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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Synonyms: 3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;3-(4-phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-Pyrazolo[3,4-d]pyrimidin-4

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-(4-Phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:0

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Basic information Product Name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Synonyms:

TIANFU-CHEM 1022150-12-4

Cas:1022150-12-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

The high quality with CAS No: 1022150-12-4

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1022150-12-4 with best quality

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine 1022150-12-4

Cas:1022150-12-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

For Ibrutinib: 3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine CAS:1022150-12-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine CAS:1022150-12-4

Cas:1022150-12-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Cas:1022150-12-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Cas:1022150-12-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Cas:1022150-12-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Btk inhibitor 1 R enantiomer IBT6A 1022150-12-4

Cas:1022150-12-4

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

3-(4-PHENOXY-PHENYL)-1-PIPERIDIN-3-YL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

Cas:1022150-12-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine/High quality/Best price

Cas:1022150-12-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-(4-Phenoxyphenyl)-1-(3R)-3-piperidinyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Btk inhibitor 1 (R enantiomer) Powder CAS 1022150-12-4

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 3-(4-Phenoxyphenyl)-1-(3-Piperdyl)Pyrazolo[3,4-d]Pyrimidin-4-Amine CAS No.:1022150-12-4 Molecule Formula:C22H22N6O Molecule Weight:386.45 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:E

High Quality 3-(4-Phenoxyphenyl)-1-(3-Piperdyl)Pyrazolo[3,4-d]Pyrimidin-4-Amine in stock

Cas:1022150-12-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best Offer3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

Cas:1022150-12-4

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Chemical Properties Boiling point 626.3±55.0 °C(Predicted) density 1.39±0.1 g/cm3(Predicted) storage temp. Keep in dark place,Inert atmosphere,2

(R)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine CAS No.: 1022150-12-4 Chemical name: 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine;(R)-3-(4-phenoxyphenyl)-1-(piperidin-3

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Cas:1022150-12-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-(4-phenoxyphenyl)-1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine

Cas:1022150-12-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice in stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermed

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine/manufacturer

Cas:1022150-12-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine
1022150-11-3

(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 2h; Inert atmosphere;100%
With hydrogenchloride In methanol; water at 50℃;98%
With hydrogenchloride In methanol at 20℃; for 2h;92%
(3R)-3-[4-(benzyloxycarbonylamino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylic acid benzyl ester

(3R)-3-[4-(benzyloxycarbonylamino)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylic acid benzyl ester

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With palladium on activated charcoal99%
4-phenoxyphenylboronic acid
51067-38-0

4-phenoxyphenylboronic acid

C10H13BrN6*2ClH

C10H13BrN6*2ClH

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water for 5h; Solvent; Reagent/catalyst; Suzuki Coupling; Inert atmosphere; Reflux;90%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water for 5h; Reagent/catalyst; Solvent; Suzuki Coupling; Inert atmosphere; Reflux;90%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(S)-3-hydroxypiperidine-N-carboxylate methyl ester

(S)-3-hydroxypiperidine-N-carboxylate methyl ester

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate In tetrahydrofuran at 35℃; Inert atmosphere;88.6%
4-phenoxyphenylboronic acid
51067-38-0

4-phenoxyphenylboronic acid

3-bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-bromo-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water for 5h; Suzuki Coupling; Inert atmosphere; Reflux;87.1%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane for 4h; Inert atmosphere; Reflux;0.5 g
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N-tert-butoxycarbonyl-3-piperidinol
85275-45-2

N-tert-butoxycarbonyl-3-piperidinol

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With diethylazodicarboxylate In 1,4-dioxane at 20℃; Inert atmosphere;85.3%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 25℃; Temperature; Mitsunobu Displacement; Inert atmosphere; Large scale;85%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 30℃; for 25h; Concentration; Temperature;80.45%
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 5h; Mitsunobu Displacement;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 5h;
69%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(S)-N-trifluoroacetyl-3-hydroxypiperidine
1126736-20-6

(S)-N-trifluoroacetyl-3-hydroxypiperidine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; (S)-N-trifluoroacetyl-3-hydroxypiperidine With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 30℃; for 4.5h; Mitsunobu Displacement; Inert atmosphere;
Stage #2: With water; sodium hydroxide In methanol at 20 - 30℃; for 2h;
Stage #3: With hydrogenchloride In methanol; water at 45 - 55℃; for 3h;
84.8%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(S)-3-hydroxypiperidine-N-carboxylate allyl ester

(S)-3-hydroxypiperidine-N-carboxylate allyl ester

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With azodicarboxylic acid diphenyl ester In ethyl acetate at 50℃; Inert atmosphere;81.3%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(S)-3-hydroxypiperidine-N-carboxylate benzyl ester
94944-69-1

