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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(S)-10-Hydroxycamptothecin Manufacturer/High quality/Best price/In stock

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 10-Hydroxycamptothecine supplier in China

Cas:19685-09-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 10-Hydroxycamptothecin 19685-09-7 GMP Manufacturer

Cas:19685-09-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(S)-10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

cas 19685-09-7 10-Hydroxycamptothecin C20H16N2O5

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality 10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 19685-09-7 with best quality

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

Appearance Light yellow crystal powder Solubility Clear yellow solution at 1mg plus 1ml of dimethyl sulfoxide Proton NMR Spectrum Consistent with structure Assay(HPLC-259nm) 99%min Suphated ash 0.3%max Loss on drying 2.0%max Melting Poi

10-hydroxycamptothecin

Cas:19685-09-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Name: Hydroxycamptothecin Synonyms: (s)-10-hydroxycamptothecin CAS: 19685-09-7 MF: C20H16N2O5 Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:APIs Transportation:By sea or by ai

Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed contai

supply 10-Hydroxycamptothecin CAS No:19685-09-7

Cas:19685-09-7

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of (S)-10-Hydroxycamptothecin from Wuhan, Hubei, Chin

(S)-10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(S)-10-Hydroxycamptothecin 19685-09-7

Cas:19685-09-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $51.0 / 56.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality 10-Hydroxy Camptothecin CAS 19685-09-7 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made

High quality 10-Hydroxy Camptothecin CAS 19685-09-7

Cas:19685-09-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(S)-10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales 10-Hydroxycamptothecin CAS 19685-09-7

Cas:19685-09-7

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

1.strict raw material selection 2.mature production process 3.perfect quality control system 4.intimate servcie 5.competitive price 6.downstream customization 7.has a number of highly qualified engineers and experts to provide guida

Beat price/Anti-cancer 10-Hydroxycamptothecin 98% Hydroxycamptothecine 99%

Cas:19685-09-7

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Name (S)-10-Hydroxycamptothecin Synonyms (4S)-4-Ethyl-4,9-dihyd

Hydroxycamptothecin

Cas:19685-09-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

(s)-10-hydroxycamptothecin

Cas:19685-09-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

10-Hydroxycamptothecin 19685-09-7

Cas:19685-09-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Anti-cancer 10-Hydroxycamptothecin 98% Hydroxycamptothecine 99% CAS 19685-09-7 CAS NO.19685-09-7 CAS NO.19685-09-7

Cas:19685-09-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(S)-10-Hydroxycamptothecin Manufacturer/High quality/Best price/In stock

Cas:19685-09-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

10-Hydroxycamptothecin CAS19685-09-7

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

(S)-10-HydroxycamptothecinCAS NO.: 19685-09-7

Cas:19685-09-7

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Anti-cancer 10-Hydroxycamptothecin 98% Hydroxycamptothecine 99% CAS 19685-09-7 CAS NO.19685-09-7 CAS NO.19685-09-7

Cas:19685-09-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

10-Hydroxycamptothecin

Cas:19685-09-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

camptothecin
7689-03-4

camptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Stage #1: camptothecin With hydrogen; acetic acid; platinum(IV) oxide
Stage #2: With lead(IV) acetate; acetic acid
51%
Yield given. Multistep reaction;
With sulfuric acid; dihydrogen peroxide; acetic acid 2) irradiation; Yield given. Multistep reaction;
10-methoxycamptothecin
19685-10-0

10-methoxycamptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
With hydrogen bromide at 110℃; for 72h;82%
With hydrogen bromide In water at 110℃; for 7h; Inert atmosphere; optical yield given as %ee;80%
With hydrogen bromide In water at 100℃; Sealed tube;80%
With hydrogen bromide72%
With hydrogen bromide In water for 2h; Reflux;
camptothecin
7689-03-4

camptothecin

A

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

B

(S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
19685-11-1

(S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

Conditions
ConditionsYield
Stage #1: camptothecin With hydrogen; acetic acid; platinum under 760.051 Torr; for 8.5h;
Stage #2: With lead(IV) acetate In acetic acid Heating / reflux;
1,2,6,7-tetrahydro-(20S)-camphthotecine
870527-52-9

1,2,6,7-tetrahydro-(20S)-camphthotecine

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; water In acetic acid Yield given;
With [bis(acetoxy)iodo]benzene; acetic acid
In acetic acid at 20℃;
With [bis(acetoxy)iodo]benzene; acetic acid In water at 20℃; for 18h; Large scale reaction;1.36 kg
tetrahydrocamptothecin acetate

tetrahydrocamptothecin acetate

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Stage #1: tetrahydrocamptothecin acetate With [bis(acetoxy)iodo]benzene In water; acetic acid at 27.5℃; for 18h;
Stage #2: With methanol In N,N-dimethyl-formamide at 27.5 - 76.5℃; for 6h;
10-hydroxycamptothecin

10-hydroxycamptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
In 1,4-dioxane; acetonitrile for 0.75h; UV-irradiation;98.5%
9-<(dimethylamino)methyl>-10-hydroxy-(20S)-camptothecin acetate salt
123948-88-9

9-<(dimethylamino)methyl>-10-hydroxy-(20S)-camptothecin acetate salt

A

(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-12-methylene-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
942429-91-6

(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-12-methylene-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

B

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C

Topotecan hydrochloride
119413-54-6, 123949-07-5

Topotecan hydrochloride

D

camptothecin
7689-03-4

camptothecin

Conditions
ConditionsYield
With hydrogenchloride In water for 0.25h;A < 0.04 %Chromat.
B < 0.001 %Chromat.
C 99.65 %Chromat.
D < 0.009 %Chromat.
1,2,6,7-tetrahydrocamptothecin
53544-22-2, 142696-57-9, 142696-58-0

