Uridine 5'-Monophosphate Disodium Salt Hydrate supplier

Name
Disodium uridine-5'-monophosphate
EINECS 222-211-9
CAS No. 3387-36-8
Article Data8
CAS DataBase
Density 1.865g/cm3
Solubility 40 g/100 mL (20 °C) in water
Melting Point 208-210 °C
Formula C₉H₁₁N₂Na₂O₉P
Boiling Point
Molecular Weight 368.148
Flash Point
Transport Information
Appearance Crystalline
Safety 22-24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 5'-Uridylicacid, disodium salt (7CI,8CI,9CI);5'-UMP disodium salt;Disodium 5'-UMP;Disodium 5'-uridylate;Disodium UMP;Disodium uridine 5'-phosphate;NSC 20257;UMP disodium salt;Uridine5'-(dihydrogen phosphate) disodium salt;Uridine 5'-monophosphate disodiumsalt;Uridylic acid disodium salt;Disodium uridine-5'-monophosphate;
PSA 186.78000
LogP -1.85850

Synthetic route

: uridine 5'-(5-dimethylaminoisoquinolin-1-yl)methylphosphate

A: 3387-36-8
disodium uridine-5'-monophosphate

B: 75795-45-8
5-dimethylamino-1-hydroxymethylisoquinoline

Conditions

Conditions	Yield
With snake venom phosphodiesterase for 3h; enzymatic hydrolysis; var.: pH;

: uridine 5'-(5-dimethylamino-2-oxidoisoquinolin-1-yl)methylphosphate

A: 3387-36-8
disodium uridine-5'-monophosphate

B: 75795-49-2
5-dimethylamino-1-hydroxymethylisoquinolin-2-oxide

Conditions

Conditions	Yield
With sodium acetate; snake venom phosphodiesterase at 37℃; for 3h; enzymatic hydrolysis, pH=8; half-life=7 h (pH=4.1), 12 h (pH=10.1), 24 h (pH=7.1), T=37 deg C;

: 154-85-8
orotic acid sodium salt

: 87372-47-2, 94902-32-6, 108321-05-7, 129136-58-9
5-phospho-D-ribosyl α-1-pyrophosphate

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With DL-dithiothreitol; magnesium chloride for 192h; PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase; Yield given;

: 58-96-8
uridine

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multistep reaction.;

: orotidine 5‘-monophosphate trisodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With ODCase from Methanobacterium thermoautotrophicum In various solvent(s) at 55℃; pH=7.5; Enzyme kinetics; Further Variations:; Temperatures;
With orotidine 5'-monophosphate decarboxylase mutant Q215A/Y217F/R235A In aq. buffer at 25℃; pH=7.1; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 532-20-7, 613-83-2, 7261-25-8, 7687-39-0, 13221-22-2, 14795-83-6, 15761-67-8, 20074-49-1, 25545-03-3, 25545-04-4, 32445-75-3, 34436-17-4, 36441-93-7, 36468-53-8, 37110-85-3, 37388-49-1, 38029-69-5, 40461-77-6, 40461-89-0, 41546-19-4, 41546-20-7, 41546-21-8, 41546-26-3, 41546-29-6, 41546-30-9, 41546-31-0, 126872-16-0, 131064-98-7
D-Ribose

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Na2ATP, MgCl26H2O, PEP-K+, DTT, K2HPO4, Na2EDTA / 72 h / PAN-immobilized pyruvate kinase, adenylate kinase, PRPP synthetase, pH 7.5 2: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: 108321-99-9, 150713-51-2
α,β-D-ribofuranose-5-phophate disodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 mmol / Na2ATP, MgCl26H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 2: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: 4578-31-8
adenosine-5'-monophosphate disodium salt

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / Dowex 50 W-X8 (H+ form) / H2O / 0.14 h / Heating 2: 70 mmol / Na2ATP, MgCl26H2O, PEP-K+, K2HPOu, Na2EDTA / 96 h / 30 °C / immobilized PRPP synthetase, pyruvate kinase, adenylate kinase, pH 7.4 3: MgCl26H2O, DTT / 192 h / PAN-immobilized O-5-decarboxylase, O-5-P-pyrophosphorylase, PPiase View Scheme

: C9H13N3O11P2(2-)*2Na(1+)

: 3387-36-8
disodium uridine-5'-monophosphate

Conditions

Conditions	Yield
With water; zinc(II) cation pH=5.5;

