Ethyl2-(2-methoxyphenoxy)acetate supplier

Name
ETHYL 2-METHOXYPHENOXYACETATE
EINECS 235-977-4
CAS No. 13078-21-2
Article Data33
CAS DataBase
Density 1.103 g/cm³
Solubility
Melting Point
Formula C₁₁H₁₄O₄
Boiling Point 278.7 °C at 760 mmHg
Molecular Weight 210.23
Flash Point 118 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aceticacid, (2-methoxyphenoxy)-, ethyl ester (9CI);Acetic acid, (o-methoxyphenoxy)-,ethyl ester (6CI,7CI,8CI);Ethyl 2-(2-methoxyphenoxy)acetate;Ethyl (2-methoxyphenoxy)acetate;AC1L34QH;AC1Q65CB;CID83114;
PSA 44.76000
LogP 1.63710

Synthetic route

: 105-36-2
ethyl bromoacetate

: 90-05-1
2-methoxy-phenol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetone Reflux;	99%
Stage #1: 2-methoxy-phenol With potassium carbonate In acetone at 20℃; for 0.25h; Inert atmosphere; Stage #2: ethyl bromoacetate In acetone at 0℃; for 8h; Inert atmosphere; Reflux;	90%
Stage #1: 2-methoxy-phenol With potassium carbonate In acetone at 20℃; for 0.25h; Stage #2: ethyl bromoacetate In acetone at 20 - 65℃;	90%

: 64-17-5
ethanol

: 1878-85-9
(2-methoxyphenoxy)acetic acid

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 20℃;	92%
With toluene-4-sulfonic acid for 5h; Heating;

: 105-39-5
chloroacetic acid ethyl ester

: 90-05-1
2-methoxy-phenol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
With ethanol; sodium
With potassium carbonate; potassium iodide In acetone
With potassium carbonate In acetone for 15h; Heating;

: 10535-17-8
1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium formate / water / 15 h / 110 °C 2: potassium carbonate / acetonitrile View Scheme
Multi-step reaction with 3 steps 1: water / 15 h / 110 °C 2: zinc; formic acid / water / 7 h / 110 °C / Sealed tube 3: potassium carbonate / acetonitrile View Scheme
Multi-step reaction with 3 steps 1: zinc / water / 7 h / 100 °C / Sealed tube 2: zinc; formic acid / water / 7 h / 110 °C / Sealed tube 3: potassium carbonate / acetonitrile View Scheme

: C19H20O7

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: zinc; formic acid / water / 7 h / 110 °C / Sealed tube 2: potassium carbonate / acetonitrile View Scheme

: 56122-34-0
1-(4-hydroxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: formic acid; sodium formate / water / 110 °C 2: potassium carbonate / acetonitrile View Scheme

: 2-(2-methoxyphenoxy)-1-phenylethan-1-ol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 130 °C / Inert atmosphere 2.1: potassium carbonate / acetone / 0.25 h / 20 °C 2.2: 20 - 65 °C View Scheme

: 14385-48-9
2-(2-methoxyphenoxy)-acetophenone

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 25 °C 2.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 130 °C / Inert atmosphere 3.1: potassium carbonate / acetone / 0.25 h / 20 °C 3.2: 20 - 65 °C View Scheme

: 1-(3-methoxylphenyl)-2-(2-methoxyphenoxy)ethanone

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 25 °C 2.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 150 °C / Inert atmosphere 3.1: potassium carbonate / acetone / 0.25 h / 20 °C 3.2: 20 - 65 °C View Scheme

: 19513-80-5
2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-one

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate / methanol / 4 h / 25 °C 2.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 150 °C / Inert atmosphere 3.1: potassium carbonate / acetone / 0.25 h / 20 °C 3.2: 20 - 65 °C View Scheme

: 1-(3-methoxyphenyl)ethylene glycol-β-guaiacyl ether

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 150 °C / Inert atmosphere 2.1: potassium carbonate / acetone / 0.25 h / 20 °C 2.2: 20 - 65 °C View Scheme

