Product Name

  • Name

    Chlorophos

  • EINECS 200-149-3
  • CAS No. 52-68-6
  • Article Data25
  • CAS DataBase
  • Density 1.574 g/cm3
  • Solubility Slightly soluble in water
  • Melting Point 77-81 °C
  • Formula C4H8Cl3O4P
  • Boiling Point 269.3 °C at 760 mmHg
  • Molecular Weight 257.438
  • Flash Point 116.7 °C
  • Transport Information UN 3077 9/PG 3
  • Appearance white crystals or powder
  • Safety 24-37-60-61-2
  • Risk Codes 22-43-50/53
  • Molecular Structure Molecular Structure of 52-68-6 (Chlorophos)
  • Hazard Symbols HarmfulXn, DangerousN
  • Synonyms O, O-Dimethyl- (2,2,2-trichlor-1-hydroxy-aethyl)phosphonat;(1S)-2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol;Dipterax;2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol;Phosphonic acid, (2,2, 2-trichloro-1-hydroxyethyl)-, dimethyl ester;Proxol;Dipterex;Clorofos;Bayer L 1359;Trichlorofon (TN);Masoten;Phosphonic acid,(2,2,2-trichloro-1-hydroxyethyl)-,dimethyl ester;Agroforotox;Anthon;Foschlor R;Chlorophosciclosom;O,O-Dimethyl (2,2, 2-trichlorohydroxyethyl)phosphonate;Foschlor R-50;Trichlorphon FN;Briton;(1R)-2,2,2-trichloro-1-dimethoxyphosphorylethanolate;Satox 20WSC;Dyvon;(1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester;Khloroftalm;O,O-Dimethyl (1-hydroxy-2,2, 2-trichloroethyl)phosphate;Aerol 1 (pesticide);(2,2, 2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester;Chloroxyphos;NCI-C54831;Phosphonic acid,(2,2,2-trichloro-1-hydroxy- ethyl)-,dimethyl ester;Onefon;BAY 15922;Trichlorphon;Volfartol;Metrifonate;Phosphonic acid, (1-hydroxy-2,2, 2-trichloroethyl)-, dimethyl ester;Votexit;Trichlorophone;O, O-Dimethyl- (1-hydroxy-2,2,2-trichlorathyl)-phosphat;Dyrex;Dimetox;Chlorophthalm;(1R)-2,2,2-trichloro-1-dimethoxyphosphoryl-ethanol;Dipterex 50;Dimethyl (2,2, 2-trichloro-1-hydroxyethyl)phosphonate;Metrifonate (USP);DEP (pesticide);(2,2,2-Trichloro-1-hydroxy)phosphonic acid, dimethyl ester;Fliegenteller;Azoxystrobi;TRICHLOPHON;Ritsifon;Ricifon;Chloroftalm;Foschlorem;O,O-Dimethyl (1-oxy-2,2, 2-trichloroethyl)phosphonate;Forotox;1-Hydroxy-2,2, 2-trichloro-ethyle phosphonate de dimethyle;Metriphonate;[(2,2, 2-Trichloro-1-hydroxyethyl) dimethylphosphonate];Diptevur;Danex;Trinex;Methyl chlorophos;Flibol E;Dylox;(2,2, 2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester;Bovinox;O,O-Dimethyl- (1-hydroxy-2,2, 2-trichloraethyl)phosphosaeure ester;Loisol;Cekufon;Trichlorophon;Bilarcil;
  • PSA 65.57000
  • LogP 2.16090

Synthetic route

methyl phosphite
96-36-6, 868-85-9

methyl phosphite

chloral
75-87-6

chloral

trichlorfon
52-68-6

trichlorfon

Conditions
ConditionsYield
at 34℃; Rate constant;
(2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid monomethyl ester
684-31-1

