Product Name

  • Name

    Isobutyl iodide

  • EINECS 208-160-5
  • CAS No. 513-38-2
  • Article Data28
  • CAS DataBase
  • Density 1.617 g/cm3
  • Solubility insoluble in water
  • Melting Point -93 °C
  • Formula C4H9I
  • Boiling Point 120 °C at 760 mmHg
  • Molecular Weight 184.02
  • Flash Point 12.8 °C
  • Transport Information UN 2391 3/PG 2
  • Appearance clear colorless to light orange liquid
  • Safety 16-26-36-9-33
  • Risk Codes 11-36/37/38-20
  • Molecular Structure Molecular Structure of 513-38-2 (Isobutyl iodide)
  • Hazard Symbols FlammableF,IrritantXi,HarmfulXn
  • Synonyms 3-Iodo-2-methylpropane;NSC 8421;2-Methylpropyl iodide;1-Iodo-2-methylpropane;1-Iodoisobutane;2-Methyl-1-iodopropane;2-Methylpropan-1-yl iodide;
  • PSA 0.00000
  • LogP 2.07740

Synthetic route

isobutyl p-toluenesulfonate
4873-56-7

isobutyl p-toluenesulfonate

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With sodium iodide In neat (no solvent) at 120℃; for 0.5h; Microwave irradiation;99%
i-Amyl alcohol
123-51-3

i-Amyl alcohol

A

3-methyltetrahydrofuran
13423-15-9

3-methyltetrahydrofuran

B

Isobutyl iodide
513-38-2

Isobutyl iodide

C

isovaleraldehyde
590-86-3

isovaleraldehyde

Conditions
ConditionsYield
With N-iodo-succinimide In chlorobenzene for 2h; Irradiation;A 94%
B 5%
C 1%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

triphenylphosphine
603-35-0

triphenylphosphine

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With quinoline; iodine In nitrobenzene74%
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With phosphoric acid; potassium iodide
With phosphorus; iodine Einw. das Reaktionsprodukt von gelbem Phosphor;
With iodophosphorus
allyl iodid
556-56-9

allyl iodid

Chloroiodomethane
593-71-5

Chloroiodomethane

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

A

2-iodo-propane
75-30-9

2-iodo-propane

B

Isobutyl iodide
513-38-2

Isobutyl iodide

C

4-iodobut-1-ene
7766-51-0

4-iodobut-1-ene

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether at -40℃; for 4.5h; Product distribution;
In tetrahydrofuran at -40℃; for 4.5h;
2,3-dimethylbutane
79-29-8

2,3-dimethylbutane

A

Isobutyl iodide
513-38-2

Isobutyl iodide

B

iodo-2 dimethyl-2,3 butane
594-59-2

iodo-2 dimethyl-2,3 butane

C

tetramethyl-2,3,6,7 octane
52670-34-5

tetramethyl-2,3,6,7 octane

D

rac-2,3-dimethyl-1-iodobutane
2300-25-6, 2300-27-8, 71486-02-7, 31295-00-8

rac-2,3-dimethyl-1-iodobutane

E

pentamethyl-2,3,3,5,6 heptane
52670-35-6

pentamethyl-2,3,3,5,6 heptane

F

tert-Butyl iodide
558-17-8

tert-Butyl iodide

Conditions
ConditionsYield
With hydrogen iodide In solid matrix at -196.1℃; Product distribution; Irradiation; γ-radiolysis 60Co; or without HI;
2,3-dimethylbutane
79-29-8

2,3-dimethylbutane

A

Isobutyl iodide
513-38-2

Isobutyl iodide

B

iodo-2 dimethyl-2,3 butane
594-59-2

iodo-2 dimethyl-2,3 butane

C

rac-2,3-dimethyl-1-iodobutane
2300-25-6, 2300-27-8, 71486-02-7, 31295-00-8

rac-2,3-dimethyl-1-iodobutane

D

tert-Butyl iodide
558-17-8

tert-Butyl iodide

Conditions
ConditionsYield
With hydrogen iodide In solid matrix at -196.1℃; Irradiation; γ-radiolysis (60Co); Further byproducts given;
Isobutyl bromide
78-77-3

Isobutyl bromide

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With pyridine; tributyltin iodide at 125℃; Thermodynamic data; Equilibrium constant; Δ G;
With sodium iodide In acetone Reflux; Inert atmosphere;
1,1,1,2,2,3,3-heptafluoro-3-iodo-propane
754-34-7

