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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Methoxy-2-Methylindole supplier in China

Cas:1076-74-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

5-Methoxy-2-Methylindole

Cas:1076-74-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 5-Methoxy-2-methylindole 1076-74-0 Producer

Cas:1076-74-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 1076-74-0--High purity 5-METHOXY-2-METHYLINDOLE in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable b

TIANFUCHEM-- 1076-74-0--High purity 5-METHOXY-2-METHYLINDOLE in stock

Cas:1076-74-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 1076-74-0 with best quality

Cas:1076-74-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to light beige powder Storage:room temperature Package:25kg/drum Application:chemicals Transportation:Express/Sea/Air Port:any port in china

5-Methoxy-2-methylindole factory price

Cas:1076-74-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1H-Indole,5-methoxy-2-methyl-

Cas:1076-74-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

5-METHOXY-2-METHYLINDOLE CAS:1076-74-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

5-METHOXY-2-METHYLINDOLE CAS:1076-74-0

Cas:1076-74-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Indole,5-methoxy-2-methyl-

Cas:1076-74-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indole,5-methoxy-2-methyl-

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

5-Methoxy-2-methyl-1H-indole

Cas:1076-74-0

Min.Order:1 Kilogram

FOB Price: $21.0 / 25.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-Methoxy-2-Methylindole

Cas:1076-74-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 5-Methoxy-2-Methylindole CAS No.:1076-74-0 Molecule Formula:C10H11NO Molecule Weight:161.20 Purity: 99.0% Package: 25kg/drum Description:Yellow to brown solid Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality 5-Methoxy-2-Methylindole in stock

Cas:1076-74-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

5-METHOXY-2-METHYLINDOLE

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

5-Methoxy-2-methyl-1H-indole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Manufacturers

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5-Methoxy-2-methylindole cas no. 1076-74-0 98%

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Greenutra Resource Inc

5-Methoxy-2-methylindoleAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Other

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 5-Methoxy-2-methylindole 5g

Cas:1076-74-0

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

5-Methoxy-2-Methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-Indole,5-methoxy-2-methyl-

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

"HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products. We supply Multiple s

5-METHOXY-2-METHYLINDOLE

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Trading Company

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BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:White to beige crystals Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use a

5-Methoxy-2-methylindole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

5-Methoxy-2-methyl-1H-indole cas 1076-74-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

5-Methoxy-2-methyl-1H-indole cas 1076-74-0

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

1076-74-0 Application:intermediate

5-Methoxy-2-methyl-1H-indole

Cas:1076-74-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

methyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With potassium hydroxide In methanol for 1h; Reflux;100%
With potassium hydroxide In methanol for 1h; Reflux; Large scale;98%
bromure d'acetylamino-2 methoxy-5 benzyltriphenylphosphonium
104894-18-0

bromure d'acetylamino-2 methoxy-5 benzyltriphenylphosphonium

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With potassium tert-butylate In toluene for 0.25h; Heating;97%
5-methoxy-2-methyl-3-(phenylthio)-1H-indole
98055-12-0

5-methoxy-2-methyl-3-(phenylthio)-1H-indole

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With thiosalicilyc acid In trifluoroacetic acid for 1.5h; Ambient temperature;96%
4-methoxy-2-(prop-1-yn-1-yl)aniline
938052-33-6

4-methoxy-2-(prop-1-yn-1-yl)aniline

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With Pd(II)-Y zeolites In toluene at 110℃; for 20h; Catalytic behavior;96%
With palladium dichloride In acetonitrile at 85℃; Inert atmosphere;
4-methoxy-aniline
104-94-9

4-methoxy-aniline

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With acetic acid for 8h; Reagent/catalyst; Reflux; Large scale;94%
5-methoxy-2-methyl-1-tosyl-1H-indole

5-methoxy-2-methyl-1-tosyl-1H-indole

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; ethanol for 6h; Reflux;92%
With ethanol; potassium hydroxide In tetrahydrofuran Reflux;
(3-Chloro-4-methoxy-phenyl)-isopropylidene-amine
153865-35-1

