Glycine supplier | CasNO.56-40-6

Name
Glycine
EINECS 200-272-2
CAS No. 56-40-6
Article Data717
CAS DataBase
Density 1.254 g/cm³
Solubility 25 g/100 mL (25 °C) in water
Melting Point 240 °C (dec.)(lit.)
Formula C₂H₅NO₂
Boiling Point 240.937 °C at 760 mmHg
Molecular Weight 75.0672
Flash Point 99.516 °C
Transport Information
Appearance White crystalline powder
Safety 22-24/25
Risk Codes 33
Molecular Structure
Hazard Symbols
Synonyms L-Glycine;FEMA No. 3287;Leimzucker;aminoacetic acid;Glicoamin;Padil;Gly;Glyzin;Glycolixir;Glycosthene;2-Aminoacetic acid;Glycine (JP14/USP);Glycin;Amitone;Glycocoll;Glycine food grade;Aminoacetic acid(Glycine);H-Gly-OH (Physic Grade);H-Gly-OH;
PSA 63.32000
LogP -0.27000

Synthetic route

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 56-40-6
glycine

Conditions

Conditions	Yield
With hydrogen; sodium hydroxide; sodium tetrachloropalladate(II) In methanol at 30℃; for 1h; Product distribution; donor: cyclohexene; deprotecting of various N-protected amino acids and dipeptides by subjecting then to hydrogen transfer with several palladium catalysts supported on different solids;	100%
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 2h;	94%
With palladium 10% on activated carbon; hydrogen at 20℃; for 24h; Neat (no solvent);	90%
With hydrogen; K3[Co(CN)5] In methanol at 20℃; for 3h;	86%
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction;

: 15455-96-6
ammonium chloroacetate

: 56-40-6
glycine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol at 62 - 67℃; for 4.5h; Temperature; Reagent/catalyst; Solvent;	99.1%
at 19.9℃; under 45003600 Torr; Product distribution; under shear deformation (360 deg);	1.05%

: 79-11-8
chloroacetic acid

: 56-40-6
glycine

Conditions

Conditions	Yield
With hexamethylenetetramine; N,N-diethylbenzylamine; ammonia In methanol at 60 - 65℃; for 4.5h; pH=7.1;	97.1%
With hexamethylenetetramine; ammonia In water at 70℃; for 0.333333h; pH=7; Substitution;	86%
With ammonium bicarbonate; urea In water at 115℃; Green chemistry;	78%

: 1738-68-7
Gly-OBz

: 56-40-6
glycine

Conditions

Conditions	Yield
With aluminum oxide at 75℃; for 0.0666667h; microwave irradiation;	95%
With hydrogen; K3[Co(CN)5] In methanol at 20℃; for 3h;	90%
With hydrogen In methanol

: 1668-10-6
glycinamide hydrochloride

: 56-40-6
glycine

Conditions

Conditions	Yield
Stage #1: glycinamide hydrochloride With sodium hydroxide In water Stage #2: In water at 130℃; for 1h; Reagent/catalyst;	94.5%

: 4530-20-5
BOC-glycine

: 56-40-6
glycine

Conditions

Conditions	Yield
With tetradecyl(trihexyl)phosphonium bistriflamide; trifluoroacetic acid at 130℃; for 0.116667h; Ionic liquid;	93%
With methanol; Amberlyst 15; ammonia 1.) CH2Cl2, 25 deg C, 5 h, 2.) 50 min; Yield given. Multistep reaction;
With trifluoroacetic acid In dichloromethane at 20℃; for 1h;
With hydrogenchloride In tetrahydrofuran; water at 20℃; for 3h;

: 117256-70-9
C8H14BOCOCH2NH2

: 56-40-6
glycine

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20℃; for 0.5h; Inert atmosphere;	93%

: 90711-56-1
2-[{(allyloxy)carbonyl}amino]acetic acid

A: 187737-37-7
propene

B: 56-40-6
glycine

Conditions

Conditions	Yield
With formic acid; triphenylphosphine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex In tetrahydrofuran at 30℃; for 1h;	A n/a B 90%

