Veratraldehyde supplier | CasNO.120-14-9

Name
Veratraldehyde
EINECS 204-373-2
CAS No. 120-14-9
Article Data569
CAS DataBase
Density 1.114 g/cm³
Solubility water: <0.1 g/100 mL at 22 ºC
Melting Point 42-45 ºC
Formula C₉H₁₀O₃
Boiling Point 281 ºC at 760 mmHg
Molecular Weight 166.177
Flash Point 110.4ºC
Transport Information
Appearance needle-shaped crystal
Safety 26-22-24/25
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms 3,4-Dimethoxybenzaldehyde;3,4-Dimethoxybenzenecarbonal;4-O-Methylvanillin;Methylvanillin;NSC 24521;NSC 8500;Protocatechualdehydedimethyl ether;Protocatechuic aldehyde dimethyl ether;Vanillin methyl ether;Veratral;Veratric aldehyde;Veratrum aldehyde;Veratryl aldehyde;3,4-Dimethoxy-benzaldehyde;Benzaldehyde,3,4-dimethoxy-;
PSA 35.53000
LogP 1.51630

Synthetic route

: 93-03-8
(3,4-dimethoxyphenyl)methanol

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With polymer supported perruthenate reagent In dichloromethane	100%
With benzyltriphenylphosphonium peroxymonosulfate for 0.0833333h; Oxidation;	100%
With butyltriphenylphosphonium chlorochromate In acetonitrile for 0.5h; Heating;	100%

: 2169-98-4, 39627-82-2
3,4-Dimethoxy-benzaldehyde oxime

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With 1-benzyl-4-aza-1-azoniabiyclo<2.2.2>octane peroxodisulfate In acetonitrile for 0.25h; Oxidation; Heating;	100%
With benzyltriphenylphosphonium dichromate; silica gel for 0.0833333h;	100%
With 1-benzyl-4-aza-1-azoniabiyclo<2.2.2>octane peroxodisulfate In acetonitrile for 0.25h; Heating;	99%

: 50766-67-1
2-(3,4-dimethoxyphenyl)-1,3-dithiane

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With silver(I) nitrite; iodine In tetrahydrofuran for 1.5h; Ambient temperature;	100%
With bismuth(III) nitrate; water In benzene at 20℃; for 5h;	93%
With eosin y In water; acetonitrile at 20℃; for 2h; Catalytic behavior; Reagent/catalyst; Solvent; Irradiation;	92%
With dipotassium peroxodisulfate; 1-n-butyl-3-methylimidazolim bromide at 60 - 70℃; for 0.166667h;	80%

: 494-99-5
1,2-dimethoxy-4-methylbenzene

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With laccase at 20℃; Reagent/catalyst; Green chemistry; Enzymatic reaction;	100%
With laccase from Trametes versicolor; oxygen; benzotriazol-1-ol In water at 45℃; for 22h; pH=4.5;	99%
With laccase of Pleurotus ostreatus MTCC-1801; 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt In 1,4-dioxane at 20℃; pH=4.5; Enzymatic reaction;	98%

: 271771-50-7
1,1-diacetoxy-1-(3,4-dimethoxyphenyl)methane

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With water; titanium(IV) fluoride at 60℃; for 1.3h; screw-capped vial;	100%
With 2,6-dicarboxypyridinium chlorochromate In acetonitrile at 20℃; for 0.0833333h;	96%
With rice husk supported FeCl3 nanoparticles In ethanol at 70℃; for 0.05h;	92%

: 121-33-5
vanillin

: 74-88-4
methyl iodide

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 1.5h;	100%
With potassium carbonate In acetone at 60 - 70℃; for 17h; Reflux;	99.3%
With 18-crown-6 ether; potassium carbonate	96%

: 61040-75-3
((3,4-dimethoxybenzyl)oxy)trimethylsilane

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With nitrogen dioxide at 20℃; for 0.166667h;	100%

: 121-33-5
vanillin

: 77-78-1
dimethyl sulfate

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone at 20℃; for 1.5h; Reflux;	99%
With potassium carbonate In acetone	95%
With potassium hydroxide In water at 20 - 23℃; for 6h;	90%

