Methyl 3-methoxypropionate supplier

Name
Methyl 3-methoxypropionate
EINECS 223-358-1
CAS No. 3852-09-3
Article Data55
CAS DataBase
Density 0.977 g/cm³
Solubility 428.60g/L(25 oC)
Melting Point
Formula C₅H₁₀O₃
Boiling Point 143.6 °C at 760 mmHg
Molecular Weight 118.133
Flash Point 43.5 °C
Transport Information UN 3272 3/PG 3
Appearance Clear colorless liquid
Safety 26-36-37/39
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Propionicacid, 3-methoxy-, methyl ester (6CI,7CI,8CI);beta-Methoxypropionic acid, methyl ester;3-Methoxypropionic acid methyl ester;Methyl b-methoxypropionate;NSC 65578;BRN 1744829;Methylester kyseliny 3-methoxypropionove;
PSA 35.53000
LogP 0.19590

Synthetic route

: 67-56-1
methanol

: 292638-85-8
acrylic acid methyl ester

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With sodium methylate at 60℃; for 8h;	99%
With sodium methylate; 4-methoxy-phenol at 40 - 60℃; for 6h; Temperature; Reagent/catalyst;	99%
With triethylamine at 20℃; for 8h; Temperature; Reagent/catalyst; Large scale;	98%

: 124-41-4
sodium methylate

: 292638-85-8
acrylic acid methyl ester

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With 4-methoxy-phenol In methanol at 40 - 60℃; for 6h; Reagent/catalyst;	99%
In methanol for 24h; Heating;	54%

: 865-34-9
lithium methanolate

: 292638-85-8
acrylic acid methyl ester

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With hydroquinone In methanol at 40℃; for 20h;	88%

: 67-56-1
methanol

Tetracarbonyleisenkomplexe des Ethylens: Tetracarbonyleisenkomplexe des Ethylens

A: 3395-91-3
Methyl 3-bromopropionate

B: 3852-09-3
methyl 3-methoxypropionate

C: 106-93-4
ethylene dibromide

D: 6482-24-2
2-Bromoethyl methyl ether

Conditions

Conditions	Yield
With bromine at -80℃; temperature up to 30 deg C;	A 67% B n/a C n/a D n/a

...Expand

: 292638-85-8
acrylic acid methyl ester

A methyl 3-methyoxypropionate: methyl 3-methyoxypropionate

B: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With sodium methylate In methanol	A 65% B n/a

: 292638-85-8
acrylic acid methyl ester

: 108-93-0
cyclohexanol

A: 3852-09-3
methyl 3-methoxypropionate

B: 3066-71-5
cyclohexyl acrylate

C: 112032-53-8
3-Methoxy-propionic acid cyclohexyl ester

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 22% B 23% C 52%

...Expand

: 584-02-1
2-pentanol

: 292638-85-8
acrylic acid methyl ester

A: 3852-09-3
methyl 3-methoxypropionate

B: 4513-35-3
3-pentyl acrylate

C: 112032-52-7
3-Methoxy-propionic acid 1-ethyl-propyl ester

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other temp., other time;	A 19% B 25% C 48%

...Expand

: 292638-85-8
acrylic acid methyl ester

: 67-63-0
isopropyl alcohol

A: 3852-09-3
methyl 3-methoxypropionate

B: 689-12-3
isopropyl acrylate

C: 10500-14-8
isopropyl 3-methoxypropionate

D: 4220-74-0
3-isopropoxy-propionic acid isopropyl ester

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other temp, other time;	A 17% B 15% C 42% D 26%

