Kaempferol supplier | CasNO.520-18-3

Name
Kaempferol
EINECS 208-287-6
CAS No. 520-18-3
Article Data168
CAS DataBase
Density 1.688 g/cm³
Solubility ethanol: 20 mg/mL in water
Melting Point 276 °C
Formula C₁₅H₁₀O₆
Boiling Point 582.1 °C at 760 mmHg
Molecular Weight 286.241
Flash Point 226.1 °C
Transport Information
Appearance Yellow solid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Flavone,3,4',5,7-tetrahydroxy- (7CI,8CI);3,4',5,7-Tetrahydroxyflavone;3'-Deoxyquercetin;5,7,4'-Trihydroxyflavonol;C.I. 75640;Indigo Yellow;Kaempferol;Kaempherol;Kampcetin;Kempferol;NSC 407289;NSC 656277;Nimbecetin;Pelargidenolon;Pelargidenon;Populnetin;Rhamnolutein;Rhamnolutin;Robigenin;Swartziol;Trifolitin;
PSA 111.13000
LogP 2.28240

Synthetic route

: 22688-78-4
kaempferol 3-O-β-D-glucuronide

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride; methanol for 2h; Heating;	100%

: 480-10-4
astragalin

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride for 1h; Heating;	91.1%
With sulfuric acid

: 1098-92-6
kaempferol 5,7,4'-trimethyl ether

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With boron tribromide In dichloromethane for 24h; Heating;	91%
With 1-butylpyridinium bromide for 0.1h; microwave irradiation;	72%
With trimethylsilyl iodide In methanol at 35℃; for 96h; Inert atmosphere;

: 23405-70-1
5,7-bis(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol under 760.051 Torr; for 12h;	72%
With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;	58%

: 724434-08-6
dihydrokaempferol

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With potassium pyrosulfite In ethanol at 100℃;	60%
With oxygen; potassium carbonate In ethanol for 8h; Reflux;	23.4 g

: 480-20-6, 22425-48-5, 104486-98-8, 118333-31-6
Aromadendrin

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid; water unter Durchleiten von Luft;
With water; sodium hydrogensulfite
With FLAVONOL SYNTHASE; TrxA-His-AtFLS1 In aq. buffer at 30℃; for 3h; pH=7.2; Kinetics; Concentration; Temperature; Enzymatic reaction;

: 480-10-4
astragalin

A: 2280-44-6
D-Glucose

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
With emulsin
With sulfuric acid
With hydrogenchloride
Hydrolysis; Acid hydrolysis;

: 22688-78-4
kaempferol 3-O-β-D-glucuronide

A: 489-91-8, 528-16-5, 552-12-5, 577-46-8, 643-33-4, 2240-07-5, 6294-16-2, 10133-02-5, 18402-78-3, 18968-14-4, 21179-08-8, 23018-83-9, 33599-45-0, 33599-46-1, 46171-67-9, 46171-69-1, 46172-26-3, 70021-34-0, 71031-08-8, 104195-06-4, 106499-29-0, 124817-72-7
D-glucuronic acid

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
Product distribution; acid hydrolysis, also mild acid hydrolysis and enzymatic hydrolysis, other flavonoid;

: 480-10-4, 23627-87-4, 31159-41-8, 69292-77-9, 107163-34-8
astragalin

: 520-18-3
kaempferol

Conditions

Conditions	Yield
acidic hydrolysis for structure determination;

: 25615-14-9
3,7-Di-O-glucosylkaempferol

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid

: 5041-97-4
kaempferol 7-O-α-L-rhamnopyranoside

A: 73-34-7
L-rhamnose

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogen cation

: 482-39-3, 22334-39-0, 28978-08-7
kaempferol 3-rhamnoside

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride; ethanol for 1h; Heating;
With naringinase In acetate buffer at 20℃; for 3h; pH=5.5; Enzymatic reaction;
With flavonol 3-O-rhamnosyltransferase UGT78D1 from arabidopsis thaliana; UDP-Rha

: 480-10-4, 23627-87-4, 31159-41-8, 69292-77-9, 107163-34-8
kaempferol 3-O-galactoside

A: 10257-28-0
D-Galactose

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
With acid hydrolysis
With sulfuric acid
With hydrogenchloride In ethanol

: 482-38-2
Kaempferol-3,7-dirhamnosid

A: 73-34-7
L-rhamnose

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
In methanol for 1.66667h; 2percent H2SO4;

: 20869-95-8
ermanin

: 520-18-3
kaempferol

Conditions

Conditions	Yield
demethylation;