(3-Chloro-4-methoxy-phenyl)-isopropylidene-amine

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With sodium amide; sodium t-butanolate In tetrahydrofuran at 20℃; for 24h;87%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

acetone
67-64-1

acetone

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With oxygen; palladium diacetate; acetic acid In dimethyl sulfoxide at 70℃; under 760.051 Torr; for 18h; Schlenk technique; Molecular sieve;79%
With oxygen; palladium diacetate; acetic acid In dimethyl sulfoxide at 70℃; for 18h; Schlenk technique; Molecular sieve;79%
With copper diacetate; palladium diacetate In dimethyl sulfoxide at 40℃; for 24h; Inert atmosphere;55%
N-(4-methoxyphenyl)-1-methylethenesulfinamide
181651-13-8

N-(4-methoxyphenyl)-1-methylethenesulfinamide

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at -30℃; for 4h;75%
2-methyl-3-methylthio-5-methoxy-1H-indole
50461-37-5

2-methyl-3-methylthio-5-methoxy-1H-indole

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
aluminum nickel72%
5-methoxy-2-nitro-benzaldehyde
20357-24-8

5-methoxy-2-nitro-benzaldehyde

tert-butyl 2-(triphenylphosphoranylidene)propionate
56904-86-0

tert-butyl 2-(triphenylphosphoranylidene)propionate

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With triphenylphosphine In diphenylether at 260℃; for 1h;48%
N,N,N-tris(2-hydroxypropyl)amine hydrochloride
58901-12-5

N,N,N-tris(2-hydroxypropyl)amine hydrochloride

4-methoxy-aniline
104-94-9

4-methoxy-aniline

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With tin(ll) chloride; dihydridotetrakis(triphenylphosphine)ruthenium In 1,4-dioxane; water at 180℃; for 20h;37%
1-(5-methoxy-2-nitrophenyl)propan-2-one
25981-89-9

1-(5-methoxy-2-nitrophenyl)propan-2-one

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With sodium dithionite In tetrahydrofuran; water at 20℃; Large scale reaction;37%
5-methoxy-2methyl-1H-indole-3-carboxylic acid
32387-22-7

5-methoxy-2methyl-1H-indole-3-carboxylic acid

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With glycerol at 140℃;
(E)-3-Ureido-but-2-enoic acid ethyl ester
5435-44-9, 22243-66-9

(E)-3-Ureido-but-2-enoic acid ethyl ester

acetone(4-methoxyphenyl)hydrazone
1078-72-4

acetone(4-methoxyphenyl)hydrazone

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
at 110℃; im Vakuum;
acetone(4-methoxyphenyl)hydrazone
1078-72-4

acetone(4-methoxyphenyl)hydrazone

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With zinc(II) chloride at 110℃;
With zinc(II) chloride at 140℃; Fisher indole cyclization;
ethyl 5-methoxy-2-methyl-1H-indole-3-carboxylate
34572-31-1

ethyl 5-methoxy-2-methyl-1H-indole-3-carboxylate

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With sodium hydroxide; ethanol; water
n-octyl acetate
112-14-1

n-octyl acetate

4-methoxy-2-trimethylsilylmethylbenzanilide
117616-04-3

4-methoxy-2-trimethylsilylmethylbenzanilide

A

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

B

n-octyl benzoate
94-50-8

n-octyl benzoate

Conditions
ConditionsYield
With 2,2,6,6-tetramethylpiperidinyl-lithium 1) -10 degC, THF, 2) 0 degC, 20 min; Yield given. Multistep reaction;
C10H10(3)HNO

C10H10(3)HNO

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With water at 25℃; Rate constant;
triisopropanolamine
122-20-3

triisopropanolamine

4-methoxy-aniline
104-94-9

4-methoxy-aniline

A

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

B

5-methoxy-3-methyl-1H-indole
21987-25-7

5-methoxy-3-methyl-1H-indole

Conditions
ConditionsYield
With tin(ll) chloride; ruthenium trichloride; triphenylphosphine In 1,4-dioxane at 180℃; for 20h; Yield given. Yields of byproduct given;
5-methoxy-2-methyl-indole-carboxylic acid-(3)

5-methoxy-2-methyl-indole-carboxylic acid-(3)

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

4-methoxyphenylhydrazine hydrochloride
19501-58-7

4-methoxyphenylhydrazine hydrochloride

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / 2-methyl-propan-2-ol / 0.5 h / Heating
2: 96 percent / thiosalicylic acid / trifluoroacetic acid / 1.5 h / Ambient temperature
View Scheme
2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene
67567-46-8