(S)-3-hydroxypiperidine-N-carboxylate benzyl ester

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In acetonitrile at 0℃; Inert atmosphere; Large scale;74.4%
(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(1-benzylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With hydrogen In methanol; water at 50℃; under 1034.32 Torr; for 2h; Acidic conditions;67.4%
With hydrogenchloride; 10 wt% Pd(OH)2 on carbon In methanol at 40 - 50℃;
With palladium 10% on activated carbon; hydrogen In methanol
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
151266-23-8

4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12.5 h / 10 - 20 °C
2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 70 °C
2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
4-Aminopyrazolo<3,4-d>pyrimidin
2380-63-4

4-Aminopyrazolo<3,4-d>pyrimidin

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide / 5 h / 80 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12.5 h / 10 - 20 °C
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C
2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h / 70 °C
3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester
1276110-38-3

(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate
1353993-49-3

tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
2: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
3: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / 5.5 h / 0 - 25 °C
2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / 5.5 h / 0 - 25 °C
2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: pyridine / 5.5 h / 0 - 25 °C
2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C
3: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
4: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
4-phenoxyphenylboronic acid
51067-38-0

4-phenoxyphenylboronic acid

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 24 h / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
C29H27N5O3

C29H27N5O3

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2-ethoxy-ethanol / 6 h / 120 °C
2: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr
View Scheme
C30H28N6O3

C30H28N6O3

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With 10 wt% Pd(OH)2 on carbon; hydrogen In methanol at 55 - 60℃; under 2250.23 Torr;
C28H27N5O

C28H27N5O

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere
2: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C
View Scheme
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile
330792-69-3

2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / ethanol; water / 1 h / 5 - 25 °C / Inert atmosphere
2: 2-ethoxy-ethanol / 6 h / 120 °C
3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / ethanol; water / 1 h / 5 - 30 °C / Inert atmosphere
2: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere
3: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrazine hydrate / ethanol / 1 h / Reflux
2.1: 8 h / 150 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 21 - 22 °C
3.2: 14 h / 80 °C
4.1: hydrogenchloride / ethyl acetate / 0.5 h
View Scheme
C13H19N3O2*2ClH

C13H19N3O2*2ClH

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / ethanol; water / 1 h / 5 - 25 °C / Inert atmosphere
2: 2-ethoxy-ethanol / 6 h / 120 °C
3: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 55 - 60 °C / 2250.23 Torr
View Scheme
(R)-tert-butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
1612774-50-1

(R)-tert-butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere
2: hydrogenchloride; methanol / 3 h / 50 °C
View Scheme
C12H19N3*2ClH

C12H19N3*2ClH

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / ethanol; water / 1 h / 5 - 30 °C / Inert atmosphere
2: 2-ethoxy-ethanol / 8 h / 20 - 120 °C / Inert atmosphere
3: hydrogenchloride; 10 wt% Pd(OH)2 on carbon / methanol / 40 - 50 °C
View Scheme
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / Heating; Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 2 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 12 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / water; ethyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
2: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
2,6-dichloro-pyrimidine carbaldehyde
5305-40-8

2,6-dichloro-pyrimidine carbaldehyde

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C
1.2: 1 h / 0 °C
2.1: manganese(IV) oxide / dichloromethane / 5 h
3.1: ammonia / ethanol / 5 h / 0 °C
4.1: hydrazine hydrate / ethanol / 1 h / 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
6.1: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
4-Bromodiphenyl ether
101-55-3

4-Bromodiphenyl ether

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -20 °C
1.2: 1 h / 0 °C
2.1: manganese(IV) oxide / dichloromethane / 5 h
3.1: ammonia / ethanol / 5 h / 0 °C
4.1: hydrazine hydrate / ethanol / 1 h / 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
6.1: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 40 °C / Inert atmosphere
1.2: 0 - 25 °C
2.1: potassium hydroxide; palladium on activated charcoal / 1,4-dioxane / Inert atmosphere; Reflux
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 h / 0 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -65 °C / Inert atmosphere
1.2: 3 h / -60 - 0 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
(4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanol

(4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanol

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: manganese(IV) oxide / dichloromethane / 5 h
2: ammonia / ethanol / 5 h / 0 °C
3: hydrazine hydrate / ethanol / 1 h / 20 °C
4: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
5: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
(4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone

(4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methanone

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ammonia / ethanol / 5 h / 0 °C
2: hydrazine hydrate / ethanol / 1 h / 20 °C
3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
4: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
(4-amino-6-chloropyrimidin-5-yl)(4-phenoxyphenyl)methanone

