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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

tianfu-chem_LCZ-696 Impurity 5;AHU09-B 1038924-70-7

Cas:1038924-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1038924-70-7 with best quality

Cas:1038924-70-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- 1038924-70-7

Cas:1038924-70-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-Pyrrolidinone,5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-,(3R,5S)-

Cas:1038924-70-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

(3R,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing HuaNuo Bio-Pharmacuetical Co.,Ltd

Independent research and development of impurities, familiar with the market and impurity characteristics; We can ship out on the same day if the products are in stock; Focus on impurity development of new products in the market; Expert in customizi

Sacubitril Impurity 1

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. https:

(3R,5S)-5-Biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one CAS No.1038924-70-7

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Asure Biochem CO.,LTD.

*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:1kg/tin 5kg/tin 25kg/carton Application:Pharmaceutical raw materials, making injection powder oral agent Tr

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

1038924-70-7

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Forever Synthesis Co.,Ltd.

As a professional chemical R&D and synthesis supplier, Shanghai Forever Synthesis Co.,Ltd. is specialized R&D and synthesizing APIs and Impurities. Besides, we value more special service, that is, to customize chemical synthesis according to client’s

Sacubitril(3R,5S)-Pyrrolidinone Impurity

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Chemlin Chemical Co., Ltd.

Nanjing Chemlin Chemical Industry Co., Ltd was established in Aug,1999, located in the industrial park of Nanjing University of Technology, It is a private enterprises in Jiangsu Province with 1200 square meters’ R&D center. Our R&D center has a well

1038924-70-7

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Simson Pharma Limited

The system can just identify the products information in first sheet, it is not be permitted to add or edit new sheet by userself.Our products are required in MG to Gram only. · Pharmaceutical Reference Standards· Traceable workin

Sacubitril Impurity 1

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan MoonZY Biological Technology Co.,Ltd

instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China

2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-,1038924-70-7

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GZ HONESTCHEM CO., LTD

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

(3R,5S)-5-biphenyl-4-ylMethyl-3-Methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou utanpharma Co., Ltd

Hangzhou Utanpharma Biology Co., Ltd. is a R&D and manufacturing based, market oriented enterprise,specialized in the R&D and marketing of active pharmaceutical ingredients and intermediates. Supported by our highly qualified professor and

(3R,5S)-5-[(Biphenyl-4-yl)methyl]-3-methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Topbatt Chemical Co., Ltd.

Topbatt Chemical Co., Ltd., Established in 2019, located in Shenzhen, Guangdong Province, is a Manufacturer and Trading company which specialized in fine chemicals like Pharmaceutical Reference Standards and Stable Isotopes. Our Stable Isotopes produ

Sacubitril Impurity 1

Cas:1038924-70-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wade Dalian Wondersun Biochemical Technology Co., Ltd.

LCZ696 intermediate Application:LCZ696 intermediate

(3R,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

Cas:1038924-70-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Synthetic route

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol95%
With lithium hydroxide In ethanol Reflux;
(3R,5S)-5-([1,1'-biphenyl]-4-ylchloromethyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-([1,1'-biphenyl]-4-ylchloromethyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With palladium on activated charcoal In methanol at 20℃; for 5h;95%
(3R,5S)-5-([1,1'-biphenyl]-4-carbonyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-([1,1'-biphenyl]-4-carbonyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid In ethanol at 50℃; under 7600.51 Torr; for 6h; Temperature;92.3%
With sulfuric acid; palladium 10% on activated carbon; hydrogen at 40℃; for 30h;80.6%
ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-azido-2-methylpentanoate

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-azido-2-methylpentanoate

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 18h;92%
(3R,5S)-5-([1,1'-biphenyl]-4-yl-methyl)-1-((R)-2-hydroxy-1-phenylethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-([1,1'-biphenyl]-4-yl-methyl)-1-((R)-2-hydroxy-1-phenylethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 80℃; under 30003 Torr; for 24h;89%
(1S,3R,5S)-1-[[3-methyl-5-(1,1'-biphenyl-4-ylmethyl)-2-pyrrolidone]benzyl]-2-naphthol

