As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for
Cas:143900-44-1
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inquiryThe company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an
Cas:143900-44-1
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiry1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients. 4. Chromatographic Purity (HPLC): not less than 99.0% Appearance:white colour Storage:commercial Pac
Cas:143900-44-1
Min.Order:0 Metric Ton
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Type:Manufacturers
inquiryhigh quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:key intermediates Port:SHA
Cas:143900-44-1
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inquiry(S)-1-Boc-3-hydroxypiperidine CAS No.:143900-44-1 Name: (S)-1-Boc-3-hydroxypiperidine Synonyms: (S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine Molecular Structure Mole
Cas:143900-44-1
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryAs a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
Cas:143900-44-1
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Cas:143900-44-1
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Type:Manufacturers
inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Cas:143900-44-1
Min.Order:1 Metric Ton
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Type:Manufacturers
inquiryAbout Product Details
Cas:143900-44-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 5.0
Type:Lab/Research institutions
inquiry(S)-1-Boc-3-hydroxypiperidine Basic information Uses Product Name: (S)-1-Boc-3-hydroxypiperidine Synonyms: (S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE;(S)-1-BOC-3-HYDROXYPIPERIDINE
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:143900-44-1
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FOB Price: $0.9 / 1.0
Type:Lab/Research institutions
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:143900-44-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:143900-44-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:143900-44-1
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FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:143900-44-1
Min.Order:0 Kilogram
FOB Price: $89.0 / 98.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:143900-44-1
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:143900-44-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d
Cas:143900-44-1
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Trading Company
inquiryBeluga chemical professional supply High quality (S)-1-Boc-3-hydroxypiperidine CAS 143900-44-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities.
Cas:143900-44-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:143900-44-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMinimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,
Cas:143900-44-1
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiry(S) -1-Boc-3-Hydroxypiperidine CAS: 143900-44-1 Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years Storage should be store
Cas:143900-44-1
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:143900-44-1
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryProduct name:(S)-1-Boc-3-hydroxypiperidine Other name : Ibrutinib intermediate Cas no. : 143900-44-1 Specification : In-house Purity: 98% Stock: Fresh Application:143900-44-1
Cas:143900-44-1
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por
Cas:143900-44-1
Min.Order:10 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:143900-44-1
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:143900-44-1
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:143900-44-1
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
(S)-3-hydroxypiperidine hydrochloride
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 66h; | 98% |
With sodium hydrogencarbonate In ethanol; water at 21 - 22℃; | 98.9% |
With triethylamine In methanol at 20℃; for 0.5h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With rac-octan-2-ol In aq. buffer at 35℃; for 12h; pH=8; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction; enantioselective reaction; | 98.08% |
With D-glucose; NADP In aq. phosphate buffer; ethanol at 30℃; for 4h; pH=6; enantioselective reaction; | 96% |
With recombinant Rhodococcus erythropolis DSM 43297 ketoredutase; nicotinamide adenine dinucleotide In aq. phosphate buffer; isopropyl alcohol at 50℃; for 0.5h; pH=7.0; Enzymatic reaction; stereoselective reaction; | 95% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 3h; Time; Large scale; | 97% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 48h; | 83% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 10℃; | 73.95% |
di-tert-butyl dicarbonate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In ethyl acetate | 65% |
vinyl n-butyrate
N-tert-butoxycarbonyl-3-piperidinol
A
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
B
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With savinase enzyme; N-ethyl-N,N-diisopropylamine In toluene for 42h; Reagent/catalyst; Solvent; Resolution of racemate; Enzymatic reaction; | A n/a B n/a C 31.7% |
vinyl acetate
N-tert-butoxycarbonyl-3-piperidinol
A
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With Lipase PS In pentane at 20℃; for 4h; | A n/a B 22% |
3-methoxymethoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h 2: HCl / methanol; H2O / 7 h / 20 °C 3: triethylamine / methanol / 0.5 h / 20 °C View Scheme |
tert-butyl (S)-3-(methoxymethoxy)piperidine-1-carboxylate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: HCl / methanol; H2O / 7 h / 20 °C 2: triethylamine / methanol / 0.5 h / 20 °C View Scheme |
