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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for

(S)-1-Boc-3-hydroxypiperidine TOP1 supplier

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Buy High Grade 143900-44-1 In Bulk Supply

Cas:143900-44-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients. 4. Chromatographic Purity (HPLC): not less than 99.0% Appearance:white colour Storage:commercial Pac

tert- butyl (3S)-3-hydroxy piperidine-1-carboxylate

Cas:143900-44-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Suzhou Lipin chemical Co., Ltd.

high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHA

(S)-1-Boc-3-hydroxypiperidine 143900-44-1

Cas:143900-44-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

(S)-1-Boc-3-hydroxypiperidine CAS No.:143900-44-1 Name: (S)-1-Boc-3-hydroxypiperidine Synonyms: (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine Molecular Structure Mole

High purity (S)-1-Boc-3-hydroxypiperidine CAS No.:143900-44-1

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

(S)-1-BOC-3-hydroxypiperidine, 143900-44-1, 99%, in stock

Cas:143900-44-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

(S)-1-Boc-3-hydroxypiperidine CAS 143900-44-1 In stock

Cas:143900-44-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Leader Biochemical Group

About Product Details

China Biggest factory Manufacturer Supply High Quality (S)-1-Boc-3-hydroxypiperidine CAS 143900-44-1

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

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Ality Chemical Corporation

(S)-1-Boc-3-hydroxypiperidine Basic information Uses Product Name: (S)-1-Boc-3-hydroxypiperidine Synonyms: (S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE;(S)-1-BOC-3-HYDROXYPIPERIDINE

Factory Supply Ibrutinib impurity 36

Cas:143900-44-1

Min.Order:1 Gram

Negotiable

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:1 Metric Ton

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 143900-44-1 (S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Hot Sales Low Prices (S) -1-Boc-3-Hydroxypiperidine CAS: 143900-44-1

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 143900-44-1 with best quality

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:0 Kilogram

FOB Price: $89.0 / 98.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 143900-44-1 (S)-1-Boc-3-hydroxypiperidine with best price

Cas:143900-44-1

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)- 143900-44-1

Cas:143900-44-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

For Ibrutinib: (S)-Tert Butyl-3-Hydroxypiperidine-1-Carboxylate

Cas:143900-44-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality (S)-1-Boc-3-hydroxypiperidine CAS 143900-44-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities.

High quality (S)-1-Boc-3-hydroxypiperidine CAS 143900-44-1

Cas:143900-44-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)-

Cas:143900-44-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

(S)-1-Boc-3-hydroxypiperidine CAS NO.143900-44-1

Cas:143900-44-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

(S) -1-Boc-3-Hydroxypiperidine CAS: 143900-44-1 Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should be store

Factory supply (S) -1-Boc-3-Hydroxypiperidine

Cas:143900-44-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Piperidinecarboxylicacid, 3-hydroxy-, 1,1-dimethylethyl ester, (3S)-

Cas:143900-44-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Product name:(S)-1-Boc-3-hydroxypiperidine Other name : Ibrutinib intermediate Cas no. : 143900-44-1 Specification : In-house Purity: 98% Stock: Fresh Application:143900-44-1

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-1-Boc-3-Hydroxypiperidine

Cas:143900-44-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

(S)-1-Boc-3-piperidinol 143900-44-1

Cas:143900-44-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(S)-1-Boc-3-hydroxypiperidine

Cas:143900-44-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-Boc-4-piperidinol

Cas:143900-44-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

(S)-3-hydroxypiperidine hydrochloride
475058-41-4

(S)-3-hydroxypiperidine hydrochloride

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 66h;98%
With sodium hydrogencarbonate In ethanol; water at 21 - 22℃;98.9%
With triethylamine In methanol at 20℃; for 0.5h;
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
98977-36-7

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With rac-octan-2-ol In aq. buffer at 35℃; for 12h; pH=8; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction; enantioselective reaction;98.08%
With D-glucose; NADP In aq. phosphate buffer; ethanol at 30℃; for 4h; pH=6; enantioselective reaction;96%
With recombinant Rhodococcus erythropolis DSM 43297 ketoredutase; nicotinamide adenine dinucleotide In aq. phosphate buffer; isopropyl alcohol at 50℃; for 0.5h; pH=7.0; Enzymatic reaction; stereoselective reaction;95%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-3-hydroxypiperidine D-pyroglutamate