(1S,3R,5S)-1-[[3-methyl-5-(1,1'-biphenyl-4-ylmethyl)-2-pyrrolidone]benzyl]-2-naphthol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; Reagent/catalyst; Solvent;88%
4-bromo-1,1'-biphenyl
92-66-0

4-bromo-1,1'-biphenyl

(3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone

(3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone With chloro-trimethyl-silane; ethylene dibromide; zinc In N,N-dimethyl acetamide at 0 - 5℃; for 1h; Inert atmosphere;
Stage #2: 4-bromo-1,1'-biphenyl With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl acetamide at 5℃; for 24h; Negishi Coupling;
87.8%
4-biphenylylmagnesium bromide
3315-91-1

4-biphenylylmagnesium bromide

(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With copper(l) cyanide In tetrahydrofuran at -30 - 20℃; Inert atmosphere;82.3%
4-bromo-1,1'-biphenyl
92-66-0

4-bromo-1,1'-biphenyl

(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-bromo-1,1'-biphenyl With iodine; magnesium In tetrahydrofuran at 0 - 60℃; Inert atmosphere;
Stage #2: (3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone With iron(III)-acetylacetonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
82%
C7H13NO4S
1447173-69-4

C7H13NO4S

4-biphenylboronic acid
5122-94-1

4-biphenylboronic acid

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In water; dimethyl sulfoxide at 80℃; for 10h; Reagent/catalyst; Solvent; Inert atmosphere;82%
4-bromo-1,1'-biphenyl
92-66-0

4-bromo-1,1'-biphenyl

(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-bromo-1,1'-biphenyl With iodine; magnesium In tetrahydrofuran at 0 - 60℃; Inert atmosphere;
Stage #2: (3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone With iron(III)-acetylacetonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
74%
(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester
752174-62-2

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethyl acetate at 40℃; Reagent/catalyst;72%
With methanol; potassium hydroxide at 60 - 65℃; for 4h;49.3%
ethyl 5-ambo-(2R,4S)-5-([1,1 '-biphenyl]-4-yl)-4-{[(tertbutoxy)carbonyl]amino}-5-hydroxy-2-ethypentanoate

ethyl 5-ambo-(2R,4S)-5-([1,1 '-biphenyl]-4-yl)-4-{[(tertbutoxy)carbonyl]amino}-5-hydroxy-2-ethypentanoate

methyl chloroformate
79-22-1

methyl chloroformate

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: ethyl 5-ambo-(2R,4S)-5-([1,1 '-biphenyl]-4-yl)-4-{[(tertbutoxy)carbonyl]amino}-5-hydroxy-2-ethypentanoate; methyl chloroformate In Isopropyl acetate at 0 - 20℃; for 0.0833333h;
Stage #2: With 2-methylbutan-2-ol (lithium salt) In n-heptane; Isopropyl acetate at 0 - 2℃; for 3h;
66%
(S)-5-biphenyl-4-ylmethylpyrrolidin-2-one
1038924-61-6

(S)-5-biphenyl-4-ylmethylpyrrolidin-2-one

methyl iodide
74-88-4

methyl iodide

A

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
1038925-00-6

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

B

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 0.5h; Heating / reflux;
Stage #2: methyl iodide In tetrahydrofuran; cyclohexane at -78℃; for 2h; Product distribution / selectivity;
ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride
149690-13-1

ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

A

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
1038925-00-6

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

B

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: ethyl (2S,4S)-4-amino-5-[(1,1'-biphenyl)-4-yl]-2-methylpentanoate hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride With triethylamine In Isopropyl acetate at 55℃; for 1h;
Stage #2: In Isopropyl acetate for 24h; Product distribution / selectivity; Heating / reflux;
(3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid
1038925-08-4

(3R,5R)-5-(biphenyl-4-yl)methyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid

(3S,5R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid
1038925-09-5

(3S,5R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxopyrrolidine-3-carboxylic acid

A

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
1038925-00-6

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

B

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
In toluene for 16h; Product distribution / selectivity; Heating / reflux;
(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one
1038924-66-1

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 1h; Product distribution / selectivity; Heating / reflux;
(3R/S,5S)-5-biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one
1174131-32-8

(3R/S,5S)-5-biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one

A

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
1038925-00-6

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

B

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With hydrogen; triethylamine; palladium on activated charcoal In ethanol at 20℃; under 750.075 Torr;A n/a
B n/a
(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

4-biphenylylmagnesium bromide
3315-91-1

4-biphenylylmagnesium bromide

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: 4-biphenylylmagnesium bromide With zinc(II) chloride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: (3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 0 - 20℃; Negishi Coupling;
0.32 g
(3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone

(3R,5S)-5-(iodomethyl)-3-methyl-2-pyrrolidinone

4-biphenylylmagnesium bromide
3315-91-1

4-biphenylylmagnesium bromide

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
With copper(II) sulfate In tetrahydrofuran at -5 - 20℃; for 48h; Inert atmosphere;1.82 g
(3R,5S)-5-(hydroxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(hydroxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap; triethylamine / dichloromethane / 5 - 20 °C
2: copper(l) cyanide / tetrahydrofuran / -30 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: dmap; triethylamine / dichloromethane / 5 - 20 °C
2.1: sodium iodide / acetone / 24 h / Reflux
3.1: ethylene dibromide; zinc; chloro-trimethyl-silane / N,N-dimethyl acetamide / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 24 h / 5 °C
View Scheme
Multi-step reaction with 3 steps
1: dmap; triethylamine / dichloromethane / 5 - 20 °C
2: sodium iodide / acetone / 24 h / Reflux
3: copper(II) sulfate / tetrahydrofuran / 48 h / -5 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: triphenylphosphine; bromine / dichloromethane / 0 - 20 °C
2.1: magnesium; iodine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 20 °C
2.1: magnesium; iodine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
View Scheme
(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(tosyloxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium iodide / acetone / 24 h / Reflux
2.1: ethylene dibromide; zinc; chloro-trimethyl-silane / N,N-dimethyl acetamide / 1 h / 0 - 5 °C / Inert atmosphere
2.2: 24 h / 5 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 24 h / Reflux
2: copper(II) sulfate / tetrahydrofuran / 48 h / -5 - 20 °C / Inert atmosphere
View Scheme
C25H38O4SSi

C25H38O4SSi

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
2: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
3: thionyl chloride / 7 h / 20 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
(2R,4R)-5-((tert-butyldimethylsilyl)oxy)-4-methylpentane-1,2-diol
1006724-46-4

(2R,4R)-5-((tert-butyldimethylsilyl)oxy)-4-methylpentane-1,2-diol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Nonafluorobutanesulfonyl fluoride / dichloromethane / 3 h / 0 °C / Inert atmosphere
2.1: magnesium; iodine / tetrahydrofuran / Heating; Inert atmosphere
2.2: 0.5 h / 0 °C
2.3: 0 - 20 °C
3.1: dmap; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere
4.1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
5.1: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
6.1: thionyl chloride / 7 h / 20 °C / Inert atmosphere
7.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
C18H19N3O2

C18H19N3O2

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 7 h / 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
tert-butyl dimethyl ((R)-2-methyl-3-((R)-oxiran-2-yl)propoxy)silane

tert-butyl dimethyl ((R)-2-methyl-3-((R)-oxiran-2-yl)propoxy)silane

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: magnesium; iodine / tetrahydrofuran / Heating; Inert atmosphere
1.2: 0.5 h / 0 °C
1.3: 0 - 20 °C
2.1: dmap; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
4.1: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
5.1: thionyl chloride / 7 h / 20 °C / Inert atmosphere
6.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
(2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-((tert-butyldimethylsilyl)oxy)-4-methylpentan-2-ol