(2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid monomethyl ester

trichlorfon
52-68-6

trichlorfon

chloral hydrate
302-17-0

chloral hydrate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

Dichlorvos
62-73-7

Dichlorvos

B

trichlorfon
52-68-6

trichlorfon

Conditions
ConditionsYield
In hexane for 1h; Product distribution; Mechanism;
In hexane for 1h;
chloral hydrate
302-17-0

chloral hydrate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

Dichlorvos
62-73-7

Dichlorvos

B

trichlorfon
52-68-6

trichlorfon

C

dichlorovinylmethyl phosphoric acid
13445-62-0

dichlorovinylmethyl phosphoric acid

Conditions
ConditionsYield
In hexane for 10h; Heating;
chloral hydrate
302-17-0

chloral hydrate

Dimethyl phosphite
868-85-9

Dimethyl phosphite

trichlorfon
52-68-6

trichlorfon

Conditions
ConditionsYield
With aluminum oxide for 0.1h; microwave irradiation;74 % Spectr.
chloral
75-87-6

chloral

Dimethyl phosphite
868-85-9

Dimethyl phosphite

trichlorfon
52-68-6

trichlorfon

Conditions
ConditionsYield
With aluminum oxide; potassium fluoride at 20℃; for 0.5h;
With aluminum oxide; potassium fluoride
With aluminum oxide; potassium fluoride
With aluminum oxide; potassium fluoride
chloral hydrate
302-17-0

chloral hydrate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

methanol
67-56-1

methanol

B

trichlorfon
52-68-6

trichlorfon

Conditions
ConditionsYield
Abramov reaction;
trichlorfon
52-68-6

trichlorfon

2-(3-chloro-4-fluorophenoxy)acetyl chloride
826990-47-0

2-(3-chloro-4-fluorophenoxy)acetyl chloride

O,O-dimethyl 1-(3-chloro-4-fluorophenoxyacetoxy)-2,2,2-trichloroethylphosphonate
866145-51-9

O,O-dimethyl 1-(3-chloro-4-fluorophenoxyacetoxy)-2,2,2-trichloroethylphosphonate

Conditions
ConditionsYield
With triethylamine In chloroform at 2 - 20℃;80%
2,6-Pyridinedicarbonyl dichloride
3739-94-4

2,6-Pyridinedicarbonyl dichloride

trichlorfon
52-68-6

trichlorfon

O,O-dimethyl-2,6-pyridinyldi(formyloxy-trichloromethyl-methylphosphonate)
1208256-21-6

O,O-dimethyl-2,6-pyridinyldi(formyloxy-trichloromethyl-methylphosphonate)

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20 - 40℃; for 5h;73%
trichlorfon
52-68-6

trichlorfon

2-(2-chloro-4-fluorophenoxy)acetyl chloride
826990-46-9

2-(2-chloro-4-fluorophenoxy)acetyl chloride

O,O-dimethyl (2-chloro-4-fluorophenoxyacetoxy)(trichloromethyl)methylphosphonate

O,O-dimethyl (2-chloro-4-fluorophenoxyacetoxy)(trichloromethyl)methylphosphonate

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃; for 2h;72.5%
trichlorfon
52-68-6

trichlorfon

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

A

C6H7Cl3F3O5P
154149-95-8

C6H7Cl3F3O5P

B

trifluoroacetic acid
76-05-1

trifluoroacetic acid

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 40℃; for 2h;A 72%
B n/a
trichlorfon
52-68-6

trichlorfon

2,2,3,3-tetrafluoropropionic acid anhydride
337-83-7

2,2,3,3-tetrafluoropropionic acid anhydride

A

2,2,3,3-tetrafluoropropanoic acid
756-09-2

2,2,3,3-tetrafluoropropanoic acid

B

C7H8Cl3F4O5P
1253045-84-9

C7H8Cl3F4O5P

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 40℃; for 2h;A n/a
B 70%
trichlorfon
52-68-6

trichlorfon

heptafluorobutyric anhydride
336-59-4

heptafluorobutyric anhydride

A

heptafluorobutyric Acid
375-22-4

heptafluorobutyric Acid

B

C8H7Cl3F7O5P
169469-22-1

C8H7Cl3F7O5P

Conditions
ConditionsYield
In 1,2-dichloro-ethane at 40℃; for 2h;A n/a
B 68%
2-[4-(trifluoromethyl)phenoxy]acetyl chloride
67273-84-1