: 473-90-5
acetonedicarboxylic acid

: 56-40-6
glycine

Conditions

Conditions	Yield
With iron sulfide; ammonium carbonate In water at 100℃; for 144h;	86%

: 4596-53-6
N-[[(4-Nitrophenyl)methoxy]carbonyl]glycine

: 56-40-6
glycine

Conditions

Conditions	Yield
With sodium hydroxide; sodium dithionite	85%

: 298-12-4
Glyoxilic acid

: 56-40-6
glycine

Conditions

Conditions	Yield
With iron sulfide; ammonium carbonate In water at 100℃; for 144h;	80%
With ammonia; water; palladium Hydrogenation;
With ethylenediaminetetraacetic acid; cetyltrimethylammonium chloride; N-Phenylglycine; DPL at 30℃; Product distribution; potassium phosphate buffer (pH 7.8); variation of incubation time, pH and DPL concentration;

: 75-09-2
dichloromethane

: 6456-74-2
Glycine tert-butyl ester

: 56-40-6
glycine

Conditions

Conditions	Yield
With dmap	75%

: 22356-89-4
glycine methylamide

: 56-40-6
glycine

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	75%

: 5680-79-5
glycine ethyl ester hydrochloride

: 56-40-6
glycine

Conditions

Conditions	Yield
With sodium hydrogen telluride In N,N-dimethyl-formamide at 70℃; for 2h;	74%

: 56187-40-7
(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-acetic acid

A: 74197-53-8
3,5-Dinitro-1-phenyl-1H-pyridin-4-one

B: 56-40-6
glycine

Conditions

Conditions	Yield
With aniline In pyridine; water Ambient temperature;	A n/a B 70%

: 64-69-7
Iodoacetic acid

: 56-40-6
glycine

Conditions

Conditions	Yield
With ammonium bicarbonate Ambient temperature; detonation; also with (NH4)2CO3;	67%

: 540-61-4
2-aminoacetonitrile

A: 56-40-6
glycine

B: 598-41-4
H-Gly-NH2

Conditions

Conditions	Yield
With water In aq. buffer at 10 - 30℃; for 300h; pH=11; Kinetics; Mechanism; Inert atmosphere; Electrolysis;	A 10% B 65%

: 67-56-1
methanol

: 673-08-5
YG

A: 538-86-3
benzyl methyl ether

B: 56-40-6
glycine

Conditions

Conditions	Yield
With potassium hydroxide; [bis(acetoxy)iodo]benzene at 0 - 5℃; for 1.5h;	A 62% B n/a

...Expand

: 83316-92-1
glycine phenacyl ester

A: 106-57-0
Glycine anhydride

B: 582-24-1
1-phenyl-2-hydroxyethanone

C: 56-40-6
glycine

Conditions

Conditions	Yield
With triethylamine hydrochloride In N,N-dimethyl-formamide for 24h; Product distribution; Ambient temperature;	A 55% B n/a C 39%

...Expand

: 632-12-2
(RS)-isoserine

: 56-40-6
glycine

Conditions

Conditions	Yield
In water at 10 - 20℃; for 1.5h; Product distribution; Mechanism; electrolysis;	50%

: 88981-32-2
H-Gly-Aep(OMe)-Gly-OEt

A: 88981-33-3
H-Gly-Aep(OLi)-Gly-OLi

B: 56-40-6
glycine

Conditions

Conditions	Yield
With lithium hydroxide In ethanol for 20h; Ambient temperature; Title compound not separated from byproducts;	A 50% B n/a

: [(S)-2-Benzyloxycarbonylamino-1-methoxy-4-methyl-pent-(E)-ylideneamino]-acetic acid

A: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

B: 56-40-6
glycine

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether Yields of byproduct given;	A 48% B n/a