allyl-(2-methoxymethoxy-but-3-enyl)-carbamic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 92 percent / Grubb's catalyst 1st generation / CH2Cl2 / 24 h / 20 °C 2: 98 percent / hydrogen / PtO2 / ethyl acetate / 1 h 3: HCl / methanol; H2O / 7 h / 20 °C 4: triethylamine / methanol / 0.5 h / 20 °C View Scheme |
(3R,8S,8aS)-8-Hydroxy-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 66 percent / BH3*THF / 3.5 h / -78 - 25 °C 2: 65 percent / H2 / Pd/C / ethyl acetate View Scheme |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
A
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
B
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With KR-134; NAD; isopropyl alcohol In aq. phosphate buffer at 25℃; for 24h; pH=7; Enzymatic reaction; | A n/a B n/a |
With D-glucose; NADP In aq. buffer at 35℃; for 5h; pH=8; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
With D-glucose; NADP In aq. buffer at 35℃; for 5h; pH=8; Reagent/catalyst; Enzymatic reaction; enantioselective reaction; | A n/a B n/a |
3-hydroxypiperazine
di-tert-butyl dicarbonate
A
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
B
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; triethylamine In dichloromethane; water at 25 - 35℃; enantiospecific reaction; |
3-HYDROXYPYRIDINE
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 5% rhodium-on-charcoal; hydrogen / water / 5 h / 85 °C / 45004.5 Torr / Autoclave; Large scale 2: ethanol / 1.5 h / Reflux; Large scale 3: sodium hydroxide / water / 3 h / 20 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: Rh/C; hydrogen / water / 44 h / 90 °C / 32253.2 Torr / Autoclave 2.1: ethanol / Reflux 3.1: triethylamine / methanol / 1 h / 20 °C 3.2: 0.3 h View Scheme |
di-tert-butyl dicarbonate
(S)-1-N-benzyl-3-hydroxypiperidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 40℃; under 15201 Torr; for 15h; Solvent; Pressure; Temperature; Autoclave; | Ca. 38 g |
(R)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 60 °C 2: sodium hydroxide / water; methanol / 20 °C View Scheme |
1-benzyl-3-hydroxypiperidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: butanone / 1 h / 20 °C 2: sodium hydroxide / dichloromethane; water / 1 h / 20 °C 3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: butanone / 1 h / 20 °C 2: sodium hydroxide / dichloromethane; water / 1 h / 20 °C 3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme | |
Multi-step reaction with 5 steps 1: isopropyl alcohol / 1 h / 20 °C 2: sodium hydroxide / dichloromethane / 1 h / 20 °C 3: N,N-dimethyl-formamide / 90 °C 4: sodium hydroxide / water; methanol / 20 °C 5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme | |
Multi-step reaction with 5 steps 1: butanone / 1 h / 20 °C 2: sodium hydroxide / dichloromethane / 1 h / 20 °C 3: N,N-dimethyl-formamide / 90 °C 4: sodium hydroxide / water; methanol / 20 °C 5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme |
(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: N,N-dimethyl-formamide / 90 °C 2: sodium hydroxide / water; methanol / 20 °C 3: triethylamine / dichloromethane / 1 h / 0 - 20 °C 4: N,N-dimethyl-formamide / 60 °C 5: sodium hydroxide / water; methanol / 20 °C View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water at 20℃; Reagent/catalyst; Solvent; | 16 g |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water; methanol / 20 °C 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / water; methanol / 20 °C 2: triethylamine / dichloromethane / 1 h / 0 - 20 °C 3: N,N-dimethyl-formamide / 60 °C 4: sodium hydroxide / water; methanol / 20 °C View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / dichloromethane; water / 1 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 0.17 h / 0 - 5 °C 2: palladium on activated charcoal; hydrogen; methanol / 20 - 30 °C / 7500.75 - 11251.1 Torr / Inert atmosphere 3: triethylamine / dichloromethane / 0 - 10 °C View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / dichloromethane / 1 h / 20 °C 2: N,N-dimethyl-formamide / 90 °C 3: sodium hydroxide / water; methanol / 20 °C 4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme |
(R)-1-benzyl-3-hydroxypiperidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 90 °C 2: sodium hydroxide / water; methanol / 20 °C 3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 15 h / 40 °C / 15201 Torr / Autoclave View Scheme |
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 60 °C 3: sodium hydroxide / water; methanol / 20 °C View Scheme |
(S)-4,5-O-isopropylidene-4,5-dihydroxypentanenitrile
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / methanol; water / 5.5 h / 15 °C 2: triethylamine / dichloromethane / 20 h / 5 - 20 °C 3: hydrogen / methanol / 17 h / 85 °C / 5250.53 Torr 4: sodium carbonate / dichloromethane / 20 h / 10 °C View Scheme | |
Multi-step reaction with 5 steps 1: hydrogenchloride / methanol; water / 5.5 h / 15 °C 2: 1H-imidazole / chloroform / 50 °C 3: hydrogen; ammonia / methanol / 70 °C / 7500.75 Torr 4: hydrogenchloride / methanol / 55 °C 5: triethylamine / chloroform / 20 °C View Scheme |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 20 h / 5 - 20 °C 2: hydrogen / methanol / 17 h / 85 °C / 5250.53 Torr 3: sodium carbonate / dichloromethane / 20 h / 10 °C View Scheme | |
Multi-step reaction with 4 steps 1: 1H-imidazole / chloroform / 50 °C 2: hydrogen; ammonia / methanol / 70 °C / 7500.75 Torr 3: hydrogenchloride / methanol / 55 °C 4: triethylamine / chloroform / 20 °C View Scheme |
di-tert-butyl dicarbonate
(S)-3-hydroxypiperidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane at 10℃; for 20h; Temperature; | 3.62 g |
methanesulfonyl chloride
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere; | 100% |