: 4362-62-3
2-(3,4-Dimethoxy-phenyl)-[1,3]dioxolane

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium dichromate; aluminium trichloride for 0.0333333h;	98%
With lithium chloride In water; dimethyl sulfoxide at 90℃; for 6h;	95%
With CuCl2*2H2O In acetonitrile for 0.5h; Ambient temperature;	93%
With sodium tetrahydroborate; nickel(II) chloride hexahydrate In methanol for 12h; Reflux; chemoselective reaction;	88%
With K5 In acetone for 0.166667h; Heating;	97 % Chromat.

: 5763-61-1
3,4-dimethoxybenzylamine

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; for 24h; pH=4.5; Enzymatic reaction;	98%
With immobilised amine transaminase from the moderate halophilic bacterium Halomonas elongata; sodium pyruvate In aq. phosphate buffer; toluene at 45℃; under 760.051 Torr; for 5h; pH=8;	96%
With sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid; trifluoroacetic acid In water; acetonitrile for 20h;	75%
Multi-step reaction with 3 steps 1: N-chloro-succinimide / 0.17 h / 20 °C / Milling 2: triethylamine / 0.17 h / 20 °C / Milling 3: water; hydrogenchloride / tetrahydrofuran / 2 h / 20 °C View Scheme

: 5763-61-1
3,4-dimethoxybenzylamine

A: 2024-83-1
veratronitrile

B: 57535-59-8
N-(3,4-dimethoxybenzyl)-1-(3,4-dimethoxyphenyl)methanimine

C: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With sodium hypochlorite In ethanol for 0.25h; Ambient temperature;	A 97% B n/a C n/a

...Expand

: 13443-56-6
β-hydroxy-3,4-dimethoxy phenethyl alcohol

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With dimanganese decacarbonyl In toluene at 120℃; Sealed tube;	97%

: 60354-22-5
((3,4-dimethoxyphenyl)methylene)bis(phenylsulfane)

A: 120-14-9
3,4-dimethoxy-benzaldehyde

B: 882-33-7
diphenyldisulfane

Conditions

Conditions	Yield
With tetrafluoroboric acid; tris(2,2'-bipyridine)iron(III) perchlorate In water; acetonitrile for 0.0833333h; Ambient temperature;	A 96% B n/a

: 148625-44-9
2-(3,4-dimethoxybenzyloxy)tetrahydro-2H-pyran

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium dichromate; aluminium trichloride for 0.05h;	96%
With aluminum oxide; potassium permanganate for 0.166667h; Product distribution; Further Variations:; Reagents; reaction times;	90%
With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In dichloromethane for 0.05h; microwave irradiation;	80%

: 5460-32-2
1-iodo-3,4-dimethoxybenzene

: 82102-37-2
9-methyl-9H-fluorene-9-carbonyl chloride

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With dichloro(1,5-cyclooctadiene)palladium(II); N-Methyldicyclohexylamine; potassium formate; tetra-(n-butyl)ammonium iodide; tricyclohexylphosphine tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); tri tert-butylphosphoniumtetrafluoroborate In acetonitrile at 80℃; for 18h; Sealed tube; Glovebox; Inert atmosphere;	96%

: 91-16-7
1,2-dimethoxybenzene

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With benzene-1,2-dicarboxylic acid; trichlorophosphate In N,N-dimethyl-formamide at 40 - 85℃; for 4h; Cooling with ice; Green chemistry;	95.2%
With trichlorophosphate
With sodium hydroxide; pyrophosphoryl chloride 1) 95 deg C, 24 h; Yield given. Multistep reaction;

: 5346-37-2
3,4-Dimethoxybenzaldehyde semicarbazone

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium dichromate; aluminium trichloride for 0.0833333h;	95%
With CuCl2*2H2O for 0.00527778h; microwave irradiation;	85%
With ammonium cerium(IV) nitrate; silica gel for 0.025h; microwave irradiation;	84%

