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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-(hydroxymethyl)isoindoline-1,3-dione supplier in China

Cas:118-29-6

Min.Order:1 Kilogram

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Type:Manufacturers

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Kono Chem Co.,Ltd

English name:N-(Hydroxymethyl)phthalimide CAS number:118-29-6 Purity:99% Best quality and Competitive price Specifications N-(Hydroxymethyl)phthalimide White crystal powder 99.0% min. N-(Hydroxymethyl)phth

CAS:118-29-6 N-(Hydroxymethyl)phthalimide best price

Cas:118-29-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of N-(Hydroxymethyl)phthalimide Cas 118-29-6 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:25kg/drum Appl

Manufacturer high quality N-(Hydroxymethyl)phthalimide Cas 118-29-6 with good price

Cas:118-29-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

Appearance: white crystalline powder Purity (%, dry): 99 min. Iron ion(wt%): 20ppm max Melting point: 140--145C Appearance:white powder Storage:Warehouse ventilation, away from open flame, high temperature, and antioxidant Package:

PHTHALIMIDOMETHANOL

Cas:118-29-6

Min.Order:3 Metric Ton

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Kilogram

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Type:Manufacturers

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EAST CHEMSOURCES LIMITED

N-(Hydroxymethyl)phthalimide Product Name: N-(Hydroxymethyl)phthalimide Molecular Weight: 177.16 CAS NO: 118-29-6 EC NO: 204-241-4 Molecular Form

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N-(Hydroxymethyl)Phthalimide

Cas:118-29-6

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-(Hydroxymethyl)-phthalimide

Cas:118-29-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: N-(Hydroxymethyl)phthalimide Synonyms: oxymethylphthalimide;Phthalimide, N-(hydroxymethyl)-;Phthalimidomethyl alcohol;phthalimidomethylalcohol;4-(Hydroxymethyl)phthalimide, 97%;1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)-;N-Hydroxy

N-(Hydroxymethyl)phthalimide 118-29-6

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/547.html Product Name N-(Hydroxymethyl)phthalimide CAS No. 118-29

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Gram

FOB Price: $22.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Hebei Nengqian Chemical Import and Export Co., LTD.. is located in xingtai City, Hebei Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutica

N-(Hydroxymethyl)phthalimide CAS NO.118-29-6

Cas:118-29-6

Min.Order:1 Gram

FOB Price: $12.0 / 15.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 118-29-6 with best quality

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

N-(Hydroxymethyl)phthalimide CAS118-29-6

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: N-(Hydroxymethyl)phthalimide Molecular Weight: 177.16 CAS NO: 118-29-6 EC NO:

N-Methylolphthalimide

Cas:118-29-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Isoindole-1,3(2H)-dione,2-(hydroxymethyl)- 118-29-6

Cas:118-29-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

N-(Hydroxymethyl)phthalimide CAS:118-29-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

N-(Hydroxymethyl)phthalimide CAS:118-29-6

Cas:118-29-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Isoindole-1,3(2H)-dione,2-(hydroxymethyl)-

Cas:118-29-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

N-Hydroxyl-Methyl-Phthalimide (NHMP)CAS NO.: CAS NO.: 118-29-6

Cas:118-29-6

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

N-(Hydroxymethyl)phthalimide CAS: 118-29-6 Specification Items Specification Product name N-(Hydroxymethyl)phthalimide CAS# 118-29-6 Appearance

Factory supply N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Kilogram

Negotiable

Type:Other

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Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales N-(Hydroxymethyl)phthalimide CAS118-29-6

Cas:118-29-6

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Isoindole-1,3(2H)-dione,2-(hydroxymethyl)-

Cas:118-29-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

N-(HYDROXYMETHYL)PHTHALIMIDE

Cas:118-29-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

N-(Hydroxymethyl)phthalimide

Cas:118-29-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Synthetic route

phthalimide
136918-14-4

phthalimide

formaldehyd
50-00-0

formaldehyd

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
In water at 100℃; for 4h;99%
In water for 0.0666667h; hydroxymethylation; Heating; ultrasound irradiation;97%
In water for 1.5h; Reflux;96%
N-(bromomethyl)phtalimide
5332-26-3

