As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:98977-36-7
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:98977-36-7
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inquiryChemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service 1-Boc-3-piperidone CAS 98977-36-7 IN Stock tert-Butyl 3-oxopiperidine-1-carboxylate CAS 98977-36-7 98977-36-7 CAS 98977-36-7 hig
Cas:98977-36-7
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inquiry1-Boc-3-piperidone Basic information Product Name: 1-Boc-3-piperidone Synonyms: T-BUTYL-3-PIPERIDONE-1-CARBOXYLATE;TERT-BUTYL 3-OXOPIPERIDINE-1-CARBOXYLATE;N-Boc-3-piperidone;N-BOC-3-PIPERIDINONE;3-OXOPIPERIDINE, N-BOC PROTECTED;3-OXO-PIPERIDIN
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:98977-36-7
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:98977-36-7
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:98977-36-7
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inquiryName: 1-Boc-3-piperidone Synonyms: tert-butyl-3-oxopiperidine-1-carboxylate CAS: 98977-36-7 MF: C10H17NO3 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:APIs Transportation:By sea or
Appearance:colorless liquid Storage: 2-8°C Package:200kg/Drum Application:1-Boc-3-piperidone, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. Transportation:Express/Sea/
Cas:98977-36-7
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:98977-36-7
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inquiryProduct Name: 1-Boc-3-piperidone CAS: 98977-36-7 MF: C10H17NO3 MW: 199.25 EINECS: 629-575-1 Mol File: 98977-36-7.mol 1-Boc-3-piperidone Structure 1-Boc-3-piperidone Chemical Properties Melting point 35-40 °C (lit.) Boiling
Cas:98977-36-7
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:98977-36-7
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inquiry1-Boc-3-piperidone CAS:98977-36-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm
Cas:98977-36-7
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:98977-36-7
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:White to yellow semisolid or solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Avarofloxacin intermediate Transportation:Common products:Sea/Air/Co
Cas:98977-36-7
Min.Order:100 Metric Ton
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inquiryProduct Name: 1-Boc-3-piperidone CAS No.:98977-36-7 Molecular Formula:C10H17NO3 Molecular Weight:199.25 Assay: 98% Place of Origin: CN EINECS NO : 629-575-1 We could give you: 1.Fast response to customer within 6 hours 2.Lower Price with hi
Cas:98977-36-7
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:98977-36-7
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inquiry1-Boc-3-piperidone CAS 98977-36-7 Description Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict
Cas:98977-36-7
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:98977-36-7
Min.Order:4 Kilogram
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inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:98977-36-7
Min.Order:1 Gram
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Type:Other
inquiryOur Advantage: 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good quali
Cas:98977-36-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:98977-36-7
Min.Order:1 Gram
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:98977-36-7
Min.Order:10 Gram
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inquirySuperior quality, moderate price & quick delivery. Appearance:White to yellow low melting solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Used as Pharmaceutical Interm
Product name: N-Boc-3-Piperidone CAS No.:98977-36-7 Molecule Formula:C10H17NO3 Molecule Weight:199.25 Purity: 97.0% Package: 25kg/drum Description:White or yellow powder Manufacture Standards:Enterprise Standard TE
Cas:98977-36-7
Min.Order:1 Kilogram
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Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:98977-36-7
Min.Order:1 Kilogram
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inquiryN-tert-butoxycarbonyl-3-piperidinol
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With sodium hypochlorite solution; sodium hydrogencarbonate; potassium bromide In dichloromethane at 5 - 10℃; pH=8.5; Reagent/catalyst; | 99.4% |
With Dess-Martin periodane In dichloromethane at 20℃; for 22h; Inert atmosphere; | 97% |