: 102-82-9
tributyl-amine

: 3387-36-8
disodium uridine-5'-monophosphate

: uridine 5′-monophosphate tributylammonium salt

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate With DOWEX IR100S resin In water Industrial scale; Stage #2: tributyl-amine In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;	91.4%
With DOWEX IR100S resin In water at 15 - 25℃; pH=6.5 - 7.5; Industrial scale;	91.4%
With DOWEX 50WX2-200 (H)

: 3387-36-8
disodium uridine-5'-monophosphate

: 108-24-7
acetic anhydride

: 79744-04-0, 89681-69-6
tributylammonium 2',3'-di-O-acetyluridine 5'-monophosphate

Conditions

Conditions	Yield
In pyridine; N,N-dimethyl-formamide	72%

: copper(II) nitrate trihydrate

: 3387-36-8
disodium uridine-5'-monophosphate

: 7732-18-5
water

: 6957-22-8
4-pyridinealdazine

: [Cu2(uridine 5'-monophosphate)2(1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene)2(H2O)3]*10H2O

Conditions

Conditions	Yield
In ethanol for 0.5h;	68%

...Expand

: 3387-36-8
disodium uridine-5'-monophosphate

: 507-09-5
thioacetic acid

: 48215-95-8
2′,3′-di-O-acetyl β-uridine-5′-phosphate

Conditions

Conditions	Yield
With propiolonitrile; sodium hydroxide In water; water-d2 pH=8;	67%

: copper(II) nitrate trihydrate

: 3387-36-8
disodium uridine-5'-monophosphate

: 7732-18-5
water

: 1135-32-6
trans-1,2-bis(4-pyridyl)ethylene

: [Cu2(uridine 5'-monophosphate)2(1,2-bis(4-pyridyl)ethylene)2(H2O)2]*7H2O

Conditions

Conditions	Yield
In ethanol for 0.5h;	63%

...Expand

: 2-chloro-1,3-dimethyl imidazolium chloride

: 3387-36-8
disodium uridine-5'-monophosphate

A: 80-73-9
1,3-dimethyl-2-imidazolidinone

B: 26184-65-6
Up2U

Conditions

Conditions	Yield
at 37℃; for 24h;	A 40% B n/a

...Expand

: 1608127-23-6
α-2-azido-2-deoxy-3,4,6-tri-O-acetyl-D-galactose 1-phosphate

: 3387-36-8
disodium uridine-5'-monophosphate

: C21H27N5O19P2(2-)

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate In water for 0.5h; Stage #2: With tributyl-amine In water at 20℃; for 0.5h; Stage #3: α-2-azido-2-deoxy-3,4,6-tri-O-acetyl-D-galactose-1-phosphate Further stages;	37%

: 3387-36-8
disodium uridine-5'-monophosphate

: 74-88-4
methyl iodide

A: 69113-66-2
3'-O-methyluridine 5'-monophosphate

B: 142657-17-8
2',3'-di-O-methyluridine 5'-monophosphate

C: 142657-18-9
2'-O-methyluridine 5'-monophosphate monosodium salt

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane for 3h; Ambient temperature; various alkyl iodides, other temperature;	A 11% B 33% C 20%
With sodium hydroxide In 1,4-dioxane for 3h; Ambient temperature;	A 11% B 33% C 20%

...Expand

: [Cu4(μ-OH)(μ-(α-D-glycopyranose-1-phosphate)2(2,2'-bipyridyl)4(H2O)2]Cl3*14H2O

: 3387-36-8
disodium uridine-5'-monophosphate

: 7732-18-5
water

: [Cu(μ-(uridine 5'-monophosphate-H))(2,2'-bipyridine)(H2O)]2[Cu4(μ-OH)(μ-(α-D-Glc-1P))2(bpy)4(H2O)2]Cl*9H2O

Conditions

Conditions	Yield
In water uridine 5'-monophosphate disodium salt (0.076 mmol) added to aq. soln. of Cu complex (0.059 mmol); stirred (12 h); concd. (vac.); concd. slowly; crystals collected; dried (vac.); elem. anal.;	30%

...Expand

: 2-azido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt

: 3387-36-8
disodium uridine-5'-monophosphate

: UDP-2-azido-2-deoxy-α-D-galactofuranose triethylammonium salt

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate With 1H-imidazole; 2-chloro-1,3-dimethylimidazolinium chloride In water-d2 at 37℃; for 1h; Inert atmosphere; Stage #2: 2-azido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt In water-d2 at 37℃; for 18h; Inert atmosphere; Stage #3: With calf intestinal alkaline phosphatase In water-d2 at 30℃; for 24h; pH=8; Inert atmosphere; Enzymatic reaction;	23%

