Tetrafluorophthalic acid supplier

Name
Tetrafluorophthalic acid
EINECS 211-483-4
CAS No. 652-03-9
Article Data38
CAS DataBase
Density 1.6239 (estimate)
Solubility
Melting Point 162-164 °C
Formula C₈H₂F₄O₄
Boiling Point 345.7 °C at 760 mmHg
Molecular Weight 238.095
Flash Point 162.9 °C
Transport Information
Appearance White to light yellow crystal powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Phthalicacid, tetrafluoro- (6CI,7CI,8CI);3,4,5,6-Tetrafluorophthalic acid;
PSA 74.60000
LogP 1.63940

Synthetic route

: 33795-85-6
N-methyl-tetrafluorophthalimide

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With sulfuric acid; benzyltriethylammonium bromide at 45 - 50℃; for 15h; Temperature;	95.7%

: 122180-11-4
octafluoro-1,3-dihydroisobenzofuran

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With sulfuric acid for 3h; Heating;	94%

: tetrafluoro-N-phenylphthalimide

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With sulfuric acid; cetyltrimethylammonim bromide at 110℃; for 8h;	88.6%
With sulfuric acid In water	67%

: 59514-37-3
perfluorobenzocyclobutenedione

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Stage #1: perfluorobenzocyclobutenedione With bromine at 130℃; for 17.5h; Stage #2: With hydrogenchloride for 120h; Further stages.;	86%
Stage #1: perfluorobenzocyclobutenedione With antimony pentafluoride at 130℃; for 4.5h; Stage #2: With hydrogenchloride Further stages.;	70%

: 52196-63-1
perfluorobenzocyclobutene

A: 59514-37-3
perfluorobenzocyclobutenedione

B: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Stage #1: perfluorobenzocyclobutene With antimony pentafluoride; silica gel at 70℃; for 5h; Stage #2: With hydrogenchloride Further stages.;	A 86% B 7%

: 52196-63-1
perfluorobenzocyclobutene

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With antimony pentafluoride; trifluoroacetic acid at 95℃; for 28h;	85%

: 652-12-0
4,5,6,7-tetrafluoroisobenzofuran-1,3-dione

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
In water	82%
With hydrogenchloride In water

: 34973-43-8
hexachloro-phthalide

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With hydrogenchloride; potassium fluoride In tetrahydrofuran; sulfolane	81%

: 201230-82-2
carbon monoxide

: 59514-38-4
perfluorobenzocyclobutenone

A: 652-03-9
3,4,5,6-tetrafluorophthalic acid

B: perfluoro-1H-isochromen-1-one

Conditions

Conditions	Yield
Stage #1: carbon monoxide; perfluorobenzocyclobutenone With antimony pentafluoride at 20℃; under 760.051 Torr; for 3h; Stage #2: With hydrogenchloride; water at 0℃;	A 10 %Spectr. B 67%

...Expand

: 313-72-4
octafluoronaphthalene

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 60℃; for 6h;	65%
With nitric acid

: 98583-34-7
Perfluoro(1-ethylindan)

A: 1025071-73-1
perfluoro(3-methyl-1-oxoisochromene-4-carboxylic acid)

B: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Stage #1: perfluoro-1-ethylindane With antimony pentafluoride; silica gel at 90 - 130℃; for 13h; Stage #2: With hydrogenchloride Further stages.;	A 39% B 36%

: 59514-38-4
perfluorobenzocyclobutenone

A: 157337-86-5
6-trifluoromethyl-2,3,4,5-tetrafluorobenzoic acid

B: 1105698-74-5
perfluoro-2-acetyl-2'-methylbenzophenone

C: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Stage #1: perfluorobenzocyclobutenone With antimony pentafluoride at 120℃; for 6.5h; Stage #2: With hydrogenchloride Further stages.;	A 18% B 16% C 0.35 g

