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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:2008,

Boc-L-Pyroglutamic acid benzyl ester

Cas:113400-36-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

(S)-2-BENZYL 1-TERT-BUTYL 5-OXOPYRROLIDINE-1,2-DICARBOXYLATE

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-benzyl 1-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

Cas:113400-36-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Leader Biochemical Group

About Product Details

China Biggest factory Manufacturer Supply High Quality BOC-L-PYROGLUTAMIC ACID BENZYL ESTER CAS 113400-36-5

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

BOC-L-PYROGLUTAMIC ACID BENZYL ESTER CAS 113400-36-5

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 113400-36-5 with competitive price

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name: Boc-Pyr-Obzl CAS#: 113400-36-5 Synonyms: Boc-Pyroglutamicacid. benzyl ester Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:Flav

Boc-Pyr-Obzl

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl)2-(phenylmethyl) ester, (S)- 113400-36-5

Cas:113400-36-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

BOC-L-PYROGLUTAMIC ACID BENZYL ESTER

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $89.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

BOC-L-PYROGLUTAMIC ACID BENZYL ESTER CAS: 113400-36-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

BOC-L-PYROGLUTAMIC ACID BENZYL ESTER CAS: 113400-36-5

Cas:113400-36-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl)2-(phenylmethyl) ester, (S)-

Cas:113400-36-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl)2-(phenylmethyl) ester, (S)-

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl)2-(phenylmethyl) ester, (S)-

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Boc-L-Pyroglutamic acid benzyl ester/High quality/Best price

Cas:113400-36-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzyl N-Boc glutamate

Cas:113400-36-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Benzyl N-Boc glutamateAppearance:White fine powder Storage:Kept in a cool,dry and ventilated place Package:according to customers' requirements Application:Meets the requirements Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB

Benzyl N-Boc glutamate

Cas:113400-36-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

113400-36-5 BOC-L-PYROGLUTAMIC ACID BENZYL ESTER

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Boc-PyroglutaMicacid.Benzylester

Cas:113400-36-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

Boc-Pyroglutamicacid. benzyl ester

Cas:113400-36-5

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

Benzyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Boc-L-Pyroglutamic acid benzyl ester

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

BOC-L-Pyr.Obzl

Cas:113400-36-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

BOC-L-Pyr.Obzl cas no. 113400-36-5 98%

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Research Peptide Biotechnology Co., Ltd.

High purity, high success rate, short cycle and moderate priceAppearance:White powder solid Storage:Negative 20 degrees Celsius Package:5mg, 10mg 100mg, 1gram Application:Applied to various scientific research

2-O-benzyl 1-O-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

Cas:113400-36-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

benzyl (L)-pyroglutamate
94885-52-6

benzyl (L)-pyroglutamate

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃;98%
With dmap; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;90%
With dmap; triethylamine In dichloromethane at 0 - 23℃; for 17h; Inert atmosphere;90%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

L-glutamic acid dibenzyl ester hydrochloride
4561-10-8

L-glutamic acid dibenzyl ester hydrochloride

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In toluene at 30 - 95℃; for 9h; Solvent; Temperature; Concentration;94.6%
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
94%
Multi-step reaction with 2 steps
1: Et3N / tetrahydrofuran / 120 h / Heating
2: 9.0 g / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 384 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 85 percent / TEA / acetone
2: 73 percent / DMAP / acetonitrile
View Scheme
(2S,4S)-4-((R)-3-Methyl-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
135347-23-8

(2S,4S)-4-((R)-3-Methyl-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[d]isothiazol-3-yl)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

A

3-methylbenzo[d]isothiazole-1,1-dioxide
34989-82-7

3-methylbenzo[d]isothiazole-1,1-dioxide

B

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran 1.) -78 deg C, 30 min, 2.) -78 deg C -> room temperature, 2 h;A 40%
B 38%
methylmagnesium bromide
75-16-1

methylmagnesium bromide

(S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

(S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

A

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

B

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate
113400-46-7

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate

Conditions
ConditionsYield
In tetrahydrofuran; toluene at -78℃; for 0.75h; Yield given. Yields of byproduct given;
(S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