2-[4-(trifluoromethyl)phenoxy]acetyl chloride

trichlorfon
52-68-6

trichlorfon

O,O-dimethyl (4-trifluoromethylphenoxyacetoxy)(trichloromethyl)methylphosphonate

O,O-dimethyl (4-trifluoromethylphenoxyacetoxy)(trichloromethyl)methylphosphonate

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃; for 2h;66.5%
trichlorfon
52-68-6

trichlorfon

(2,4-difluoro-phenoxy)-acetyl chloride
399-42-8

(2,4-difluoro-phenoxy)-acetyl chloride

O,O-dimethyl 1-(2,4-difluorophenoxyacetoxy)trichloromethylmethylphosphonate

O,O-dimethyl 1-(2,4-difluorophenoxyacetoxy)trichloromethylmethylphosphonate

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃;65.2%
trichlorfon
52-68-6

trichlorfon

2-(2,4-dichlorophenoxy)acetyl chloride
774-74-3

2-(2,4-dichlorophenoxy)acetyl chloride

O,O-dimethyl 1-(2,4-dichlorophenoxyacetoxy)-2,2,2-trichloroethylphosphonate

O,O-dimethyl 1-(2,4-dichlorophenoxyacetoxy)-2,2,2-trichloroethylphosphonate

Conditions
ConditionsYield
With pyridine In chloroform at 10 - 42℃;62%
(3,5-difluoro-phenoxy)-acetyl chloride
916771-35-2

(3,5-difluoro-phenoxy)-acetyl chloride

trichlorfon
52-68-6

trichlorfon

O,O-dimethyl 1-(3,5-difluorophenoxyacetoxy)trichloromethylmethylphosphonate

O,O-dimethyl 1-(3,5-difluorophenoxyacetoxy)trichloromethylmethylphosphonate

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃;59.7%
trichlorfon
52-68-6

trichlorfon

phosphorochloridic acid diisobutyl ester
17158-87-1

phosphorochloridic acid diisobutyl ester

(2,2,2-trichloro-1-diisobutoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
100386-60-5

(2,2,2-trichloro-1-diisobutoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
trichlorfon
52-68-6

trichlorfon

Dichlorvos
62-73-7

Dichlorvos

Conditions
ConditionsYield
With sodium hydroxide
trichlorfon
52-68-6

trichlorfon

propionyl chloride
79-03-8

propionyl chloride

(2,2,2-trichloro-1-propionyloxy-ethyl)-phosphonic acid dimethyl ester
4414-11-3

(2,2,2-trichloro-1-propionyloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; triethylamine
trichlorfon
52-68-6

trichlorfon

Diisopropyl chlorophosphate
2574-25-6

Diisopropyl chlorophosphate

(2,2,2-trichloro-1-diisopropoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
99862-91-6

(2,2,2-trichloro-1-diisopropoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
trichlorfon
52-68-6

trichlorfon

dipropyl chlorophosphate
2510-89-6

dipropyl chlorophosphate

(2,2,2-trichloro-1-dipropoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
99862-92-7

(2,2,2-trichloro-1-dipropoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
trichlorfon
52-68-6

trichlorfon

acetyl chloride
75-36-5

acetyl chloride

(1-acetoxy-2,2,2-trichloro-ethyl)-phosphonic acid dimethyl ester
5952-41-0

(1-acetoxy-2,2,2-trichloro-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; triethylamine
trichlorfon
52-68-6

trichlorfon

isobutyryl chloride
79-30-1

isobutyryl chloride

(2,2,2-trichloro-1-isobutyryloxy-ethyl)-phosphonic acid dimethyl ester
4414-14-6

(2,2,2-trichloro-1-isobutyryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; triethylamine
trichlorfon
52-68-6

trichlorfon

butyryl chloride
141-75-3

butyryl chloride

(1-butyryloxy-2,2,2-trichloro-ethyl)-phosphonic acid dimethyl ester
126-22-7

(1-butyryloxy-2,2,2-trichloro-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; triethylamine
trichlorfon
52-68-6

trichlorfon

Dimethyl chlorophosphate
813-77-4

Dimethyl chlorophosphate

(2,2,2-trichloro-1-diethoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
117888-19-4