: 68413-92-3
Sodium; (3,4-dimethoxy-phenyl)-hydroxy-methanesulfonate

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With Montmorillonite KSF clay for 0.00277778h; Elimination; microwave irradiation;	95%
With ammonium acetate for 0.00416667h; microwave irradiation;	89%

: 4-(Bis-ethylsulfanyl-methyl)-1,2-dimethoxy-benzene

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With aluminium trichloride; 1-benzyl-1-aza-4-azoniabicyclo<2.2.2>octane periodate at 20℃; for 0.2h;	95%
With bismuth(lll) trifluoromethanesulfonate In dichloromethane; water at 20℃; for 0.166667h;	90%

: 114131-33-8
1,2-dimethoxy-4-(nitromethyl)benzene

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,2-dimethoxy-4-(nitromethyl)benzene With potassium hydroxide In methanol Nef reaction; Continuous flow conditions; Stage #2: With potassium permanganate; water In methanol at 25℃; Nef reaction; Sonication; Continuous flow conditions; chemoselective reaction;	95%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;	95%
With 1H-imidazole; C17H16ClMnN2O2; tetrabutylammonium periodite In chloroform at 20℃; for 0.416667h;	94%
With tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1-λ3-benzo[d][1,2]iodaoxol-3(1H)-one In 2,2,2-trifluoroethanol at 40℃; for 3h; UV-irradiation;	94%

: 121-33-5
vanillin

: 616-38-6
carbonic acid dimethyl ester

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate at 88℃; for 40h; Catalytic behavior; Reagent/catalyst;	94.68%
With N,N'-dimethylimidazolium-2-carboxylate In acetonitrile at 160℃; for 2.66667h; Microwave irradiation; Green chemistry;	77%
at 160℃; for 2h; Kinetics; Catalytic behavior; Reagent/catalyst; Temperature; Time; Concentration; Autoclave;

: 621-59-0
isovanillin

: 77-78-1
dimethyl sulfate

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In acetone for 0.0833333h; Etherification; methylation; microwave irradiation;	94%
With potassium hydroxide at 20℃; Darst.;

: 2-(3,4-dimethoxyphenyl)-1,3-oxathiane

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With silver(I) nitrite; iodine In tetrahydrofuran for 5h; Ambient temperature;	94%

: 139-85-5
3,4-dihydroxybenzaldehyde

: 74-88-4
methyl iodide

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h;	94%
With potassium carbonate	93%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	68%

: 91-16-7
1,2-dimethoxybenzene

: 93-61-8
N-methyl-N-phenylformamide

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
Stage #1: 1,2-dimethoxybenzene; N-methyl-N-phenylformamide With sulfuryl dichloride at 35℃; Stage #2: In water; toluene at 65℃; for 6h; Temperature;	93.4%
With trichlorophosphate
With sodium hydroxide; pyrophosphoryl chloride 1) 1.1) 115 deg C, 1 h, 1.2) 100 deg C, 18 h; Yield given. Multistep reaction;

: 6379-72-2
1,2-dimethoxy-4-(E)-propenylbenzene

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With oxygen In dimethyl sulfoxide at 120℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Sealed tube;	93%
With ozone; thiourea 1) -10-(-15) deg C, 65 min, CH3OH; 2) 0 deg C, 55 min; Yield given. Multistep reaction;

: 41764-74-3
3,4-dimethoxybenzohydrazide

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With ammonia; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform at 20℃; for 0.166667h;	93%

: 55665-95-7
sulfamic acid methyl ester

: 121-33-5
vanillin

: 120-14-9
3,4-dimethoxy-benzaldehyde

Conditions

Conditions	Yield
With potassium bisulfite; sodium chloride; tin(ll) chloride In nitromethane at 9℃; for 13h; Concentration; Temperature; Reflux;	93%

: 67-52-7
BARBITURIC ACID

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 66386-22-9
5-(3,4-dimethoxybenzylidene)-2,4,6(1H,3H,5H)-pyrimidinetrione

Conditions

Conditions	Yield
In water for 1h; Heating;	100%
In ethanol; water at 80℃; Knoevenagel condensation;	96%
In ethanol; water at 80℃; for 9h;	96.6%