(S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

A

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

B

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate
113400-46-7

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate

Conditions
ConditionsYield
With methylmagnesium bromide In tetrahydrofuran; toluene at -78℃; for 0.75h; Yield given. Yields of byproduct given;
benzyl chloride
100-44-7

benzyl chloride

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / tetrahydrofuran / 120 h / Heating
2: 9.0 g / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 384 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 120 h / 70 °C
2: triethylamine; dmap / dichloromethane / 16 h / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / acetone / 24 °C / Reflux; Inert atmosphere
2: dmap / dichloromethane / Inert atmosphere
View Scheme
benzyl chloride
100-44-7

benzyl chloride

N,N-diethyl-glycine-<4-hydroxy-anilide>

N,N-diethyl-glycine-<4-hydroxy-anilide>

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / TEA / acetone
2: 73 percent / DMAP / acetonitrile
View Scheme
benzyl bromide
100-39-0

benzyl bromide

(1R,2R)-O-Merrifield bound N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2'-phenylacetamide

(1R,2R)-O-Merrifield bound N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2'-phenylacetamide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-diisopropylethylamine / CH2Cl2 / 5 h / Heating
2: 37.5 g / 4-dimethylaminopyridine / acetonitrile / 3 h / 25 °C
View Scheme
benzyl bromide
100-39-0

benzyl bromide

XOOC-CH2-COOX

XOOC-CH2-COOX

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / Et3N / acetone / 24 h / 20 °C
2: 90 percent / DIEA; DMAP / dimethylformamide / 3 h / 20 °C
View Scheme
L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

Fmoc-Pro-Rink amide-MBHA resin

Fmoc-Pro-Rink amide-MBHA resin

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / Et3N / acetone / 24 h / 20 °C
2: 90 percent / DIEA; DMAP / dimethylformamide / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / SOCl2; DMF / 20 °C
2: 98 percent / dimethylaminopyridine / CH2Cl2 / 0 - 20 °C
View Scheme
benzyl alcohol
100-51-6

benzyl alcohol

BocNH-C(=NBoc)-SCH2-terminated resin

BocNH-C(=NBoc)-SCH2-terminated resin

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / SOCl2; DMF / 20 °C
2: 98 percent / dimethylaminopyridine / CH2Cl2 / 0 - 20 °C
View Scheme
benzyl alcohol
100-51-6

benzyl alcohol

NaCpW(CO)3

NaCpW(CO)3

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / SOCl2 / 0 - 20 °C
2: Et3N; DMAP
View Scheme
benzyl bromide
100-39-0

benzyl bromide

t-BuOCOCH2-X

t-BuOCOCH2-X

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: DIEA / CH2Cl2 / Heating
2: 9.56 g / DMAP; Et3N / acetonitrile / 20 °C
View Scheme
Boc-Glu-OBn
30924-93-7

Boc-Glu-OBn

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C
2: tetrahydrofuran; toluene / 0.75 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1: 4-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C
2: methylmagnesium bromide / tetrahydrofuran; toluene / 0.75 h / -78 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

sodium-compound of 1-cyclopentyl-ethanone

sodium-compound of 1-cyclopentyl-ethanone

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NEt3 / tetrahydrofuran / 120 h / Heating
2: NEt3 / CH2Cl2
View Scheme
benzyl chloride
100-44-7

benzyl chloride

hydroxylamine hydrochloride

hydroxylamine hydrochloride

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / triethylamine / acetone / 168 h / Heating
2: 75 percent / DMAP / acetonitrile / 1.) 0 deg C, 2 h, 2.) r.t., overnight
View Scheme
tert-butyldicarbonate
34619-03-9

tert-butyldicarbonate

benzyl (L)-pyroglutamate
94885-52-6

benzyl (L)-pyroglutamate

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 4h;
benzyl alcohol
100-51-6

benzyl alcohol

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / N,N-dimethyl-formamide / 0 - 20 °C
2: dmap / dichloromethane / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 16 h / 0 - 23 °C / Inert atmosphere
2: dmap; triethylamine / dichloromethane / 17 h / 0 - 23 °C / Inert atmosphere
View Scheme
benzyl chloride
100-44-7

benzyl chloride

L-Pyroglutamic acid
98-79-3

L-Pyroglutamic acid

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; potassium iodide / toluene / 80 °C
2: 4-pyrrolidin-1-ylpyridine / 50 °C
View Scheme
benzyl bromide
100-39-0

benzyl bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / acetone / 16 h / Reflux
2: dmap; triethylamine / dichloromethane / 16 h / 50 °C / Inert atmosphere
View Scheme
trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate

benzyl (2S)-2-((tert-butoxycarbonyl)amino)-6-(dimethyl(oxo)-λ6-sulfanylidene)-5-oxohexanoate