: 64-18-6
formic acid

: 107-11-9
1-amino-2-propene

A: 107-10-8
propylamine

B: 10569-72-9
DL-3-aminoisobutyric acid

C: 56-40-6
glycine

D: 107-95-9
3-amino propanoic acid

E: 56-12-2
4-amino-n-butyric acid

Conditions

Conditions	Yield
With hydrogen; oxygen In water for 3h; Product distribution; various unsaturated amines; investigation of the direct carboxylation of C=C bond, the effect of formic acid concentration as well as the flame composition on product(s); radical mechanism is proposed;	A n/a B 38% C n/a D n/a E 5%

...Expand

: 64-18-6
formic acid

: 107-11-9
1-amino-2-propene

A: 10569-72-9
DL-3-aminoisobutyric acid

B: 56-40-6
glycine

C: 107-95-9
3-amino propanoic acid

D: 56-12-2
4-amino-n-butyric acid

Conditions

Conditions	Yield
With hydrogen; oxygen In water for 3h; Further byproducts given;	A 38% B n/a C n/a D 5%

...Expand

: 56-41-7
L-alanin

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

A: 56-45-1
L-serin

B: 70-47-3
L-asparagine

C: 56-40-6
glycine

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Concentration; Electrolysis; Inert atmosphere;	A n/a B 27% C n/a

...Expand

: C2H3NO2*H(1+)

: 56-40-6
glycine

Conditions

Conditions	Yield
With hydrogenchloride In acetic acid at 100℃; for 48h; biomimetic reduction;	22%

: 85-44-9
phthalic anhydride

: 56-40-6
glycine

: 4702-13-0
N-phthaloylglycine

Conditions

Conditions	Yield
for 0.0472222h; microwave irradiation;	100%
	98%
With triethylamine In toluene for 6h; Heating;	98.9%

: 108-24-7
acetic anhydride

: 56-40-6
glycine

: 543-24-8
N-acetylglycine

Conditions

Conditions	Yield
In methanol for 6h; Reflux;	100%
In methanol for 16h; Inert atmosphere; Reflux;	97%
at 20℃; for 2h;	91%

: 501-53-1
benzyl chloroformate

: 56-40-6
glycine

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

Conditions

Conditions	Yield
With sodium hydroxide In water at 0 - 20℃;	100%
With potassium carbonate In tetrahydrofuran; water at 20℃; for 12h;	96%
Stage #1: glycine With sodium hydroxide In water Inert atmosphere; Stage #2: benzyl chloroformate In water at 0℃; for 0.833333h; Inert atmosphere;	95%

: 64-18-6
formic acid

: 56-40-6
glycine

: 2491-15-8
formylglycine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 110℃; for 0.666667h;	100%
In N,N-dimethyl-formamide at 153℃; for 0.333333h; futher solvents, further temperatures, further reaction times;	97%
Stage #1: formic acid With acetic anhydride at 45℃; for 1h; Inert atmosphere; Stage #2: glycine at 20℃; for 72h; Inert atmosphere;	93%

: 64-17-5
ethanol

: 56-40-6
glycine

: 459-73-4
GlyOEt*HCl

Conditions

Conditions	Yield
With thionyl chloride	100%
With thionyl chloride at -5℃; for 3h; Heating / reflux;	86.7%
With thionyl chloride at -5℃; for 3h; Heating / reflux;	86.7%

: 56-40-6
glycine

: 99-63-8
benzene-1,3-dicarbonyl dichloride

: 124842-39-3
[(3-{[(carboxymethyl)amino]carbonyl}benzoyl)amino]acetic acid

Conditions

Conditions	Yield
Stage #1: glycine With sodium hydroxide In water at 10℃; Cooling with ice; Stage #2: benzene-1,3-dicarbonyl dichloride In water; toluene for 1h; pH=1;	100%
With sodium hydroxide In diethyl ether	87%
With sodium hydroxide
With sodium hydroxide

: 56-40-6
glycine

: 6000-44-8
sodium glycinate

Conditions

Conditions	Yield
With sodium hydroxide In glycerol at 120℃; for 1h;	100%
With ammonia; sodium
With ethanol; sodium