1,1,1,2,2,3,3-heptafluoro-3-iodo-propane

Diisobutoxy-ethylphosphin
24681-02-5

Diisobutoxy-ethylphosphin

A

Isobutyl iodide
513-38-2

Isobutyl iodide

B

isobutyl ethyl(heptafluoropropyl)phosphinate
77529-59-0

isobutyl ethyl(heptafluoropropyl)phosphinate

Conditions
ConditionsYield
In octane Rate constant; Kinetics; Thermodynamic data; E (activ.); ΔH(excit.); ΔS(excit.); ΔG(excit.);
isobutyryl chloride
513-36-0

isobutyryl chloride

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With pyridine; tributyltin iodide at 125℃; Thermodynamic data; Equilibrium constant; Δ G;
isobutene
115-11-7

isobutene

Isobutyl iodide
513-38-2

Isobutyl iodide

Conditions
ConditionsYield
With borane; iodine; sodium methylate 1.) THF, 25 deg C, 1 h, 2.) MeOH, 24 h; Yield given. Multistep reaction;
2-methyl-propan-1-ol
78-83-1

2-methyl-propan-1-ol

phosphorus triiodide

phosphorus triiodide

CS2

CS2

Isobutyl iodide
513-38-2

Isobutyl iodide

2-methyl-1-propoxy-propane
15268-49-2

2-methyl-1-propoxy-propane

concentrated HI

concentrated HI

A

Isobutyl iodide
513-38-2

Isobutyl iodide

B

1-iodo-propane
107-08-4

1-iodo-propane

α-isobutoxy-isobutyric acid
17860-06-9

α-isobutoxy-isobutyric acid

hydrogen iodide
10034-85-2

hydrogen iodide

red phosphorus

red phosphorus

A

Isobutyl iodide
513-38-2

Isobutyl iodide

B

isobutyric Acid
79-31-2

isobutyric Acid

2,4-dimethylpentane
108-08-7

2,4-dimethylpentane

A

2-iodo-propane
75-30-9

2-iodo-propane

B

1-iodo-2,4-dimethylpentane
55717-79-8

1-iodo-2,4-dimethylpentane

C

Isobutyl iodide
513-38-2

Isobutyl iodide

D

2-iodo-2,4-dimethylpentane
24556-57-8

2-iodo-2,4-dimethylpentane

Conditions
ConditionsYield
With iodine at 20℃; Irradiation;A 0.78 % Spectr.
B 0.99 % Spectr.
C 0.86 % Spectr.
D 1.73 % Spectr.
methyl 4-({2-[(phenylsulfonyl)amino]-5-(trifluoromethyl)phenoxy}methyl)benzoate
209685-47-2

methyl 4-({2-[(phenylsulfonyl)amino]-5-(trifluoromethyl)phenoxy}methyl)benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[2-[isobutyl(phenylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate
907587-58-0

methyl 4-{[2-[isobutyl(phenylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;100%
methyl 4-[(5-methyl-2-{[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoate
916913-85-4

methyl 4-[(5-methyl-2-{[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-methylphenoxy)methyl]benzoate
916913-94-5

methyl 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-methylphenoxy)methyl]benzoate

Conditions
ConditionsYield
With caesium carbonate; dimethyl amine at 80℃;100%
methyl 4-{[2-{[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-12-7

methyl 4-{[2-{[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[2-{isobutyl[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-27-4

methyl 4-{[2-{isobutyl[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;100%
methyl 4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate
916913-87-6

methyl 4-{[(6-{[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[(6-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate
916913-96-7

methyl 4-{[(6-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-2,3-dihydro-1H-inden-5-yl)oxy]methyl}benzoate

Conditions
ConditionsYield
With caesium carbonate; dimethyl amine at 80℃;100%
methyl 4-{[(3-{[(5-methyl-2-furyl)sulfonyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]methyl}benzoate
916913-88-7

methyl 4-{[(3-{[(5-methyl-2-furyl)sulfonyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[(3-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]methyl}benzoate
916913-97-8

methyl 4-{[(3-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]methyl}benzoate

Conditions
ConditionsYield
With caesium carbonate; dimethyl amine at 80℃;100%
methyl 4-{[2-{[(3,5-dimethylisoxazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-15-0

methyl 4-{[2-{[(3,5-dimethylisoxazol-4-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[2-{[(3,5-dimethylisoxazol-4-yl)sulfonyl](isobutyl)amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-29-6

methyl 4-{[2-{[(3,5-dimethylisoxazol-4-yl)sulfonyl](isobutyl)amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;100%
5,6-bis(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one
225668-16-6