N-(bromomethyl)phtalimide

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With cesium formate In methanol for 18h; Reflux; Inert atmosphere;95%
With water
phthalimide
136918-14-4

phthalimide

formaldehyd
50-00-0

formaldehyd

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
In 1,1,2,2-tetrachloroethylene at 110℃; for 8h;84%
2-(2-Hydroperoxy-2-methoxy-ethyl)-isoindole-1,3-dione
124536-28-3

2-(2-Hydroperoxy-2-methoxy-ethyl)-isoindole-1,3-dione

A

N-methylphthalimide
550-44-7

N-methylphthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

Methyl formate
107-31-3

Methyl formate

D

N-phthaloylglycine methyl ester
23244-58-8

N-phthaloylglycine methyl ester

Conditions
ConditionsYield
In acetonitrile at 0℃; Irradiation;A 3%
B 72%
C 79%
D 5%
In acetonitrile at 0℃; Irradiation; other solvents; other phthalimide;A 3%
B 72%
C 79%
D 5%
2-(iodomethyl)isoindoline-1,3-dione
203255-55-4

2-(iodomethyl)isoindoline-1,3-dione

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With dimethyl zinc(II) In n-heptane; dichloromethane at 20℃; for 18h; Inert atmosphere;43%
2-(2-Hydroperoxy-2-methoxy-ethyl)-isoindole-1,3-dione
124536-28-3

2-(2-Hydroperoxy-2-methoxy-ethyl)-isoindole-1,3-dione

A

N-methylphthalimide
550-44-7

N-methylphthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

N-phthaloylglycine methyl ester
23244-58-8

N-phthaloylglycine methyl ester

Conditions
ConditionsYield
In dimethyl sulfoxide Irradiation;A 15%
B 35%
C 40%
2-(iodomethyl)isoindoline-1,3-dione
203255-55-4

2-(iodomethyl)isoindoline-1,3-dione

A

N-methylphthalimide
550-44-7

N-methylphthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

1,3,4,5-tetrahydro-2,4-benzoxazepine-1,5-dione
1380112-97-9

1,3,4,5-tetrahydro-2,4-benzoxazepine-1,5-dione

Conditions
ConditionsYield
With diethylzinc In hexane; dichloromethane at 20℃; for 2h; Inert atmosphere;A 39%
B 14%
C 22%
N-(bromomethyl)phtalimide
5332-26-3

N-(bromomethyl)phtalimide

diisopropylamine
108-18-9

diisopropylamine

A

phthalimide
136918-14-4

phthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

N-(di-isopropylaminomethyl)phthalimide

N-(di-isopropylaminomethyl)phthalimide

Conditions
ConditionsYield
In benzene for 12h; Heating; Title compound not separated from byproducts;
methanol
67-56-1

methanol

phthalimide DBU salt
119812-51-0

phthalimide DBU salt

A

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

B

3-hydroxy-2-(hydroxymethyl)isoindolin-1-one

3-hydroxy-2-(hydroxymethyl)isoindolin-1-one

Conditions
ConditionsYield
With sodium methylate 1.) electrolysis, current density 0.05 A/cm2, 1.5 h, 2.) electrolysis, current density 0.02 A/cm2, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
methanol
67-56-1

methanol

phthalimide
136918-14-4

phthalimide

A

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

B

3-hydroxy-2-(hydroxymethyl)isoindolin-1-one

3-hydroxy-2-(hydroxymethyl)isoindolin-1-one

Conditions
ConditionsYield
With sodium methylate 1.) electrolysis, current density 0.05 A/cm2, 2 h, 2.) electrolysis, current density 0.02 A/cm2, 5 h; Yield given. Multistep reaction. Yields of byproduct given;
N-(bromomethyl)phtalimide
5332-26-3

N-(bromomethyl)phtalimide

water
7732-18-5

water

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

phthalimide
136918-14-4

phthalimide

formaldehyde <10%>

formaldehyde <10%>

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
at 100℃;
Phosmet
732-11-6

Phosmet

isopropyl alcohol
67-63-0

isopropyl alcohol

A

phthalimide
136918-14-4

phthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

N-(methoxymethyl)phthalimide
1954-06-9

N-(methoxymethyl)phthalimide

D

2-<(isopropyloxy)methyl>-isoindole-1,3(2H)-dione
1954-04-7

2-<(isopropyloxy)methyl>-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
for 15h; UV-irradiation;A n/a
B n/a
C n/a
D 5 mg
Phosmet
732-11-6