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide In diethyl ether; water; toluene at 0 - 4℃; | 95% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogen; palladium dihydroxide In methanol; dichloromethane | 97% |
1-benzyl-3-piperidone
di-tert-butyl dicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 1-benzyl-3-piperidone With hydrogenchloride; palladium 10% on activated carbon; hydrogen In methanol; water at 20℃; for 2h; Stage #2: With N-ethyl-N,N-diisopropylamine In methanol; water for 0.5h; Stage #3: di-tert-butyl dicarbonate In methanol; water at 20℃; for 5h; Concentration; Reagent/catalyst; | 84.2% |
C12H23NO4S
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride In 1,2-dichloro-ethane at 70℃; | 82% |
With bis(1,5-cyclooctadiene)diiridium(I) dichloride In 1,2-dichloro-ethane at 70℃; for 18h; Inert atmosphere; | 82% |
oxalyl dichloride
N-tert-butoxycarbonyl-3-piperidinol
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With ammonium chloride; trimethylamine In dichloromethane; dimethyl sulfoxide | 78% |
tert-butyl 3-methylidenepiperidine-1-carboxylate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; sodium periodate; ruthenium(III) chloride trihydrate In dichloromethane; water; acetonitrile at 20℃; for 1h; Inert atmosphere; | 68% |
di-tert-butyl dicarbonate
piperidin-3-one
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0℃; for 2h; Yield given; | |
With sodium hydrogencarbonate In tetrahydrofuran for 4h; | 2.93 g |
With sodium hydrogencarbonate In tetrahydrofuran; water for 4h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0℃; for 1h; Swern oxidation; |
di-tert-butyl dicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 1-benzyl-3-piperidone monohydrochloride monohydrate With hydrogen; palladium on activated charcoal In methanol under 2844.31 Torr; Stage #2: di-tert-butyl dicarbonate With sodium hydrogencarbonate In tetrahydrofuran for 48h; | 56.6 g |
3-hydroxypiperazine
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H2O / 1 h / 20 °C 2: triethylamine; SO3*NMe3; DMSO / 18 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaOH / H2O; tetrahydrofuran / 1 h / 20 °C 2: 15.6 g / triethylamine; trioxide-trimethylamine complex / dimethylsulfoxide / 18 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H2O / 1 h / 20 °C 2: 15.6 g / DMSO; SO3*Me3N; triethylamine / 18 h / 20 °C View Scheme |
di-tert-butyl dicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H2O / 1 h / 20 °C 2: triethylamine; SO3*NMe3; DMSO / 18 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: NaOH / H2O; tetrahydrofuran / 1 h / 20 °C 2: 15.6 g / triethylamine; trioxide-trimethylamine complex / dimethylsulfoxide / 18 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 90 percent / NaHCO3 / tetrahydrofuran / 14 h 2: tetrapropylammonium perruthenate; NMO; 4A molecular sieves / CH2Cl2; acetonitrile / 1 h View Scheme |
N-benzyl-3-piperidinone hydrochloride
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / Pd/C / methanol; H2O / 16 h / 2844.31 Torr 2: 2.93 g / aq. NaHCO3 / tetrahydrofuran / 4 h View Scheme |
di-tert-butyl dicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NaOH / tetrahydrofuran; H2O / 1 h / 20 °C 2: 15.6 g / DMSO; SO3*Me3N; triethylamine / 18 h / 20 °C View Scheme |
3-hydroxypiperazine
A
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CH2Cl2 2: SO3*pyridine; Et3N / CH2Cl2 View Scheme |
di-tert-butyl dicarbonate
A
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: CH2Cl2 2: SO3*pyridine; Et3N / CH2Cl2 View Scheme |
3-hydroxypiperazine
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: Cr2O3, Ac2O, Py / CH2Cl2 View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: Cr2O3, Ac2O, Py / CH2Cl2 View Scheme |
1-Benzyl-3,3-dihydroxypiperidine hydrobromide
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / 10percent Pd/C / ethanol; H2O / 2205.2 Torr 2: triethylamine / tetrahydrofuran / 2 h / 0 °C View Scheme |
1-benzyl-3-piperidone
tert-butyldicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogen; triethylamine; 20% palladium hydroxide on carbon In methanol at 50℃; under 3102.97 Torr; for 0.666667h; |
3-hydroxypiperazine
TEMPO
di-tert-butyl dicarbonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium bromide; sodium chloride; sodium hydrogencarbonate In dichloromethane; water |
tetrapropylammonium perruthennate
4-methylmorpholine N-oxide
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
molecular sieves In dichloromethane |
