4
benzyl acetoacetate

: 762-04-9
phosphonic acid diethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 24h; Inert atmosphere; Schlenk technique; chemoselective reaction;	60%

: 762-04-9
phosphonic acid diethyl ester

: 123-54-6
acetylacetone

A: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

B: diethyl (2-hydroxy-4-oxopent-2-en-3-yl)phosphonate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 4h; Time; Inert atmosphere; Schlenk technique; chemoselective reaction;	A 58% B 20%
With dipotassium peroxodisulfate; silver(I) acetate In water; N,N-dimethyl-formamide at 85℃; for 0.5h; Time; Inert atmosphere; Schlenk technique; chemoselective reaction;	A 23% B 53%

...Expand

: 34170-81-5
diethyl (2-chloro-2-oxoethyl)phosphonate

: 917-54-4
methyllithium

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With copper(l) iodide; dimethylsulfide In tetrahydrofuran; diethyl ether 1.) from -78 deg C to -45 deg C; 2.) -45 deg C, 2.5 h;	55%

: 34170-81-5
diethyl (2-chloro-2-oxoethyl)phosphonate

(CH3)2CuLi: (CH3)2CuLi

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
In tetrahydrofuran; diethyl ether -78 deg C to -40 deg C; -40 deg C, 90 min;	55%

: diethyl ((2R,3R)-3-(hydroxymethyl)oxiran-2-yl)phosphonate

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With diethylamino-sulfur trifluoride In dichloromethane at -84 - 20℃; for 4h;	51%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 100-52-7
benzaldehyde

: 1896-62-4
(E)-benzalacetone

Conditions

Conditions	Yield
With potassium carbonate In water at 20℃; for 15h;	100%
With potassium carbonate In water at 20℃; for 18h;	100%
With potassium carbonate In water at 20℃; for 18h; other aldehyde;	100%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 68426-09-5
(4-methoxyphenoxy)acetaldehyde

: (E)-5-(4-methoxyphenoxy)pent-3-en-2-one

Conditions

Conditions	Yield
With potassium carbonate In water at 0 - 20℃; for 1h; Wadsworth-Emmonds-Horner reaction;	100%

: 104-53-0
3-phenyl-propionaldehyde

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 33046-41-2, 56161-62-7
(E)-6-phenyl-3-hexen-2-one

Conditions

Conditions	Yield
Stage #1: Diethyl (2-oxopropyl)phosphonate With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride In acetonitrile at 23℃; for 0.25h; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Stage #2: 3-phenyl-propionaldehyde In acetonitrile at 0 - 23℃; for 0.5h; Inert atmosphere;	99%
With lithium hydroxide monohydrate In tetrahydrofuran at 0℃; for 2h;	85%
Stage #1: Diethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran for 0.0833333h; Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran	82%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 19790-60-4
3-Benzyloxypropanal

: 34591-98-5
(E)-6-(benzyloxy)hex-3-en-2-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;	99%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 1122-91-4
4-bromo-benzaldehyde

: 20511-04-0, 3815-31-4
(E)-4-(4-bromophenyl)but-3-ene-2-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;	99%
Stage #1: Diethyl (2-oxopropyl)phosphonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 4-bromo-benzaldehyde In tetrahydrofuran at 0℃; for 2h; Horner-Emmons reaction;	81%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran Horner-Emmons reaction;

: 872-85-5
pyridine-4-carbaldehyde

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 94445-75-7
4-(pyridin-4-yl)-3-buten-2-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;	99%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: diethyl (+)-(R)-2-hydroxypropanephosphonate

Conditions

Conditions	Yield
With RuCl2((R)-binap)(dmf)n; hydrogen In methanol at 50℃; under 3040 Torr; for 50h;	98%
With baker's yeast In water at 28 - 30℃; for 120h;	78%
With Geotrichum candidum IFO 4597 In water; isopropyl alcohol at 30℃; for 96h;	72%
With (R)-TriMe-NAPhePHOS; hydrogen bromide; hydrogen; [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II) In ethanol at 50℃; under 7500.6 Torr; for 24h;
With Rhodotorula rubra; chloroacetic acid ethyl ester

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 837364-61-1
Ethyl-{5-[3-formyl-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester

: Ethyl-{4-methyl-5-[3-(3-oxo-but-1-enyl)-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-yl]-pyridin-3-ylmethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran; water at 20℃; for 20h;	98%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 21047-57-4
diethyl (1-diazo-2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With 4-toluenesulfonyl azide; triethylamine In acetonitrile Inert atmosphere;	97%
With 4-acetamidobenzenesulfonyl azide; triethylamine In acetonitrile at 0 - 20℃;	95%
With 4-toluenesulfonyl azide; sodium hydride In tetrahydrofuran	91%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 472965-44-9
4-(14-bromo-tetradec-2-ynyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 472965-45-0
4-[17-(diethoxy-phosphoryl)-16-oxo-heptadec-2-ynyloxymethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: Diethyl (2-oxopropyl)phosphonate With n-butyllithium; sodium hydride In tetrahydrofuran at -78℃; Stage #2: 4-(14-bromo-tetradec-2-ynyloxymethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester In tetrahydrofuran Further stages.;	97%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 123-11-5
4-methoxy-benzaldehyde

: 3815-30-3
4-(4-methoxyphenyl)-3-buten-2-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 16h; Inert atmosphere;	97%
With lithium hydroxide In tetrahydrofuran at 0 - 23℃; Horner-Wadsworth-Emmons reaction;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 620-23-5
m-tolyl aldehyde

: 15753-84-1, 95416-57-2
(E)-4-(m-tolyl)but-3-en-2-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane; water at 20℃; for 3h; Inert atmosphere;	97%
With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 2h; Inert atmosphere;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 34713-70-7
2-Phenylpropanal

: 60405-50-7
5-phenyl-3-hexene-2-one

Conditions

Conditions	Yield
barium dihydroxide In 1,4-dioxane at 70℃; for 0.166667h; Product distribution; further method; further 2-oxoalkanephosphonates;	96%
barium dihydroxide In 1,4-dioxane at 70℃; for 0.166667h;	96%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 86429-26-7
(+/-)-3,3-dimethyl-2-phenylbutanal

: (E)-6,6-Dimethyl-5-phenyl-hept-3-en-2-one

Conditions

Conditions	Yield
barium dihydroxide In 1,4-dioxane at 70℃; for 0.25h;	96%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 1846-67-9
hept-2-ynal

: 63922-98-5
trans-3-decen-5-yn-2-one

Conditions

Conditions	Yield
With potassium carbonate In water	96%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 555-16-8
4-nitrobenzaldehdye

: 57-13-6
urea

: 5-(O,O-diethylphosphoryl)-6-methyl-4-(4-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In acetonitrile for 24h; Biginelli Pyrimidone Synthesis; Reflux;	96%
With zinc trifluoromethanesulfonate In toluene for 3h; Reflux; Green chemistry;	86%
ytterbium trifluoromethanesulfonate In toluene for 12h; Heating;	58%

...Expand

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 20180-08-9
(R,S)-Diethyl-(2-hydroxypropyl)phosphonat

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at 0℃;	95%
With pyridine; sodium tetrahydroborate In ethanol 1.) -30 deg C, 10 min, 2.) r.t., 45 min;	89%
With diethyl ether Irradiation;
With sodium tetrahydroborate In ethanol for 2h; Reduction;
With sodium tetrahydroborate In methanol at 0 - 20℃;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 98934-28-2
diethoxyphosphinyl-3 N,N-dimethylamino-4 butene-3 one-2

Conditions

Conditions	Yield
With calcium chloride for 2h; Heating;	95%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 109-73-9
N-butylamine

: 82101-95-9
N-[(1-methyl-2-diethoxyphosphoryl)ethyl]-N-n-butylamine

Conditions

Conditions	Yield
With hydrogenchloride; sodium cyanoborohydride In methanol for 4h; Ambient temperature;	95%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 6780-49-0
ethyl N-phenylformimidate

: {2-Oxo-1-[1-phenylamino-meth-(E)-ylidene]-propyl}-phosphonic acid diethyl ester

Conditions

Conditions	Yield
at 130℃; for 8h;	95%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 2158-14-7
4-acetamidobenzenesulfonyl azide

