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HANGZHOU YUNUO CHEMICAL CO.,LTD

Hangzhou Yunuo Chemical Co., Ltd is located in Hangzhou city China. As a global supplier in the chemical industry, Yunuochem is to create added value for customers around the world. Sticking to such business idea of "Good faith wins the busine

Ramatroban

Cas:116649-85-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Hysen Pharma co.,Ltd.

We can provide high quality,cheap price,spot supply and good service. If you have any questions,pls do not hesitate to contact us. Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and

Ramatroban CAS116649-85-5

Cas:116649-85-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ramatroban

Cas:116649-85-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 116649-85-5 Ramatroban

Cas:116649-85-5

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ramatroban supplier in China

Cas:116649-85-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shangha

Ramatroban 116649-85-5

Cas:116649-85-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ramatroban

Cas:116649-85-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Ramatroban cas 116649-85-5

Cas:116649-85-5

Min.Order:1 Kilogram

FOB Price: $48.0 / 58.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 116649-85-5 with best quality

Cas:116649-85-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ramatroban 116649-85-5

Cas:116649-85-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Ramatroban CAS 116649-85-5 For research Use only

Cas:116649-85-5

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Ramatroban

Cas:116649-85-5

Min.Order:1 Gram

FOB Price: $100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Ramatroban CAS:116649-85-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Ramatroban CAS:116649-85-5

Cas:116649-85-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ramatroban

Cas:116649-85-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Hot selling factory price Pure Ramatroban

Cas:116649-85-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

BAY u3405 Ramatroban 116649-85-5

Cas:116649-85-5

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

afine-RAMATROBAN

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Ramatroban CAS 116649-85-5

Cas:116649-85-5

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ramatroban

Cas:116649-85-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Other

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferRamatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Ramatroban

Cas:116649-85-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ramatroban

Cas:116649-85-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Ramatroban

Cas:116649-85-5

Min.Order:1 Kilogram

Negotiable

Type:Other

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.116649-85-5 98% Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Senova Technology Company Limited

Good price, high purity, mature production technology, accept custom synthesis per customer's requirements Package:As per Customer‘ requirements Application:Pharmaceutical intermediate

Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Other

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

Ramatroban

Cas:116649-85-5

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

(R)-N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide
118699-38-0

(R)-N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Stage #1: (R)-N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide With water; sodium hydroxide In isopropyl alcohol at 100℃; for 24h;
Stage #2: With hydrogenchloride In water
79%
acrylonitrile
107-13-1

acrylonitrile

(R)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide
116650-36-3

(R)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
With potassium hydroxide; sodium hydride 1.) dimethylformamide, 2 h, room temperature, 2.) isopropanol, reflux, 16 h; Yield given. Multistep reaction;
1,2,3,4-tetrahydrocarbazol-3-one
51145-61-0

1,2,3,4-tetrahydrocarbazol-3-one

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2.) tetrabutylammonium borohydride, 3.) 2N sulfuric acid / 1.) benzene, reflux, 1 h, 2.) CH2Cl2, -50 deg C to room temperature, 3.) methanol, room temperature, 1 h
2: 1.) 2N NaOH, conc. HCl, 2.) ammonium formiate / 2.) 10percent Pd/C / 1.) methanol, ethyl acetate, 2.) dimethylformamide, reflux, 20 min
3: 84 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
4: 1.) 80percent sodium hydride (in mineral oil), 2.) 10percent potassium hydroxide / 1.) dimethylformamide, 2 h, room temperature, 2.) isopropanol, reflux, 16 h
View Scheme
Multi-step reaction with 6 steps
1.1: D-glucose / water / 24 h / 30 °C / Enzymatic reaction
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 10 h / -25 - -15 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
2.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
3.2: 10 h / -25 - -15 °C
4.1: water; triphenylphosphine / 15 h / 65 °C
5.1: triethylamine / dichloromethane / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
6.2: 1 h / 20 °C
7.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(3R)-3-(1S-phenylethylamino)-1,2,3,4-tetrahydrocarbazole hydrogensulfate

(3R)-3-(1S-phenylethylamino)-1,2,3,4-tetrahydrocarbazole hydrogensulfate

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) 2N NaOH, conc. HCl, 2.) ammonium formiate / 2.) 10percent Pd/C / 1.) methanol, ethyl acetate, 2.) dimethylformamide, reflux, 20 min
2: 84 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
3: 1.) 80percent sodium hydride (in mineral oil), 2.) 10percent potassium hydroxide / 1.) dimethylformamide, 2 h, room temperature, 2.) isopropanol, reflux, 16 h
View Scheme
(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-amine
116650-33-0

(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-amine

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
2: 1.) 80percent sodium hydride (in mineral oil), 2.) 10percent potassium hydroxide / 1.) dimethylformamide, 2 h, room temperature, 2.) isopropanol, reflux, 16 h
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 1 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
2.2: 1 h / 20 °C
3.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
cyclohexanedione monoethylene ketal
4746-97-8

cyclohexanedione monoethylene ketal

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Pseudomonas cepacia lipase / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Candida antarctica lipase B / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(S)-2,3,4,9-tetrahydro-1H-carbazol-3-yl methanesulfonate
1374648-17-5

(S)-2,3,4,9-tetrahydro-1H-carbazol-3-yl methanesulfonate

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium azide / dimethyl sulfoxide / 24 h / 20 °C
2.1: water; triphenylphosphine / 15 h / 65 °C
3.1: triethylamine / dichloromethane / 1 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
4.2: 1 h / 20 °C
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
2.1: water; triphenylphosphine / 15 h / 65 °C
3.1: triethylamine / dichloromethane / 1 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
4.2: 1 h / 20 °C
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(R)-3-azido-2,3,4,9-tetrahydro-1H-carbazole
1374648-18-6