Yield

Stage #1: disodium uridine-5'-monophosphate With 1H-imidazole; 2-chloro-1,3-dimethylimidazolinium chloride In water-d2 at 37℃; for 1h; Inert atmosphere;
Stage #2: 2-azido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt In water-d2 at 37℃; for 18h; Inert atmosphere;
Stage #3: With calf intestinal alkaline phosphatase In water-d2 at 30℃; for 24h; pH=8; Inert atmosphere; Enzymatic reaction;

23%

: 3387-36-8
disodium uridine-5'-monophosphate

: 75-03-6
ethyl iodide

A: 51785-61-6
3'-O-ethyluridine 5'-monophosphate

B: 50582-57-5
2'-O-ethyluridine 5'-monophosphate

C: 142657-19-0
2',3'-di-O-ethyluridine 5'-monophosphate disodium salt

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 65℃; for 3h;	A 22% B 18% C 18%

...Expand

: 3387-36-8
disodium uridine-5'-monophosphate

: 57-50-1
Sucrose

: 133-89-1
UDP-glucose

Conditions

Conditions	Yield
With bovine serum albumine; phospho(enol)pyruvate CHA-salt; tris hydrochloride; uridine 5'-triphosphate trisodium salt; magnesium chloride; diothiothreitol at 30℃; for 21h; sucrose synthase, pyruvate kinase, nucleoside monophosphate kinase;	21%

: 2-acetamido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt

: 3387-36-8
disodium uridine-5'-monophosphate

: UDP-2-acetamido-2-deoxy-α-D-galactofuranose triethylammonium salt

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate With 1H-imidazole; 2-chloro-1,3-dimethylimidazolinium chloride In water-d2 at 37℃; for 1h; pH=8; Inert atmosphere; Stage #2: 2-acetamido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt In water-d2 at 37℃; for 24h; Inert atmosphere; Stage #3: With calf intestinal alkaline phosphatase In water-d2 at 30℃; for 24h; pH=8; Inert atmosphere; Enzymatic reaction;	16%

Yield

Stage #1: disodium uridine-5'-monophosphate With 1H-imidazole; 2-chloro-1,3-dimethylimidazolinium chloride In water-d2 at 37℃; for 1h; pH=8; Inert atmosphere;
Stage #2: 2-acetamido-2-deoxy-α-D-galactofuranosyl phosphate triethylammonium salt In water-d2 at 37℃; for 24h; Inert atmosphere;
Stage #3: With calf intestinal alkaline phosphatase In water-d2 at 30℃; for 24h; pH=8; Inert atmosphere; Enzymatic reaction;

16%

: 3387-36-8
disodium uridine-5'-monophosphate

: 107-08-4
1-iodo-propane

A: 142657-21-4
2'-O-n-propyluridine 5'-monophosphate

B: 142657-20-3
2',3'-di-O-n-propyluridine 5'-monophosphate monosodium salt

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 70℃; for 3h;	A 13% B 13%

...Expand

: 75-30-9
2-iodo-propane

: 3387-36-8
disodium uridine-5'-monophosphate

A: 142657-23-6
3'-O-isopropyluridine 5'-monophosphate monosodium salt

B: 142657-22-5
uridine 5'-monophosphate isopropyl ester monosodium salt

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 70℃; for 3h;	A 9% B 10%

...Expand

: 586-39-0
1-nitro-3-vinyl-benzene

: 3387-36-8
disodium uridine-5'-monophosphate

: 72045-18-2
5(E)-(3-nitrostyryl)uridine 5'-phosphate

Conditions

Conditions	Yield
With lithium pentachloropalladate; mercury(II) diacetate 1) water, 50 deg C, 5 h; 2) methanol, 30 min; Yield given. Multistep reaction;

: 3387-36-8
disodium uridine-5'-monophosphate

: 54430-64-7, 86194-94-7, 92008-48-5
[(1S)-2-imidazol-1-yl-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

A: C17H24N3O12P(2-)*2Na(1+)

B: C17H24N3O12P(2-)*2Na(1+)

Conditions

Conditions	Yield
In water at 20 - 22℃; for 2.5h; various nucleoside 5'-phosphates, syntheses of 2'(3')-O-aminoacylnucleosides;

...Expand

: 3387-36-8
disodium uridine-5'-monophosphate

: 75795-52-7
5-dimethylamino-2-oxidoisoquinolin-1-yl diazomethane

: uridine 5'-(5-dimethylamino-2-oxidoisoquinolin-1-yl)methylphosphate

Conditions

Conditions	Yield
In water for 0.333333h; Ambient temperature; pH=5 (HCl);