: 21047-57-4
diethyl (1-diazo-2-oxopropyl)phosphonate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0 - 20℃; Inert atmosphere;	95%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 28663-68-5
ethyl (phenylhydrazono)chloroacetate

: 81153-64-2
5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h; regioselective reaction;	95%
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h; regioselective reaction;	95%
With lithium hydroxide In 1,2-dimethoxyethane at 20℃; for 10h;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 74-88-4
methyl iodide

: (E)-9,9-Dimethoxy-non-3-en-2-one

Conditions

Conditions	Yield
With sodium hydride	94%

: 97-96-1
2-Ethylbutyraldehyde

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 147224-13-3
5-ethyl-hept-3-en-2-one

Conditions

Conditions	Yield
With potassium carbonate In water at 100℃; for 0.166667h;	93%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 111252-30-3
α-diethoxyphosphoryl-α,α-dichloroacetone

Conditions

Conditions	Yield
With sulfuryl dichloride In dichloromethane for 2h;	93%
With chlorine In tetrachloromethane at 0℃; for 2h;	93%

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 106-95-6
allyl bromide

: diethyl <2-hydroxy-2-methyl-4-pentenyl>phosphonate

Conditions

Conditions	Yield
With indium In tetrahydrofuran at 20℃; for 0.583333h;	93%
With zinc 1.) THF, room temperature, 2.) THF, -78 deg C, 30 min; Yield given; Multistep reaction;

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 3-hydroxy-2,2-dimethyl-6-methylenecyclohexanecarbaldehyde

: 357924-22-2
8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]octan-7-ol

: 357924-23-3
1-(8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]oct-7-yl)acetone

Conditions

Conditions	Yield
Stage #1: Diethyl (2-oxopropyl)phosphonate With barium dihydroxide at 140℃; for 2h; Stage #2: 3-hydroxy-2,2-dimethyl-6-methylenecyclohexanecarbaldehyde; 8,8-dimethyl-2-methylene-6-oxabicyclo[3.2.1]octan-7-ol In tetrahydrofuran; water at 20℃; for 30h; Further stages.;	92%

...Expand

Diethyl (2-oxopropyl)phosphonate Chemical Properties

Molecule structure of Phosphonic acid,P-(2-oxopropyl)-, diethyl ester (CAS NO.1067-71-6):

IUPAC Name: 1-Diethoxyphosphorylpropan-2-one
Molecular Weight: 194.165361 [g/mol]
Molecular Formula: C₇H₁₅O₄P
Index of Refraction: 1.417
Molar Refractivity: 44.87 cm³
Molar Volume: 178 cm³
Surface Tension: 33.1 dyne/cm
Density: 1.09 g/cm³
Flash Point: 126.9 °C
Enthalpy of Vaporization: 50.09 kJ/mol
Melting Point: 126 °C at 9 mm Hg(lit.)
Boiling Point: 263.1 °C at 760 mmHg
Vapour Pressure: 0.0105 mmHg at 25 °C
H-Bond Acceptor: 4
Rotatable Bond Count: 6
Tautomer Count: 3
Exact Mass: 194.070795
MonoIsotopic Mass: 194.070795
Topological Polar Surface Area: 52.6
Heavy Atom Count: 12
Canonical SMILES: CCOP(=O)(CC(=O)C)OCC
InChI: InChI=1S/C7H15O4P/c1-4-10-12(9,11-5-2)6-7(3)8/h4-6H2,1-3H3
InChIKey: RSAFKRSMGOSHRK-UHFFFAOYSA-N
Product Categories: C-C Bond Formation; Horner-Wadsworth-Emmons Reagents; Olefination

Diethyl (2-oxopropyl)phosphonate Safety Profile

Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3

Diethyl (2-oxopropyl)phosphonate Specification

Phosphonic acid,P-(2-oxopropyl)-, diethyl ester (CAS NO.1067-71-6) is also called Diethyl acetonylphosphonate ; Diethyl (2-oxopropyl)phosphonate ; (2-Oxo-propyl)-phosphonicaciddiethylester .

Product Name

Diethyl (2-oxopropyl)phosphonate

Synthetic route

Diethyl (2-oxopropyl)phosphonate Chemical Properties

Diethyl (2-oxopropyl)phosphonate Safety Profile

Diethyl (2-oxopropyl)phosphonate Specification

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