Conditions
ConditionsYield
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 1h;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran; dimethyl sulfoxide at -10℃;
100%
With potassium carbonate In dimethyl sulfoxide at 50℃; for 23h; Temperature; Reagent/catalyst; Solvent;96%
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate In tetrahydrofuran; dimethyl sulfoxide at 20℃;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran; dimethyl sulfoxide at -12℃;
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate; dimethyl sulfoxide In tetrahydrofuran at 25℃; for 1h; Large scale; Industrial scale;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran at -12℃; Large scale; Industrial scale;
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate In tetrahydrofuran; dimethyl sulfoxide at 25℃; for 2h;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran; dimethyl sulfoxide at 0 - 10℃; for 8h;
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S)-N-tert-butoxycarbonyl-5-hydroxypyrrolidine-2-carboxylate
331949-29-2

benzyl (2S)-N-tert-butoxycarbonyl-5-hydroxypyrrolidine-2-carboxylate

Conditions
ConditionsYield
With lithium triethylborohydride In tetrahydrofuran at -78℃; for 2h;99%
With lithium triethylborohydride In tetrahydrofuran at -78℃; for 0.5h;95%
With lithium triethylborohydride In tetrahydrofuran at -78℃; for 2h;88%
With diisobutylaluminium hydride In tetrahydrofuran at -78℃;70%
With lithium triethylborohydride In tetrahydrofuran at -78℃;
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

L-N-t-butoxycarbonylpyroglutamic acid
53100-44-0

L-N-t-butoxycarbonylpyroglutamic acid

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate for 120h; Ambient temperature;98%
With hydrogen; 10percent Pd/C In ethyl acetate under 2280.15 Torr; for 1h;98%
With hydrogen; palladium on activated charcoal In methanol for 6h;93%
methanol
67-56-1

methanol

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate
331949-31-6

benzyl (2S)-N-tert-butoxycarbonyl-5-methoxypyrrolidine-2-carboxylate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With diisobutylaluminium hydride In tetrahydrofuran at -78℃;
Stage #2: methanol With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; Further stages.;
95%
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium triethylborohydride In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: With dihydrogen peroxide In tetrahydrofuran; water at -78 - 20℃; Inert atmosphere;
Stage #3: methanol With toluene-4-sulfonic acid In water at 20℃; Inert atmosphere; chemoselective reaction;
86%
2-bromo-1,4-difluorobenzene
399-94-0

2-bromo-1,4-difluorobenzene

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

C23H25F2NO5

C23H25F2NO5

Conditions
ConditionsYield
Stage #1: 2-bromo-1,4-difluorobenzene With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 2h;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran at 0℃; for 4h;
93%
hexenylmagnesium bromide
32359-01-6

hexenylmagnesium bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

(S)-2-tert-Butoxycarbonylamino-5-oxo-undec-6-ynoic acid benzyl ester
113400-48-9

(S)-2-tert-Butoxycarbonylamino-5-oxo-undec-6-ynoic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;92%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester
91229-97-9

(S)-2-[N-(tert-butoxycarbonyl)amino]-5-hydroxypentanoic acid benzyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; potassium dihydrogenphosphate In methanol; water at 0℃; for 1.5h; Reduction;92%
With sodium tetrahydroborate; water In tetrahydrofuran at 0 - 23℃; for 2h; Inert atmosphere;49%
With sodium tetrahydroborate; potassium dihydrogenphosphate In methanol; water at 0℃; for 2h;12%
methyllithium
917-54-4

methyllithium

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate
113400-46-7

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether at -78 - 20℃; for 2h; Inert atmosphere;91%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate
91229-91-3

tert-butyl (S)-N-tert-butoxycarbonylpyroglutamate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With hydrogen; palladium on activated charcoal In ethyl acetate
Stage #2: di-tert-butyl dicarbonate With dmap; TEA In acetonitrile Further stages.;
83%
With dmap; hydrogen; triethylamine 2.) CH3CN; Multistep reaction;
vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