: 106-49-0
p-toluidine

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 67101-90-0
1,2-dimethoxy-4-<<(4-methylphenyl)imino>methyl>benzene

Conditions

Conditions	Yield
In toluene Heating;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 62-53-3
aniline

: 27895-67-6
N-(3,4-dimethoxybenzylidene)aniline

Conditions

Conditions	Yield
In toluene Heating;	100%
sodium hydrogen sulfate; silica gel at 56 - 58℃; for 0.0222222h; microwave irradiation;	95%
magnesium(II) perchlorate In 1,2-dichloro-ethane at 20℃; for 4h;	94%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 2286-55-7
ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate

Conditions

Conditions	Yield
With piperidine; acetic acid In benzene at 120 - 130℃; for 12h; Heating / reflux;	100%
With polymer supported poly(propylene imine)dendrimer In ethanol at 20℃; for 0.166667h; Knoevenagel Condensation; Green chemistry;	99%
With ammonium sulphamate for 0.00416667h; Knoevenagel condensation; Microwave irradiation; neat (no solvent);	97%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 156-43-4
4-Ethoxyaniline

: 82363-25-5
(3,4-dimethoxybenzylidene)(4-ethoxyphenyl)amine

Conditions

Conditions	Yield
In toluene Heating;	100%
In ethanol Heating;	94%
at 110℃;

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 74-89-5
methylamine

: 17972-14-4
N-(3,4-dimethoxybenzylidene)methanamine

Conditions

Conditions	Yield
With 4 A molecular sieve In toluene at 0℃;	100%
With benzene
In methanol at 40℃; for 5h;
In ethanol at 50℃;
In benzene for 2h; Reflux;

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 109-77-3
malononitrile

: 2972-80-7
3,4-dimethoxybenzylidenemalononitrile

Conditions

Conditions	Yield
With polymer supported poly(propylene imine)dendrimer In ethanol at 20℃; for 0.0833333h; Knoevenagel Condensation; Green chemistry;	100%
With third generation polystyrene supported poly(amidoamine) dendrimer In ethanol at 30℃; for 0.333333h; Knoevenagel condensation;	99%
With antimony(III) chloride for 0.0416667h; Knoevenagel condensation; microwave irradiation;	97%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

Conditions

Conditions	Yield
With bromine; acetic acid at 20℃; for 0.25h;	100%
Stage #1: 3,4-dimethoxy-benzaldehyde With bromine In methanol at 20℃; for 4h; Stage #2: With sodium hydroxide In methanol; water pH=9 - 10;	98%
With bromine at 20℃; for 1.5h;	98%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 20357-25-9
2-nitroveratraldehyde

Conditions

Conditions	Yield
With nitric acid at 20℃; for 0.166667h;	100%
With nitric acid at 0 - 20℃; for 2h;	95%
With nitric acid at 0 - 20℃; for 3h; Inert atmosphere; Green chemistry;	91%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 93-03-8
(3,4-dimethoxyphenyl)methanol

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; phenylboronic acid In dichloromethane at 20℃; for 21h;	100%
With sodium tetrahydroborate In methanol at 20℃; for 1h;	100%
With sodium tetrahydroborate In methanol at 0℃; Inert atmosphere;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 24393-47-3
ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate

Conditions

Conditions	Yield
With third generation polystyrene supported poly(amidoamine) dendrimer In ethanol at 50℃; for 0.333333h; Knoevenagel condensation;	100%
With ASCPEI In ethanol at 43℃; for 2h; Knoevenagel condensation;	98%
With ammonium acetate for 0.25h; Knoevenagel condensation; microwave irradiation;	94%

: 403-42-9
1-(4-fluorophenyl)ethanone

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 28081-14-3
(E)-1-(4-fluorophenyl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium hydroxide In ethanol at 20℃;	100%
With sodium hydroxide In methanol at 20℃; for 18h;	79%
With potassium hydroxide
With sodium hydroxide In ethanol at 20℃; for 2h;