...Expand

: 52196-63-1
perfluorobenzocyclobutene

: 407-25-0
trifluoroacetic anhydride

A: 652-03-9
3,4,5,6-tetrafluorophthalic acid

B: perfluoro-1H-isochromen-1-one

Conditions

Conditions	Yield
Stage #1: perfluorobenzocyclobutene; trifluoroacetic anhydride With antimony pentafluoride at 20℃; for 75h; Sealed tube; Stage #2: With hydrogenchloride; water at 0℃;	A 14% B n/a

...Expand

: 1024-60-8
hexafluoro-1,4-naphthoquinone

A: 20927-18-8
2-hydroxy-3,5,6,7,8-pentafluoro-1,4-naphthoquinone

B: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 80℃; for 20h; Mechanism;	A 0.25 g B 0.33 g

: 313-72-4
octafluoronaphthalene

A: 20927-18-8
2-hydroxy-3,5,6,7,8-pentafluoro-1,4-naphthoquinone

B: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

C: 652-03-9
3,4,5,6-tetrafluorophthalic acid

D: 34283-00-6
2-(heptafluoronaphthalen-1-yloxy)pentafluoro-1,4-naphthoquinone

E: 69472-72-6
2,3,4,5-tetrafluoro-6-(fluoromethyl)phenylglyoxylic acid

F: 93343-13-6
1-oxoperfluoro-1,2-dihydronaphthalene

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 100℃; for 30h; Product distribution; Mechanism; var. conc.;	A 0.38 g B 0.30 g C 0.65 g D 0.05 g E 0.21 g F 0.30 g

...Expand

: 5386-30-1
1-perfluoronaphthol

A: 1024-60-8
hexafluoro-1,4-naphthoquinone

B: 20927-18-8
2-hydroxy-3,5,6,7,8-pentafluoro-1,4-naphthoquinone

C: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

D: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 80℃; for 20h; Product distribution; Mechanism; var. conc., var. temp.;	A 0.94 g B 0.21 g C 0.24 g D 1.02 g

...Expand

: 727-49-1
1,3,4,5,6,7,8-heptafluoro-2-naphthol

A: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

B: 652-03-9
3,4,5,6-tetrafluorophthalic acid

C: 69472-72-6
2,3,4,5-tetrafluoro-6-(fluoromethyl)phenylglyoxylic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In acetonitrile at 100℃; for 30h; Product distribution; Mechanism; var. conc., var. temp.;	A 0.36 g B 1.32 g C 0.24 g

...Expand

: 1835-65-0
Tetrafluorophthalonitrile

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
(hydrolysis);
In water
hydrolysis;
hydrolysis;
With sodium hydroxide; zinc

: [1S(R),4S(R)]-5,6,7,8-tetrafluoro-1,4-dihydro-1,4-ethenonaphthalene

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With potassium permanganate In acetone

: 41481-27-0
1,3-Dihydroxyhexafluornaphthalin

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With nitric acid Heating;

: 27041-18-5
3,4,5,6,7,8-Hexafluoro-4-nitro-4H-naphthalen-1-one

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With nitric acid

: 1736-47-6
perfluoroindane

A: 4,5,6,7-tetrafluoro-3-hydroxy-3-trifluoromethyl-2-benzofuran-1-one

B: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With antimony pentafluoride; silica gel at 85 - 180℃; for 9h; Title compound not separated from byproducts;

: 58161-60-7
hexafluoro-1,3-indanedione

A: perfluoro(3-methylphthalide)

B: 4,5,6,7-tetrafluoro-3-hydroxy-3-trifluoromethyl-2-benzofuran-1-one

C: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
With antimony pentafluoride at 130℃; for 2h;

...Expand

: 1736-47-6
perfluoroindane

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 34 percent / SiO2; SbF5 / 4.5 h / 70 - 75 °C 2: SbF5 / 2 h / 130 °C View Scheme

: 20687-94-9
4,5,6,7-tetrachloro-1,1,3,3-tetrafluoro-1,3-dihydroisobenzofuran

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 92 percent / potassium fluoride / tetrahydrothiophene 1,1-dioxide / 1.5 h / 210 - 220 °C 2: 94 percent / sulphuric acid / 3 h / Heating View Scheme