(S)-3-hydroxypiperidine D-pyroglutamate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 3h; Time; Large scale;97%
(3S)-piperidin-3-ol (R) camphor sulphonic acid salt

(3S)-piperidin-3-ol (R) camphor sulphonic acid salt

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 48h;83%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C5H11NO*C2H4O2

C5H11NO*C2H4O2

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 10℃;73.95%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-piperidin-3-ol

(S)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-piperidin-3-ol

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate65%
vinyl n-butyrate
123-20-6

vinyl n-butyrate

N-tert-butoxycarbonyl-3-piperidinol
85275-45-2

N-tert-butoxycarbonyl-3-piperidinol

A

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
143900-43-0

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

B

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C

3-(S)-butyroxy-N-Boc-piperidine

3-(S)-butyroxy-N-Boc-piperidine

Conditions
ConditionsYield
With savinase enzyme; N-ethyl-N,N-diisopropylamine In toluene for 42h; Reagent/catalyst; Solvent; Resolution of racemate; Enzymatic reaction;A n/a
B n/a
C 31.7%
vinyl acetate
108-05-4

vinyl acetate

N-tert-butoxycarbonyl-3-piperidinol
85275-45-2

N-tert-butoxycarbonyl-3-piperidinol

A

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

B

tert-butyl (3R)-3-acetoxypiperidine-1-carboxylate

tert-butyl (3R)-3-acetoxypiperidine-1-carboxylate

Conditions
ConditionsYield
With Lipase PS In pentane at 20℃; for 4h;A n/a
B 22%
3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
924651-53-6

3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h
2: HCl / methanol; H2O / 7 h / 20 °C
3: triethylamine / methanol / 0.5 h / 20 °C
View Scheme
tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate
924651-55-8

tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / methanol; H2O / 7 h / 20 °C
2: triethylamine / methanol / 0.5 h / 20 °C
View Scheme
allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester
924651-52-5

allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / Grubb's catalyst 1st generation / CH2Cl2 / 24 h / 20 °C
2: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h
3: HCl / methanol; H2O / 7 h / 20 °C
4: triethylamine / methanol / 0.5 h / 20 °C
View Scheme
(3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
374890-30-9

(3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 66 percent / BH3*THF / 3.5 h / -78 - 25 °C
2: 65 percent / H2 / Pd/C / ethyl acetate
View Scheme
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
98977-36-7

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

A

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
143900-43-0

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

B

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With KR-134; NAD; isopropyl alcohol In aq. phosphate buffer at 25℃; for 24h; pH=7; Enzymatic reaction;A n/a
B n/a
With D-glucose; NADP In aq. buffer at 35℃; for 5h; pH=8; Enzymatic reaction; enantioselective reaction;A n/a
B n/a
With D-glucose; NADP In aq. buffer at 35℃; for 5h; pH=8; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;A n/a
B n/a
3-hydroxypiperazine
6859-99-0

3-hydroxypiperazine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

A

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
143900-43-0

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

B

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate; triethylamine In dichloromethane; water at 25 - 35℃; enantiospecific reaction;
3-HYDROXYPYRIDINE
109-00-2

3-HYDROXYPYRIDINE

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 5% rhodium-on-charcoal; hydrogen / water / 5 h / 85 °C / 45004.5 Torr / Autoclave; Large scale
2: ethanol / 1.5 h / Reflux; Large scale
3: sodium hydroxide / water / 3 h / 20 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: Rh/C; hydrogen / water / 44 h / 90 °C / 32253.2 Torr / Autoclave
2.1: ethanol / Reflux
3.1: triethylamine / methanol / 1 h / 20 °C
3.2: 0.3 h
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-1-N-benzyl-3-hydroxypiperidine
91599-79-0

(S)-1-N-benzyl-3-hydroxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 40℃; under 15201 Torr; for 15h; Solvent; Pressure; Temperature; Autoclave;Ca. 38 g
(R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
404577-34-0

(R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 60 °C
2: sodium hydroxide / water; methanol / 20 °C
View Scheme
1-benzyl-3-hydroxypiperidine
14813-01-5