: 90-04-0
2-methoxy-phenylamine

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 82363-28-8
N-m,p-dimethoxybenzylidene-o-anisidine

Conditions

Conditions	Yield
In toluene Heating;	100%
In neat (no solvent) Time; Irradiation; Green chemistry;	72.6%
With 5A molecular sieve In toluene for 4h;

: 20948-67-8
5-chloro-1H-indole-2-carbohydrazide

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 97132-96-2
5-Chlor-N'-<(3,4-dimethoxyphenyl)-methylen>-2-indolcarbohydrazid

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	100%

: 106-47-8
4-chloro-aniline

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 38608-18-3
4-chloro-N-(3,4-dimethoxyphenyl)methylenebenzenamine

Conditions

Conditions	Yield
In toluene Heating;	100%
magnesium(II) perchlorate In 1,2-dichloro-ethane at 20℃; for 8h;	90%
In ethanol for 0.75h; Heating;
With Montmorillonite K10 clay Condensation; microwave irradiation;
In neat (no solvent) Heating;

: 104-94-9
4-methoxy-aniline

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 82363-24-4
(3,4-dimethoxybenzylidene)-(4-methoxyphenyl)amine

Conditions

Conditions	Yield
In toluene Heating;	100%
With aqueous extract of pericarp of Sapindus trifoliatus fruits at 20℃; for 0.166667h;	95%
With sulfuric acid In neat (no solvent) Microwave irradiation; Sealed tube; Green chemistry;	80%

: 495-69-2
Hippuric Acid

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 25349-38-6
4-[(E)-(3,4-dimethoxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one

Conditions

Conditions	Yield
With sodium acetate for 0.0833333h; microwave irradiation;	100%
Stage #1: Hippuric Acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In tetrahydrofuran at 20℃; for 0.5h; Stage #2: 3,4-dimethoxy-benzaldehyde In tetrahydrofuran at 75℃; for 0.233333h;	90%
clinoptilolite for 0.2h; Product distribution; Further Variations:; Catalysts; Temperatures; reaction times, with or without microwave irradiation; microwave irradiation;	81%

: 1738-16-5
4-acetyltropolone

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 4-(3,4-dimethoxycinnamoyl)tropolone

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 0℃;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 540-63-6
ethane-1,2-dithiol

: 69922-36-7
2-(3,4-dimethoxyphenyl)-1,3-dithiolane

Conditions

Conditions	Yield
amberlyst-15 In chloroform for 48h; Ambient temperature;	100%
With N-Bromosuccinimide for 0.05h;	98%
With silica-supported sulfuric acid at 20℃; for 0.133333h; Neat (no solvent); chemoselective reaction;	98%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 120-92-3
cyclopentanone

: 106115-49-5
2,5-Bis<(3,4-dimethoxyphenyl)methylen>cyclopentanon

Conditions

Conditions	Yield
With lithium perchlorate; triethylamine at 20℃; for 96h;	100%
With hydrogenchloride; acetic acid at 25 - 30℃; for 2h;	85%
With hydrogenchloride In acetic acid at 25 - 30℃; for 2h;	85%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 108-42-9
3-chloro-aniline

: 82363-26-6
(3-Chloro-phenyl)-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
In toluene Heating;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 95-55-6
2-amino-phenol

: 80241-83-4
2-(3,4-dimethoxyphenylmethyleneimino)phenol

Conditions

Conditions	Yield
In toluene Heating;	100%
In ethanol for 3h; Reflux;	75%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 108-44-1
1-amino-3-methylbenzene

: 3,4-dimethoxybenzal-3-toluidine

Conditions

Conditions	Yield
In toluene Heating;	100%
In methanol	93%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 591-27-5
m-Hydroxyaniline

: 23837-30-1
3,4-Methoxybenzyliden-m-hydroxyanilin

Conditions

Conditions	Yield
In toluene Heating;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 99-09-2
3-nitro-aniline

: 82363-29-9
[1-(3,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-(3-nitro-phenyl)-amine

Conditions

Conditions	Yield
In toluene Heating;	100%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 22483-09-6
2,2-dimethoxyethylamine