: 784-00-9
1,3,4,5,6,7,8-heptafluoronaphthalene

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HNO3 / -10 °C 2: HNO3 View Scheme

: 71-43-2
benzene

(+-)-pentane-1,4-diol: (+-)-pentane-1,4-diol

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: aq. KMnO4 / acetone View Scheme

: 827-08-7
1,2-dibromo-3,4,5,6-tetrafluorobenzene

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 160 - 170 °C 2: (hydrolysis) View Scheme

: 1122-58-3
dmap

: 27607-77-8
trimethylsilyl trifluoromethanesulfonate

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 2,3,4,5-tetrakis[4-(dimethylamino)-1-pyridinio]benzoic acid tetrakis(trifluoromethanesulfonate)

Conditions

Conditions	Yield
In chlorobenzene for 24h; Heating;	99%

...Expand

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

Conditions

Conditions	Yield
With ammonium hydroxide at 180℃; for 2.5h; Autoclave; Green chemistry;	97.2%
With ammonia at 179.99℃; for 1h; pH=1.94; Temperature;	90%
In tributyl-amine at 130℃; for 4h;	81.6%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 652-12-0
4,5,6,7-tetrafluoroisobenzofuran-1,3-dione

Conditions

Conditions	Yield
With thionyl chloride at 90℃; for 14h;	97%
With thionyl chloride	94%
With acetyl chloride

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 169542-84-1
4-amino-3,5,6-trifluorophthalic acid

Conditions

Conditions	Yield
With ammonia at 110℃; for 100h; Autoclave;	95%

: 2588-88-7
pentaphenylphosphorane

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: bis(tetraphenylphosphonium) tetrafluorophthalate

Conditions

Conditions	Yield
With water In benzene at 20 - 80℃;	95%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 14900-74-4
3,4,5,6-tetrafluorophthaloyl dichloride

Conditions

Conditions	Yield
With phosphorus pentachloride at 180℃; for 2h;	94%
With thionyl chloride; N,N-dimethyl-formamide for 18h; Heating;
With thionyl chloride; N,N-dimethyl-formamide for 24h; Inert atmosphere; Schlenk technique; Reflux;
With thionyl chloride for 48h; Schlenk technique; Reflux;

: 142-96-1
dibutyl ether

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

Conditions

Conditions	Yield
With sulfuric acid; dimethyl sulfoxide; triethylamine In water; toluene	94%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: bis(trimethylsilyl) 3,4,5,6-tetrafluorophthalate

Conditions

Conditions	Yield
In neat (no solvent) at 110 - 120℃; for 2h; Inert atmosphere;	93%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 108-46-3
recorcinol

: 4,5,6,7-tetrafluoro-7a-(6'-hydroxy-3'-oxo-3H-xanthen-9'-yl)benzoic acid

Conditions

Conditions	Yield
With methanesulfonic acid at 90℃; for 48h;	91%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 116751-24-7
2,4,5-trifluoro-3-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: 3,4,5,6-tetrafluorophthalic acid With sodium hydroxide In water at 90℃; for 9h; Stage #2: With hydrogenchloride; tri-n-propylamine In water at 140℃; under 7500.75 Torr; for 7h; pH=1; Temperature;	90.35%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 551-62-2
1,2,3,4-tetrafluorobenzene

Conditions

Conditions	Yield
With ammonium hydroxide at 250℃; for 0.416667h; Temperature; Time; Autoclave; Green chemistry;	90.1%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

A: 551-62-2
1,2,3,4-tetrafluorobenzene

B: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

Conditions

Conditions	Yield
With ammonium hydroxide at 190℃; for 2h; Temperature; Time; Autoclave; Green chemistry;	A 10.5% B 86.1%
With ammonium hydroxide at 240℃; for 0.666667h; Temperature; Time; Autoclave; Green chemistry;	A 82% B 8.1%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 75-31-0
isopropylamine