Phosmet

A

phthalimide
136918-14-4

phthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

N-(methoxymethyl)phthalimide
1954-06-9

N-(methoxymethyl)phthalimide

Conditions
ConditionsYield
In methanol for 7h; Product distribution; Further Variations:; Solvents; UV-irradiation;
phthalic anhydride
85-44-9

phthalic anhydride

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water / Destillation des entstandenen sauren phthalsauren Methylamins
2: bromine / 160 - 170 °C
3: water
View Scheme
Multi-step reaction with 2 steps
1: urea / 0.33 h / 140 °C
2: water / 1 h / Reflux
View Scheme
N-methylphthalimide
550-44-7

N-methylphthalimide

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / 160 - 170 °C
2: water
View Scheme
N-(chloromethyl)phthalimide
17564-64-6

N-(chloromethyl)phthalimide

A

N-methylphthalimide
550-44-7

N-methylphthalimide

B

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

C

1,3,4,5-tetrahydro-2,4-benzoxazepine-1,5-dione
1380112-97-9

1,3,4,5-tetrahydro-2,4-benzoxazepine-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 4 h / 20 °C / Darkness
2: diethylzinc / hexane; dichloromethane / 2 h / 20 °C / Inert atmosphere
View Scheme
N-(chloromethyl)phthalimide
17564-64-6

N-(chloromethyl)phthalimide

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 4 h / 20 °C / Darkness
2: dimethyl zinc(II) / n-heptane; dichloromethane / 18 h / 20 °C / Inert atmosphere
View Scheme
phthalimide
136918-14-4

phthalimide

tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

A

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

B

2-(tert-butoxymethyl)isoindoline-1,3-dione
1373155-17-9

2-(tert-butoxymethyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide at 75℃; for 5h; Sealed tube; Overall yield = 65 %;
1,3-Dioxo-1,3-dihydro-isoindole-2-carbaldehyde
82524-62-7

1,3-Dioxo-1,3-dihydro-isoindole-2-carbaldehyde

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 0 - 20℃; Inert atmosphere; Sealed tube;
1,2,3,4-tetrahydrocarbazole
942-01-8

1,2,3,4-tetrahydrocarbazole

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

N-(5,6,7,8-tetrahydro-carbazol-3-ylmethyl)-phthalimide
68375-17-7

N-(5,6,7,8-tetrahydro-carbazol-3-ylmethyl)-phthalimide

Conditions
ConditionsYield
In sulfuric acid for 30h; Ambient temperature;100%
2,3-dimethylindole
91-55-4

2,3-dimethylindole

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

N-(2,3-dimethyl-indol-5-ylmethyl)-phthalimide
36798-28-4

N-(2,3-dimethyl-indol-5-ylmethyl)-phthalimide

Conditions
ConditionsYield
In sulfuric acid for 30h; Ambient temperature;98%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,8-Dimethyl-4-phenoxathiinessigsaeure-10,10-dioxid
119071-84-0

2,8-Dimethyl-4-phenoxathiinessigsaeure-10,10-dioxid

2,8-dimethyl-4-(carboxymethyl)-6-(phthalimidomethyl)-phenoxathiin S-dioxide
100815-36-9

2,8-dimethyl-4-(carboxymethyl)-6-(phthalimidomethyl)-phenoxathiin S-dioxide

Conditions
ConditionsYield
With sulfuric acid for 168h; Ambient temperature;98%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2-mercaptopropanoic acid
79-42-5

2-mercaptopropanoic acid

2-(phthalimidomethylsulfanyl)propionic acid

2-(phthalimidomethylsulfanyl)propionic acid

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride In trifluoroacetic acid98%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

MINOCYCLINE
10118-90-8

MINOCYCLINE

C41H37N5O11

C41H37N5O11

Conditions
ConditionsYield
Stage #1: 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione; MINOCYCLINE With hydrogenchloride; sulfuric acid; trifluoroacetic acid at 40 - 50℃; Inert atmosphere;
Stage #2: With monomethanolamine
97%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