: 22153-44-2, 68170-52-5, 72691-81-7, 104641-16-9, 20316-62-5
trans-tiliroside

A: 2280-44-6
D-Glucose

B: 7400-08-0
p-Coumaric Acid

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 2h;

...Expand

: 22153-44-2, 68170-52-5, 72691-81-7, 104641-16-9, 20316-62-5
trans-tiliroside

A: 50-99-7
D-glucose

B: 7400-08-0
p-Coumaric Acid

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 1.5h; Product distribution; Heating; hydrolysis;

...Expand

: 569-92-6
rhamnocitrin

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogen iodide; acetic anhydride; phenol at 130℃; for 0.5h;

: 152390-63-1
kaempferol 3-O-[β-D-glucopyranosyl-(1->2)-β-D-glucopyranoside]

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 0.5h;

: 131573-90-5
kaempferol 3-O-β-D-<2G-O-β-D-xylopyranosyl-6G-O-α-L-rhamnopyranosyl>glucopyranoside

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 1h;

: 135095-52-2
3-O-[(2-O-β-D-galactopyranosyl-6-O-α-L-rhamnopyranosyl)-β-D-glucopyranosyl]-kaempferol

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 1h;

: 94474-72-3
Kaempferol-3-O-<3,6-di-O-acetyl-2,4-di-O-(p-cumaroyl)-β-D-glucopyranosid>

A: 2280-44-6
D-Glucose

B: 7400-08-0
p-Coumaric Acid

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
acid total hydrolysis;

...Expand

: kaempferol-5-O-arabinoside

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride

: Kaempferol-3-O-<2Glc-(p-cumaroyl)-α-L-rhamnopyranosyl(1->6)-β-D-glucopyranosid>

A: 3615-41-6
L-Rhamnose

B: 50-99-7
D-glucose

C: 7400-08-0
p-Coumaric Acid

D: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 1.5h; Product distribution; Heating; hydrolysis;

...Expand

: 89946-00-9
lepidoside

: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid In methanol for 0.5h; Heating;

: 70324-47-9, 78386-03-5
astragalin

A: 2280-44-6
D-Glucose

B: 520-18-3
kaempferol

Conditions

Conditions	Yield
acid hydrolysis;

: 55804-74-5, 109008-28-8
clitorin

A: 2280-44-6
D-Glucose

B: 73-34-7, 87-96-7, 488-79-9, 551-63-3, 609-01-8, 643-17-4, 643-18-5, 4164-09-4, 6014-42-2, 6155-36-8, 6189-71-5, 6696-41-9, 6736-43-2, 13224-93-6, 22611-09-2, 28161-49-1, 28161-50-4, 28161-52-6, 45864-36-6, 63814-64-2, 71116-59-1, 71116-61-5, 72598-05-1, 87936-88-7, 87936-89-8, 97466-79-0, 116908-82-8, 120442-60-6, 123484-22-0, 133576-32-6
L-rhamnose

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid for 3h; Product distribution; Heating; sugar-like hydrolysis products were identified as their trimethylsilyl derivatives by GC-MS;

...Expand

: 78527-48-7
7-O-β-D-glucopyranosyl-kaempferol-3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside

A: 2280-44-6
D-Glucose

B: 73-34-7
L-rhamnose

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 2h; Heating;

...Expand

: 74712-68-8
kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside

A: 2280-44-6
D-Glucose

B: 7400-08-0
p-Coumaric Acid

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 3h;

...Expand

: 108906-96-3, 32602-81-6
nicotiflorin

A: 2280-44-6
D-Glucose

B: 73-34-7
L-rhamnose

C: 520-18-3
kaempferol

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Heating;

...Expand

: 520-18-3
kaempferol

: 108-24-7
acetic anhydride

: 16274-11-6
3,5,7-triacetoxy-2-(4-acetoxy-phenyl)-chromen-4-one

Conditions

Conditions	Yield
With pyridine at 20℃; for 4h;	95%
With pyridine at 20℃;	94%
With pyridine	94%

: 520-18-3
kaempferol

: 108-24-7
acetic anhydride

: 35688-42-7
5,7-dihydroxy-3,3',4',6-tetramethoxyflavone

Conditions

Conditions	Yield
With pyridine at 20℃; for 4h; Inert atmosphere;	95%

: 520-18-3
kaempferol

: 108-24-7
acetic anhydride

: 143724-69-0
kaempferol triacetate

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.25h; Inert atmosphere;	95%
With pyridine at 20℃; for 0.25h;	95%
With pyridine at 100 - 140℃;	90.5%