2‐(bromomethyl)‐4‐methoxy‐1‐nitrobenzene

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C
2: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
3: 92 percent / pyridine / CH2Cl2 / 1 h / Heating
4: 97 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
5-methoxy-2-nitrotoluene
5367-32-8

5-methoxy-2-nitrotoluene

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: N-bromosuccinimide (NBS), azoisobutyronitrile (AIBN) / CCl4 / 3 h / Heating
2: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C
3: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
4: 92 percent / pyridine / CH2Cl2 / 1 h / Heating
5: 97 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
bromure d'amino-2 methoxy-5 benzyltriphenylphosphonium
104894-16-8

bromure d'amino-2 methoxy-5 benzyltriphenylphosphonium

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / pyridine / CH2Cl2 / 1 h / Heating
2: 97 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
bromure de nitro-2 methoxy-5 benzyltriphenylphosphonium
104894-14-6

bromure de nitro-2 methoxy-5 benzyltriphenylphosphonium

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating
2: 92 percent / pyridine / CH2Cl2 / 1 h / Heating
3: 97 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

2-bromo-5-methoxy-1H-indole
169383-96-4

2-bromo-5-methoxy-1H-indole

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane Suzuki coupling; Reflux;
ethyl 2-(5-fluoro-2-nitrophenyl)-3-oxobutanoate
1266659-05-5

ethyl 2-(5-fluoro-2-nitrophenyl)-3-oxobutanoate

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction
2: methanol / 30 - 35 °C / Large scale reaction
3: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction
View Scheme
1-(5-fluoro-2-nitrophenyl)propan-2-one
1266659-06-6

1-(5-fluoro-2-nitrophenyl)propan-2-one

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 30 - 35 °C / Large scale reaction
2: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction
View Scheme
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2-methyl-5-methoxy-3-iodo-1H-indole

2-methyl-5-methoxy-3-iodo-1H-indole

Conditions
ConditionsYield
Stage #1: 5-methoxy-2-methyl-1H-indole With potassium hydroxide In N,N-dimethyl-formamide for 0.333333h;
Stage #2: With iodine In N,N-dimethyl-formamide for 1h;
100%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate
194720-38-2

2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

A

5-methoxy-2-methyl-3-(phenylthio)-1H-indole
98055-12-0

5-methoxy-2-methyl-3-(phenylthio)-1H-indole

B

4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile for 0.166667h; Yields of byproduct given;A 99%
B n/a
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate
194720-38-2

2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate

5-methoxy-2-methyl-3-(phenylthio)-1H-indole
98055-12-0

5-methoxy-2-methyl-3-(phenylthio)-1H-indole

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 0 - 20℃; for 0.166667h;99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

1-(2,3,4,5,6-pentafluorophenylthio)-2,3,5,6-tetramethyl-4-oxocyclohexa-2,5-dienyl 2-chloroacetate
335642-28-9

1-(2,3,4,5,6-pentafluorophenylthio)-2,3,5,6-tetramethyl-4-oxocyclohexa-2,5-dienyl 2-chloroacetate

A

4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

4-hydroxy-2,3,5,6-tetramethylphenyl 2-chloroacetate

B

3-(2,3,4,5,6-pentafluorophenylthio)-5-methoxy-2-methylindole

3-(2,3,4,5,6-pentafluorophenylthio)-5-methoxy-2-methylindole

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at -30 - 0℃; for 0.166667h;A n/a
B 99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

3-bromo-5-methoxy-2-methyl-1H-indole
883141-55-7

3-bromo-5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With N-Bromosuccinimide; silica gel In dichloromethane for 0.5h;99%
With N-Bromosuccinimide; silica gel In dichloromethane at 20℃; for 0.5h;99%
With N-Bromosuccinimide; silica gel In dichloromethane at 20℃; for 0.5h; Inert atmosphere;93%
With bromine In N,N-dimethyl-formamide at 20℃; for 0.5h;
With N-Bromosuccinimide In dichloromethane at 20℃; for 1h; Inert atmosphere;
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde

2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde

3-(2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

3-(2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With diphenyl hydrogen phosphate In 1,2-dichloro-ethane at 20℃;99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