2-tert-butoxycarbonylamino-5-oxo-hept-6-enoic acid benzyl ester
113400-37-6

2-tert-butoxycarbonylamino-5-oxo-hept-6-enoic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;82%
methyl magnesium iodide
917-64-6

methyl magnesium iodide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate
113400-46-7

benzyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-oxohexanoate

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;78%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

phenyllithium
591-51-5

phenyllithium

(S)-2-tert-Butoxycarbonylamino-5-oxo-5-phenyl-pentanoic acid benzyl ester
148626-26-0

(S)-2-tert-Butoxycarbonylamino-5-oxo-5-phenyl-pentanoic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;77%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

(2S)-α-benzyl 2-N-(tert-butyloxycarbonyl)amino-5-oxo-6-(dimethylphosphonyl)hexanoate
270585-72-3

(2S)-α-benzyl 2-N-(tert-butyloxycarbonyl)amino-5-oxo-6-(dimethylphosphonyl)hexanoate

Conditions
ConditionsYield
Stage #1: dimethyl methane phosphonate With n-butyllithium In toluene at -78℃; for 0.333333h; Metallation;
Stage #2: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In toluene at -78 - 20℃; Addition; Further stages.;
74%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

(S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester
208519-99-7

(S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -105 - -100℃; for 0.166667h;71%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

allylmagnesium bromide
1730-25-2

allylmagnesium bromide

(S)-2-tert-Butoxycarbonylamino-5-oxo-oct-7-enoic acid benzyl ester
113400-47-8

(S)-2-tert-Butoxycarbonylamino-5-oxo-oct-7-enoic acid benzyl ester

Conditions
ConditionsYield
In tetrahydrofuran at -40℃; for 2h;70%
benzyl bromide
100-39-0

benzyl bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

2-benzyl 1-(tert-butyl) (2S)-4-benzyl-5-oxo-1,2-pyrrolidinedicarboxylate
1243255-28-8

2-benzyl 1-(tert-butyl) (2S)-4-benzyl-5-oxo-1,2-pyrrolidinedicarboxylate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.08333h; Inert atmosphere;
Stage #2: benzyl bromide In tetrahydrofuran at -78℃; for 16.05h; Inert atmosphere; stereoselective reaction;
69%
(trifluoromethyl)trimethylsilane
81290-20-2

(trifluoromethyl)trimethylsilane

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

N-Boc-5-trifluoromethyl-5-trimethylsilyloxy-L-proline benzyl ester

N-Boc-5-trifluoromethyl-5-trimethylsilyloxy-L-proline benzyl ester

Conditions
ConditionsYield
With cesium fluoride In tetrahydrofuran at 0℃; for 2h; Inert atmosphere;66%
eschenmoser's salt
33797-51-2

eschenmoser's salt

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

(S)-4,4-Bis-dimethylaminomethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
159829-96-6

(S)-4,4-Bis-dimethylaminomethyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.666667h;65%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

methyl iodide
74-88-4

methyl iodide

(2S,4R)-4-methyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

(2S,4R)-4-methyl-5-oxo-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -80℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran at -80 - 20℃;
64.9%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (L)-pyroglutamate
94885-52-6

benzyl (L)-pyroglutamate

Conditions
ConditionsYield
With trimethylaluminum In dichloromethane Ambient temperature;64%
4-but-1-enylmagnesium bromide
7103-09-5