: 39964-87-9
N-(2,2-dimethoxyethyl)-1-(3,4-dimethoxyphenyl)methanimine

Conditions

Conditions	Yield
In benzene for 4h; Heating;	100%
With magnesium sulfate In chloroform at 20℃; for 24h;	100%
In benzene for 4h; Reflux;	99.1%

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 106-40-1
4-bromo-aniline

: 82363-27-7
3,4-dimethoxybenzal-4-bromoaniline

Conditions

Conditions	Yield
In toluene Heating;	100%
In methanol at 20℃;	76%

Veratraldehyde Specification

1. Introduction of Veratraldehyde
Veratraldehyde is derivative of vanillin, widely used as a flavorant and odorant. The IUPAC name of Veratraldehyde is 3,4-dimethoxybenzaldehyde, it is off-white crystalline solid. It is also called 3,4-dimethoxy-benzaldehyd ; 4-O-Methylvanillin ; Benzaldehyde, 3,4-dimethoxy-veratraldehyde ; Protocatechuecaldehyde dimethyl ether ; Protocatechuecaldehydedimethylether ; P-Veratric aldehyde ; P-veratricaldehyde and so on.

2. Properties of Veratraldehyde
Veratraldehyde is incompatible with strong oxidizing agents and strong bases.Veratraldehyde is an aldehyde. Aldehydes are readily oxidized to give carboxylic acids. Flammable and/or toxic gases are generated by the combination of aldehydes with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. Aldehydes can react with air to give first peroxo acids, and ultimately carboxylic acids. These autoxidation reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction).

Physical properties about Veratraldehyde are:
Appearance: off-white crystalline solid
Nominal Mass: 166 Da
Average Mass: 166.1739 Da
Monoisotopic Mass: 166.062994 Da
Index of Refraction: 1.534
Molar Refractivity: 46.36 cm3
Molar Volume: 149.1 cm3
Surface Tension: 36.1 dyne/cm
Density: 1.114 g/cm3
Flash Point: 110.4 °C
Enthalpy of Vaporization: 51.98 kJ/mol
Boiling Point: 281 °C at 760 mmHg
Vapour Pressure: 0.00366 mmHg at 25°C
Water Solubility: <0.1 g/100 mL at 22 ºC
Sensitive: Air Sensitive
Stability: Stable. Incompatible with strong bases, strong oxidizing agents.

3. Toxicity of Veratraldehyde

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	3200mg/kg (3200mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION	National Technical Information Service. Vol. OTS0533446,
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)		Food and Cosmetics Toxicology. Vol. 13, Pg. 923, 1975.
rat	LD50	oral	2gm/kg (2000mg/kg)		Food and Cosmetics Toxicology. Vol. 13, Pg. 923, 1975.

4. Safety Information of Veratraldehyde
Hazard Codes:

Xn
Risk Statements: 22-38-36/37/38-36/38
R22: Harmful if swallowed
R38: Irritating to skin
R36/37/38: Irritating to eyes, respiratory system and skin
R36/38: Irritating to eyes and skin
Safety Statements: 26-22-24/25-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36: Wear suitable protective clothing
WGK Germany: 3
RTECS: YX5088000
F: 9-23
HS Code: 29124900

5. Use of Veratraldehyde
Pharmaceutical industry for synthetic drugs methyldopa, also for the production of veterinary sulfonamide synergist bacteria enemy net. This kind of veterinary medicine to 0.02% (weight) distribution into the feed, so iodine added to feed efficiency amine drugs for prevention and control of poultry infections.

6. Preparation of Veratraldehyde
Veratraldehyde has been prepared by treatment of veratrole with hydrogen cyanide in the presence of aluminum chloride; by condensing veratrole with formylpiperidine and hydrolyzing the product; and by methylating vanillin with methyl iodide, methyl sulfate, methyl p-toluenesulfonate, or trimethylphenylammonium hydroxide.

7. Other details of Veratraldehyde
Personal Protection:
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Fire Fighting:Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam.

Product Name

Veratraldehyde

Synthetic route

Veratraldehyde Specification

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