: 141-97-9
ethyl acetoacetate

: 56-40-6
glycine

: 32085-79-3
potassium α-methyl-β-ethoxycarbonylethenylaminoacetate

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 40℃;	100%
With potassium hydroxide In methanol for 1h; Heating;	97%

: 67-56-1
methanol

: 56-40-6
glycine

: 5680-79-5
glycine ethyl ester hydrochloride

Conditions

Conditions	Yield
With acetyl chloride at 0 - 20℃;	100%
Stage #1: methanol With thionyl chloride for 1h; Cooling with ice; Stage #2: glycine at 20 - 66℃; for 6.5h;	100%
With thionyl chloride at 0℃; Reflux; Inert atmosphere;	100%

: 67-56-1
methanol

: 56-40-6
glycine

: 616-34-2
methoxycarbonylmethylamine

Conditions

Conditions	Yield
With chloro-trimethyl-silane at 0 - 4℃; for 24h; Inert atmosphere;	100%
With thionyl chloride at 0 - 65℃; for 4.25h;	100%
With thionyl chloride at 0 - 65℃; for 4.25h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 56-40-6
glycine

: 4530-20-5
BOC-glycine

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 20℃; for 12h;	100%
Stage #1: glycine With sodium hydroxide In 1,4-dioxane; water at 0℃; for 0.25h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃;	100%
With sodium hydroxide In 1,4-dioxane	100%

: 72909-34-3
pyrroloquinoline quinone

: 56-40-6
glycine

: 132847-84-8
C15H7N3O7

Conditions

Conditions	Yield
In water at 30℃; for 24h; pH = 6.6;	100%
at 30℃; Rate constant; Mechanism; Product distribution; pH = 9.1; other pH values; other aminoacids;
With phosphate buffer pH 6.5; bovine serum In water Rate constant; Ambient temperature; pH range of 3.0 - 9.0;

: 80-40-0
ethyl ester of p-toluenesulfonic acid

: 56-40-6
glycine

: 71260-62-3
toluene-4-sulfonic acid salt of ethyl glycinate

Conditions

Conditions	Yield
In ethanol for 36h; Esterification; Heating;	100%

: 5324-30-1
diethyl 2-bromoethylphosphonate

: 56-40-6
glycine

: 210306-41-5
N-(2-diethylphosphonylethyl)glycine

Conditions

Conditions	Yield
With potassium carbonate In water at 80℃; for 3h;	100%

: 100-39-0
benzyl bromide

: 56-40-6
glycine

: 17360-47-3
N,N-dibenzylglycine

Conditions

Conditions	Yield
Stage #1: benzyl bromide; glycine With potassium hydroxide In ethanol; water at 25℃; for 16h; Stage #2: With potassium hydroxide In ethanol; water for 0.5h; reflux;	100%

: 56-40-6
glycine

: 36394-85-1
4,6,4',6'-tetrachloro-2,2'-(3,6-dioxa-octane-1,8-diyldioxy)-bis-[1,3,5]triazine

: C16H18Cl2N8O8(2-)*2Na(1+)

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃;	100%

: 14529-12-5
6-chloro-N-methylisatoic anhydride

: 56-40-6
glycine

: 5973-28-4
7-chloro-1-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione

Conditions

Conditions	Yield
Stage #1: 6-chloro-N-methylisatoic anhydride; glycine With acetic acid at 130℃; for 7h; Stage #2: With sodium hydroxide; water; sodium hydrogencarbonate pH=~ 9 - 10;	100%
With acetic acid at 130℃; for 7h;
With acetic acid at 130℃; for 7h;

: 919-30-2
3-aminopropyltriethoxysilane

: 56-40-6
glycine

: 76444-79-6
C11H26N2O4Si

Conditions

Conditions	Yield
at 200℃; for 0.05h; Product distribution / selectivity; Microwave irradiation (300 W);	100%