(2,2,2-trichloro-1-diethoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
trichlorfon
52-68-6

trichlorfon

Dimethyl chlorophosphate
813-77-4

Dimethyl chlorophosphate

(2,2,2-trichloro-1-dimethoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
114255-16-2

(2,2,2-trichloro-1-dimethoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
trichlorfon
52-68-6

trichlorfon

2-Bromopropionyl chloride
7148-74-5

2-Bromopropionyl chloride

[1-(2-bromo-propionyloxy)-2,2,2-trichloro-ethyl]-phosphonic acid dimethyl ester
118897-78-2

[1-(2-bromo-propionyloxy)-2,2,2-trichloro-ethyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; triethylamine
trichlorfon
52-68-6

trichlorfon

dibutyl chlorophosphate
819-43-2

dibutyl chlorophosphate

(2,2,2-trichloro-1-dibutoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester
100386-59-2

(2,2,2-trichloro-1-dibutoxyphosphoryloxy-ethyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With diethyl ether; diethylamine
dichloroacethyl chloride
79-36-7

dichloroacethyl chloride

trichlorfon
52-68-6

trichlorfon

<1-Dichloracetoxy-2.2.2-trichlor-aethyl>-phosphonsaeure-dimethylester
74940-62-8

<1-Dichloracetoxy-2.2.2-trichlor-aethyl>-phosphonsaeure-dimethylester

Conditions
ConditionsYield
With triethylamine In diethyl ether; benzene
trichlorfon
52-68-6

trichlorfon

diisopropyl phosphorisocyanatidate
13561-73-4

diisopropyl phosphorisocyanatidate

O,O-Diisopropyl-phosphonocarbamidsaeure-<2,2,2-trichlor-1-(O,O-dimethyl-phosphono)-aethylester>
13664-42-1

O,O-Diisopropyl-phosphonocarbamidsaeure-<2,2,2-trichlor-1-(O,O-dimethyl-phosphono)-aethylester>

Conditions
ConditionsYield
In diethyl ether
trichlorfon
52-68-6

trichlorfon

O,O-dimethyl-2,2-dichlorovinyl phosphate
1185-97-3

O,O-dimethyl-2,2-dichlorovinyl phosphate

Conditions
ConditionsYield
(electrochemical reduction);
trichlorfon
52-68-6

trichlorfon

(2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid monomethyl ester
684-31-1

(2,2,2-trichloro-1-hydroxy-ethyl)-phosphonic acid monomethyl ester

Conditions
ConditionsYield
With sodium iodide In butanone Heating;
trichlorfon
52-68-6

trichlorfon

acryloyl chloride
814-68-6

acryloyl chloride

Acrylic acid 2,2,2-trichloro-1-(dimethoxy-phosphoryl)-ethyl ester
42078-31-9

Acrylic acid 2,2,2-trichloro-1-(dimethoxy-phosphoryl)-ethyl ester

Conditions
ConditionsYield
With sodium carbonate; hydroquinone In benzene
trichlorfon
52-68-6

trichlorfon

ethyl isocyanate
109-90-0

ethyl isocyanate

O,O-Dimethyl-2,2,2-trichlor-1-(N-ethyl)-carbamoylethyl-phosphonat
22012-33-5

O,O-Dimethyl-2,2,2-trichlor-1-(N-ethyl)-carbamoylethyl-phosphonat

Conditions
ConditionsYield
With triethylamine In benzene Heating;

Trichlorfon Chemical Properties

Product Name: Trichlorfon (CAS NO.52-68-6)


