L-Serine supplier | CasNO.56-45-1

Name
L-Serine
EINECS 200-274-3
CAS No. 56-45-1
Article Data200
CAS DataBase
Density 1.416 g/cm³
Solubility 250 g/L (20 ºC)
Melting Point 222ºC
Formula C₃H₇NO₃
Boiling Point 394.822 °C at 760 mmHg
Molecular Weight 105.093
Flash Point 192.582 °C
Transport Information
Appearance White crystalline powder
Safety 24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms (S)-alpha-Amino-beta-hydroxypropionic acid;Propanoic acid, 2-amino-3-hydroxy-, (S)-;(2S)-2-amino-3-hydroxypropanoic acid;L-2-Amino-3-hydroxypropionic acid;L-(-)-serine;beta-Hydroxyalanine;2-Amino-3-hydroxypropanoic acid, (S)-;alpha-Amino-beta-hydroxypropionic acid;
PSA 83.55000
LogP -0.90910

Synthetic route

: 4726-96-9
O-Benzyl-L-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With Nafion H; trifluoroacetic acid for 3h;	100%
With Nafion H; dimethylsulfide; 3-methyl-phenol; trifluoroacetic acid for 3h; Product distribution; other deprotection agents;	100%
With dimethylsulfide; trifluorormethanesulfonic acid; 30 (v/v); trifluoroacetic acid at 0℃; for 4h; Yield given;

: 23680-31-1
BOC-O-benzyl-L-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With dimethylsulfide; hydrogen fluoride at 0℃; for 2h; Product distribution; Var.: HF in anisole;	100%
With hydrogen; sodium dodecyl-sulfate; Lindlar's catalyst In methanol; water under 3.4 Torr; Yield given;

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With palladium/alumina; hydrogen at 70℃; neat (no solvent);	100%
With hydrogen; hydroxyapatite-bound Pd In methanol at 40℃; for 3h;	92%
With ethylenediaminetetraacetic acid; phenylmethylsulphonyl fluoride; water In aq. phosphate buffer at 30℃; Kinetics; Reagent/catalyst; Microbiological reaction; Enzymatic reaction;

: C3H7NO3*H3N*ClH

: 56-45-1
L-serin

Conditions

Conditions	Yield
With ruthenium nanoparticles dispersed in a polyvinylpyrrolidone matrix; amberlyst A-21 In methanol; dichloromethane	99%

: 4218-63-7
N-(4-Methoxybenzyloxycarbonyl)-O-benzyl-L-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; diphenyl sulfide In trifluoroacetic acid at 0℃; for 0.5h; Product distribution; New peptide deprotection procedure: hard-soft acid-base concept; the role of soft bases (thioanisole, dimethylsulfide, diphenylsulfide) employed; effect of var. hard bases; var. reaction cond.;	97.8%
With methyl-phenyl-thioether; trimethyl(2,4,6-trimethylphenoxy)silane In trifluoroacetic acid at 22℃; for 1h;	93.5%

: 111-26-2
hexan-1-amine

: 78641-68-6
(S)-2-(3,5-Dinitro-4-oxo-4H-pyridin-1-yl)-3-hydroxy-propionic acid

A: 56-45-1
L-serin

B: 74197-48-1
1-hexyl-3,5-dinitro-4-pyridone

Conditions

Conditions	Yield
In pyridine Product distribution;	A 90.9% B n/a

...Expand

: 30406-21-4
N-carbamyl-DL-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With NH4Cl-NH4OH buffer pH 8.5; nickel dichloride at 60℃; for 24h; N-carbamyl-L-amino acid aminohydrolase;	86%

: C11H20BNO3

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20℃; for 0.5h; Inert atmosphere;	85%

: methyl (-)-(2S,1'S)-1-(1-phenylethyl)aziridine-2-carboxylate

: 56-45-1
L-serin

Conditions

Conditions	Yield
With perchloric acid at 80℃; for 0.5h;	67%

: β-hydroxypyruvic acid, sodium salt

: 56-45-1
L-serin

Conditions

Conditions	Yield
With sodium formate; ammonium chloride; NADH In aq. phosphate buffer at 25℃; for 6h; pH=8.0; Kinetics; Reagent/catalyst; Green chemistry; Enzymatic reaction;	36.6%

/PBISF090--660/: /PBISF090--660/

: 56-45-1
L-serin

Conditions

Conditions	Yield
With Folitixorin; NAD at 34℃; for 72h; pH 7; by Corynebacterium glycinophilum;	33%