: 61-90-5
L-leucine

: 63-91-2
L-phenylalanine

: 60-18-4
L-tyrosine

: 56-40-6
glycine

: 60117-24-0
H-Tyr-Gly-Gly-Phe-Leu-NH2

Conditions

Conditions	Yield
Stage #1: L-tyrosine With BF4(1-)*C7H13N3Pol(1+); benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction; Stage #2: glycine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction; Stage #3: L-leucine; L-phenylalanine Further stages;	100%

Yield

Stage #1: L-tyrosine With BF4(1-)*C7H13N3Pol(1+); benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction;
Stage #2: glycine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h; Ionic liquid; Automated synthesizer; solid phase reaction;
Stage #3: L-leucine; L-phenylalanine Further stages;

100%

...Expand

: S-ethyl-N'-ethylisothiourea hydroiodide

: 56-40-6
glycine

: 16974-45-1
(N'-ethylguanidino)acetic acid

Conditions

Conditions	Yield
Stage #1: glycine With sodium hydroxide In water Stage #2: S-ethyl-N'-ethylisothiourea hydroiodide In diethyl ether; water at 0℃; for 42.15h;	100%

: 1529785-10-1
(bis-2-cyclopentadienylethoxybenzene)titanium dichloride

: 56-40-6
glycine

: 1529785-11-2
(bis-2-cyclopentadienylethoxybenzene)titanium bisglycine

Conditions

Conditions	Yield
In methanol; water at 20℃; for 4h; Glovebox;	100%

: nickel(II) acetate tetrahydrate

: (R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)-methyl]-2-pyrrolidinecarboxamide hydrochloride

: 56-40-6
glycine

: nickel, [N-[[5-chloro-2-[[[(R)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinyl-kN]carbonyl]amino-kN]phenyl]phenylmethylene]-glycinato(2-)-kN,kO], (SP-4-4)

Conditions

Conditions	Yield
Stage #1: nickel(II) acetate tetrahydrate; (R)-N-(2-benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)-methyl]-2-pyrrolidinecarboxamide hydrochloride; glycine In methanol at 20℃; Stage #2: With sodium carbonate In methanol at 65℃;	100%

...Expand

: C26H34N2O10

: 56-40-6
glycine

: C22H34N2O9

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile for 67h;	100%

: 1644308-41-7
((S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide)

: 373-02-4, 14998-37-9, 33025-09-1, 94044-50-5, 98268-31-6
nickel diacetate

: 56-40-6
glycine

: Ni(II)-(S)-N-(2-benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide/2-aminoacetic acid

Conditions

Conditions	Yield
With potassium carbonate In methanol at 50℃;	100%

...Expand

: 98-09-9
benzenesulfonyl chloride

: 56-40-6
glycine

: 5398-96-9
N-phenylsulfonylglycine

Conditions

Conditions	Yield
With sodium carbonate In water for 5h;	99.61%
With sodium carbonate In water for 4h;	99.61%
With zinc oxide-nanoparticle at 50℃; for 2h; Neat (no solvent); chemoselective reaction;	95%

: 98-59-9
p-toluenesulfonyl chloride

: 56-40-6
glycine

: 1080-44-0
N-Tosylglycine

Conditions

Conditions	Yield
With sodium carbonate In water for 5h;	99.34%
With sodium carbonate In water for 4h;	99.34%
With triethylamine In tetrahydrofuran; water at 0 - 20℃; for 4h; Inert atmosphere;	94%

: 107-13-1
acrylonitrile

: 56-40-6
glycine

: 6295-23-4
[N,N-Bis(2-cyanoethyl)]-glycine

Conditions

Conditions	Yield
With tetramethyl ammoniumhydroxide In water at 10 - 50℃; Heating / reflux;	99.3%
With sodium hydroxide; water at 100℃; for 24h; Alkylation;	94%
With sodium hydroxide