: 520-18-3
kaempferol

: 108-24-7
acetic anhydride

: C19H14O8

Conditions

Conditions	Yield
With piperidine at 100 - 140℃;	92.4%

: 520-18-3
kaempferol

: 108-24-7
acetic anhydride

: 3,4',5-tri-O-acetylkaempferol

Conditions

Conditions	Yield
With 4-methylpiperidin at 100 - 140℃;	91.8%

: 520-18-3
kaempferol

: 952585-00-1
uridine-5'-diphosphoglucose

: 562068-65-9
kaempferol 8-C-β-D-glucoside

Conditions

Conditions	Yield
With TcCGT1-C-glycosyltransferase from Trolliuschinensisuridine in complex with uridine diphosphate In aq. phosphate buffer; dimethyl sulfoxide pH=8; Enzymatic reaction;	91.6%

: 520-18-3
kaempferol

: 77-78-1
dimethyl sulfate

: 16692-52-7
3,4',5,7-tetramethoxyflavone

Conditions

Conditions	Yield
With potassium carbonate In acetone at 50℃; for 48h;	90%
With potassium carbonate In acetone at 50℃;	90%
With potassium carbonate In acetone at 50℃; for 48h;	86.3%
With potassium carbonate
With potassium carbonate In acetone for 4h; Heating;

: 520-18-3
kaempferol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1246814-11-8
3,7,4'-tri-O-tert-butyldimethylsilylkaempferol

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 0.25h;	90%
In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	81%

: 520-18-3
kaempferol

: 100-39-0
benzyl bromide

: 3,4',7-tri-O-benzylkaempferol

Conditions

Conditions	Yield
With potassium carbonate In acetone	90%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	72%

: 520-18-3
kaempferol

: 2106-10-7
1-deoxy-1-fluoro-α-D-glucose

: 16290-07-6
kaempferol 7-α-O-glucoside

Conditions

Conditions	Yield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;	90%

: 520-18-3
kaempferol

: 147-85-3
L-proline

: kaempferol L-proline cocrystals (1:2)

Conditions

Conditions	Yield
In tetrahydrofuran; methanol at 50℃;	89.6%

: 520-18-3
kaempferol

: 528-04-1, 2616-63-9, 7277-98-7, 16465-33-1, 19014-00-7, 26234-54-8, 26575-17-7, 27963-82-2, 29217-44-5, 125639-14-7
uridine 5'-diphospho-N-acetylglucosamine

: kaempferol 3-O-N-acetylglucosamine

Conditions

Conditions	Yield
With 3-O-glycosyltransferase from Scutellaria baicalensis In dimethyl sulfoxide at 45℃; for 4h; pH=9; Enzymatic reaction; regiospecific reaction;	88%

: 51-21-8
5-fluorouracil

: 520-18-3
kaempferol

: C15H10O6*C4H3FN2O2

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	83.3%
In ethanol at 20℃; for 5h; Solvent;	83.3%

: 133-89-1
UDP-glucose

: 520-18-3
kaempferol

: 16290-07-6
kaempferol 7-glucoside

Conditions

Conditions	Yield
With glycosyltransferase from Carthamus tinctorius (L.) (Honghua) recombinant In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Enzymatic reaction;	80%
With flavonoid 7-O-glucosyltransferase from Andrographis paniculata In methanol at 30℃; for 12h; Enzymatic reaction;

: 2956-16-3
uridine 5'-diphospho-D-galactose

: 520-18-3
kaempferol

: 480-10-4, 23627-87-4, 31159-41-8, 69292-77-9, 107163-34-8
kaempferol 3-O-galactoside

Conditions

Conditions	Yield
With 3-O-glycosyltransferase from Scutellaria baicalensis In dimethyl sulfoxide at 45℃; for 4h; pH=9; Catalytic behavior; Enzymatic reaction; regiospecific reaction;	79%
With 7-O-glucosyltransferase from Epimedium pseudowushanense In dimethyl sulfoxide at 30℃; for 12h; pH=7.4; Green chemistry; Enzymatic reaction;	17.1%

: 520-18-3
kaempferol

: 74-88-4
methyl iodide

: 16692-52-7
3,4',5,7-tetramethoxyflavone

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;	78%

: 66-71-7
1,10-Phenanthroline

: 520-18-3
kaempferol

: 7646-85-7
zinc(II) chloride

: 1482348-51-5
(κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride

Conditions

Conditions	Yield
Stage #1: kaempferol; zinc(II) chloride With sodium hydroxide In methanol at 20℃; for 1h; Stage #2: 1,10-Phenanthroline In methanol for 2h; Reflux;	77%