5,6-bis(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

Isobutyl iodide
513-38-2

Isobutyl iodide

5,6-bis(3-fluoro-4-methoxyphenyl)-2-isobutyl-2H-pyridazin-3-one

5,6-bis(3-fluoro-4-methoxyphenyl)-2-isobutyl-2H-pyridazin-3-one

Conditions
ConditionsYield
100%
Isobutyl iodide
513-38-2

Isobutyl iodide

trimethylstannyl sodium
16643-09-7

trimethylstannyl sodium

isobutyl-trimethyl stannane
1118-10-1

isobutyl-trimethyl stannane

Conditions
ConditionsYield
In tetrahydrofuran 0°C in N2-atmosphere; various yields for various conditions;100%
Isobutyl iodide
513-38-2

Isobutyl iodide

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
123148-78-7

4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-5-iodo-7-isobutyl-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-5-iodo-7-isobutyl-7H-pyrrolo[2,3-d]pyrimidine

Conditions
ConditionsYield
Stage #1: 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.05h;
Stage #2: Isobutyl iodide In N,N-dimethyl-formamide at 20℃;
100%
Isobutyl iodide
513-38-2

Isobutyl iodide

(2S)-3,4-dihydro-2H-chromene-2-carboxylic acid
83780-46-5

(2S)-3,4-dihydro-2H-chromene-2-carboxylic acid

(2S)-Chromancarboxylic acid isobutyl ester

(2S)-Chromancarboxylic acid isobutyl ester

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide for 8h; Heating / reflux;99%
With caesium carbonate In N-methyl-acetamide99%
Isobutyl iodide
513-38-2

Isobutyl iodide

2-hydroxy-4-nitro-benzoic acid methyl ester
13684-28-1

2-hydroxy-4-nitro-benzoic acid methyl ester

methyl 2-isobutoxy-4-nitrobenzoate

methyl 2-isobutoxy-4-nitrobenzoate

Conditions
ConditionsYield
Stage #1: 2-hydroxy-4-nitro-benzoic acid methyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: Isobutyl iodide In N,N-dimethyl-formamide at 50℃; for 16h;
99%
Isobutyl iodide
513-38-2

Isobutyl iodide

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide
159213-03-3

N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

(R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylpentanamide
192060-46-1

(R)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylpentanamide

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine; lithium chloride In tetrahydrofuran; hexane at -78 - 20℃; for 13h;98%
With n-butyllithium; diisopropylamine; lithium chloride In tetrahydrofuran at 0℃; for 6h;89%
Isobutyl iodide
513-38-2

Isobutyl iodide

(1R,2R)-(-)-pseudoephedrinepropionamide
192060-67-6

(1R,2R)-(-)-pseudoephedrinepropionamide

(S)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylpentanamide
618448-72-9

(S)-N-((1R,2R)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4-trimethylpentanamide

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine; lithium chloride In tetrahydrofuran; hexane at -78 - 20℃; for 13h;98%
Stage #1: (1R,2R)-(-)-pseudoephedrinepropionamide With n-butyllithium; diisopropylamine; lithium chloride In tetrahydrofuran; hexane at -78 - 23℃; for 1.33h; Inert atmosphere;
Stage #2: Isobutyl iodide In tetrahydrofuran; hexane at 0 - 5℃; for 18h; Inert atmosphere;
86%
Isobutyl iodide
513-38-2

Isobutyl iodide

(2'S)-{2'-[(Benzyloxy)methyl]-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl}(3-methyl-2-furyl)methanone
328575-51-5

(2'S)-{2'-[(Benzyloxy)methyl]-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl}(3-methyl-2-furyl)methanone

(2'S)-(2'-hydroxymethyl-pyrrolidin-1'-yl)-(2-isobutyl-3-methyl-2,5-dihydrofuran-2-yl)-methanone

(2'S)-(2'-hydroxymethyl-pyrrolidin-1'-yl)-(2-isobutyl-3-methyl-2,5-dihydrofuran-2-yl)-methanone