5-methoxy-2-methyl-3-(1-methylheptyl)-1H-indole
1251532-65-6

5-methoxy-2-methyl-3-(1-methylheptyl)-1H-indole

Conditions
ConditionsYield
With indium(III) tris[bis(trifluoromethanesulfonyl)amide]; methyldiphenylsilane In 1,4-dioxane at 50℃; for 24h; Inert atmosphere; Schlenk technique;99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

(-)-5-methoxy-2-methylindoline

(-)-5-methoxy-2-methylindoline

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol; RuBF4((S,S)-N-Me-Msdpen)(p-cymene); hydrogen at 10℃; under 37503.8 Torr; for 7h; Autoclave; enantioselective reaction;99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

(S)-2-methyl-5-methoxyindoline

(S)-2-methyl-5-methoxyindoline

Conditions
ConditionsYield
With hydrogenchloride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (S,R)-ZhaoPhos; hydrogen; acetic acid In dichloromethane at 25℃; under 30402 Torr; for 48h; Autoclave; enantioselective reaction;99%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

methyl iodide
74-88-4

methyl iodide

5-methoxy-1,2-dimethyl-1H-indole
17591-06-9

5-methoxy-1,2-dimethyl-1H-indole

Conditions
ConditionsYield
With sodium hydroxide In N,N-dimethyl-formamide at 20℃; for 0.833333h;98%
With sodium hydride In N,N-dimethyl-formamide at 60℃; for 1h;80%
Stage #1: 5-methoxy-2-methyl-1H-indole With sodium hydride In N,N-dimethyl-formamide Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;
80%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2-methyl-1H-indol-5-ol
13314-85-7

2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 0 - 20℃; for 2h;98%
With boron tribromide In dichloromethane; water93%
Stage #1: 5-methoxy-2-methyl-1H-indole With boron tribromide In dichloromethane at -78 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: With water; sodium hydrogencarbonate In dichloromethane Cooling with ice;
93%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

tert-butyl 5-methoxy-2-methyl-1H-indole-1-carboxylate

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃; for 22h;98%
With dmap In acetonitrile at 20℃;0.92 g
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

tert-butyl ((ethylthio)(phenyl)methyl)carbamate
1323902-49-3

tert-butyl ((ethylthio)(phenyl)methyl)carbamate

tert-butyl (5-methoxy-2-methyl-1H-indol-3-yl)(phenyl)methylcarbamate
1612786-56-7

tert-butyl (5-methoxy-2-methyl-1H-indol-3-yl)(phenyl)methylcarbamate

Conditions
ConditionsYield
With N-iodo-succinimide In dichloromethane at -78℃; for 0.0833333h; Friedel-Crafts Alkylation; Sealed tube; Inert atmosphere; chemoselective reaction;98%
3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde
445262-62-4

3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

3-(1,3-dimethoxy-9H-fluoren-9-yl)-5-methoxy-2-methyl-1H-indole
1372797-84-6

3-(1,3-dimethoxy-9H-fluoren-9-yl)-5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
Stage #1: 5-methoxy-2-methyl-1H-indole With (S)-3,3’-bis(9-anthracenyl)-1,1’-binaphthyl-2,2’-diyl N-triflyl-phosphoramide In o-xylene at -15 - 20℃; for 0.166667h; Friedel Crafts alkylation; Molecular sieve; Inert atmosphere;
Stage #2: 3',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde In o-xylene at -15℃; Friedel Crafts acylation; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
97%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

ethyl-3,3,3-trifluoropyruvate
13081-18-0

ethyl-3,3,3-trifluoropyruvate

Ethyl 3,3,3-trifluoro-2-hydroxy-2-(5-methoxy-2-methyl-indol-3-yl)propionate
1297914-66-9

Ethyl 3,3,3-trifluoro-2-hydroxy-2-(5-methoxy-2-methyl-indol-3-yl)propionate

Conditions
ConditionsYield
With (SIr,RC)-[(η5-C5Me5)Ir{(R)-propane-1,2-diylbis(diphenylphosphane)}(H2O)][SbF6]2 In dichloromethane for 0.233333h; Friedel-Crafts Alkylation; Inert atmosphere; Schlenk technique; Optical yield = 55 %ee;97%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methylbenzaldehyde