1-benzyl-3-hydroxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: butanone / 1 h / 20 °C
2: sodium hydroxide / dichloromethane; water / 1 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: butanone / 1 h / 20 °C
2: sodium hydroxide / dichloromethane; water / 1 h / 20 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
Multi-step reaction with 5 steps
1: isopropyl alcohol / 1 h / 20 °C
2: sodium hydroxide / dichloromethane / 1 h / 20 °C
3: N,N-dimethyl-formamide / 90 °C
4: sodium hydroxide / water; methanol / 20 °C
5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
Multi-step reaction with 5 steps
1: butanone / 1 h / 20 °C
2: sodium hydroxide / dichloromethane / 1 h / 20 °C
3: N,N-dimethyl-formamide / 90 °C
4: sodium hydroxide / water; methanol / 20 °C
5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
940890-90-4

(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N,N-dimethyl-formamide / 90 °C
2: sodium hydroxide / water; methanol / 20 °C
3: triethylamine / dichloromethane / 1 h / 0 - 20 °C
4: N,N-dimethyl-formamide / 60 °C
5: sodium hydroxide / water; methanol / 20 °C
View Scheme
(S)-1-tert-butoxycarbonyl-3-acetoxypiperidine

(S)-1-tert-butoxycarbonyl-3-acetoxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; Reagent/catalyst; Solvent;16 g
(S)-1-benzyl-3-benzoyloxypiperidine

(S)-1-benzyl-3-benzoyloxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; methanol / 20 °C
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
tert-butyl (3R)-3-acetoxypiperidine-1-carboxylate

tert-butyl (3R)-3-acetoxypiperidine-1-carboxylate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / water; methanol / 20 °C
2: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3: N,N-dimethyl-formamide / 60 °C
4: sodium hydroxide / water; methanol / 20 °C
View Scheme
(S)-1-benzyl-3-hydroxypiperidine camphorsulfonate

(S)-1-benzyl-3-hydroxypiperidine camphorsulfonate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / dichloromethane; water / 1 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water / 0.17 h / 0 - 5 °C
2: palladium on activated charcoal; hydrogen; methanol / 20 - 30 °C / 7500.75 - 11251.1 Torr / Inert atmosphere
3: triethylamine / dichloromethane / 0 - 10 °C
View Scheme
(R)-1-benzyl-3-hydroxypiperidine camphorsulfonate

(R)-1-benzyl-3-hydroxypiperidine camphorsulfonate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / dichloromethane / 1 h / 20 °C
2: N,N-dimethyl-formamide / 90 °C
3: sodium hydroxide / water; methanol / 20 °C
4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
(R)-1-benzyl-3-hydroxypiperidine
91599-81-4

(R)-1-benzyl-3-hydroxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 90 °C
2: sodium hydroxide / water; methanol / 20 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave
View Scheme
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
143900-43-0

tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
2: N,N-dimethyl-formamide / 60 °C
3: sodium hydroxide / water; methanol / 20 °C
View Scheme
(S)-4,5-O-isopropylidene-4,5-dihydroxypentanenitrile
94944-62-4

(S)-4,5-O-isopropylidene-4,5-dihydroxypentanenitrile

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / methanol; water / 5.5 h / 15 °C
2: triethylamine / dichloromethane / 20 h / 5 - 20 °C
3: hydrogen / methanol / 17 h / 85 °C / 5250.53 Torr
4: sodium carbonate / dichloromethane / 20 h / 10 °C
View Scheme
Multi-step reaction with 5 steps
1: hydrogenchloride / methanol; water / 5.5 h / 15 °C
2: 1H-imidazole / chloroform / 50 °C
3: hydrogen; ammonia / methanol / 70 °C / 7500.75 Torr
4: hydrogenchloride / methanol / 55 °C
5: triethylamine / chloroform / 20 °C
View Scheme
(S)-4,5-dihydroxyvaleronitrile

(S)-4,5-dihydroxyvaleronitrile

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 20 h / 5 - 20 °C
2: hydrogen / methanol / 17 h / 85 °C / 5250.53 Torr
3: sodium carbonate / dichloromethane / 20 h / 10 °C
View Scheme
Multi-step reaction with 4 steps
1: 1H-imidazole / chloroform / 50 °C
2: hydrogen; ammonia / methanol / 70 °C / 7500.75 Torr
3: hydrogenchloride / methanol / 55 °C
4: triethylamine / chloroform / 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-3-hydroxypiperidine
24211-55-0