(R)-3-azido-2,3,4,9-tetrahydro-1H-carbazole

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; triphenylphosphine / 15 h / 65 °C
2.1: triethylamine / dichloromethane / 1 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
3.2: 1 h / 20 °C
4.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide
116650-12-5

4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
1.2: 20 °C
2.1: chiralpak IC / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
3.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1.1: chiralpak IC / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
2.2: 1 h / 20 °C
3.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide

N-[9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluorobenzenesulfonamide

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chiralpak IC / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
2: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
2,3,4,9-tetrahydro-1H-carbazol-3-yl methanesulfonate

2,3,4,9-tetrahydro-1H-carbazol-3-yl methanesulfonate

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium azide / 24 h
2.1: chiralcel OD / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium azide / 24 h
2.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C
3.1: triethylamine / dichloromethane / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
4.2: 20 °C
5.1: chiralpak IC / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium azide / 24 h
2.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C
3.1: triethylamine / dichloromethane / 20 °C
4.1: chiralpak IC / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: chiralcel OD / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
2.1: sodium azide / dimethyl sulfoxide / 24 h / 20 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: chiralcel OD / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
2.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(S)-(-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol
1374648-14-2

(S)-(-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
1.2: 10 h / -25 - -15 °C
2.1: water; triphenylphosphine / 15 h / 65 °C
3.1: triethylamine / dichloromethane / 1 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
4.2: 1 h / 20 °C
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: sodium azide / dimethyl sulfoxide / 24 h / 20 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(+/-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol
128432-38-2, 14384-34-0

(+/-)-2,3,4,9-tetrahydro-1H-carbazol-3-ol

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 10 h / -25 - -15 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: Candida antarctica lipase B / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 10 h / -25 - -15 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 6 steps
1.1: Pseudomonas cepacia lipase / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 10 h / -25 - -15 °C
3.1: water; triphenylphosphine / 15 h / 65 °C
4.1: triethylamine / dichloromethane / 1 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 1 h / 20 °C
6.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
4-Fluorobenzenesulfonyl chloride
349-88-2

4-Fluorobenzenesulfonyl chloride

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 1 h / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
2.2: 1 h / 20 °C
3.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
3-azido-2,3,4,9-tetrahydro-1H-carbazole

3-azido-2,3,4,9-tetrahydro-1H-carbazole

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C
2.1: triethylamine / dichloromethane / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
3.2: 20 °C
4.1: chiralpak IC / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C
2.1: triethylamine / dichloromethane / 20 °C
3.1: chiralpak IC / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
4.2: 1 h / 20 °C
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 5 steps
1.1: chiralcel OD / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
2.1: water; triphenylphosphine / 15 h / 65 °C
3.1: triethylamine / dichloromethane / 1 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
4.2: 1 h / 20 °C
5.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
2,3,4,9-tetrahydro-1H-carbazol-3-yl-amine
61894-99-3, 116650-33-0, 116650-34-1, 134525-54-5

2,3,4,9-tetrahydro-1H-carbazol-3-yl-amine

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
2.2: 20 °C
3.1: chiralpak IC / hexane; isopropyl alcohol / 40 °C / Resolution of racemate
4.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 20 °C
2.1: chiralpak IC / hexane; isopropyl alcohol / 30 °C / Resolution of racemate
3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
3.2: 1 h / 20 °C
4.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
phenylhydrazine
100-63-0

phenylhydrazine

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Pseudomonas cepacia lipase / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Candida antarctica lipase B / tetrahydrofuran / 8 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
(R)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide
116650-36-3

(R)-4-fluoro-N-(2,3,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
1.2: 1 h / 20 °C
2.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
1,2,4,9-tetrahydrospiro[3H-carbazole-3,2*-[1,3]doxolane]
54621-12-4

1,2,4,9-tetrahydrospiro[3H-carbazole-3,2*-[1,3]doxolane]

ramatroban
116649-85-5

ramatroban

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid / acetone / 24 h / 65 °C
2.1: D-glucose / water / 24 h / 30 °C / Enzymatic reaction
3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
3.2: 10 h / -25 - -15 °C
4.1: water; triphenylphosphine / 15 h / 65 °C
5.1: triethylamine / dichloromethane / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
6.2: 1 h / 20 °C
7.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / acetone / 24 h / 65 °C
2.1: D-glucose / water / 24 h / 30 °C / Enzymatic reaction
3.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
5.1: water; triphenylphosphine / 15 h / 65 °C
6.1: triethylamine / dichloromethane / 1 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
7.2: 1 h / 20 °C
8.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / acetone / 24 h / 65 °C
2.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
3.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
4.2: 10 h / -25 - -15 °C
5.1: water; triphenylphosphine / 15 h / 65 °C
6.1: triethylamine / dichloromethane / 1 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
7.2: 1 h / 20 °C
8.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C
View Scheme
methanol
67-56-1

methanol

ramatroban
116649-85-5

ramatroban

(R)-methyl 3-[3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl]propanoate
141307-19-9

(R)-methyl 3-[3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl]propanoate

Conditions
ConditionsYield
With sulfuric acid In water at 65℃; for 15h;60%
ramatroban
116649-85-5

ramatroban

(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-terahydro-9-carbazolepropanoic acid sodium salt

(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-terahydro-9-carbazolepropanoic acid sodium salt

Conditions
ConditionsYield
With sodium hydroxide
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