(4-amino-6-chloropyrimidin-5-yl)(4-phenoxyphenyl)methanone

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine hydrate / ethanol / 1 h / 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C
3: hydrogenchloride / methanol / 2 h / 20 °C
View Scheme
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

2-chloropropionyl chloride
625-36-5

2-chloropropionyl chloride

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidin-1-yl)-3-chloropropyl-1-one

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidin-1-yl)-3-chloropropyl-1-one

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at -20℃; for 3h; Concentration; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;99%
With sodium acetate In water at 5 - 15℃; for 1h; Reagent/catalyst; Solvent; Inert atmosphere;94.9%
Stage #1: (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine With 2,6-di-tert-butyl-4-methyl-phenol In 2-methyltetrahydrofuran at 10℃; for 0.333333h;
Stage #2: 2-chloropropionyl chloride With sodium hydrogencarbonate In 2-methyltetrahydrofuran; water at 10℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere;
87.9%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -20 - -10℃; Inert atmosphere;830 mg
With sodium hydrogencarbonate In 2-methyltetrahydrofuran; water
3-bromopropionyl bromide
7623-16-7

3-bromopropionyl bromide

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidin-1-yl)-3-bromopropyl-1-one

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-piperidin-1-yl)-3-bromopropyl-1-one

Conditions
ConditionsYield
In tetrahydrofuran at -20℃; for 3h; Inert atmosphere;99%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-[2-(4-tert-butoxycarbonylpiperazin-1-yl)pyrimidin-5-yl]piperidine-4-carboxylic acid

1-[2-(4-tert-butoxycarbonylpiperazin-1-yl)pyrimidin-5-yl]piperidine-4-carboxylic acid

tert-butyl 4-[5-[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-1-piperidyl]pyrimidin-2-yl]piperazine-1-carboxylate

tert-butyl 4-[5-[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-1-piperidyl]pyrimidin-2-yl]piperazine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 3h;99%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

cyanoacetic acid
372-09-8

cyanoacetic acid

(R)-3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(3-keto)propionitrile
1412418-10-0

(R)-3-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(3-keto)propionitrile

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 2h; Cooling with ice;95%
Stage #1: cyanoacetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 0.166667h; Cooling with ice;
Stage #2: (R)-3-(4-phenoxyphenyl)-1-(piperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine In dichloromethane at 20℃; for 2h; Cooling with ice;
95%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide90%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(2E)‐4‐[4‐(2‐{[(tert‐butoxy)carbonyl]amino}ethyl)piperazin‐1‐yl]but‐2‐enoic acid

(2E)‐4‐[4‐(2‐{[(tert‐butoxy)carbonyl]amino}ethyl)piperazin‐1‐yl]but‐2‐enoic acid

tert-butyl (R,E)-(2-(4-(4-(3-(4-amino-3-(4-phenoxyphenyl)-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)piperazin-1-yl)ethyl)carbamate

tert-butyl (R,E)-(2-(4-(4-(3-(4-amino-3-(4-phenoxyphenyl)-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)piperazin-1-yl)ethyl)carbamate

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide Inert atmosphere;87%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

5-chloro-1H-benzo[d][1,2,3]triazol-1-yl acrylate

5-chloro-1H-benzo[d][1,2,3]triazol-1-yl acrylate

ibrutinib

ibrutinib

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 30℃; for 1h;86.64%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octanoic acid

8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]octanoic acid

C43H45N9O6

C43H45N9O6

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;86%
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;86%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(R)-1-(1-(methylsulfonyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(1-(methylsulfonyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;85%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

9-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino]nonanoic acid

9-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino]nonanoic acid

C44H47N9O6

C44H47N9O6

Conditions
ConditionsYield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;85%
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;85%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Ethanesulfonyl chloride
594-44-5

Ethanesulfonyl chloride

(R)-1-(1-(ethylsulfonyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(1-(ethylsulfonyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;83%
n-propanesulfonyl chloride
10147-36-1

n-propanesulfonyl chloride

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(1-(propylsulfonyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(1-(propylsulfonyl)piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;83%
3,3-dimethylbutanoic acid chloride
7065-46-5

3,3-dimethylbutanoic acid chloride

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3,3-dimethylbutan-1-one

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-3,3-dimethylbutan-1-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;82%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

(R)-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(cyclopropyl)methanone

(R)-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)(cyclopropyl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃;82%
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

ibrutinib

ibrutinib

Conditions
ConditionsYield
With zirconium(IV) tert-butoxide; benzotriazol-1-ol In toluene at 60℃; for 12h; Temperature;82%

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