Phenethyl chloride supplier

Name
Benzene,(2-chloroethyl)-
EINECS 210-725-6
CAS No. 622-24-2
Article Data140
CAS DataBase
Density 1.052 g/cm³
Solubility 0.1 g/L (20 °C) in water
Melting Point -60 °C
Formula C₈H₉Cl
Boiling Point 198.2 °C at 760 mmHg
Molecular Weight 140.612
Flash Point 66.7 °C
Transport Information
Appearance clear liquid
Safety 23-24/25-37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Benzene, (b-chloroethyl)- (3CI);(2-Chloroethyl)benzene;(b-Chloroethyl)benzene;1-Chloro-2-phenylethane;2-Phenyl-1-chloroethane;2-Phenylethyl chloride;NSC 27886;Phenylethyl chloride;b-Phenethyl chloride;b-Phenylethyl chloride;
PSA 0.00000
LogP 2.46790

Synthetic route

: 60-12-8
2-phenylethanol

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With trichloroacetamide; triphenylphosphine In dichloromethane at 30℃; for 0.25h;	99%
Stage #1: 2-phenylethanol With N,N-dimethylthiourea In dichloromethane at 20℃; Stage #2: With N-chloro-succinimide In dichloromethane at 20℃; for 1h; Irradiation;	98%
With 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide In dichloromethane at 25℃; for 0.25h;	97%

: o-(N-methylcarbamoyl)phenyl 2-phenylethyl sulphoxide

A: 2527-66-4
2-methyl-1,2-benzisothiazole-3(2H)-one

B: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane for 1h; Heating;	A 99% B 97%

: 20020-27-3
2-phenylethyl mesylate

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium chloride at 50℃; for 1h; Inert atmosphere; Green chemistry;	98%

: 36794-46-4
diphenethyl-1,1 trimethylene-4,4' bipiperidine

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With phenyl chloroformate In neat (no solvent) Heating;	93%

: 60-12-8
2-phenylethanol

: 2570-00-5
3,3-dichloro-1,2-diphenylcyclopropene

A: 622-24-2
2-phenylethyl chloride

B: 886-38-4
diphenylcyclopropenone

Conditions

Conditions	Yield
In dichloromethane at 23℃; for 0.25h; Mechanism; Solvent; Inert atmosphere;	A 89% B n/a
In dichloromethane at 23℃; for 0.25h;

...Expand

: 60-12-8
2-phenylethanol

: 98-07-7
Benzotrichlorid

A: 98-87-3
benzylidene dichloride

B: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With TOP; phenylsilane In neat (no solvent) at 100℃; for 24h; Appel Halogenation; Inert atmosphere;	A n/a B 88%

...Expand

: 32327-70-1
1-chloro-4-(2-chloroethyl)benzene

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With palladium on activated charcoal; formic acid; N,N-dimethyl-formamide for 5h; Heating;	85%

: 122-78-1
phenylacetaldehyde

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With dichloromethylsilane; iron(III) chloride In 1,2-dimethoxyethane for 4h; Heating;	85%

: 532-27-4
1-chloroacetophenone

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With titanium tetrachloride In 1,2-dichloro-ethane for 3h; Reflux;	85%

: 60-12-8
2-phenylethanol

: 98-88-4
benzoyl chloride

A: 94-47-3
2-Phenylethyl benzoate

B: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With 2,3-diethyl-2-cyclopropen-1-one In tert-butyl methyl ether at 40℃; for 15h;	A n/a B 83%

...Expand

: 3558-60-9
1-methoxy-2-phenylethane

A: 622-24-2
2-phenylethyl chloride

B: 103-45-7
acetic acid phenethyl ester

Conditions

Conditions	Yield
With acetyl chloride; zinc In Petroleum ether at 28℃; for 4h;	A 78% B 20%

: 3558-60-9
1-methoxy-2-phenylethane

: 75-36-5
acetyl chloride

A: 622-24-2
2-phenylethyl chloride

B: 103-45-7
acetic acid phenethyl ester

Conditions

Conditions	Yield
With zinc In Petroleum ether at 28℃; for 4h;	A 78% B 20%

...Expand

: 332-14-9
1-phenethylpiperidine

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With potassium hydrogencarbonate; phenyl chloroformate Heating;	74%
With methanol; carbonochloridic acid 1-chloro-ethyl ester 1) 1,2-dichloroethane; Yield given. Multistep reaction;

: 100-41-4
ethylbenzene

A: 1074-11-9
1-(1,2-dichloroethyl)benzene

B: 622-24-2
2-phenylethyl chloride

C: 672-65-1
(1-chloroethyl)benzene

Conditions

Conditions	Yield
With N-chloro-succinimide; benzophenone In acetonitrile at 27℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Wavelength; Irradiation; regioselective reaction;	A 19 %Spectr. B 7 %Spectr. C 72%

