Product Name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Synonyms: 3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-Pyrazolo[3,4-d]pyrimidin-4
Cas:1022150-12-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:1022150-12-4
Min.Order:0
Negotiable
Type:Trading Company
inquiry
Cas:1022150-12-4
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiry3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Basic information Product Name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Synonyms:
Cas:1022150-12-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:1022150-12-4
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:1022150-12-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiry3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine CAS:1022150-12-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical
Cas:1022150-12-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1022150-12-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:1022150-12-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:1022150-12-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Cas:1022150-12-4
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1022150-12-4
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:1022150-12-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co
Cas:1022150-12-4
Min.Order:100 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:1022150-12-4
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:1022150-12-4
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $8.2 / 8.8
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1022150-12-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProduct name: 3-(4-Phenoxyphenyl)-1-(3-Piperdyl)Pyrazolo[3,4-d]Pyrimidin-4-Amine CAS No.:1022150-12-4 Molecule Formula:C22H22N6O Molecule Weight:386.45 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:E
Cas:1022150-12-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:1022150-12-4
Min.Order:0
Negotiable
Type:Trading Company
inquiry3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Chemical Properties Boiling point 626.3±55.0 °C(Predicted) density 1.39±0.1 g/cm3(Predicted) storage temp. Keep in dark place,Inert atmosphere,2
Cas:1022150-12-4
Min.Order:1 Gram
FOB Price: $66.0
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:1022150-12-4
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryProduct name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine CAS No.: 1022150-12-4 Chemical name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;(R)-3-(4-phenoxyphenyl)-1-(piperidin-3
Cas:1022150-12-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1022150-12-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirylow price high quality high purity good sevice in stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermed
Cas:1022150-12-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 2h; Inert atmosphere; | 100% |
With hydrogenchloride In methanol; water at 50℃; | 98% |
With hydrogenchloride In methanol at 20℃; for 2h; | 92% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With palladium on activated charcoal | 99% |
4-phenoxyphenylboronic acid
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water for 5h; Solvent; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Reflux; | 90% |
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water for 5h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere; Reflux; | 90% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate In tetrahydrofuran at 35℃; Inert atmosphere; | 88.6% |
4-phenoxyphenylboronic acid
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water for 5h; Suzuki Coupling; Inert atmosphere; Reflux; | 87.1% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane for 4h; Inert atmosphere; Reflux; | 0.5 g |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
N-tert-butoxycarbonyl-3-piperidinol
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With diethylazodicarboxylate In 1,4-dioxane at 20℃; Inert atmosphere; | 85.3% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 25℃; Temperature; Mitsunobu Displacement; Inert atmosphere; Large scale; | 85% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 30℃; for 25h; Concentration; Temperature; | 80.45% |
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 5h; Mitsunobu Displacement; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 5h; | 69% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(S)-N-trifluoroacetyl-3-hydroxypiperidine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; (S)-N-trifluoroacetyl-3-hydroxypiperidine With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 30℃; for 4.5h; Mitsunobu Displacement; Inert atmosphere; Stage #2: With water; sodium hydroxide In methanol at 20 - 30℃; for 2h; Stage #3: With hydrogenchloride In methanol; water at 45 - 55℃; for 3h; | 84.8% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With azodicarboxylic acid diphenyl ester In ethyl acetate at 50℃; Inert atmosphere; | 81.3% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(S)-3-hydroxypiperidine-N-carboxylate benzyl ester
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile) In acetonitrile at 0℃; Inert atmosphere; Large scale; | 74.4% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With hydrogen In methanol; water at 50℃; under 1034.32 Torr; for 2h; Acidic conditions; | 67.4% |
With hydrogenchloride; 10 wt% Pd(OH)2 on carbon In methanol at 40 - 50℃; | |
With palladium 10% on activated carbon; hydrogen In methanol |
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12.5 h / 10 - 20 °C 2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 70 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme |
4-Aminopyrazolo<3,4-d>pyrimidin
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 5 h / 80 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12.5 h / 10 - 20 °C 3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C 2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 70 °C 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme |
(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme |
tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / 5.5 h / 0 - 25 °C 2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine / 5.5 h / 0 - 25 °C 2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: pyridine / 5.5 h / 0 - 25 °C 2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C 3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme |
4-phenoxyphenylboronic acid
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2-ethoxy-ethanol / 6 h / 120 °C 2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With 10 wt% Pd(OH)2 on carbon; hydrogen In methanol at 55 - 60℃; under 2250.23 Torr; |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere 2: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C View Scheme |
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / ethanol; water / 1 h / 5 - 25 °C / Inert atmosphere 2: 2-ethoxy-ethanol / 6 h / 120 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / ethanol; water / 1 h / 5 - 30 °C / Inert atmosphere 2: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere 3: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrazine hydrate / ethanol / 1 h / Reflux 2.1: 8 h / 150 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 21 - 22 °C 3.2: 14 h / 80 °C 4.1: hydrogenchloride / ethyl acetate / 0.5 h View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / ethanol; water / 1 h / 5 - 25 °C / Inert atmosphere 2: 2-ethoxy-ethanol / 6 h / 120 °C 3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr View Scheme |
(R)-tert-butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere 2: hydrogenchloride; methanol / 3 h / 50 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / ethanol; water / 1 h / 5 - 30 °C / Inert atmosphere 2: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere 3: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C View Scheme |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Heating; Inert atmosphere 2: hydrogenchloride / 1,4-dioxane / 2 h / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 1.2: 12 h / 0 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / water; ethyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 2: hydrogenchloride / methanol / 2 h / 20 °C View Scheme |
2,6-dichloro-pyrimidine carbaldehyde
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C 1.2: 1 h / 0 °C 2.1: manganese(IV) oxide / dichloromethane / 5 h 3.1: ammonia / ethanol / 5 h / 0 °C 4.1: hydrazine hydrate / ethanol / 1 h / 20 °C 5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 6.1: hydrogenchloride / methanol / 2 h / 20 °C View Scheme |
4-Bromodiphenyl ether
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C 1.2: 1 h / 0 °C 2.1: manganese(IV) oxide / dichloromethane / 5 h 3.1: ammonia / ethanol / 5 h / 0 °C 4.1: hydrazine hydrate / ethanol / 1 h / 20 °C 5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 6.1: hydrogenchloride / methanol / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran / 40 °C / Inert atmosphere 1.2: 0 - 25 °C 2.1: potassium hydroxide; palladium on activated charcoal / 1,4-dioxane / Inert atmosphere; Reflux 3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 h / 0 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -65 °C / Inert atmosphere 1.2: 3 h / -60 - 0 °C 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: manganese(IV) oxide / dichloromethane / 5 h 2: ammonia / ethanol / 5 h / 0 °C 3: hydrazine hydrate / ethanol / 1 h / 20 °C 4: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 5: hydrogenchloride / methanol / 2 h / 20 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ammonia / ethanol / 5 h / 0 °C 2: hydrazine hydrate / ethanol / 1 h / 20 °C 3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 4: hydrogenchloride / methanol / 2 h / 20 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrazine hydrate / ethanol / 1 h / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C 3: hydrogenchloride / methanol / 2 h / 20 °C View Scheme |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2-chloropropionyl chloride
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran at -20℃; for 3h; Concentration; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 99% |
With sodium acetate In water at 5 - 15℃; for 1h; Reagent/catalyst; Solvent; Inert atmosphere; | 94.9% |
Stage #1: (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine With 2,6-di-tert-butyl-4-methyl-phenol In 2-methyltetrahydrofuran at 10℃; for 0.333333h; Stage #2: 2-chloropropionyl chloride With sodium hydrogencarbonate In 2-methyltetrahydrofuran; water at 10℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere; | 87.9% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -20 - -10℃; Inert atmosphere; | 830 mg |
With sodium hydrogencarbonate In 2-methyltetrahydrofuran; water |
3-bromopropionyl bromide
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at -20℃; for 3h; Inert atmosphere; | 99% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 3h; | 99% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
cyanoacetic acid
(R)-3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(3-keto)propionitrile
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 2h; Cooling with ice; | 95% |
Stage #1: cyanoacetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 0.166667h; Cooling with ice; Stage #2: (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine In dichloromethane at 20℃; for 2h; Cooling with ice; | 95% |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide | 90% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide Inert atmosphere; | 87% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 30℃; for 1h; | 86.64% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 86% |
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 86% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
methanesulfonyl chloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; | 85% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 85% |
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 85% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Ethanesulfonyl chloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; | 83% |
n-propanesulfonyl chloride
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; | 83% |
3,3-dimethylbutanoic acid chloride
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; | 82% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
cyclopropanecarboxylic acid chloride
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; | 82% |
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
acrylic acid methyl ester
Conditions | Yield |
---|---|
With zirconium(IV) tert-butoxide; benzotriazol-1-ol In toluene at 60℃; for 12h; Temperature; | 82% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View