: 3387-36-8
disodium uridine-5'-monophosphate

: 108-24-7
acetic anhydride

: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-(acetoxy-hydroxy-phosphoryloxymethyl)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Conditions

Conditions	Yield
With pyridine In N,N-dimethyl-formamide for 24h; Ambient temperature;

: 3387-36-8
disodium uridine-5'-monophosphate

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 32452-87-2
uridine 5'-(diphenyl diphosphate)

Conditions

Conditions	Yield
With tributyl-amine In 1,4-dioxane; N,N-dimethyl-formamide

: 3387-36-8
disodium uridine-5'-monophosphate

: Acetic acid (1S,2S,3R,5S,6R)-2,6-diacetoxy-3-acetoxymethyl-5-phosphonooxy-cyclohexyl ester

: C24H34N2O20P2

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole 1.) acetone, 18 h, room temp., 2.) DMF, 18 h, room temp.; Multistep reaction;

: 3387-36-8
disodium uridine-5'-monophosphate

: Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-(2-azido-acetylamino)-6-phosphonooxy-tetrahydro-pyran-4-yl ester

: C23H32N6O20P2

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 0℃; for 3h;

: 3387-36-8
disodium uridine-5'-monophosphate

: 78377-23-8
pyrenyl-1-diazomethane

: 1-pyrenylmethyl uridine-5'-phosphate

Conditions

Conditions	Yield
With boric acid In ethyl acetate; acetonitrile at 60℃;

: 616-47-7
1-methyl-1H-imidazole

: 3387-36-8
disodium uridine-5'-monophosphate

: 407-25-0
trifluoroacetic anhydride

: UMP-N-methylimidazolide

Conditions

Conditions	Yield
Stage #1: disodium uridine-5'-monophosphate; trifluoroacetic anhydride With triethylamine In acetonitrile at 0 - 20℃; Stage #2: 1-methyl-1H-imidazole With triethylamine In acetonitrile at 0℃; for 0.166667h;

...Expand

Uridine 5'-Monophosphate Disodium Salt Hydrate Specification

Uridine 5'-Monophosphate Disodium Salt Hydrate, with the CAS NO.3387-36-8, is also called Disodium [(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate; 5'-UMP disodium; CCRIS 6562; Disodium 5'-UMP; Disodium 5'-uridylate; Disodium UMP ; Disodium uridine 5'-monophosphate; Disodium uridine 5'-phosphate; EINECS 222-211-9 ; NSC 20257; Uridine 5'MP, disodium salt; Uridine-5-monophosphate disodium salt. It belongs to Biochemistry; Nucleosides, Nucleotides & Related Reagents; Nucleotides and their analogs; Nucleic acids. Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent.

Physical properties about Uridine 5'-Monophosphate Disodium Salt Hydrate are: (1)ACD/LogP: -1.583; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -4.92; (4)ACD/LogD (pH 7.4): -5.90; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4):1.00; (9)#H bond acceptors: 11; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 6

Uses of Uridine 5'-Monophosphate Disodium Salt Hydrate: Uridine 5'-Monophosphate Disodium Salt Hydrate is used as flavoring agent: nucleotide added to the milk to increase volume to make it closer to human milk composition, increase resistance to infants and young children. And it can be used as auxiliary liver disease drug. It also used as production of intermediate nucleic acid drugs asn health food and biochemical reagents. And it for the manufacture of uridine triphosphate (UTP), poly gland urine, drugs such Furtulon.

When you are using this chemical, please be cautious about it as the following:
1. Do not breathe dust;
2. Avoid contact with skin and eyes;
3. Wear suitable protective clothing;
4. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H13N2O9P.2Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7+,8-;;/m1../s1;
(2)InChIKey=KURVIXMFFSNONZ-WAJQJQIOSA-L;
(3)Smilesc1cn(c(=O)[nH]c1=O)[C@H]2[C@H]([C@@H]([C@H](O2)COP(=O)([O-])[O-])O)O.[Na+].[Na+]

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	3394mg/kg (3394mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse	LD50	oral	> 12gm/kg (12000mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
mouse	LD50	subcutaneous	3698mg/kg (3698mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	intraperitoneal	3111mg/kg (3111mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	oral	> 12gm/kg (12000mg/kg)		Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.
rat	LD50	subcutaneous	> 6gm/kg (6000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 22, Pg. 618, 1975.

Product Name

Disodium uridine-5'-monophosphate

Synthetic route

Uridine 5'-Monophosphate Disodium Salt Hydrate Specification

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