...Expand

: 292638-85-8
acrylic acid methyl ester

: 78-92-2, 15892-23-6
iso-butanol

A: 3852-09-3
methyl 3-methoxypropionate

B: 2998-08-5
sec-butyl acrylate

C: 112032-50-5
3-methoxy-propionic acid sec-butyl ester

D: 112032-51-6
3-sec-butoxy-propionic acid sec-butyl ester

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 27% B 28% C 33% D 6%

...Expand

: 292638-85-8
acrylic acid methyl ester

: 75-65-0
tert-butyl alcohol

A: 1663-39-4
tert-Butyl acrylate

B: 3852-09-3
methyl 3-methoxypropionate

C: 81048-08-0
3-tert.-Butoxypropionsaeuremethylester

D: 112032-54-9
3-Methoxy-propionic acid tert-butyl ester

E: 21150-74-3
tert-butyl β-tert-butoxypropionate

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution; other time, other temp.;	A 33% B 26% C 9% D 32% E 3%

...Expand

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 292638-85-8
acrylic acid methyl ester

A: 3852-09-3
methyl 3-methoxypropionate

B: 108945-28-4
(1S,2R,5S)‐2‐isopropyl‐5‐methylcyclohexyl acrylate

Conditions

Conditions	Yield
With n-butyllithium; bis(acetylacetonate)nickel(II) In benzene at 90℃; for 5h; Product distribution;	A 22% B 23%

...Expand

: 67-56-1
methanol

: 624-45-3
levulinic acid methyl ester

A: 7424-91-1
methyl 3,3-dimethoxypropionate

B: 79-20-9
acetic acid methyl ester

C: 3852-09-3
methyl 3-methoxypropionate

D: 108-59-8
malonic acid dimethyl ester

E: 106-65-0
Dimethyl succinate

Conditions

Conditions	Yield
With dihydrogen peroxide; toluene-4-sulfonic acid In water at 80℃; for 6h; Reagent/catalyst; Solvent; Baeyer-Villiger Ketone Oxidation; Overall yield = 22 %;	A 13% B n/a C n/a D 8% E n/a

...Expand

: 463-51-4
Ketene

: 109-87-5
Dimethoxymethane

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
at -80 - 10℃; in Gegenwart von sauren Katalysatoren;
With boron trifluoride at -80℃;

: 67-56-1
methanol

: 57-57-8
β-Propiolactone

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With sulfuric acid at 65℃;

: 5029-66-3
methyl 3-iodopropanoate

: 124-41-4
sodium methylate

: 3852-09-3
methyl 3-methoxypropionate

: 67-56-1
methanol

: 292638-85-8
acrylic acid methyl ester

A: 2544-06-1
3-Methoxypropionic acid

B: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With sodium

...Expand

: 124-41-4
sodium methylate

: 6001-87-2
methyl 3-chloropropionate

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
beim nachfolgendes Kochen;

: 67-56-1
methanol

: 89601-13-8
3-(N-Nitroso-methoxycarbonylamino)-propionsaeure-methylester

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With potassium carbonate

: 67-56-1
methanol

: methyl 3-bromopropanimidate hydrochloride

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
In diethyl ether

: 999-55-3
allyl acrylate

: 124-41-4
sodium methylate

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
In methanol

: 78-94-4
methyl vinyl ketone

: 292638-85-8
acrylic acid methyl ester

A: 6975-85-5
1-methoxybutan-3-one

B: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In dichloromethane	A 28 % Chromat. B 10 % Chromat.

...Expand

: 108-98-5
thiophenol

: 292638-85-8
acrylic acid methyl ester

A: 3852-09-3
methyl 3-methoxypropionate

B: 22198-59-0
methyl 3-phenylthiopropanoate

Conditions

Conditions	Yield
With sodium 1.) methanol; 2.) reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 67-56-1
methanol

: 292638-85-8
acrylic acid methyl ester

A: 3852-09-3
methyl 3-methoxypropionate

B: 22198-59-0
methyl 3-phenylthiopropanoate

Conditions

Conditions	Yield
With sodium; thiophenol 1.) methanol; 2.) reflux, 1 h; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 67-56-1
methanol

