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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

cis-N-Benzyl-3-methylamino-4-methylpiperidine dihydrochloride

Cas:1062580-52-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

- Analysis tests Standard Results Appearance White crystalline powder conforms H-NMR S

High purity 1062580-52-2 (3r,4r)-n,4-dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

Cas:1062580-52-2

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product Name (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride CAS No. 1062580-52-2 Assay ≥99% Appearance White powder Capacity 50mt/year

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

Cas:1062580-52-2

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride CAS No.:1062580-52-2 Name: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride Molecular Structure Molecular Formula: C14

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine hydrochloride

Cas:1062580-52-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) CAS NO:1062580-52-2 Grade:Medical scientific research and export Molecular formula:C14H22N2·2(HCl) Molecular weight:291.26 Product Quality 12 years of chemical ra

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

Cas:1062580-52-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

High Purity CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

ProfessionalCAS 1062580-52-2 with best price

Cas:1062580-52-2

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride Synonyms: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride CAS:1062580-52-2 MF: C14H22N2·2(HCl) Appearance: white powder Storage:Store in cool and dr

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

Cas:1062580-52-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

1062580-52-2 (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Cas:1062580-52-2

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 1062580-52-2 Tofacitinib interMediate A with best price

Cas:1062580-52-2

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) 1062580-52-2

Cas:1062580-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

Cas:1062580-52-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Synonyms: CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE);cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride;cis-1-Benzyl-4-methyl-3-(methyl

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Cas:1062580-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride CAS:1062580-52-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediate

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride CAS:1062580-52-2

Cas:1062580-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Synonyms: (3R,4R)-1-苄基-N,4-二甲基哌啶-3-胺二盐酸盐;CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE);cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochlorid

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE supplier best quality

Cas:1062580-52-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidi

Cas:1062580-52-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE

Cas:1062580-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

cis-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride

Cas:1062580-52-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE

Cas:1062580-52-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

Cas:1062580-52-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine
477600-70-7

N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 0 - 5℃; pH=3 - 4;94%
With hydrogenchloride In n-heptane; isopropyl alcohol at 20℃; for 0.666667h; Reflux;60%
1-benzyl-4-methyl-piperidin-3-one
32018-96-5

1-benzyl-4-methyl-piperidin-3-one

methylamine
74-89-5

methylamine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Stage #1: 1-benzyl-4-methyl-piperidin-3-one; methylamine With titanium tetrachloride; triethylamine In tetrahydrofuran at 20℃; for 4h;
Stage #2: With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 25℃;
Stage #3: With hydrogenchloride In ethanol
85%
1-benzyl-4-methyl-piperidin-3-one
32018-96-5

1-benzyl-4-methyl-piperidin-3-one

methylamine acetate
6998-30-7

methylamine acetate

A

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

B

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

Conditions
ConditionsYield
Stage #1: 1-benzyl-4-methyl-piperidin-3-one; methylamine acetate With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S)-3,5-di-tert-butyl-4-methoxyphenyl-(6,6’-dimethoxybiphenyl-2,2’-diyl)-bis(diphenylphosphine); hydrogen In dichloromethane; isopropyl alcohol at 70℃; under 37503.8 Torr; for 18h;
Stage #2: With hydrogenchloride In dichloromethane; water; isopropyl alcohol Overall yield = 86%; Overall yield = 498 mg; enantioselective reaction;
A n/a
B 74%
(1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine
384338-23-2

(1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine

A

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

B

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; acetone for 1h; Inert atmosphere; Overall yield = 498 mg;
1-benzyl-4-methyl-piperidin-3-one
32018-96-5

1-benzyl-4-methyl-piperidin-3-one

A

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

B

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 5 h / 20 °C / Inert atmosphere
2: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-diMe-PipPhos / isopropyl alcohol / 18 h / 20 °C / 37503.8 Torr / Glovebox; Inert atmosphere
3: hydrogenchloride / acetone; diethyl ether / 1 h / Inert atmosphere
View Scheme
C14H20N2

C14H20N2

A

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

B

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidine-3-amine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-diMe-PipPhos / isopropyl alcohol / 18 h / 20 °C / 37503.8 Torr / Glovebox; Inert atmosphere
2: hydrogenchloride / acetone; diethyl ether / 1 h / Inert atmosphere
View Scheme
methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate

methyl ((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)carbamate

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 2.83 h / 0 °C / Reflux
2: hydrogenchloride / isopropyl alcohol; n-heptane / 0.67 h / 20 °C / Reflux
View Scheme
(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamic acid methyl ester
923036-28-6

(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamic acid methyl ester

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen; bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-1-[(Sp)-2-(di-tert-butylphosphino)ferrocenyl]ethylbis(2-methylphenyl)phosphine / 2,2,2-trifluoroethanol / 6 h / 30 - 50 °C / 2625.26 Torr
2: lithium aluminium tetrahydride / tetrahydrofuran / 2.83 h / 0 °C / Reflux
3: hydrogenchloride / isopropyl alcohol; n-heptane / 0.67 h / 20 °C / Reflux
View Scheme
3-amino-4-methylpyridine
3430-27-1

3-amino-4-methylpyridine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane; toluene / 10 h / 20 - 25 °C / Large scale
1.2: 70 - 80 °C / Large scale
1.3: 14 h / 10 °C / Large scale
2.1: hydrogenchloride / water; n-heptane / 70 - 75 °C / Large scale
2.2: 0 - 5 °C / Large scale
3.1: Di-p-toluoyl-L-tartaric acid / methanol / 1 h / 50 - 55 °C / Large scale
3.2: 2 h / pH 3 / Large scale
View Scheme
N-(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridine-3-yl)acetylamine