: 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethan-1-ol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: nano-Pd1Ni4 /MIL-100(Fe) / water / 6 h / 150 °C / Inert atmosphere 2.1: potassium carbonate / acetone / 0.25 h / 20 °C 2.2: 20 - 65 °C View Scheme

: 7382-59-4
guaiacylglycerol-β-guaiacyl ether

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium t-butanolate; oxygen / tert-butyl alcohol / 16 h / 30 °C / 760.05 Torr / Green chemistry 2.1: potassium carbonate / acetone / 0.5 h / Reflux 2.2: 12 h / Reflux View Scheme

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-phenylpropanoate

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 60 °C 2.1: sodium t-butanolate; oxygen / tert-butyl alcohol / 16 h / 30 °C / 760.05 Torr / Green chemistry 3.1: potassium carbonate / acetone / 0.5 h / Reflux 3.2: 12 h / Reflux View Scheme

: ethyl 2-(2'-methoxyphenoxy)-3-hydroxy-3-(4''-hydroxy-3''-methoxyphenyl) propanoate

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 60 °C 2.1: sodium t-butanolate; oxygen / tert-butyl alcohol / 16 h / 30 °C / 760.05 Torr / Green chemistry 3.1: potassium carbonate / acetone / 0.5 h / Reflux 3.2: 12 h / Reflux View Scheme

: 227300-29-0
2-(2-methoxyphenoxy)-1-phenylpropane-1,3-diol

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium t-butanolate; oxygen / tert-butyl alcohol / 16 h / 30 °C / 760.05 Torr / Green chemistry 2.1: potassium carbonate / acetone / 0.5 h / Reflux 2.2: 12 h / Reflux View Scheme

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 1878-85-9
(2-methoxyphenoxy)acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol; water at 20℃; Inert atmosphere;	99%
With sodium hydroxide; water In methanol
With potassium hydroxide In ethanol; water at 20℃; for 1.5h;
With water; sodium hydroxide In ethanol at 20℃; for 4h;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 100-52-7
benzaldehyde

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-phenylpropanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2.5h; Stage #2: benzaldehyde In tetrahydrofuran at -78℃; for 2.5h;	85%
With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.5h;	53.4%
With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: erythro-1-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78℃;	84%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1416781-26-4
ethyl-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)-3-methylpropanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78 - 0℃; for 0.583333h; Inert atmosphere; Stage #2: 1-(3,4-dimethoxyphenyl)ethanone In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere;	83%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: ethyl 3-hydroxy-3-(3,4,5-trimethoxyphenyl)-2-(methoxyphenyloxy)propionate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1h; Aldol Condensation; Stage #2: 3,4,5-trimethoxy-benzaldehyde In tetrahydrofuran at -78℃; for 3h;	76%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 123-11-5
4-methoxy-benzaldehyde

: ethyl 3-hydroxy-3-(4-methoxyphenyl)-2-(methoxyphenyloxy)propionate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1h; Aldol Condensation; Stage #2: 4-methoxy-benzaldehyde In tetrahydrofuran at -78℃; for 3h;	70%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 107967-88-4
ortho-anisoxyacetic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 12h; Heating;	65%
With hydrazine hydrate In ethanol for 3h; Heating;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 6527-32-8
4-(benzyloxy)-3,5-dimethoxybenzaldehyde

: 136863-17-7
1-<3,5-Dimethoxyphenyl-4-(phenylmethoxy)phenyl>-2-carbethoxy-2-(2-methoxyphenoxy)ethanol

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1h; Stage #2: 4-(benzyloxy)-3,5-dimethoxybenzaldehyde In tetrahydrofuran; hexane at -78℃; for 3h;	56%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 94687-10-2
ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.5h;	52.9%
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 45℃; for 2h; Inert atmosphere;	40%
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;	37%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 120-14-9
3,4-dimethoxy-benzaldehyde