With dmap; triethylamine In dichloromethane at 20℃; for 7h; | 98% |
With triethylamine In ethyl acetate at -5℃; for 1h; | 96% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With cyanomethylenetributyl-phosphorane In toluene at 100℃; for 2h; Inert atmosphere; Microwave irradiation; | 100% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 4h; | 99% |
acryloyl chloride
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: C17H13N5O; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With triphenylphosphine In tetrahydrofuran for 0.333333h; Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 10 - 15℃; for 2h; Darkness; Stage #3: acryloyl chloride Temperature; Solvent; Further stages; | 95.1% |
p-toluenesulfonyl chloride
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
tert-butyl (3S)-3-[[(4-methylbenzene)sulfonyl]oxy]piperidine-1-carboxylate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; Cooling with ice; | 93% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 40h; | 91% |
In pyridine at 0 - 25℃; for 5.5h; | 85% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; | 93% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran for 0.0833333h; Stage #2: 3-bromo-1H-pyrazolo[3,4-d]pyrimidine In tetrahydrofuran for 4h; | 92% |
methanesulfonic acid
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(S)-3-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
Stage #1: C20H16N2O3 With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 25℃; for 16h; | 90% |
tert-butyl-5-chloro-2,4-di-fluorobenzoate
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 75℃; for 72h; Inert atmosphere; | 89% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(3R)‐4‐amino‐3‐(4-phenoxyphenyl)‐1‐(1‐tert-butoxycarbonylpiperidine-3-yl)-1H-pyrazolo[3,4-d]pyrimidine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In ethyl acetate at 10 - 30℃; Solvent; Darkness; Industrial scale; | 88.1% |
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 5℃; Mitsunobu Displacement; Inert atmosphere; Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine In tetrahydrofuran at 0 - 20℃; for 5h; Stage #3: With zinc(II) chloride In tetrahydrofuran at 30 - 40℃; for 2.5h; | 80.2% |
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 5℃; for 0.166667h; Mitsunobu Displacement; Inert atmosphere; Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine In tetrahydrofuran at 0 - 20℃; for 5h; Mitsunobu Displacement; Inert atmosphere; | 72% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 12h; | 86% |
4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrole[2,3-d]pyrimidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(S)-tert-butyl 3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 1.5h; Inert atmosphere; Stage #2: 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine In dimethyl sulfoxide; mineral oil at 20 - 50℃; | 85% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(R)-3-(4-phenoxyphenyl)-1-(1-piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 25℃; Temperature; Mitsunobu Displacement; Inert atmosphere; Large scale; | 85% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 30℃; for 25h; Concentration; Temperature; | 80.45% |
Stage #1: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 5h; Mitsunobu Displacement; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 5h; | 69% |
3-bromo-4-aminopyrazolo<3,4-d>pyrimidine
triphenylphosphine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; for 1h; Mitsunobu Displacement; Inert atmosphere; Stage #2: 3-bromo-4-aminopyrazolo<3,4-d>pyrimidine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃; | 85% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
triphenylphosphine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: triphenylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; Mitsunobu Displacement; Inert atmosphere; Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃; Reagent/catalyst; | 84% |
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
(R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h; Mitsunobu Displacement; | 83% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; | 80% |
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 20h; | 75% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 3-fluoro-5-(5-methyl-1,3-thiazol-2-yl)benzonitrile In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; | 82% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 20h; | 80% |
2,6-Dibromopyridine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In 1,4-dioxane at 100℃; for 4h; Inert atmosphere; | 79% |
5-bromo-3-nitropyridine-2-carbonitrile
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h; Stage #2: 5-bromo-3-nitropyridine-2-carbonitrile In tetrahydrofuran at 0 - 20℃; for 3h; | 78% |
3-bromo-6-chloro-2-fluorophenol
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 23℃; for 16h; Mitsunobu Displacement; | 77% |
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
tributylphosphine
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: tributylphosphine With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 5℃; for 1h; Mitsunobu Displacement; Inert atmosphere; Stage #2: 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate In tetrahydrofuran at 0 - 5℃; | 75% |
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
2,6-dimethyl-pyridin-4-ylmethyl chloride
Conditions | Yield |
---|---|
Stage #1: tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.25h; Stage #2: 2,6-dimethyl-pyridin-4-ylmethyl chloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; | 74% |
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 25℃; for 8h; | 73% |
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