(S)-3-hydroxypiperidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
With sodium carbonate In dichloromethane at 10℃; for 20h; Temperature;3.62 g
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
940890-90-4

(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere;100%
With dmap; triethylamine In dichloromethane at 20℃; for 7h;98%
With triethylamine In ethyl acetate at -5℃; for 1h;96%
5-((4-(4-hydroxy-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-N,1-dimethyl-1H-indazole-3-carboxamide

5-((4-(4-hydroxy-3-methyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-N,1-dimethyl-1H-indazole-3-carboxamide

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (R)-3-((3-methyl-1-(2-((1-methyl-3-(methylcarbamoyl)-1H-indazol-5-yl)amino)pyrimidin-4-yl)-1H-pyrazol-4-yl)oxy)piperidine-1-carboxylate

tert-butyl (R)-3-((3-methyl-1-(2-((1-methyl-3-(methylcarbamoyl)-1H-indazol-5-yl)amino)pyrimidin-4-yl)-1H-pyrazol-4-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With cyanomethylenetributyl-phosphorane In toluene at 100℃; for 2h; Inert atmosphere; Microwave irradiation;100%
7-bromo-3-iodo-1H-pyrazolo[4,3-c]pyridine

7-bromo-3-iodo-1H-pyrazolo[4,3-c]pyridine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (R)-3-(7-bromo-3-iodo-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate

tert-butyl (R)-3-(7-bromo-3-iodo-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h;99%
C17H13N5O

C17H13N5O

acryloyl chloride
814-68-6

acryloyl chloride

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

ibrutinib

ibrutinib

Conditions
ConditionsYield
Stage #1: C17H13N5O; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With triphenylphosphine In tetrahydrofuran for 0.333333h;
Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 10 - 15℃; for 2h; Darkness;
Stage #3: acryloyl chloride Temperature; Solvent; Further stages;
95.1%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate
1353993-49-3

tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; Cooling with ice;93%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 40h;91%
In pyridine at 0 - 25℃; for 5.5h;85%
3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile

3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-[3-cyano-5-(5-methyl-1,3-thiazol-2-yl)phenoxy]piperidine-1-carboxylate

tert-butyl (3S)-3-[3-cyano-5-(5-methyl-1,3-thiazol-2-yl)phenoxy]piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: 3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h;
93%
3-bromo-1H-pyrazolo[3,4-d]pyrimidine

3-bromo-1H-pyrazolo[3,4-d]pyrimidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (R)-3-(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

tert-butyl (R)-3-(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 0.0833333h;
Stage #2: 3-bromo-1H-pyrazolo[3,4-d]pyrimidine In tetrahydrofuran for 4h;
92%
methanesulfonic acid
75-75-2

methanesulfonic acid

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
940890-90-4

(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;91%
C20H16N2O3

C20H16N2O3

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C30H33N3O5

C30H33N3O5

Conditions
ConditionsYield
Stage #1: C20H16N2O3 With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 25℃; for 16h;
90%
tert-butyl-5-chloro-2,4-di-fluorobenzoate
1354961-13-9

tert-butyl-5-chloro-2,4-di-fluorobenzoate

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(S)-tert-butyl 3-(4-(tert-butoxycarbonyl)-2-chloro-5-fluorophenoxy)piperidine-1-carboxylate

(S)-tert-butyl 3-(4-(tert-butoxycarbonyl)-2-chloro-5-fluorophenoxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 75℃; for 72h; Inert atmosphere;89%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine
1022150-11-3

(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In ethyl acetate at 10 - 30℃; Solvent; Darkness; Industrial scale;88.1%
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 5℃; Mitsunobu Displacement; Inert atmosphere;
Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine In tetrahydrofuran at 0 - 20℃; for 5h;
Stage #3: With zinc(II) chloride In tetrahydrofuran at 30 - 40℃; for 2.5h;
80.2%
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 5℃; for 0.166667h; Mitsunobu Displacement; Inert atmosphere;
Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine In tetrahydrofuran at 0 - 20℃; for 5h; Mitsunobu Displacement; Inert atmosphere;
72%
4-chloro-6-(4-phenoxyphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one

4-chloro-6-(4-phenoxyphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C29H29ClN4O4

C29H29ClN4O4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 12h;86%
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine
941685-26-3

4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(S)-tert-butyl 3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
1374242-58-6