: 19525-95-2
(4S)-2-oxooxazolidine-4-carboxylic acid

: 56-45-1
L-serin

Conditions

Conditions	Yield
In various solvent(s) at 30℃; for 22h; enzymatic production by Pseudomonas testosteroni AJ-2770, pH = 7, other time, other bacteria;	30%

: 56-41-7
L-alanin

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

A: 56-45-1
L-serin

B: 70-47-3
L-asparagine

C: 471-46-5
Oxalamide

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Concentration; Electrolysis; Inert atmosphere;	A n/a B 27% C n/a

...Expand

: 56-41-7
L-alanin

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

A: 56-45-1
L-serin

B: 70-47-3
L-asparagine

C: 56-40-6
glycine

Conditions

Conditions	Yield
With sulfuric acid In water for 2h; Concentration; Electrolysis; Inert atmosphere;	A n/a B 27% C n/a

...Expand

: 6791-49-7
L-serinamide

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogenchloride

: 302-84-1
serin

: 56-45-1
L-serin

Conditions

Conditions	Yield
enzymatische Herstellung;

: 473-81-4
glyceric acid

: 56-45-1
L-serin

Conditions

Conditions	Yield
Biosynthese;

: 4582-71-2
benzoyl-DL-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
enzymatische Herstellung;

: 4582-71-2
benzoyl-DL-serine

A: 56-45-1
L-serin

B: 86808-09-5
N-(p-methylbenzoyl)-D-serine

Conditions

Conditions	Yield
With pseudomonas-extract

: N-benzoyl-L-serine anilide

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogenchloride

: 1738-72-3
L-serine benzyl ester

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogenchloride
at 25℃; for 0.833333h; enzyme alcalase from Bacillus licheniforms; pH 8.2;

: 93527-55-0
(S)-2-(dibenzylamino)-3-hydroxypropanoic acid

: 56-45-1
L-serin

Conditions

Conditions	Yield
durch Hydrogenolyse;

: 86091-63-6
N-(3,5-dinitrobenzoyl)-D-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogenchloride

: 39741-31-6
(S)-3-amino-2-benzoylamino-propionic acid methyl ester; hydrochloride

: 56-45-1
L-serin

Conditions

Conditions	Yield
With cis-nitrous acid Kochen des Reaktionsprodukts mit wss.HBr;

: 56-40-6
glycine

: 56-45-1
L-serin

Conditions

Conditions	Yield
durch Torulopsis utilis;

: 51293-45-9
O-methyl-N,N-phthaloyl-L-serine

: 56-45-1
L-serin

Conditions

Conditions	Yield
With hydrogen iodide; acetic acid

: 34557-54-5
methane

A: 56-41-7
L-alanin

B: 56-45-1
L-serin

C: 72-19-5
L-threonine

D: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A 5.69E-3 mmol B n/a C n/a D n/a

...Expand

: 34557-54-5
methane

A: 1492-24-6
L-2-aminobutyric acid

B: 56-45-1
L-serin

C: 72-19-5
L-threonine

D: 56-84-8
L-Aspartic acid

Conditions

Conditions	Yield
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A 0.62E-3 mmol B n/a C n/a D n/a

...Expand

: 34557-54-5
methane

A: 56-45-1
L-serin

B: 72-19-5
L-threonine

C: 56-84-8
L-Aspartic acid

D: 56-40-6
glycine

Conditions

Conditions	Yield
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A n/a B n/a C n/a D 26.0E-3 mmol
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A 0.95E-3 mmol B n/a C n/a D n/a
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A n/a B 0.88E-3 mmol C n/a D n/a
With sodium molybdate; ammonium iron (II) sulfate; water; sodium carbonate; ammonium chloride; calcium chloride; magnesium chloride; zinc(II) chloride for 5h; Ambient temperature; Irradiation; pH=8.7; Further byproducts given. Yields of byproduct given;	A n/a B n/a C 0.19E-3 mmol D n/a

...Expand

: 64-17-5
ethanol

: 56-45-1
L-serin

: 26348-61-8
L-serine ethyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; Inert atmosphere;	100%
With hydrogenchloride for 0.5h;	98%
With thionyl chloride at 0 - 20℃; for 17h;	98%

: 56-45-1
L-serin

: 501-53-1
benzyl chloroformate

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In diethyl ether; water at 0 - 20℃; for 6h;	100%
With sodium hydroxide In water at 0℃; for 24h;	94%
With sodium hydrogencarbonate for 4h; Ambient temperature;	93%

: 67-56-1
methanol

: 56-45-1
L-serin

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride at 0℃;	100%
With thionyl chloride at 20℃; for 24h;	100%
With thionyl chloride at 25℃; for 24h;	100%