N-(1-benzyl-4-methyl-1,2,5,6-tetrahydropyridine-3-yl)acetylamine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water; n-heptane / 70 - 75 °C / Large scale
1.2: 0 - 5 °C / Large scale
2.1: Di-p-toluoyl-L-tartaric acid / methanol / 1 h / 50 - 55 °C / Large scale
2.2: 2 h / pH 3 / Large scale
View Scheme
1-benzyl-4-methyl-piperidin-3-one
32018-96-5

1-benzyl-4-methyl-piperidin-3-one

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Stage #1: 1-benzyl-4-methyl-piperidin-3-one With Di-p-toluoyl-L-tartaric acid In methanol at 50 - 55℃; for 1h; Large scale;
Stage #2: With hydrogenchloride In methanol; water for 2h; pH=3; Large scale;
1.7 kg
benzyl chloride
100-44-7

benzyl chloride

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane; toluene / 10 h / 20 - 25 °C / Large scale
1.2: 70 - 80 °C / Large scale
1.3: 14 h / 10 °C / Large scale
2.1: hydrogenchloride / water; n-heptane / 70 - 75 °C / Large scale
2.2: 0 - 5 °C / Large scale
3.1: Di-p-toluoyl-L-tartaric acid / methanol / 1 h / 50 - 55 °C / Large scale
3.2: 2 h / pH 3 / Large scale
View Scheme
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine
90213-66-4

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

Conditions
ConditionsYield
Stage #1: N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride; 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine With potassium carbonate In water at 98 - 102℃; for 10h;
Stage #2: at 20 - 25℃; for 4h;
93.6%
With potassium carbonate In water at 90℃; Reagent/catalyst; Solvent; Temperature;89.5%
With potassium carbonate In water for 10h; Reflux;82.3%
Stage #1: N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride With potassium carbonate In water Large scale;
Stage #2: 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine In water at 100℃; Large scale;
4.72 kg
4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1

4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
923036-30-0

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In water; dimethyl sulfoxide at 107℃; for 9h; Temperature; Large scale;93%
Stage #1: N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride With potassium carbonate In water
Stage #2: 4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine In water at 90 - 95℃;
155 g
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

C14H10ClN3O2

C14H10ClN3O2

C28H31N5O2

C28H31N5O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide at 115 - 120℃; for 12h;82%
4-chloropyrrolo[3,2-d]pyrimidine

4-chloropyrrolo[3,2-d]pyrimidine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

Conditions
ConditionsYield
With potassium carbonate; p-toluenesulfonyl chloride; sodium hydroxide In water; acetone; acetonitrile at 0 - 95℃; for 1h;77%
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

3,4,6-trichloro-1H-pyrazolo[3,4-d]pyrimidine

3,4,6-trichloro-1H-pyrazolo[3,4-d]pyrimidine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-3,6-dichloro-N-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-3,6-dichloro-N-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Conditions
ConditionsYield
Stage #1: N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride With N-ethyl-N,N-diisopropylamine In ethanol at 20℃; for 0.166667h;
Stage #2: 3,4,6-trichloro-1H-pyrazolo[3,4-d]pyrimidine In ethanol at 100℃; for 2h;
24.9%
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

4-chloro-1H-pyrrolo[2,3-d]pyrimidine
3680-69-1

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

Conditions
ConditionsYield
With potassium carbonate In water for 24h; Reflux;0.48%
With potassium carbonate In water at 90℃;145 g
7-benzyl-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

7-benzyl-2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

C27H30ClN5

C27H30ClN5

Conditions
ConditionsYield
With potassium carbonate In ethanol; water Reagent/catalyst; Solvent; Reflux;280 g
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

Tofacitinib citrate

Tofacitinib citrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; water / 9 h / 107 °C / Large scale
2: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 80 °C / Large scale
3: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 3 h / 61 °C / 760.05 Torr / Large scale
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 1 h / 49 °C / Large scale
5: water / 96 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 10 h / Reflux
2: acetic acid; 5%-palladium/activated carbon; triethylsilane / methanol / 0.17 h / 30 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / butan-1-ol / 0.17 h / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: dichloromethane / -20 °C
4: water; ethanol / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: tetrahydrofuran / 45 °C
4: water; ethanol / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: tetrahydrofuran / 45 °C
4: water; ethanol / 0 °C
View Scheme
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; water / 9 h / 107 °C / Large scale
2: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 80 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / water
1.2: 90 - 95 °C
2.1: potassium hydroxide; methanol / 40 - 45 °C
View Scheme
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine dihydrochloride

((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; water / 9 h / 107 °C / Large scale
2: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 80 °C / Large scale
3: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 3 h / 61 °C / 760.05 Torr / Large scale
View Scheme
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

tasocitinib

tasocitinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide; water / 9 h / 107 °C / Large scale
2: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 80 °C / Large scale
3: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 3 h / 61 °C / 760.05 Torr / Large scale
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 1 h / 49 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 90 °C
2: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / butan-1-ol
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: dichloromethane / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: tetrahydrofuran / 45 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
3: tetrahydrofuran / 45 °C
View Scheme
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride
1062580-52-2

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methylamine dihydrochloride

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / water / 24 h / Reflux
2: palladium 10% on activated carbon; hydrogen / methanol / 24 h
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / water / 10 h / Reflux
2: acetic acid; 5%-palladium/activated carbon; triethylsilane / methanol / 0.17 h / 30 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / water / 90 °C
2: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / water / 90 °C
2: hydrogen; hydrogenchloride; palladium on carbon / water / 120 °C / 2068.65 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / water
1.2: 90 - 95 °C
2.1: potassium hydroxide; methanol / 40 - 45 °C
3.1: hydrogenchloride / water / 20 °C / pH 3.5 - 4.5
3.2: 45 - 50 °C
View Scheme

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