...Expand

: 100-41-4
ethylbenzene

A: 622-24-2
2-phenylethyl chloride

B: 672-65-1
(1-chloroethyl)benzene

Conditions

Conditions	Yield
With N-chloro-succinimide; N-hydroxyphthalimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 80℃; for 16h; Time; Sealed tube; Inert atmosphere;	A 22% B 71%
With N-chloro-succinimide; acetophenone In acetonitrile at 27℃; for 24h; Irradiation; regioselective reaction;	A 13 %Spectr. B 70%
With chlorine bei Tageslicht;

: 109-72-8, 29786-93-4
n-butyllithium

: 116386-53-9
(-)-(RS,R)-1-chloro-2-phenylethyl p-tolyl sulfoxide

: 676593-26-3
5,5-dimethyl-2-(2-phenylethyl)benzo-1,3,2-dioxaborinate

A: (RS,S)-1-chloro-2-phenylethyl p-tolyl sulfoxide

B: 30506-35-5
butyl(p-tolyl)sulfoxide

C: 622-24-2
2-phenylethyl chloride

D: (S)-1,4-diphenylbutan-2-ol

Conditions

Conditions	Yield
Stage #1: n-butyllithium; (-)-(RS,R)-1-chloro-2-phenylethyl p-tolyl sulfoxide; 5,5-dimethyl-2-(2-phenylethyl)benzo-1,3,2-dioxaborinate In tetrahydrofuran; hexane at -78 - 0℃; for 2.5h; Stage #2: With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran; hexane; water at 20℃; for 2.5h;	A n/a B 53% C 10% D 70%

...Expand

: 5783-00-6
1,4-Bis(2-phenylethyl)piperazin

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With phenyl chloroformate In neat (no solvent) Heating;	62%

: 60-12-8
2-phenylethanol

: 98-59-9
p-toluenesulfonyl chloride

A: 4455-09-8
2-phenylethyl tosylate

B: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
Stage #1: 2-phenylethanol; p-toluenesulfonyl chloride With dmap; triethylamine In dichloromethane at 0 - 5℃; Stage #2: In methanol; dichloromethane at 40 - 42℃; for 7h;	A 58% B 32%

...Expand

: 159690-31-0
1-p-Toluolsulfonyl-1-phenethyl-hydrazin

A: 622-24-2
2-phenylethyl chloride

B: 98-59-9
p-toluenesulfonyl chloride

Conditions

Conditions	Yield
With N-chloro-succinimide In tetrahydrofuran for 16h; Ambient temperature; Irradiation;	A 57% B n/a

: 60-12-8
2-phenylethanol

: 67-68-5
dimethyl sulfoxide

A: 101746-67-2
bis(2-phenylethyloxy)methane

B: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With 2,4-Dichloro-6-methoxy-1,3,5-triazine In toluene at 80℃; for 4h;	A 50% B 32%

...Expand

: 292638-84-7
styrene

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With 4-Methoxybenzenethiol; 10-methyl-9-(2,4,6-trimethylphenyl) acridinium tetrafluoroborate; 2,6-lutidine hydrochloride In chloroform; 2,2,2-trifluoroethanol for 24h; Irradiation; Inert atmosphere;	49%

: 60-12-8
2-phenylethanol

: 142-62-1
hexanoic acid

A: 6290-37-5
2-phenylethyl ester of hexanoic acid

B: 104-62-1
formic acid phenethyl ester

C: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With pyridine; N,N-dimethylchloromethyleniminium chloride Ambient temperature;	A 26% B 29% C 39%
With pyridine; N,N-dimethylchloromethyleniminium chloride Ambient temperature;	A 26% B 39% C 39%

...Expand

: 17376-04-4
2-phenethyl iodide

: 38841-98-4
n-octylmagnesium chloride

A: 292638-84-7
styrene

B: 544-76-3
Hexadecane

C: 1083-56-3
1,4-diphenylbutane

D: 104-72-3
decylbenzene

E: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With C32H30ClN2NiP In tetrahydrofuran; N,N-dimethyl acetamide at -20℃; for 0.5h; Kumada coupling reaction; Inert atmosphere;	A 20 %Chromat. B 13 %Chromat. C 16% D 29 %Chromat. E 23 %Chromat.

...Expand

: 165904-22-3
4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane

: 116386-53-9
(-)-(RS,R)-1-chloro-2-phenylethyl p-tolyl sulfoxide

A: 935662-21-8
(S)-2-(1,4-diphenyl-2-butyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

B: 1142-21-8
(Z)-1,4-diphenylbut-2-ene

C: 1142-22-9
(E)-1,4-diphenylbut-2-ene

D: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With tert.-butyl lithium In toluene; pentane at -78 - 20℃; for 15h; Title compound not separated from byproducts.;	A n/a B n/a C n/a D 13%

...Expand

: 91-22-5
quinoline

: 57913-41-4
2-phenylethyl chloroformate

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
at 43℃;

: 60-29-7
diethyl ether

: 80-41-1
2-chloroethyl tosylate

: phenylmagnesium bromide

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
reagiert analog mit weiteren Aryl-magneisumhalogeniden;