Molecular Formula: C4H8Cl3O4P
Molecular Weight: 257.44g/mol
Mol File: 52-68-6.mol
Einecs: 257.44
Appearance: White crystals or powder
Melting Point: 77-81 °C
Boiling point: 269.3 °C at 760 mmHg
Flash Point: 116.7 °C
Density: 1.574 g/cm3
Water Solubility: Slightly soluble. 1-5 g/100 mL at 21 ºC
Surface Tension: 46.6 dyne/cm
Enthalpy of Vaporization: 58.92 kJ/mol
Vapour Pressure: 0.00097 mmHg at 25°C
XLogP3-AA: 0.5
H-Bond Donor: 1
H-Bond Acceptor: 4
Structure Descriptors of Trichlorfon (CAS NO.52-68-6):
  IUPAC Name: 2,2,2-trichloro-1-dimethoxyphosphorylethanol
  Canonical SMILES: COP(=O)(C(C(Cl)(Cl)Cl)O)OC
  InChI: InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 
  InChIKey: NFACJZMKEDPNKN-UHFFFAOYSA-N
Product Categories: INSECTICIDE; Bases & Related Reagents; Carbohydrates & Derivatives; Isotope Labeled Compounds; Nucleotides; Phosphorylating and Phosphitylating Agents

Trichlorfon Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 37mg/kg (37mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LD50 oral 97mg/kg (97mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 60, 1982.
cat LD50 unreported 98mg/kg (98mg/kg) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Russian Pharmacology and Toxicology Vol. 50, Pg. 61, 1987.
chicken LD50 oral 75mg/kg (75mg/kg)   Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
chicken LD50 subcutaneous 125mg/kg (125mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Biochemical Pharmacology. Vol. 12, Pg. 1377, 1963.
dog LD50 intravenous 150mg/kg (150mg/kg) CARDIAC: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE
Archives of Toxicology. Vol. 41, Pg. 3, 1978.
dog LD50 oral 400mg/kg (400mg/kg) CARDIAC: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE
Archives of Toxicology. Vol. 41, Pg. 3, 1978.
dog LD50 subcutaneous 269mg/kg (269mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: OTHER CHANGES
Revista do Centro de Ciencias Rurais Vol. 7(1), Pg. 23, 1977.
guinea pig LD50 intraperitoneal 300mg/kg (300mg/kg)   AMA Archives of Industrial Health. Vol. 11, Pg. 53, 1955.
guinea pig LDLo oral 420mg/kg (420mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Bulletin of the University of Miami School of Medicine and Jackson Memorial Hospital. Vol. 9, Pg. 7, 1955.
hamster LD50 intraperitoneal 1gm/kg (1000mg/kg)   Archives of Toxicology. Vol. 58, Pg. 152, 1986.
human TCLo inhalation 1710ug/m3/90D (1.71mg/m3)   British Journal of Industrial Medicine. Vol. 43, Pg. 414, 1986.
mammal (species unspecified) LD50 skin > 2800mg/kg (2800mg/kg)   Archives of Toxicology. Vol. 41, Pg. 3, 1978.
mammal (species unspecified) LD50 unreported 295mg/kg (295mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 38(8), Pg. 101, 1973.
monkey LD oral > 1gm/kg (1000mg/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES

MUSCULOSKELETAL: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
mouse LD50 intraperitoneal 196mg/kg (196mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960.
mouse LD50 intravenous 290mg/kg (290mg/kg) CARDIAC: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE
Archives of Toxicology. Vol. 41, Pg. 3, 1978.
mouse LD50 oral 300mg/kg (300mg/kg)   Special Publication of the Entomological Society of America. Vol. 78-1, Pg. 26, 1978.
mouse LD50 skin 1710mg/kg (1710mg/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 597, 1986.
mouse LD50 subcutaneous 267mg/kg (267mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
mouse LD50 unreported 445mg/kg (445mg/kg)   Pharmaceutical Chemistry Journal Vol. 3, Pg. 508, 1969.
quail LD50 oral 73110ug/kg (73.11mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. Vol. 24, Pg. 35, 1974.
rabbit LD skin > 1500mg/kg (1500mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(10), Pg. 54, 1964.
rabbit LD50 intraperitoneal 60mg/kg (60mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
American Journal of Ophthalmology. Vol. 53, Pg. 512, 1962.
rabbit LD50 oral 160mg/kg (160mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 555, 1981.
rabbit LDLo intramuscular 500mg/kg (500mg/kg) VASCULAR: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE
Medycyna Weterynaryjna. Veterinary Medicine. Vol. 35, Pg. 479, 1979.
rat LC50 inhalation 1300mg/m3 (1300mg/m3)   Archiv fuer Geschwulstforschung. Vol. 48, Pg. 112, 1978.
rat LD50 intramuscular 395mg/kg (395mg/kg) CARDIAC: OTHER CHANGES

LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE
Archives of Toxicology. Vol. 41, Pg. 3, 1978.
rat LD50 intraperitoneal 160mg/kg (160mg/kg)   Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat LD50 oral 450mg/kg (450mg/kg)   United States Patent Document. Vol. #5006545,
rat LD50 skin 2gm/kg (2000mg/kg)   Archiv fuer Geschwulstforschung. Vol. 48, Pg. 112, 1978.
rat LD50 subcutaneous 400mg/kg (400mg/kg)   Journal of Economic Entomology. Vol. 50, Pg. 356, 1957.
rat LD50 unreported 550mg/kg (550mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 21, 1982.
women TDLo oral 1mL/kg (1mL/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: COMA
Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
women TDLo oral 1200uL/kg (1.2mL/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES

AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: COMA
Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.
women TDLo oral 1364uL/kg (1.364mL/kg) AUTONOMIC NERVOUS SYSTEM: GAGLION BLOCK

BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: SLEEP
Rinsho Shinkeigaku. Clinical Neurology. Vol. 21, Pg. 993, 1981.
women TDLo oral 240mg/kg (240mg/kg) SPINAL CORD: OTHER DEGENERATIVE CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: COMA
Journal of UOEH Vol. 5(Suppl), Pg. 125, 1983.

Trichlorfon Safety Profile

Safety Information of Trichlorfon (CAS NO.52-68-6):
Hazard Codes: XnHarmful,NDangerous
Risk Statements: 22-43-50/53
22:  Harmful if swallowed 
43:  May cause sensitization by skin contact 
50:  Very Toxic to aquatic organisms 
53:  May cause long-term adverse effects in the aquatic environment 
Safety Statements: 24-37-60-61-2
2:  Keep out of the reach of children 
24:  Avoid contact with skin 
37:  Wear suitable gloves 
60:  This material and/or its container must be disposed of as hazardous waste 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 

Trichlorfon Specification

 Trichlorfon ,its CAS NO. is 52-68-6,the synonyms is (+-)-Trichlorfon ; (2,2,2-Trichloro-1-hydroxyethyl)-phosphonic acid dimethyl ester ; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle ; 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester ; AI3-19763 ; Agroforotox ; Anthon ; Bovinox ; Chlorophosciclosom ; Chlorophthalm ; Chloroxyphos ; Combot equine ; Dicontal Fort ; Dimethoxy-2,2,2-trichloro-1-hydroxy-ethyl phosphine oxide ; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate ; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate ; Dimethyl 1-hydroxy-2,2,2-trichloroethyl phosphonate ; Dimethyl 2,2,2-trichloro-1-hydroxyethylphosphonate ; Dimethyltrichlorohydroxyethyl phosphonate ; EPA Pesticide Chemical Code 057901 ; Equino-aid ; Fliegenteller ; Foschlorem ; Hypodermacid ; Khloroftalm ; Leivasom ; Loisol ; Methyl chlorophos ; Metriphonate ; Metriphonatum ; Neguvon ; O,O Dimetil 2,2,2-trichloro 1 hidroxietil fosfonato (Portugese) ; O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate ; O,O-Dimethyl (1-oxy-2,2,2-trichloroethyl)phosphonate ; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate ; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphonsaeure ester ; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat ; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat ; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat ; O,O-Dimethyl-1-hydroxy-2,2,2-trichloroethylphosphonate ; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato ; OMS 800 ; Phoschlor ; Phoschlor R50 ; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester ; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester ; Polfoschlor .

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