N-tert-butoxycarbonyl-3-piperidinol
Dess-Martin periodane
B
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With NaHCO3 In dichloromethane | A 1.80 g (95%) B n/a |
tert‐butyl 3‐aminopiperidine‐1‐carboxylate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With recombinant Rhodobacter sphaeroides amine-transaminase In dimethyl sulfoxide at 20℃; pH=7.5; aq. buffer; Enzymatic reaction; |
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene In dichloromethane at 20℃; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In dichloromethane; ethyl acetate at 20℃; for 1.5h; | 100% |
With hydrogenchloride In water at 20℃; | 63% |
With hydrogenchloride In 1,4-dioxane; dichloromethane at 20℃; for 3h; | |
With hydrogenchloride In diethyl ether; dichloromethane at 20℃; for 3h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
toluene-4-sulfonic acid hydrazide
1,1-dimethylethyl 3-[2-[(4-methylphenyl)sulphonyl]hydrazono]-1-piperidinecarboxylate
Conditions | Yield |
---|---|
In dichloromethane for 2h; | 100% |
methylmagnesium bromide
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl 3-hydroxy-3-methylpiperidine-1-carboxylate
Conditions | Yield |
---|---|
With ammonium chloride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 18h; Inert atmosphere; | 100% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With acetamide; acetic acid; acetyl chloride at 20℃; Cooling with ice; Stage #2: With phosphorus trichloride at 75℃; Cooling with ice; Stage #3: With hydrogenchloride In water for 8h; Reflux; | 100% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-aminopiperidine-1-carboxylate
Conditions | Yield |
---|---|
With pyridoxal 5'-phosphate; isopropylamine In dimethyl sulfoxide at 50℃; for 50h; pH=7.5; Reagent/catalyst; Temperature; Enzymatic reaction; enantioselective reaction; | 99% |
With pyridoxal 5'-phosphate; transaminase pQR2189; isopropylamine In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 18h; pH=7.5; Kinetics; Reagent/catalyst; | 60 %Chromat. |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 7-chloroisoquinolin-5-amine; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With acetic acid at 20℃; for 0.5h; Stage #2: With sodium tris(acetoxy)borohydride at 20℃; for 18h; | 99% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With rac-octan-2-ol In aq. buffer at 35℃; for 12h; pH=8; Reagent/catalyst; pH-value; Temperature; Enzymatic reaction; enantioselective reaction; | 98.08% |
With D-glucose; NADP In aq. phosphate buffer; ethanol at 30℃; for 4h; pH=6; enantioselective reaction; | 96% |
With recombinant Rhodococcus erythropolis DSM 43297 ketoredutase; nicotinamide adenine dinucleotide In aq. phosphate buffer; isopropyl alcohol at 50℃; for 0.5h; pH=7.0; Enzymatic reaction; stereoselective reaction; | 95% |
N,N-phenylbistrifluoromethane-sulfonimide
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
5-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.333333h; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 0℃; for 3.25h; | 98% |
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at -78 - 20℃; | 85% |
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at 20℃; Inert atmosphere; | 44% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
phenylmagnesium bromide
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; phenylmagnesium bromide In tetrahydrofuran at 0℃; for 1.5h; Inert atmosphere; Stage #2: With trifluoroacetic acid at 22 - 75℃; | 98% |
diethoxyphosphoryl-acetic acid ethyl ester
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Stage #2: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester In tetrahydrofuran at 20℃; for 5h; Horner-Wadsworth-Emmons Olefination; | 98% |
t-butoxycarbonylhydrazine
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3E)-3-[(tert-butoxycarbonyl)hydrazono]piperidine-1-carboxylate
Conditions | Yield |
---|---|
In toluene at 60℃; for 4h; | 95% |
2-aminoacetophenone
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
C18H22N2O2
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate; N,N-dimethyl-formamide at 90℃; Friedlaender reaction; | 95% |
(S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
cyclopentyl N-[1-(tert-butoxycarbonyl)piperidin-3-yl]-L-leucinate
Conditions | Yield |
---|---|
Stage #1: (S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With sodium tris(acetoxy)borohydride In 1,1-dichloroethane at 20℃; for 18h; Stage #2: With sodium hydrogencarbonate In 1,1-dichloroethane; water at 20℃; for 0.333333h; | 95% |