...Expand

: 3558-60-9
1-methoxy-2-phenylethane

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride

: 100-41-4
ethylbenzene

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
durch Chlorierung im diffusen Tageslicht;
With chlorine

: 80-41-1
2-chloroethyl tosylate

: phenylmagnesium bromide

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With diethyl ether

: 17376-04-4
2-phenethyl iodide

: 622-24-2
2-phenylethyl chloride

Conditions

Conditions	Yield
With Iodine monochloride

: 79-03-8
propionyl chloride

: 622-24-2
2-phenylethyl chloride

: 117922-95-9
4-(2-chloroethyl)propiophenone

Conditions

Conditions	Yield
With aluminium trichloride In 1,2-dichloro-ethane for 0.416667h; Ambient temperature;	100%
aluminium trichloride In 1,2-dichloro-ethane
aluminium trichloride In 1,2-dichloro-ethane

: 865-47-4
potassium tert-butylate

: 622-24-2
2-phenylethyl chloride

: 292638-84-7
styrene

Conditions

Conditions	Yield
18-crown-6 ether In tert-butyl alcohol at 40℃; Rate constant; Mechanism; secondary α-deuterium isotope effects investigated; also in absence of catalyst;	100%

: 622-24-2
2-phenylethyl chloride

: 59216-77-2
methyl 5-hydroxy-2-nitro-benzoate

: methyl 2-nitro-5-phenethoxybenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 18h;	100%

: 622-24-2
2-phenylethyl chloride

: 27846-24-8
bis(2-phenylethyl)sulfide

Conditions

Conditions	Yield
Stage #1: 2-phenylethyl chloride With thiourea Stage #2: With sodium hydroxide Stage #3: 2-phenylethyl chloride	98%
With potassium sulfide; ethanol
With sodium sulfide; ethanol
With sodium sulfide In dimethyl sulfoxide

: 622-24-2
2-phenylethyl chloride

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 645-59-0
dihydrocinnamonitrile

Conditions

Conditions	Yield
Stage #1: 2-hydroxy-2-methylpropanenitrile With lithium hydroxide monohydrate In tetrahydrofuran at 50℃; for 1h; Stage #2: 2-phenylethyl chloride In tetrahydrofuran	97.9%

: 622-24-2
2-phenylethyl chloride

: 60-12-8
2-phenylethanol

Conditions

Conditions	Yield
With iron(III) sulfate; water In toluene at 110℃; for 1h; Ionic liquid;	97%
With sodium carbonate at 160 - 165℃;
With sodium carbonate at 175℃;

: 873-73-4
4-n-chlorophenylacetylene

: 622-24-2
2-phenylethyl chloride

: 1161695-61-9
1-chloro-4-(4-phenylbut-1-yn-1-yl)benzene

Conditions

Conditions	Yield
With copper(l) iodide; C21H23ClNiP2S; caesium carbonate; sodium iodide In dimethyl sulfoxide at 50℃; for 12h; Sonogashira Cross-Coupling; Schlenk technique; Inert atmosphere;	97%

: 622-24-2
2-phenylethyl chloride

: 344411-57-0
1-chloro-2-pentachlorophenylethane

Conditions

Conditions	Yield
With disulfur dichloride; aluminium trichloride; sulfuryl dichloride at 80℃; for 3h;	96%
With disulfur dichloride; aluminium trichloride; sulfuryl dichloride at 70 - 85℃;

Phenethyl chloride Chemical Properties

Product Name: 1-Chloro-2-phenylethane
CAS Registry Number: 622-24-2
IUPAC Name: 1-chloro-2-ethylbenzene
Molecular Weight: 140.61006 [g/mol]
Molecular Formula: C₈H₉Cl
XLogP3: 3.5
Surface Tension: 33.8 dyne/cm
EINECS: 210-725-6
Density: 1.052 g/cm³
Flash Point: 66.7 °C
Melting Point: -60 °C
Refractive index: n20/D 1.53(lit.)
Water Solubility: 0.1 g/L (20 ºC)
Enthalpy of Vaporization: 41.67 kJ/mol
Boiling Point: 198.2 °C at 760 mmHg
Vapour Pressure: 0.512 mmHg at 25°C
Product Categories: Benzene derivates
Following is the molecular structure of 1-Chloro-2-phenylethane (CAS NO.622-24-2) is:

Phenethyl chloride Safety Profile

Safty information about 1-Chloro-2-phenylethane (CAS NO.622-24-2) is:
Hazard Codes:
Irritant Xi
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HS Code: 29036990

Phenethyl chloride Specification

1-Chloro-2-phenylethane (CAS NO.622-24-2) is a clear, colorless liquid.
First Aid Measures about it:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Handling and Storage about it:
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container.

Product Name

Benzene,(2-chloroethyl)-

Synthetic route

Phenethyl chloride Chemical Properties

Phenethyl chloride Safety Profile

Phenethyl chloride Specification

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