: 1187587-72-9
isopropylammonium tetrafluorohydrogenphthalate

Conditions

Conditions	Yield
In water at 20℃; for 0.166667h;	84%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 81684-80-2
N1-methylbenzene-1,2-diamine hydrochloride

: 2-(2,3,4,5-tetrafluoro-6-(1-methyl-1H-benzo[d]imidazol-2-yl)phenyl)-1-methyl-1H-benzo[d]imidazole

Conditions

Conditions	Yield
Stage #1: N1-methylbenzene-1,2-diamine hydrochloride With polyphosphoric acid at 80 - 85℃; for 0.25h; Green chemistry; Stage #2: 3,4,5,6-tetrafluorophthalic acid With polyphosphoric acid at 80 - 150℃; Green chemistry;	84%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 3,4,5,6-Tetrafluoro-cyclohexa-3,5-diene-1,2-dicarboxylic acid

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane at 25℃; electroreduction (divided cells, lead plates, 0.20 A);	83%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 618-87-1
3, 5-dinitroaniline

: 2-(3,5-dinitrophenyl)-4,5,6,7-(tetrafluoroisoindoline)-1,3-dione

Conditions

Conditions	Yield
With acetic acid at 130℃; for 10h; Temperature;	79.1%

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 6156-78-1
manganese (II) acetate tetrahydrate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: Mn(1,2-BDC-F4)(H2O)2(DMF)

Conditions

Conditions	Yield
In water for 0.005h;	78%

...Expand

: thallium(I) carbonate

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: thallium(I) tetrafluorophthalate

Conditions

Conditions	Yield
In water Boiling of stoich. amts. of the starting materials in H2O until a clear soln. is obtained.; Filtn., isolation by evapn. under vac., elem. anal.;	76%

: 366-18-7
[2,2]bipyridinyl

: cobalt(II) nitrate hexahydrate

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: 1425942-02-4
C36H24Co2F8N4O12

Conditions

Conditions	Yield
With sodium hydroxide In water at 120℃; Sealed tube;	76%

...Expand

: 652-03-9
3,4,5,6-tetrafluorophthalic acid

: silver nitrate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 4C8F4O4(2-)*8Ag(1+)*2C3H7NO

Conditions

Conditions	Yield
In methanol for 0.25h;	75%

...Expand

Tetrafluorophthalic acid Chemical Properties

Molecular Formula:C₈H₂F₄O₄
Molar mass:238.092693g/mol
Structure of Tetrafluorophthalic acid(652-03-9):

Synonyms of Tetrafluorophthalic acid(652-03-9):3,4,5,6-Tetrafluorophthalic acid;1,2-Benzenedicarboxylic acid, 3,4,5,6-tetrafluoro-;2,3,5,6-Tetrafluoro terephthalic acid;3,4,5,6-TETRAFLUOROBENZENE-1,2-DICARBOXYLIC ACID;2,3,4,5-TETRAFLUORO-PHTHALIC ACID
Density:1.812 g/cm³
Flash Point:162.9 °C
Boiling Point:345.7 °C at 760 mmHg
Index of Refraction:1.522
Vapour Pressure:2.3E-05 mmHg at 25°C
Melting point:152-154 °C(lit.)
Appearance:White to light yellow crystal powder

Tetrafluorophthalic acid Uses

Tetrafluorophthalic acid(652-03-9) can be used for lubricants, surface active agent and so on.

Tetrafluorophthalic acid Safety Profile

Hazard Codes:Xi

Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection

Tetrafluorophthalic acid Specification

Product Categories of Tetrafluorophthalic acid(652-03-9): API intermediates;Polymer Science;Phthalic Acids,Esters and Derivatives;Carboxylic Acid Monomers;Monomers

Product Name

Tetrafluorophthalic acid

Synthetic route

Tetrafluorophthalic acid Chemical Properties

Tetrafluorophthalic acid Uses

Tetrafluorophthalic acid Safety Profile

Tetrafluorophthalic acid Specification

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