: erythro-ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; optical yield given as %de;	52%
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; for 1h; Aldol Condensation; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at -78℃; for 3h;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-(3,4,5-trimethoxyphenyl)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 3,4,5-trimethoxy-benzaldehyde In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;	42%
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran Stage #2: 3,4,5-trimethoxy-benzaldehyde In tetrahydrofuran at -78 - 20℃;
With lithium diisopropyl amide

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 6527-32-8
4-(benzyloxy)-3,5-dimethoxybenzaldehyde

: 151541-15-0
ethyl 3-(4-(benzyloxy)-3,5-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 4-(benzyloxy)-3,5-dimethoxybenzaldehyde In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;	41%
With lithium diisopropyl amide In tetrahydrofuran at -70℃; Addition;
With lithium diisopropyl amide In tetrahydrofuran at -78℃;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 135-02-4
ortho-anisaldehyde

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-(2-methoxyphenyl)propanoate

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.5h;	38.4%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 591-31-1
3-methoxy-benzaldehyde

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-(3-methoxyphenyl)propaneate

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.5h;	38.4%

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 120-14-9
3,4-dimethoxy-benzaldehyde

: ethyl (2R*,3S*)-3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

: erythro-ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.5h; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at -78℃; for 3h; Stage #3: With water In tetrahydrofuran	A 6% B 34%
With lithium diisopropyl amide	A n/a B n/a
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With sodium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.166667h; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at -78 - 20℃; for 2h; Overall yield = 42 %; Overall yield = 1.59 g;

...Expand

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: erythro-ethyl 3-(4-benzyloxy-3-methoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

: threo-ethyl 3-(4-benzyloxy-3-methoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 3-methoxy-4-(phenylmethoxy)benzaldehyde In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere; optical yield given as %de; diastereoselective reaction;	A 30% B n/a

...Expand

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 123-11-5
4-methoxy-benzaldehyde

: ethyl 3-hydroxy-2-(2-methoxyphenoxy)-3-(4-methoxyphenyl)propanoate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.16667h; Inert atmosphere; Stage #2: 4-methoxy-benzaldehyde In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;	28%
With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1.5h;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 790-16-9
4-benzoyloxy-3-methoxybenzaldehyde

: ethyl erythro-3-(4-(benzoyloxy)-3-methoxyphenyl)-2-(2-methoxyphenoxy)-3-hydroxypropionate

: ethyl threo-3-(4-(benzoyloxy)-3-methoxyphenyl)-2-(2-methoxyphenoxy)-3-hydroxypropionate

Conditions

Conditions	Yield
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With n-butyllithium; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; Stage #2: 4-benzoyloxy-3-methoxybenzaldehyde In tetrahydrofuran at -78℃; for 3h;	A 25% B 20%

...Expand

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 100-44-7
benzyl chloride

: ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

: 58497-34-0
Ethyl β-hydroxy-3-methoxy-α-(2-methoxyphenoxy)-4-(phenylmethoxy)benzenepropanoate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium chloride; sodium hydroxide In water; toluene at 90℃; for 2h; Reflux;	A 2% B 3%

...Expand

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 183427-87-4
2-(2-methoxyphenoxy)acetamide

Conditions

Conditions	Yield
With ammonia

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 100-36-7
N,N-diethylethylenediamine

: 47083-20-5
N,N-Diethyl-N'-<(2-methoxy-phenoxy)-acetyl>-ethylendiamin

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 58497-34-0
Ethyl β-hydroxy-3-methoxy-α-(2-methoxyphenoxy)-4-(phenylmethoxy)benzenepropanoate

Conditions

Conditions	Yield
With lithium diisopropyl amide 1.) THF, -75 deg C, 2.) THF, -75 deg C; Yield given. Multistep reaction;
With lithium diisopropyl amide In tetrahydrofuran at -78℃;

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 6527-32-8
4-(benzyloxy)-3,5-dimethoxybenzaldehyde

: 136863-17-7
1-<3,5-Dimethoxyphenyl-4-(phenylmethoxy)phenyl>-2-carbethoxy-2-(2-methoxyphenoxy)ethanol

: 136863-17-7
1-<3,5-Dimethoxyphenyl-4-(phenylmethoxy)phenyl>-2-carbethoxy-2-(2-methoxyphenoxy)ethanol