N-(bromomethyl)phtalimide
5332-26-3

N-(bromomethyl)phtalimide

Conditions
ConditionsYield
With sulfuric acid; hydrogen bromide In water at 0 - 70℃; for 17.25h;96.4%
With sulfuric acid; hydrogen bromide In water at 70℃; Cooling with ice;95%
With phosphorus tribromide In dichloromethane80%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2-methyl-5-(phtalimidomethyl)indole
58867-56-4

2-methyl-5-(phtalimidomethyl)indole

Conditions
ConditionsYield
In sulfuric acid for 30h; Ambient temperature;96%
methanol
67-56-1

methanol

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

3-methoxy-2-(methoxymethyl)isoindolin-1-one

3-methoxy-2-(methoxymethyl)isoindolin-1-one

Conditions
ConditionsYield
With tris(2,4-pentanedionato)ruthenium(III); methanesulfonic acid; hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] at 130℃; under 11251.1 Torr; for 18h; Autoclave;96%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,3,3-trimethyl-3H-indolium

2,3,3-trimethyl-3H-indolium

5-phthalimidomethyl-2,3,3-trimethylindolenine

5-phthalimidomethyl-2,3,3-trimethylindolenine

Conditions
ConditionsYield
Stage #1: 2,3,3-trimethyl-3H-indolium With sulfuric acid for 0.333333h; Inert atmosphere; Reflux;
Stage #2: 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione for 70h;
95.8%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,6-dibromophenol
608-33-3

2,6-dibromophenol

C15H9Br2NO3

C15H9Br2NO3

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran at 20℃; Cooling with ice;95%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2-bromo-5-nitrotoluene
7149-70-4

2-bromo-5-nitrotoluene

2-[(2-bromo-3-methyl-5-nitrophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione
1312290-85-9

2-[(2-bromo-3-methyl-5-nitrophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione

Conditions
ConditionsYield
Stage #1: 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione With trifluorormethanesulfonic acid at 0℃; for 0.333333h; Tcherniak-Einhorn reaction;
Stage #2: 2-bromo-5-nitrotoluene at 0 - 20℃; for 18h; Tcherniak-Einhorn reaction;
94%
Stage #1: 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione With trifluorormethanesulfonic acid at 0℃; for 0.333333h;
Stage #2: 2-bromo-5-nitrotoluene at 0 - 20℃; for 18h;
94%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

N-(chloromethyl)phthalimide
17564-64-6

N-(chloromethyl)phthalimide

Conditions
ConditionsYield
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2.5h;93%
With trichlorophosphate
With hydrogenchloride at 50℃;
2,3-dimethyl-5-methoxyindole
828-94-4

2,3-dimethyl-5-methoxyindole

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,3-dimethyl-5-methoxy-6-(phtalimidomethyl)indole
101004-44-8

2,3-dimethyl-5-methoxy-6-(phtalimidomethyl)indole

Conditions
ConditionsYield
In sulfuric acid for 30h; Ambient temperature;93%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

ethyl acetoacetate
141-97-9

ethyl acetoacetate

ethyl 2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-3-oxobutanoate
16880-35-6

ethyl 2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-3-oxobutanoate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 20℃; for 24h;93%
With boron trifluoride diethyl etherate at 0 - 20℃; for 0.5h;
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

1,2-Dichloroethylene
540-59-0

1,2-Dichloroethylene

2-chloro-3-phthalimido-propionaldehyde
50667-66-8

2-chloro-3-phthalimido-propionaldehyde

Conditions
ConditionsYield
With sulfuric acid93%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

1-methyl-1'-forrnyl-spiro[piperidine-4,3'-(2H)-indole]
1025687-97-1

1-methyl-1'-forrnyl-spiro[piperidine-4,3'-(2H)-indole]

5'-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1'-formyl-1-methyl-spiro[piperidine-4,3'-(2H)-indole]
1025687-98-2

5'-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-1'-formyl-1-methyl-spiro[piperidine-4,3'-(2H)-indole]

Conditions
ConditionsYield
With sulfuric acid Tscherniac-Einhorn reaction;93%
Stage #1: 2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione; 1-methyl-1'-forrnyl-spiro[piperidine-4,3'-(2H)-indole] With sulfuric acid at 5 - 20℃; Inert atmosphere;
Stage #2: With sodium carbonate In water pH=10;
93%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

para-difluorobenzene
540-36-3

para-difluorobenzene

2-(2,5-difluorobenzyl)isoindoline-1,3-dione

2-(2,5-difluorobenzyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With trifluorormethanesulfonic acid Ambient temperature;92%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