: 75-59-2
tetramethyl ammoniumhydroxide

: 107-13-1
acrylonitrile

: 56-40-6
glycine

: 6295-23-4
[N,N-Bis(2-cyanoethyl)]-glycine

Conditions

Conditions	Yield
In water; acetone	99.3%

...Expand

: 56-40-6
glycine

: 38464-20-9
4-chloro-3-nitro-chromen-2-one

: 78795-04-7
N-(3-nitrocoumarin-4-yl)glycine

Conditions

Conditions	Yield
With triethylamine In ethanol for 6h; Ambient temperature;	99.2%

Glycine Standards and Recommendations

In the USA, glycine is typically sold in two grades: USP ("United States Pharmacopeia"), and technical grade.the two grades have diverse uses.
Pharmaceutical grade Glycine (CAS NO.56-40-6) is use in some pharmaceutical applications, such as intravenous injections, where the customer's purity requirements often exceed the minimum required under the USP grade designation.
Technical grade glycine, which may or may not meet USP grade standards, often use in industrial applications; such as an agent in metal complexing and finishing.

Glycine Specification

1. Introduction of Glycine

Glycine, with the IUPAC Name of 2-Aminoacetic acid, is one kind of white crystalline powder. This chemical belongs to the Classification Code which include Component of irrigating solution; Glycine Agents; Mutation data; Neurotransmitter Agents.

2. Properties of Glycine

Glycine has the following property datas: (1)Melting point: 240 °C; (2)Index of Refraction: 1.46; (3)Molar Refractivity: 16.41 cm3; (4)Molar Volume: 59.8 cm3; (5)Surface Tension: 54.4 dyne/cm; (6)Density: 1.254 g/cm3; (7)Flash Point: 99.5 °C; (8)Enthalpy of Vaporization: 52.63 kJ/mol; (9)Boiling Point: 240.9 °C at 760 mmHg; (10)Vapour Pressure: 0.0123 mmHg at 25°C.

3. Structure Descriptors of Glycine

You could convert the following datas into the molecular structure:
InChI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey: InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles: C(=O)(CN)O

4. Uses of Glycine

Glycine has many uesage:
1).Animal and human foodstuffs:
use an additive in pet food and animal feed. For humans, glycine is used as a sweetener/taste enhancer. such as Food supplements and protein drinks.some drug formulations use glycine to improve gastric absorption.
2).Chemical feedstock
Glycine is an intermediate in the synthesis of a variety of chemical products. It is used in the manufacture of the herbicide Glyphosate. Glyphosate (N-(phosphonomethyl) glycine) is a non-selective systemic herbicide used to kill weeds, especially perennials and broadcast or used in the cut-stump treatment as a forestry herbicide. Initially, Glyphosate was sold only by Monsanto under the Monsanto tradename Roundup, but is no longer under patent
3).Cosmetics and other applications:
Glycine can be used as a buffering agent in analgesics, antacids, cosmetics, antiperspirants, and toiletries.Many products use glycine or its derivatives, such as the production of rubber sponge products, fertilizers, metal complexants.

5. Safety information of Glycine

Risk Statements of Glycine (CAS NO.56-40-6): 33
R33: Danger of cumulative effects.
Safety Statements: 22-24/25
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.

6. Production of Glycine

Glycine (CAS NO.56-40-6)e is manufactured by treating chloroacetic acid with ammonia industrially
ClCH₂COOH + 2 NH₃ → H₂NCH₂COOH + NH₄Cl
It also can be produced via the Strecker amino acid synthesis.

7. Toxicity information of Glycine

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	3gm/kg (3000mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 306, 1942.
mouse	LD50	intraperitoneal	4450mg/kg (4450mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse	LD50	intravenous	2370mg/kg (2370mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse	LD50	oral	4920mg/kg (4920mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
mouse	LD50	subcutaneous	5060mg/kg (5060mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat	LD50	intravenous	2600mg/kg (2600mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat	LD50	oral	7930mg/kg (7930mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.
rat	LD50	subcutaneous	5200mg/kg (5200mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 5, Pg. 1502, 1977.

Product Name

Glycine

Synthetic route

Glycine Standards and Recommendations

Glycine Specification

Related Products

Hot Products