2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methylbenzaldehyde

5-methoxy-2-methyl-3-(4-methyl-2-(1H-pyrrol-1-yl)benzyl)-1H-indole

5-methoxy-2-methyl-3-(4-methyl-2-(1H-pyrrol-1-yl)benzyl)-1H-indole

Conditions
ConditionsYield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;97%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

(2-nitroethenyl)benzene
102-96-5

(2-nitroethenyl)benzene

5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole
1227380-56-4

5-methoxy-2-methyl-3-(2-nitro-1-phenylethyl)-1H-indole

Conditions
ConditionsYield
In water at 150℃; for 0.1h; Michael addition; Microwave irradiation;96%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2,2,2-trifluoroethyl(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate

2,2,2-trifluoroethyl(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate

5-methoxy-2-methyl-3-(2,2,2-trifluoroethyl)-1H-indole

5-methoxy-2-methyl-3-(2,2,2-trifluoroethyl)-1H-indole

Conditions
ConditionsYield
With 2,6-di-tert-butyl-pyridine In dichloromethane at 25℃; for 0.666667h; regioselective reaction;96%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

cyclopent-2-enone
930-30-3

cyclopent-2-enone

3-(2-methyl-5-methoxy-1H-indol-3-yl)cyclopentanone
1321804-40-3

3-(2-methyl-5-methoxy-1H-indol-3-yl)cyclopentanone

Conditions
ConditionsYield
With aminosulfonic acid In acetonitrile at 80℃; for 8h; Michael condensation;95%
With gluconic acid In water at 100℃; for 10h; Michael addition;90%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

5-bromo-2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde
742100-39-6

5-bromo-2-(2,5-dihydro-1H-pyrrol-1-yl)benzaldehyde

3-(5-bromo-2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

3-(5-bromo-2-(1H-pyrrol-1-yl)benzyl)-5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;95%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

4-toluenesulfonyl azide
941-55-9

4-toluenesulfonyl azide

carbon monoxide
201230-82-2

carbon monoxide

2-methyl-5-methoxy-N-p-toluenesulfonyl-1H-indole-3-carboxamide

2-methyl-5-methoxy-N-p-toluenesulfonyl-1H-indole-3-carboxamide

Conditions
ConditionsYield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer In acetonitrile at 80℃; for 12h;95%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer In acetonitrile at 80℃; under 760.051 Torr; for 12h; Schlenk technique;95%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methoxybenzaldehyde

2-(2,5-dihydro-1H-pyrrol-1-yl)-4-methoxybenzaldehyde

5-methoxy-3-(4-methoxy-2-(1H-pyrrol-1-yl)benzyl)-2-methyl-1H-indole

5-methoxy-3-(4-methoxy-2-(1H-pyrrol-1-yl)benzyl)-2-methyl-1H-indole

Conditions
ConditionsYield
With diphenyl hydrogen phosphite In 1,2-dichloro-ethane at 20℃;94%
ammonium thiocyanate

ammonium thiocyanate

5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

5-methoxy-2-methyl-3-thiocyanato-1H-indole

5-methoxy-2-methyl-3-thiocyanato-1H-indole

Conditions
ConditionsYield
With dipotassium peroxodisulfate In dichloromethane at 20℃; for 5h; regioselective reaction;94%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

1-(1-azidovinyl)-4-fluorobenzene
1374152-38-1

1-(1-azidovinyl)-4-fluorobenzene

3-(1-(4-fluorophenyl)vinyl)-5-methoxy-2-methyl-1H-indole

3-(1-(4-fluorophenyl)vinyl)-5-methoxy-2-methyl-1H-indole

Conditions
ConditionsYield
With indium(III) chloride In dichloromethane at 28 - 30℃; for 6h; Inert atmosphere;94%
5-methoxy-2-methyl-1H-indole
1076-74-0

5-methoxy-2-methyl-1H-indole

4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

5-methoxy-3-(1-(4-methoxyphenyl)vinyl)-2-methyl-1H-indole

5-methoxy-3-(1-(4-methoxyphenyl)vinyl)-2-methyl-1H-indole

Conditions
ConditionsYield
With bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) In acetonitrile at 30℃; for 24h;94%

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