: 79-10-7
acrylic acid

A: 3852-09-3
methyl 3-methoxypropionate

B: 292638-85-8
acrylic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 111.1℃; for 0.25h; Product distribution; Kinetics; other times, temp.;

...Expand

: 67-56-1
methanol

: 292638-85-8
acrylic acid methyl ester

A: 7424-91-1
methyl 3,3-dimethoxypropionate

B: 5788-17-0
methyl (2E)-3-methoxy-2-propenoate

C: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h; Product distribution; various catalysts and temperatures;
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 40℃; for 12h;	A 91.7 % Chromat. B 1.2 % Chromat. C 2.0 % Chromat.
With supercritical CO2; oxygen; dichloro bis(acetonitrile) palladium(II); copper dichloride at 50℃; for 12h;	A 81.1 % Chromat. B 8.8 % Chromat. C 3.5 % Chromat.
With supercritical CO2; oxygen; copper dichloride; palladium dichloride at 50℃; for 12h;	A 42.9 % Chromat. B 3.1 % Chromat. C 6.6 % Chromat.

...Expand

: 67-56-1
methanol

: 292638-85-8
acrylic acid methyl ester

sodium: sodium

: 3852-09-3
methyl 3-methoxypropionate

...Expand

: 463-51-4
Ketene

: 109-87-5
Dimethoxymethane

: 7664-93-9
sulfuric acid

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
at 4℃;

...Expand

: 463-51-4
Ketene

: 109-87-5
Dimethoxymethane

: 7637-07-2
boron trifluoride

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
at -80℃;

...Expand

: 463-51-4
Ketene

: 109-87-5
Dimethoxymethane

ZnCl2: ZnCl2

: 3852-09-3
methyl 3-methoxypropionate

Conditions

Conditions	Yield
at 4℃;

...Expand

: 3852-09-3
methyl 3-methoxypropionate

: 124-40-3
dimethyl amine

: 53185-52-7
β-methoxy-N,N-dimethylpropionic acid amide

Conditions

Conditions	Yield
With zinc(II) trifluoroacetate at 0 - 40℃; for 8h; Reagent/catalyst; Autoclave;	99%
With sodium methylate; glycerol at 60℃; for 6h; Autoclave;	86%
With potassium tert-butylate at 20℃; under 600.06 Torr; for 4h; Product distribution / selectivity; Autoclave;
With sodium methylate; ethylene glycol at 60℃; for 8h; Product distribution / selectivity; Autoclave;

: 3852-09-3
methyl 3-methoxypropionate

: 22374-89-6
(RS)-1-methyl-3-phenylpropylamine

: 1322805-06-0
(R)-3-methoxy-N-(4-phenylbutan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 24h; Concentration; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	98%

: 3852-09-3
methyl 3-methoxypropionate

: 124-30-1
1-aminooctadecane

: β-methoxy-N-stearylamide

Conditions

Conditions	Yield
With iron(II) triflate In N,N-dimethyl-formamide at 80℃; for 2h;	98%

: 3852-09-3
methyl 3-methoxypropionate

: 60-15-1, 156-34-3, 51-64-9, 300-62-9
2-amino-1-phenylpropane

: 1322805-08-2
(R)-3-methoxy-N-(1-phenylpropan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	97%

: 3852-09-3
methyl 3-methoxypropionate

: C12H19N

: (R)-N-(4-(3,5-dimethylphenyl) butan-2-yl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	96%

: 3852-09-3
methyl 3-methoxypropionate

: C12H19N

: (R)-N-(4-(2,4-dimethylphenyl)butan-2-yl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	95%

: 3852-09-3
methyl 3-methoxypropionate

: 64-11-9
4-methylamphetamine

: (R)-3-methoxy-N-(1-(p-tolyl)propan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	95%

: 3852-09-3
methyl 3-methoxypropionate

: C11H17N

: (R)-3-methoxy-N-(4-(o-tolyl)butan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	94%