Conditions

Conditions	Yield
With lithium diisopropyl amide 1.) THF, -75 dg C, 2.) THF, -75 deg C; Yield given. Multistep reaction. Yields of byproduct given;
With lithium diisopropyl amide 1.) THF, -75 deg C, 2.) THF, -75 deg C; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 7572-96-5
1-(3,4-Dimethoxyphenyl)-2-carbethoxy-2-(2-methoxyphenoxy)ethanol

Conditions

Conditions	Yield
With lithium diisopropyl amide 1.) THF, -75 deg C, 2.) THF, -75 deg C, 90 min; Yield given. Multistep reaction;
Stage #1: ethyl 2-(2-methoxyphenoxy)acetate With lithium diisopropyl amide In tetrahydrofuran at -78 - 20℃; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: 15267-78-4
(2-Methoxy-phenoxy)-acethydroxamsaeure

Conditions

Conditions	Yield
With hydroxylamine; sodium methylate In methanol

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 13078-21-2
ethyl 2-(2-methoxyphenoxy)acetate

: ethyl 3-(4-(benzyloxy)-3-methoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -70℃; Addition;
With lithium diisopropyl amide In tetrahydrofuran at -78℃;

Ethyl2-(2-methoxyphenoxy)acetate Specification

The Acetic acid,2-(2-methoxyphenoxy)-, ethyl ester with CAS registry number of 13078-21-2 is also known as Ethyl (2-methoxyphenoxy)acetate. The IUPAC name is Ethyl 2-(2-methoxyphenoxy)acetate. Its EINECS registry number is 235-977-4. In addition, the formula is C₁₁H₁₄O₄ and the molecular weight is 210.23.

Physical properties about Acetic acid,2-(2-methoxyphenoxy)-, ethyl ester are: (1)ACD/LogP: 1.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.76; (4)ACD/LogD (pH 7.4): 1.76; (5)ACD/BCF (pH 5.5): 12.86; (6)ACD/BCF (pH 7.4): 12.86; (7)ACD/KOC (pH 5.5): 216.55; (8)ACD/KOC (pH 7.4): 216.55; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 44.76Å²; (13)Index of Refraction: 1.492; (14)Molar Refractivity: 55.28 cm³; (15)Molar Volume: 190.4 cm³; (16)Polarizability: 21.91×10^-24cm³; (17)Surface Tension: 35.4 dyne/cm; (18)Density: 1.103 g/cm³; (19)Flash Point: 118 °C; (20)Enthalpy of Vaporization: 51.74 kJ/mol; (21)Boiling Point: 278.7 °C at 760 mmHg; (22)Vapour Pressure: 0.00419 mmHg at 25 °C.

Uses of Acetic acid,2-(2-methoxyphenoxy)-, ethyl ester: it is used to produce (2-Methoxy-phenoxy)-acetic acid hydrazide. The reaction occurs with reagent Hydrazine hydrate and solvent Ethanol. Besides, the reaction needs other condition of heating for 12 hours. The yield is 65%.

Acetic acid, 2-(2-methoxyphenoxy)-, ethyl ester is used to produce (2-Methoxy-phenoxy)-acetic acid hydrazide.

You can still convert the following datas into molecular structure:
1. SMILES: O=C(OCC)COc1ccccc1OC
2. InChI: InChI=1/C11H14O4/c1-3-14-11(12)8-15-10-7-5-4-6-9(10)13-2/h4-7H,3,8H2,1-2H3
3. InChIKey: BZCGGCRVJFWCIW-UHFFFAOYAV
4. Std. InChI: InChI=1S/C11H14O4/c1-3-14-11(12)8-15-10-7-5-4-6-9(10)13-2/h4-7H,3,8H2,1-2H3
5. Std. InChIKey: BZCGGCRVJFWCIW-UHFFFAOYSA-N

Product Name

ETHYL 2-METHOXYPHENOXYACETATE

Synthetic route

Ethyl2-(2-methoxyphenoxy)acetate Specification

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