: 50-00-0
formaldehyd

: 56-45-1
L-serin

: 45521-08-2
(S)-oxazolidine-4-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 2℃; for 24h;	100%
Stage #1: L-serin With sodium hydroxide In water at 0℃; for 0.166667h; Stage #2: formaldehyd In water at 20℃;	62.3%
With sodium hydroxide at 5℃; for 18h;

: 64-17-5
ethanol

: 56-45-1
L-serin

: 4117-31-1
ethyl L-serinate

Conditions

Conditions	Yield
With hydrogenchloride for 5h; Heating;	100%
With toluene-4-sulfonic acid In benzene azeotropic esterification; Yield given;
With hydrogenchloride for 5h; Heating;

: 56-45-1
L-serin

: 24424-99-5
di-tert-butyl dicarbonate

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

Conditions

Conditions	Yield
	100%
With sodium hydroxide In water; tert-butyl alcohol	100%
With sodium hydroxide In 1,4-dioxane; water at 0℃;	100%

: 56-45-1
L-serin

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 73724-45-5
N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine

Conditions

Conditions	Yield
With sodium hydrogencarbonate	100%
With sodium carbonate In 1,4-dioxane	97%
With sodium hydrogencarbonate In water; acetonitrile	94%

: 56-45-1
L-serin

: 107-07-3
2-chloro-ethanol

: 88962-24-7
L-Serin-2-chlorethylester-hydrochlorid

Conditions

Conditions	Yield
With thionyl chloride Ambient temperature;	100%

: 56-45-1
L-serin

: 540-51-2
2-bromoethanol

: 88962-25-8
Serin-2-bromethylester-hydrochlorid

Conditions

Conditions	Yield
With thionyl chloride Ambient temperature;	100%

: 67-56-1
methanol

: 56-45-1
L-serin

: 24424-99-5
di-tert-butyl dicarbonate

: 2766-43-0
N-(tert-butoxycarbonyl)-L-serine methyl ester

Conditions

Conditions	Yield
Stage #1: methanol; L-serin With acetyl chloride Stage #2: di-tert-butyl dicarbonate With triethylamine	100%
Stage #1: methanol; L-serin With thionyl chloride at 20℃; for 10h; Reflux; Large scale; Stage #2: di-tert-butyl dicarbonate With triethylamine In dichloromethane at 20℃; for 8h; Reagent/catalyst; Solvent; Cooling with ice; Large scale;	94%
Stage #1: methanol; L-serin With thionyl chloride at 0 - 20℃; for 6h; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 12h;	89%

...Expand

: 56-45-1
L-serin

: 24424-99-5
di-tert-butyl dicarbonate

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

Conditions

Conditions	Yield
With sodium hydroxide Acylation;	100%

: 67-56-1
methanol

: 56-45-1
L-serin

: 18162-48-6
tert-butyldimethylsilyl chloride

: 98642-61-6
(2S)-2-amino-3-(tert-butyldimethylsilanyloxy)propionic acid methyl ester

Conditions

Conditions	Yield
Stage #1: methanol; L-serin With thionyl chloride Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole In acetonitrile	100%
Stage #1: methanol; L-serin With thionyl chloride Stage #2: tert-butyldimethylsilyl chloride With 1H-imidazole	79%

...Expand

: 56-45-1
L-serin

: 75-36-5
acetyl chloride

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Conditions

Conditions	Yield
Stage #1: acetyl chloride In methanol at 20℃; for 0.166667h; Stage #2: L-serin In methanol at 80℃; for 2h;	100%
In methanol at 20℃;

: 67-56-1
methanol

: 56-45-1
L-serin

: 2788-84-3
(S)-serine methyl ester

Conditions

Conditions	Yield
With acetyl chloride In methanol	99%
With thionyl chloride	98%
With acetyl chloride at 50℃; Inert atmosphere;	96%

: 56-45-1
L-serin

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

Conditions

Conditions	Yield
With di-tert-butyl dicarbonate; sodium hydroxide In 1,4-dioxane; water at 0 - 20℃; for 7h;	99%
With triethylamine In water; N,N-dimethyl-formamide for 7h; Ambient temperature;	95%

: 56-45-1
L-serin

: 134920-16-4
N-methoxycarbonyl-3-phenyloxaziridine

: L-N-(methoxycarbonylamino)serine

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide 1.) MeOH, 30 min, 2.) CHCl3, -15 deg C, 1 h;	99%

: 186581-53-3, 908094-01-9
diazomethane

: 56-45-1
L-serin

: 2788-84-3
(S)-serine methyl ester

Conditions

Conditions	Yield
In methanol; diethyl ether at 20℃;	99%
In methanol; diethyl ether for 0.166667h;