(2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-((tert-butyldimethylsilyl)oxy)-4-methylpentan-2-ol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dmap; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere
2: sodium azide / N,N-dimethyl-formamide / 6 h / 60 °C / Inert atmosphere
3: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
4: thionyl chloride / 7 h / 20 °C / Inert atmosphere
5: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
(((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-azido-2-methylpentyl)oxy)(tert-butyl)dimethylsilane

(((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-azido-2-methylpentyl)oxy)(tert-butyl)dimethylsilane

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere
2: thionyl chloride / 7 h / 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C
View Scheme
(2R)-2-methyl-4-oxobutanoic acid

(2R)-2-methyl-4-oxobutanoic acid

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene / 36 h / 40 - 50 °C
2.1: ethyl bromide; magnesium / tetrahydrofuran / 20 °C / Inert atmosphere
2.2: -78 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
(4S,1'R)-4,5-dihydro-2-(1-methyl-3-butenyl)-4-(1-methylethyl)oxazole
88362-53-2

(4S,1'R)-4,5-dihydro-2-(1-methyl-3-butenyl)-4-(1-methylethyl)oxazole

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: water; hydrogenchloride / 3 h / 0 - 5 °C / Inert atmosphere
2.1: ozone / dichloromethane / 0.25 h / -78 - 20 °C
3.1: toluene / 36 h / 40 - 50 °C
4.1: ethyl bromide; magnesium / tetrahydrofuran / 20 °C / Inert atmosphere
4.2: -78 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C
View Scheme
ethanol
64-17-5

ethanol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester sulfuric acid salt
1038924-74-1

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester sulfuric acid salt

Conditions
ConditionsYield
With sulfuric acid at 75 - 85℃; for 16h; Reagent/catalyst;88.2%
With sulfuric acid at 80 - 120℃; for 24h; Product distribution / selectivity;
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 16h; Time; Reflux;85.6%
With hydrogenchloride In methanol at 70 - 85℃; for 24h;82%
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride
1038924-71-8

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; acetic acid for 20h; Reflux;80%
With hydrogenchloride; acetic acid In water for 20h; Heating / reflux;
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

C7H11ClO4

C7H11ClO4

C25H29NO4

C25H29NO4

Conditions
ConditionsYield
With sodium hydride In 1,4-dioxane; N,N-dimethyl-formamide at -15 - 0℃; Inert atmosphere;68%
pyrrolidine
123-75-1

pyrrolidine

formaldehyd
50-00-0

formaldehyd

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-1-pyrrolidin-1-ylmethylpyrrolidin-2-one
1038924-80-9

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-1-pyrrolidin-1-ylmethylpyrrolidin-2-one

Conditions
ConditionsYield
In ethanol; water for 3h; Product distribution / selectivity; Heating / reflux;
(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one
1038925-00-6

(3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

pivaloyl chloride
3282-30-2

pivaloyl chloride

A

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one
1038924-66-1

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one

B

(3S,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one
1038924-67-2

(3S,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (3S,5S)-5-biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one; (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃;
Stage #2: pivaloyl chloride at -78 - 20℃; for 4h; Product distribution / selectivity;
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

pivaloyl chloride
3282-30-2

pivaloyl chloride

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one
1038924-66-1

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: pivaloyl chloride In tetrahydrofuran; hexane at -78 - 20℃; for 0.5h; Product distribution / selectivity;
ethanol
64-17-5

ethanol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 80 - 120℃; for 24h; Product distribution / selectivity;
ethanol
64-17-5

ethanol

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (p-toluenesulphonate salt)
1039357-84-0

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (p-toluenesulphonate salt)

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 80 - 120℃; for 24h; Product distribution / selectivity;
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
1038924-76-3

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; triethylamine In ethyl acetate at 50℃; for 1h; Product distribution / selectivity;
Stage #1: (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one With dmap at 20℃;
Stage #2: di-tert-butyl dicarbonate With triethylamine

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