(S)-tert-butyl 3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 1.5h; Inert atmosphere;
Stage #2: 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine In dimethyl sulfoxide; mineral oil at 20 - 50℃;
85%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1022150-12-4

(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 25℃; Temperature; Mitsunobu Displacement; Inert atmosphere; Large scale;85%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 30℃; for 25h; Concentration; Temperature;80.45%
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 5h; Mitsunobu Displacement;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 5h;
69%
3-bromo-4-aminopyrazolo<3,4-d>pyrimidine
83255-86-1

3-bromo-4-aminopyrazolo<3,4-d>pyrimidine

triphenylphosphine
603-35-0

triphenylphosphine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C33H34BrN6O2P

C33H34BrN6O2P

Conditions
ConditionsYield
Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; for 1h; Mitsunobu Displacement; Inert atmosphere;
Stage #2: 3-bromo-4-aminopyrazolo<3,4-d>pyrimidine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃;
85%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

triphenylphosphine
603-35-0

triphenylphosphine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C45H43N6O3P

C45H43N6O3P

Conditions
ConditionsYield
Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; Mitsunobu Displacement; Inert atmosphere;
Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃; Reagent/catalyst;
84%
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
151266-23-8

4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester
1276110-38-3

(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; Mitsunobu Displacement;83%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;80%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 20h;75%
3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile

3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3R)-3-[3-cyano-5-(5-methyl-1,3-thiazol-2-yl)phenoxy]piperidine-1-carboxylate

tert-butyl (3R)-3-[3-cyano-5-(5-methyl-1,3-thiazol-2-yl)phenoxy]piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: 3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h;
82%
4-[(1R,2S)-1-(p-tolyl)-2-[(2,2,2-trifluoroacetyl)amino]propoxy]benzoic acid

4-[(1R,2S)-1-(p-tolyl)-2-[(2,2,2-trifluoroacetyl)amino]propoxy]benzoic acid

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (3S)-3-[4-[(1R,2S)-1-(p-tolyl)-2-[(2,2,2-trifluoroacetyl)amino]propoxy]benzoyl]oxypiperidine-1-carboxylate

tert-butyl (3S)-3-[4-[(1R,2S)-1-(p-tolyl)-2-[(2,2,2-trifluoroacetyl)amino]propoxy]benzoyl]oxypiperidine-1-carboxylate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h;80%
2,6-Dibromopyridine
626-05-1

2,6-Dibromopyridine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (S)-3-((6-bromopyridin-2-yl)oxy)piperidine-1-carboxylate

tert-butyl (S)-3-((6-bromopyridin-2-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Inert atmosphere;79%
5-bromo-3-nitropyridine-2-carbonitrile
573675-25-9

5-bromo-3-nitropyridine-2-carbonitrile

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

tert-butyl (S)-3-((5-bromo-2-cyanopyridin-3-yl)oxy)piperidine-1-carboxylate

tert-butyl (S)-3-((5-bromo-2-cyanopyridin-3-yl)oxy)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: 5-bromo-3-nitropyridine-2-carbonitrile In tetrahydrofuran at 0 - 20℃; for 3h;
78%
3-bromo-6-chloro-2-fluorophenol
943830-14-6

3-bromo-6-chloro-2-fluorophenol

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

(R)-tert-butyl 3-(3-bromo-6-chloro-2- fluorophenoxy)piperidine-1-carboxylate

(R)-tert-butyl 3-(3-bromo-6-chloro-2- fluorophenoxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 23℃; for 16h; Mitsunobu Displacement;77%
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
330786-24-8

3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

tributylphosphine
998-40-3

tributylphosphine

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C43H47N6O3P

C43H47N6O3P

Conditions
ConditionsYield
Stage #1: tributylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; for 1h; Mitsunobu Displacement; Inert atmosphere;
Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃;
75%
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

2,6-dimethyl-pyridin-4-ylmethyl chloride
120739-87-9

2,6-dimethyl-pyridin-4-ylmethyl chloride

C18H28N2O3

C18H28N2O3

Conditions
ConditionsYield
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h;
Stage #2: 2,6-dimethyl-pyridin-4-ylmethyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h;
74%
C21H19IN2O3

C21H19IN2O3

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
143900-44-1

tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate

C31H36IN3O5

C31H36IN3O5

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 25℃; for 8h;73%
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