Conditions
ConditionsYield
Stage #1: (2'S)-{2'-[(Benzyloxy)methyl]-2',3',4',5'-tetrahydro-1'H-pyrrol-1'-yl}(3-methyl-2-furyl)methanone With ammonia; lithium In tetrahydrofuran at -78℃; for 0.5h; Birch reduction;
Stage #2: Isobutyl iodide With isoprene In tetrahydrofuran for 1h; Further stages.;
98%
methyl 4-[(4,5-dimethyl-2-{[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoate
916913-86-5

methyl 4-[(4,5-dimethyl-2-{[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-4,5-dimethylphenoxy)methyl]benzoate
916913-95-6

methyl 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-4,5-dimethylphenoxy)methyl]benzoate

Conditions
ConditionsYield
With caesium carbonate; dimethyl amine at 80℃;98%
dimethyl 4-hydroxypyridine-2,6-dicarboxylate
19872-91-4

dimethyl 4-hydroxypyridine-2,6-dicarboxylate

Isobutyl iodide
513-38-2

Isobutyl iodide

dimethyl 4-isobutyloxy-2,6-pyridine dicarboxylate

dimethyl 4-isobutyloxy-2,6-pyridine dicarboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 70℃; Inert atmosphere;98%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 3h;
Isobutyl iodide
513-38-2

Isobutyl iodide

5-bromo-2-hydroxybenzonitrile
40530-18-5

5-bromo-2-hydroxybenzonitrile

5-bromo-2-isobutoxy-benzonitrile
876918-26-2

5-bromo-2-isobutoxy-benzonitrile

Conditions
ConditionsYield
With potassium carbonate In acetone for 48h; Reflux;98%
With potassium carbonate In acetone at 20℃; for 48h; Reflux;91%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 20h;53%
Isobutyl iodide
513-38-2

Isobutyl iodide

4-methylpentyl phenyl sulfone

4-methylpentyl phenyl sulfone

Conditions
ConditionsYield
With water; sodium chloride In acetonitrile pH=2; Electrochemical reaction; Green chemistry;98%
methyl 4-{[2-[(thien-3-ylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-03-6

methyl 4-{[2-[(thien-3-ylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[2-{isobutyl[(thien-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-22-9

methyl 4-{[2-{isobutyl[(thien-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;97%
methyl 4-{[2-[(3-furylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-05-8

methyl 4-{[2-[(3-furylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate

Isobutyl iodide
513-38-2

Isobutyl iodide

methyl 4-{[2-[(3-furylsulfonyl)(isobutyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate
909897-23-0

methyl 4-{[2-[(3-furylsulfonyl)(isobutyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;97%
3-morpholin-2-yl-1H-indole-6-carboxylic acid methyl ester
1005458-28-5

3-morpholin-2-yl-1H-indole-6-carboxylic acid methyl ester

Isobutyl iodide
513-38-2

Isobutyl iodide

3-(4-isobutyl-morpholin-2-yl)-1H-indole-6-carboxylic acid methyl ester
1005458-29-6

3-(4-isobutyl-morpholin-2-yl)-1H-indole-6-carboxylic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane for 16h; Heating / reflux;97%
Isobutyl iodide
513-38-2

Isobutyl iodide

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester
526222-96-8

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

methyl iodide
74-88-4

methyl iodide

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

Conditions
ConditionsYield
Stage #1: Isobutyl iodide; (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;
Stage #2: methyl iodide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 14h;
97%
Isobutyl iodide
513-38-2

Isobutyl iodide

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester
526222-96-8

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

7-benzyl 8-(tert-butyl) (5S,8S)-3-isobutyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

7-benzyl 8-(tert-butyl) (5S,8S)-3-isobutyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;97%
Isobutyl iodide
513-38-2

Isobutyl iodide

2-bromomethylnaphthyl bromide
939-26-4

2-bromomethylnaphthyl bromide

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester
526222-96-8

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-(naphthalen-2-ylmethyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-(naphthalen-2-ylmethyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

Conditions
ConditionsYield
Stage #1: Isobutyl iodide; (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;
Stage #2: 2-bromomethylnaphthyl bromide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 14h;
97%
Isobutyl iodide
513-38-2

Isobutyl iodide

bromoacetic acid methyl ester
96-32-2

bromoacetic acid methyl ester

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester
526222-96-8

(5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-(2-methoxy-2-oxoethyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

7-benzyl 8-(tert-butyl) (5R,8S)-3-isobutyl-1-(2-methoxy-2-oxoethyl)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylate

Conditions
ConditionsYield
Stage #1: Isobutyl iodide; (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;
Stage #2: bromoacetic acid methyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;
97%
10H-phenothiazine
92-84-2

10H-phenothiazine

Isobutyl iodide
513-38-2

Isobutyl iodide

10-isobutylphenothiazine
68825-24-1

10-isobutylphenothiazine

Conditions
ConditionsYield
With sodium amide at 121℃; for 6h;96%
With sodium hydride In N,N-dimethyl-formamide at 70℃; for 2h; Yield given;
benzoic acid methyl ester
93-58-3

benzoic acid methyl ester

Isobutyl iodide
513-38-2

Isobutyl iodide

2,6-dimethyl-4-phenylheptan-4-ol
19965-72-1

2,6-dimethyl-4-phenylheptan-4-ol

Conditions
ConditionsYield
With strontium In tetrahydrofuran at 20℃; for 0.5h; Barbier reaction;96%
Isobutyl iodide
513-38-2

Isobutyl iodide

mulina‐11,13‐dien‐20‐oic acid

mulina‐11,13‐dien‐20‐oic acid

mulin-11,13-dien-20-oic acid iso-butyl ester
1251850-36-8

mulin-11,13-dien-20-oic acid iso-butyl ester

Conditions
ConditionsYield
With sodium carbonate In acetone at 20℃;96%
ethyl 3,4-dichlorophenylacetate
6725-45-7

ethyl 3,4-dichlorophenylacetate

Isobutyl iodide
513-38-2

Isobutyl iodide

2-(3,4-dichlorophenyl)-4-methyl-pentanoic acid ethyl ester
300356-46-1

2-(3,4-dichlorophenyl)-4-methyl-pentanoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 3,4-dichlorophenylacetate With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.75h; Inert atmosphere;
Stage #2: Isobutyl iodide In tetrahydrofuran at -78 - 25℃; Inert atmosphere;
96%

ISOBUTYL IODIDE Chemical Properties

Product Name: Isobutyl iodide
The MF of Isobutyl iodide (513-38-2) is C4H9I.
                           
The MW of Isobutyl iodide (513-38-2) is 184.02.
Synonyms: ISOBUTYL IODIDE ; 1-IODOMETHYLPROPANE ; 1-IODO-2-METHYLPROPANE ; 1-Iodo-iso-butane ; iodomethylpropanes ; 1-iodo-2-methyl-propan ; 1-Jod-2-methylpropan ; 2-methylpropyliodide
Product Categories: Iodine Compounds
EINECS: 208-160-5
Flash Point: 12.8°C   
Boiling Point: 120°C   
Melting Point: -93°C
density: 1.599 g/mL at 25°C(lit.)
vapor density: 6 (vs air)
vapor pressure: 20 mm Hg (20°C)
refractive index: n20/D 1.496(lit.)
storage temp: Flammables area
Water Solubility: insoluble
Sensitive: Light Sensitive
Appearance: Clear, pink liquid.
Merck: 14,5144
BRN: 1730927

ISOBUTYL IODIDE Uses

   Isobutyl iodide (513-38-2) is used as solvents, analytical reagents, organic synthesis of raw materials.

ISOBUTYL IODIDE Toxicity Data With Reference

1.   

ihl-rat LC50:6700 mg/m3/4H

   34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,756.
2.   

ipr-rat LD50:1241 mg/kg

   34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,756.
3.   

ipr-mus LD50:594 mg/kg

   34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,756.

ISOBUTYL IODIDE Consensus Reports

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

ISOBUTYL IODIDE Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by inhalation. A flammable liquid. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of I. See also IODIDES.
Safety information of Isobutyl iodide (513-38-2):
Hazard Codes  F,Xi,Xn
Risk Statements  11-36/37/38-20
R11: Highly Flammable
R36/37/38: Irritating to eyes, respiratory system and skin
R20: Harmful by inhalation
Safety Statements  16-26-36-9-33
S16: Keep away from sources of ignition - No smoking
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36: Wear suitable protective clothing
S9: Keep container in a well-ventilated place
S33: Take precautionary measures against static discharges 
RIDADR  UN 2391 3/PG 2
WGK Germany  3
RTECS  TZ4250000
F  8-10-23
HazardClass  3
PackingGroup  II
HS Code  29033080

ISOBUTYL IODIDE Standards and Recommendations

DOT Classification:  3; Label: Flammable Liquid

ISOBUTYL IODIDE Specification

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
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