5-amino-3,4-dimethylisoxazol
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
Stage #1: 5-amino-3,4-dimethylisoxazol; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With acetic acid In 1,2-dichloro-ethane at 25℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 0 - 25℃; for 48h; | 95% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
acetylenemagnesium bromide
tert-butyl 3-ethynyl-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; acetylenemagnesium bromide In tetrahydrofuran at 0℃; for 4h; Stage #2: With ammonium chloride In tetrahydrofuran; water | 94% |
In tetrahydrofuran at 0 - 20℃; for 12h; | 80% |
N,N-dimethyl-formamide dimethyl acetal
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
4-((dimethylamino)methylene)-3-oxopiperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
at 100℃; for 2h; | 94% |
In N,N-dimethyl-formamide at 80℃; for 12h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With ammonium acetate In ethanol for 7h; Reflux; Large scale; | 93.7% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
Conditions | Yield |
---|---|
With recombinant Chryseobacterium sp. CA 49 ketoreductase; nicotinamide adenine dinucleotide In aq. phosphate buffer; isopropyl alcohol at 40℃; for 6h; pH=7.0; Enzymatic reaction; stereoselective reaction; | 93% |
With SmADH31 Kinetics; Enzymatic reaction; stereoselective reaction; | 89% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 110℃; for 16h; Sealed tube; | 93% |
1-(5-Amino-1H-indazol-1-yl)-2,2-dimethylpropan-1-one Maleate
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl 3-(1-pivaloyl-1H-indazol-5-ylamino)piperidine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 1-(5-Amino-1H-indazol-1-yl)-2,2-dimethylpropan-1-one Maleate; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane | 91% |
Stage #1: 1-(5-Amino-1H-indazol-1-yl)-2,2-dimethylpropan-1-one Maleate; 3-oxo-piperidine-1-carboxylic acid tert-butyl ester In 1,2-dichloro-ethane at 20℃; for 1h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane Stage #3: With sodium hydrogencarbonate In 1,2-dichloro-ethane |
(4-fluorobenzyl)magnesium chloride
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 3h; | 90% |
In tetrahydrofuran at 20℃; for 3h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
2-nitrobenzyl chloride
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With lithium diisopropyl amide In tetrahydrofuran at -78 - -40℃; for 1h; Inert atmosphere; Stage #2: 2-nitrobenzyl chloride In tetrahydrofuran at -40 - 30℃; for 3h; Inert atmosphere; | 90% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
6-(4-chlorophenyl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile
Conditions | Yield |
---|---|
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.8h; Irradiation; Sonication; Green chemistry; | 89% |
With sodium amide; dimethyl sulfoxide at 25 - 35℃; for 3h; regioselective reaction; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
6-(4-chloro-phenyl)-2-oxo-4-(4-phenyl-piperazin-1-yl)-2H-pyran-3-carbonitrile
Conditions | Yield |
---|---|
With potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.833333h; Irradiation; Sonication; Green chemistry; | 89% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
tert-butyl 3-(dimethylamino)piperidinyl-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Stage #2: With sodium hydrogencarbonate In water; 1,2-dichloro-ethane | 88% |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
dimethyl amine
tert-butyl 3-(dimethylamino)piperidinyl-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; dimethyl amine In tetrahydrofuran; dichloromethane at 20℃; for 0.0833333h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran; dichloromethane at 20℃; | 88% |
Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl ester; dimethyl amine In ethanol at 0 - 20℃; for 2h; Stage #2: With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 16h; |
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With NAD; isopropyl alcohol In aq. phosphate buffer at 30℃; for 12h; pH=7; Reagent/catalyst; Microbiological reaction; Green chemistry; Enzymatic reaction; stereoselective reaction; | 88% |
6-azaindole
3-oxo-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With potassium hydroxide In methanol; water at 75℃; for 48h; | 87% |
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