: 3852-09-3
methyl 3-methoxypropionate

: C11H17N

: (R)-3-methoxy-N-(4-(m-tolyl)butan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	94%

: 3852-09-3
methyl 3-methoxypropionate

: <1,1-(2)H2>-3-methoxypropanol

Conditions

Conditions	Yield
With lithium deuteride In diethyl ether for 1h; Heating;	91%
With lithium aluminium deuteride	54%
With lithium aluminium deuteride	1.82 g

: 3852-09-3
methyl 3-methoxypropionate

: C12H19N

: (R)-N-(4-(4-ethylphenyl)butan-2-yl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	87%

: 3852-09-3
methyl 3-methoxypropionate

: 89538-71-6
1-methyl-3-p-tolyl-propylamine

: (R)-3-methoxy-N-(4-(p-tolyl)butan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	85%

: 3852-09-3
methyl 3-methoxypropionate

: 4352-49-2, 5913-13-3, 17430-98-7, 54423-01-7
1-cyclohexylethylamine

: (R)-N-(1-cyclohexylethyl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	84%

: 3852-09-3
methyl 3-methoxypropionate

: 123-82-0
2-heptylamine

: (R)-N-(heptan-2-yl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 60h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	81%

: 3852-09-3
methyl 3-methoxypropionate

: 75-31-0
isopropylamine

: β-methoxy-N-isopropylpropionic acid amide

Conditions

Conditions	Yield
With iron(II) triflate In N,N-dimethyl-formamide at 0 - 90℃; for 1h; Autoclave;	79%

: 2016-57-1
1-aminodecane

: 3852-09-3
methyl 3-methoxypropionate

: β-methoxy-N-decylpropionamide

Conditions

Conditions	Yield
With iron(II) triflate at 0 - 40℃; under 760.051 Torr; for 1h; Autoclave;	79%

: 44855-57-4, 693-16-3
rac-2-aminooctane

: 3852-09-3
methyl 3-methoxypropionate

: 1322805-09-3
(R)-3-methoxy-N-(octan-2-yl) propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	79%
With novozyme 435 In cyclohexane at 70℃; under 7500.75 Torr; for 24h; Resolution of racemate; Inert atmosphere; Autoclave; Enzymatic reaction;

: 3852-09-3
methyl 3-methoxypropionate

: 459-02-9
4-fluoroamphetamine

: (R)-N-(1-(4-fluorophenyl)propan-2-yl)-3-methoxypropanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	78%

: 3852-09-3
methyl 3-methoxypropionate

: 109-89-7
diethylamine

: 5830-19-3
3-methoxy-N,N-diethylpropionic acid amide

Conditions

Conditions	Yield
With iron(II) triflate at 0 - 100℃; for 1h; Autoclave;	76%

: 3852-09-3
methyl 3-methoxypropionate

: 108-91-8
cyclohexylamine

: β-methoxy-N-cyclohexylpropionic acid amide

Conditions

Conditions	Yield
With iron(II) triflate at 0 - 50℃; under 760.051 Torr; for 1h; Autoclave;	75%

: 543-82-8
1,5-dimethylhexylamine

: 3852-09-3
methyl 3-methoxypropionate

: 1322805-10-6
(R)-3-methoxy-N-(6-methylheptan-2-yl) propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 48h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	74%

: 3852-09-3
methyl 3-methoxypropionate

: 64-13-1
2-amino-1-(4-methyoxyphenyl)propane

: (R)-3-methoxy-N-(1-(4-methoxyphenyl)propan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	72%

: 3852-09-3
methyl 3-methoxypropionate

: 135773-25-0
4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

: 1258289-24-5
4,4'-(1-hydroxy-3-methoxypropane-1,1-diyl)bis(N,N-dimethyl-1H-imidazole-1-sulfonamide)