4-but-1-enylmagnesium bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

(S)-2-tert-butoxycarbonylamino-5-oxo-non-8-enoic acid benzyl ester
1282532-98-2

(S)-2-tert-butoxycarbonylamino-5-oxo-non-8-enoic acid benzyl ester

Conditions
ConditionsYield
Stage #1: 4-but-1-enylmagnesium bromide; benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran at -40℃; for 3h;
Stage #2: With ammonium chloride In tetrahydrofuran; water
62%
Stage #1: 4-but-1-enylmagnesium bromide; benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate In tetrahydrofuran at -40℃; for 3h;
Stage #2: With water; ammonium chloride In tetrahydrofuran
62%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

methyl chloroformate
79-22-1

methyl chloroformate

5-oxo-pyrrolidine-1,2,4-tricarboxylic acid 2-benzyl ester 1-tert-butyl ester 4-methyl ester

5-oxo-pyrrolidine-1,2,4-tricarboxylic acid 2-benzyl ester 1-tert-butyl ester 4-methyl ester

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h;
Stage #2: methyl chloroformate In tetrahydrofuran at -78℃; for 3h;
60%
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

prenyl bromide
870-63-3

prenyl bromide

2-benzyl 1-(tert-butyl) (2S)-4-(3-methyl-2-butenyl)-5-oxo-1,2-pyrrolidinedicarboxylate
1243255-29-9

2-benzyl 1-(tert-butyl) (2S)-4-(3-methyl-2-butenyl)-5-oxo-1,2-pyrrolidinedicarboxylate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1.08333h; Inert atmosphere;
Stage #2: prenyl bromide In tetrahydrofuran at -78℃; for 16.05h; Inert atmosphere; stereoselective reaction;
60%
1-(4-bromophenyl)-1-propen-3-yl bromide
96090-12-9, 124854-99-5

1-(4-bromophenyl)-1-propen-3-yl bromide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

A

benzyl (2S,4R,E)-N-BOC-4-(4-bromocinnamyl)pyroglutamate

benzyl (2S,4R,E)-N-BOC-4-(4-bromocinnamyl)pyroglutamate

B

benzyl (2S,4S,E)-N-BOC-4-(4-bromocinnamyl)pyroglutamate

benzyl (2S,4S,E)-N-BOC-4-(4-bromocinnamyl)pyroglutamate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Activation;
Stage #2: 1-(4-bromophenyl)-1-propen-3-yl bromide In tetrahydrofuran at -78℃; for 2h; Alkylation;
A 58%
B n/a
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h; Substitution;
Stage #2: 1-(4-bromophenyl)-1-propen-3-yl bromide In tetrahydrofuran at -78℃; for 2h; Alkylation;
A 58%
B n/a
benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

benzyl (2S,4R)-1-tert-butoxycarbonyl-4-hydroxy-5-oxopyrrolidine-2-carboxylate
116857-24-0

benzyl (2S,4R)-1-tert-butoxycarbonyl-4-hydroxy-5-oxopyrrolidine-2-carboxylate

Conditions
ConditionsYield
Stage #1: benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 1h;
Stage #2: With N-(benzenesulfonyl)-3-phenyloxaziridine In tetrahydrofuran at -78℃; for 0.75h;
Stage #3: With camphor-10-sulfonic acid; water In tetrahydrofuran at -78 - 20℃; stereoselective reaction;
55%
With 2-toluenesulfonyl-3-phenyloxazolidine; lithium hexamethyldisilazane 1.) THF, -78 deg C; Yield given. Multistep reaction;
methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

A

benzyl (2S,4S)-N-tert-butoxycarbonyl-4-(2-carboxymethylprop-2-enyl)pyroglutamate

benzyl (2S,4S)-N-tert-butoxycarbonyl-4-(2-carboxymethylprop-2-enyl)pyroglutamate

B

benzyl (2S,4R)-N-tert-butoxycarbonyl-4-(2-carboxymethylprop-2-enyl)pyroglutamate

benzyl (2S,4R)-N-tert-butoxycarbonyl-4-(2-carboxymethylprop-2-enyl)pyroglutamate

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h; Yields of byproduct given;A 54%
B n/a
With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 2h; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
lithium hexamethydisilylazide

lithium hexamethydisilylazide

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate
113400-36-5

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Cinnamyl bromide
4392-24-9

Cinnamyl bromide

Boc-4(R)-(3-phenylpropyl)proline
220424-73-7

Boc-4(R)-(3-phenylpropyl)proline

Conditions
ConditionsYield
With ammonium chloride In tetrahydrofuran54%

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