...Expand

: 50-00-0
formaldehyd

: 520-18-3
kaempferol

: 124-40-3
dimethyl amine

: 8-((dimethylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.5h; Mannich Aminomethylation;	76%

...Expand

: 366-18-7
[2,2]bipyridinyl

: 520-18-3
kaempferol

: 7646-85-7
zinc(II) chloride

: 1482348-52-6
(κ2-O,O-kaempferol)(κ2-N,N-2,20-bipyridine)zinc(II) chloride

Conditions

Conditions	Yield
Stage #1: kaempferol; zinc(II) chloride With sodium hydroxide In methanol at 20℃; for 1h; Stage #2: [2,2]bipyridinyl In methanol for 2h; Reflux;	75%

...Expand

: 50-00-0
formaldehyd

: 520-18-3
kaempferol

: 108-18-9
diisopropylamine

: 6-((diisopropylamino)methyl)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions

Conditions	Yield
In ethanol at 20℃; for 0.5h; Mannich Aminomethylation;	74%

...Expand

: 66-71-7
1,10-Phenanthroline

: copper(II) choride dihydrate

: 520-18-3
kaempferol

: (κ2-O,O-kaempferol) (κ2-N,N-1,10-phenanthroline)copper(II) chloride

Conditions

Conditions	Yield
Stage #1: copper(II) choride dihydrate; kaempferol With sodium hydroxide In methanol at 20℃; for 1h; Stage #2: 1,10-Phenanthroline In methanol for 2h; Reflux;	71%

...Expand

: 520-18-3
kaempferol

: 77-78-1
dimethyl sulfate

: 15486-34-7
5-hydroxy-3,4',7-trimethoxyflavone

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetone at 20℃; for 1h;	70%
With potassium hydroxide
With potassium carbonate; acetone

: 520-18-3
kaempferol

A: 116115-04-9
C15H8O12S2(2-)*2K(1+)

B: 116097-12-2
C15H7O15S3(3-)*3K(1+)

Conditions

Conditions	Yield
With potassium acetate; tetra(n-butyl)ammonium hydrogensulfate; dicyclohexyl-carbodiimide In pyridine at 25℃; for 48h; Yields of byproduct given;	A 69% B n/a

: 520-18-3
kaempferol

: 106-95-6
allyl bromide

: 1307876-11-4
7-O-allylkaempherol

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In water; N,N-dimethyl-formamide at 50℃; for 3h;	69%

: 366-18-7
[2,2]bipyridinyl

: copper(II) choride dihydrate

: 520-18-3
kaempferol

: 1482348-49-1
(κ2-O,O-kaempferol)(κ2-N,N-2,2'-bipyridine)copper(II) chloride

Conditions

Conditions	Yield
Stage #1: copper(II) choride dihydrate; kaempferol With sodium hydroxide In methanol at 20℃; for 1h; Stage #2: [2,2]bipyridinyl In methanol for 2h; Reflux;	68%

...Expand

: 520-18-3
kaempferol

: 142-61-0
Hexanoyl chloride

: 3,7,4'-tri(O-hexanoyl)kaempferol

Conditions

Conditions	Yield
With triethylamine In acetone at 0 - 20℃; for 3h;	68%
With triethylamine In acetone at 20℃; Inert atmosphere;	61%

Kaempferol Chemical Properties

Indigo yellow is also named as Kaempferol;3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;5,7,4’-trihydroxyflavonol;c.i.75640;campherol;kaempherol,and so on.

Molecular Formula: C₁₅H₁₀O₆
Molecular Weight: 286.24
EINECS: 208-287-6
Melting point: 276°C
Storage temp.: -20°C
Solubility: ethanol: 20 mg/mL
Form: powder
Colour Index: 75640
Color: yellow
Merck: 5274

Kaempferol Uses

Indigo yellow can commonly induce significant nuclear DNA degradation concurrent with lipid peroxidation.

Kaempferol Toxicity Data With Reference

1.		mma-sat 166 nmol/plate		MUREAV Mutation Research. 54 (1978),297.
2.		mnt-mus-ipr 200 mg/kg		MUREAV Mutation Research. 89 (1981),69.

RTECS: LK9275200

Kaempferol Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 31 , 1983,p. 171.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) .

Kaempferol Safety Profile

Questionable carcinogen. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
F: 8-10-23

Product Name

Kaempferol

Synthetic route

Kaempferol Chemical Properties

Kaempferol Uses

Kaempferol Toxicity Data With Reference

Kaempferol Consensus Reports

Kaempferol Safety Profile

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