Conditions

Conditions	Yield
Stage #1: 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide With ethylmagnesium bromide In diethyl ether; dichloromethane at 20℃; for 2h; Double Grignard reaction; Inert atmosphere; Stage #2: methyl 3-methoxypropionate In diethyl ether; dichloromethane at 20℃; for 48h; Double Grignard reaction; Inert atmosphere; Stage #3: With water; ammonium chloride In diethyl ether; dichloromethane	71%

: 20352-67-4
N-ethylhexylamine

: 3852-09-3
methyl 3-methoxypropionate

: β-methoxy-N-ethylhexylpropionic acid amide

Conditions

Conditions	Yield
With iron(II) triflate at 0 - 25℃; under 760.051 Torr; for 1h; Autoclave;	66%

: 3852-09-3
methyl 3-methoxypropionate

: 51062-15-8
(+)-(R)-1-Methyl-3-(4-methoxyphenyl)-1-propylamine

: (R)-3-methoxy-N-(4-(4-methoxyphenyl)butan-2-yl)propanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 72h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;	64%

Methyl 3-methoxypropionate Consensus Reports

Reported in EPA TSCA Inventory.

Methyl 3-methoxypropionate Specification

The 3-Methoxypropionic acid methyl ester with CAS registry number of 3852-09-3 is also known as Propanoic acid,3-methoxy-, methyl ester. The IUPAC name is Methyl 3-methoxypropionate. It belongs to product categories of Aromatic Propionic Acids; C2 to C5; Carbonyl Compounds; Esters. Its EINECS registry number is 223-358-1. In addition, the formula is C₅H₁₀O₃ and the molecular weight is 118.13. This chemical is a clear colorless liquid that may cause inflammation to the skin or other mucous membranes. It should be sealed in ventilated and dry without light at roon temperature. What's more, this chemical can be used as pharmaceutical intermediate.

Physical properties about 3-Methoxypropionic acid methyl ester are: (1)ACD/LogP: 0.19; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.19; (4)ACD/LogD (pH 7.4): 0.19; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 30.11; (8)ACD/KOC (pH 7.4): 30.11; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.391; (13)Molar Refractivity: 28.73 cm³; (14)Molar Volume: 120.9 cm³; (15)Surface Tension: 26.9 dyne/cm; (16)Density: 0.976 g/cm³; (17)Flash Point: 43.5 °C; (18)Enthalpy of Vaporization: 38.07 kJ/mol; (19)Boiling Point: 143.6 °C at 760 mmHg; (20)Vapour Pressure: 5.3 mmHg at 25 °C.

Preparation of 3-Methoxypropionic acid methyl ester: it is prepared by reaction of acrylic acid methyl ester with methanol; sodium salt. The reaction needs reagent methanol with other condition of heating for 24 hours. The yield is about 54%.

3-Methoxypropionic acid methyl ester is prepared by reaction of acrylic acid methyl ester with methanol; sodium salt.

Uses of 3-Methoxypropionic acid methyl ester: it is used to produce 4-methoxy-2-methyl-butan-2-ol by reaction with methylmagnesium iodide. The reaction occurs with reagent diethyl ether at 20 °C for 18 hours. The yield is about 59%.

3-Methoxypropionic acid methyl ester is used to produce 4-methoxy-2-methyl-butan-2-ol by reaction with methylmagnesium iodide.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, it is flammable. During using it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: COCCC(=O)OC
2. InChI: InChI=1S/C5H10O3/c1-7-4-3-5(6)8-2/h3-4H2,1-2H3
3. InChIKey: BDJSOPWXYLFTNW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LC50	inhalation	40gm/m³ (40000mg/m³)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(3), Pg. 48, 1974.
rat	LCLo	inhalation	3656ppm/6H (3656ppm)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0486-0599,
rat	LDLo	oral	1700mg/kg (1700mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0486-0599,

Product Name

Methyl 3-methoxypropionate

Synthetic route

Methyl 3-methoxypropionate Consensus Reports

Methyl 3-methoxypropionate Specification

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