3-benzyl-2,3-dihydropyrimidin-4(1H)-one
28734-85-2

3-benzyl-2,3-dihydropyrimidin-4(1H)-one

diamide
10465-78-8

diamide

A

N-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimid-1-yl)methylphthalimide

N-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimid-1-yl)methylphthalimide

B

C18H24N6O4

C18H24N6O4

Conditions
ConditionsYield
With triphenylphosphine In N,N-dimethyl-formamideA 0.3 % Chromat.
B 92%
4-nitro-phenol
100-02-7

4-nitro-phenol

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,6-bis(phthaloylmethyl)-4-nitrophenol

2,6-bis(phthaloylmethyl)-4-nitrophenol

Conditions
ConditionsYield
With sulfuric acid for 2h; Ambient temperature;90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one
298-81-7

9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one

A

5,5'-Bis-N-Phthalimidomethyl-8-methoxypsoralen
96548-68-4

5,5'-Bis-N-Phthalimidomethyl-8-methoxypsoralen

B

5-N-Phthalimidomethyl-8-methoxypsoralen
81759-49-1

5-N-Phthalimidomethyl-8-methoxypsoralen

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trifluoroacetic acid In dichloromethane for 6h; Ambient temperature;A 90%
B n/a
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

ethyl propanoylacetate
4949-44-4

ethyl propanoylacetate

ethyl α-(phenylimidomethyl)propionylacetate

ethyl α-(phenylimidomethyl)propionylacetate

Conditions
ConditionsYield
With boron trifluoride diethyl etherate90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C29H21N3O7
1352172-54-3

C29H21N3O7

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 12h;90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

tetramethylammonium trifluoromethylselenate(0)
75264-92-5

tetramethylammonium trifluoromethylselenate(0)

2-(((trifluoromethyl)selanyl)methyl)isoindoline-1,3-dione

2-(((trifluoromethyl)selanyl)methyl)isoindoline-1,3-dione

Conditions
ConditionsYield
With calcium chloride In acetonitrile at 80℃; for 2h; Time; Inert atmosphere; Sealed tube; Glovebox;90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,6-difluorophenol
28177-48-2

2,6-difluorophenol

C15H9F2NO3

C15H9F2NO3

Conditions
ConditionsYield
With sulfuric acid In water at -5 - 20℃; for 24h;90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

acrylonitrile
107-13-1

acrylonitrile

N-(acryloylamino-methyl)-phthalimide
80500-94-3

N-(acryloylamino-methyl)-phthalimide

Conditions
ConditionsYield
With sulfuric acid 0 deg C, than 18 deg C., 20 h;89.7%
With sulfuric acid; acetic acid
7-methoxy-2,3-dimethyl-1H-indole
53918-89-1

7-methoxy-2,3-dimethyl-1H-indole

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2-(7-Methoxy-2,3-dimethyl-1H-indol-6-ylmethyl)-isoindole-1,3-dione
101004-45-9

2-(7-Methoxy-2,3-dimethyl-1H-indol-6-ylmethyl)-isoindole-1,3-dione

Conditions
ConditionsYield
In sulfuric acid for 30h; Ambient temperature;89%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

2,8-dimethylphenoxathiin 10,10-dioxide
21797-74-0

2,8-dimethylphenoxathiin 10,10-dioxide

2,8-dimethyl-4,6-bis(phthalimidomethyl)-phenoxathiin-10,10-dioxide
154459-09-3

2,8-dimethyl-4,6-bis(phthalimidomethyl)-phenoxathiin-10,10-dioxide

Conditions
ConditionsYield
With sulfuric acid for 168h; Ambient temperature;89%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

D-glucal triacetate
2873-29-2

D-glucal triacetate

phthalimidomethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside
354152-80-0

phthalimidomethyl 4,6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In toluene at -20℃; Ferrier rearrangement;89%
With niobium pentachloride In tetrahydrofuran for 0.833333h; Ferrier rearrangement; Heating;80%
With montmorillonite K-10 for 0.166667h; Ferrier rearrangement; microwave irradiation;77%
With boron trifluoride diethyl etherate In benzene at 20℃; for 1.25h;76.3%

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