: 56-45-1
L-serin

: 403-43-0
4-fluorobenzoyl chloride

: 1102888-26-5
(S)-2-(4-fluorobenzamido)-3-hydroxypropanoic acid

Conditions

Conditions	Yield
With sodium carbonate In 1,4-dioxane; water at 0℃; for 1h;	99%

: 15861-36-6
1H-Indole-6-carbonitrile

: 56-45-1
L-serin

: 6-cyanotryptophan

Conditions

Conditions	Yield
With Pf0A9 enzyme In aq. phosphate buffer; water; dimethyl sulfoxide at 75℃; for 12h; pH=8; Enzymatic reaction;	99%

: 53924-05-3
7-chloro-1H-indole

: 56-45-1
L-serin

: 153-97-9, 73945-46-7, 75102-74-8
7-chloro-L-tryptophan

Conditions

Conditions	Yield
With Pf0A9 enzyme In aq. phosphate buffer; water; dimethyl sulfoxide at 75℃; for 12h; pH=8; Enzymatic reaction;	99%

: 387-43-9
4-fluoroindole

: 56-45-1
L-serin

: 2-(4-fluoro-1H-indol-3-yl) ethan-1-amine

Conditions

Conditions	Yield
Stage #1: 4-fluoroindole; L-serin With engineered tryptophan synthase In methanol; aq. phosphate buffer at 75℃; for 12h; pH=8.0; Enzymatic reaction; Stage #2: With pyridoxal 5'-phosphate; Ruminococcus gnavus L-tryptophan decarboxylase In methanol; aq. phosphate buffer at 37℃; pH=8.0; Enzymatic reaction;	99%

: 67-56-1
methanol

: 593-75-9, 685498-28-6
methyl isocyanate

: 56-45-1
L-serin

: 78-84-2
isobutyraldehyde

: N-[1-(N-methylcarbamoyl)-2-methylpropyl]-L-serine methyl ester

Conditions

Conditions	Yield
at -30 - 20℃;	98%

...Expand

L-Serine Chemical Properties

Molecular Structure:

Molecular Formula: C₃H₇NO₃
Molecular Weight: 105.0926
IUPAC Name: (2S)-2-Amino-3-hydroxypropanoic acid
Synonyms of L-serine (CAS NO.56-45-1): (S)-2-Amino-3-hydroxypropanoic acid ; (S)-Serine ; 2-Amino-3-hydroxypropanoic acid ; 2-Amino-3-hydroxypropanoic acid, (S)- ; 4-04-00-03118 (Beilstein Handbook Reference) ; BRN 1721404 ; EINECS 200-274-3 ; HSDB 680 ; NSC 118365 ; Propanoic acid, 2-amino-3-hydroxy-, (S)- ; SER (IUPAC abbrev) ; Serene ; Serina ; Serina [Spanish] ; Serine ; Serine (VAN) ; Serinum ; Serinum [Latin] ; UNII-452VLY9402 ; alpha-Amino-beta-hydroxypropionic acid ; beta-Hydroxyalanine
CAS NO: 56-45-1
Classification Code: Amino acid ; Mutation data
Melting point: 222 °C
Water Solubility: 250 g/L (20 °C)
Alpha: 15.2 o (c=10, 2N HCl)
Storage temp.: Store at 0-5
Solubility H₂O: 50 mg/mL
form: powder
Sublimation: 150 °C
Density: 1.415 g/cm³
Flash Point: 192.6 °C
Index of Refraction: 1.519
Surface Tension: 72.2 dyne/cm
Enthalpy of Vaporization: 74.56 kJ/mol
Boiling Point: 394.8 °C at 760 mmHg
Vapour Pressure: 7.17E-08 mmHg at 25 °C
Appearance of L-serine (CAS NO.56-45-1): White crystalline powder

L-Serine Production

Racemic serine can be prepared from METHYL ACRYLATE via several steps

L-Serine Safety Profile

Hazard Codes of L-serine (CAS NO.56-45-1): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25: Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
F: 3

L-Serine Specification

L-serine (CAS NO.56-45-1) is Stable, and incompatible with strong oxidizing agents. It is stable under normal temperatures and pressures. It should avoid incompatible materials, light, exposure to moist air or water, and it's incompatibilities with strong oxidizing agents. Its hazardous decomposition products are nitrogen oxides, carbon monoxide and carbon dioxide.

Product Name

L-Serine

Synthetic route

L-Serine Chemical Properties

L-Serine Production

L-Serine Safety Profile

L-Serine Specification

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