1,2,6,7-tetrahydrocamptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 98 percent / pyridine / 1 h / 70 °C
2: 96.3 percent / H2SO4, conc. aq. HNO3 / 1 h
3: 82.3 percent / 20percent aq. H2SO4 / 2 h / Heating
4: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 2 h / Heating
5: 96.2 percent / H2 / PtO2 / ethanol; dioxane / 2 h / 760 Torr
6: 1.) 20percent aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h
View Scheme
Multi-step reaction with 3 steps
1: 12 percent / Pb(OAc)4, trifluoroacetic acid / 0.25 h / Ambient temperature
2: 90.6 percent / 30percent aq. H2O2, acetic acid / 3.5 h / 70 - 80 °C
3: 22.5 percent / 1 N H2SO4 / dioxane / 0.5 h / Irradiation
View Scheme
Multi-step reaction with 3 steps
1: 12 percent / Pb(OAc)4, trifluoroacetic acid / 0.25 h / Ambient temperature
2: 90.6 percent / 30percent aq. H2O2, acetic acid / 3.5 h / 70 - 80 °C
3: 25 percent / 1 N aq. H2SO4 / dioxane / 0.5 h / Irradiation
View Scheme
Multi-step reaction with 3 steps
1: 12 percent / Pb(OAc)4, trifluoroacetic acid / 0.25 h / Ambient temperature
2: 90.6 percent / 30percent aq. H2O2, acetic acid / 3.5 h / 70 - 80 °C
3: 58 percent / 1 N aq. H2SO4 / dioxane / 0.5 h / Irradiation
View Scheme
2-[2,2-Dimethoxy-eth-(Z)-ylidene]-malonic acid benzyl ester methyl ester
161681-84-1

2-[2,2-Dimethoxy-eth-(Z)-ylidene]-malonic acid benzyl ester methyl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: LDA / tetrahydrofuran / -78 up to -20 deg C
2: H2 / 5percent Pd/C / methanol
3: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
4: TFA / H2O; toluene
5: DDQ
6: diisobutylaluminum hydride (DIBAH) / CH2Cl2
7: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
8: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 8 steps
1: LDA / tetrahydrofuran / -78 up to -20 deg C
2: H2 / 5percent Pd/C / methanol
3: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
4: TFA / H2O; toluene
5: DDQ
6: diisobutylaluminum hydride (DIBAH) / CH2Cl2
7: NaBH4 / methanol
8: 72 percent / 48percent HBr
View Scheme
2-[1-((2R,4S)-2-tert-Butyl-4-ethyl-5-oxo-[1,3]dioxolan-4-yl)-2,2-dimethoxy-ethyl]-malonic acid benzyl ester methyl ester

2-[1-((2R,4S)-2-tert-Butyl-4-ethyl-5-oxo-[1,3]dioxolan-4-yl)-2,2-dimethoxy-ethyl]-malonic acid benzyl ester methyl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: H2 / 5percent Pd/C / methanol
2: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
3: TFA / H2O; toluene
4: DDQ
5: diisobutylaluminum hydride (DIBAH) / CH2Cl2
6: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
7: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 7 steps
1: H2 / 5percent Pd/C / methanol
2: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
3: TFA / H2O; toluene
4: DDQ
5: diisobutylaluminum hydride (DIBAH) / CH2Cl2
6: NaBH4 / methanol
7: 72 percent / 48percent HBr
View Scheme
(S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone
173442-34-7

(S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 78 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h
2: 51 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation
3: 82 percent / aq. HBr / 72 h / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
2: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one
174092-79-6

(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 73 percent / Me3SiCl, NaI / acetonitrile; H2O / 5 h / 65 °C
2: 78 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h
3: 51 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation
4: 82 percent / aq. HBr / 72 h / 110 °C
View Scheme
Multi-step reaction with 3 steps
1: 72 percent / aq. HI
2: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
3: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
Camptothecin 1-oxide
86639-48-7

Camptothecin 1-oxide

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 11.5 percent / 1 N aq. H2SO4 / dioxane / 0.5 h / Irradiation
2: H2, acetic acid / PtO2 / dioxane / 760 Torr
3: 98 percent / pyridine / 1 h / 70 °C
4: 96.3 percent / H2SO4, conc. aq. HNO3 / 1 h
5: 82.3 percent / 20percent aq. H2SO4 / 2 h / Heating
6: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 2 h / Heating
7: 96.2 percent / H2 / PtO2 / ethanol; dioxane / 2 h / 760 Torr
8: 1.) 20percent aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h
View Scheme
Multi-step reaction with 3 steps
1: 11.5 percent / 1 N aq. H2SO4 / dioxane / 0.5 h / Irradiation
2: H2, acetic acid / PtO2 / dioxane / 760 Torr
3: 73.5 percent / Pb(OAc)4, trifluoroacetic acid / 0.25 h / Ambient temperature
View Scheme
Camptothecin 1-oxide
86639-48-7

Camptothecin 1-oxide

A

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

B

((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-ylsulfanyl)-acetic acid ethyl ester
86639-49-8

((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-ylsulfanyl)-acetic acid ethyl ester

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane for 0.5h; Irradiation;A 58%
B 11.9%
10-nitro-(20S)-camptothecin
86639-62-5

10-nitro-(20S)-camptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96.2 percent / H2 / PtO2 / ethanol; dioxane / 2 h / 760 Torr
2: 1.) 20percent aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h
View Scheme

N,20-O-diacetyl-1,2,6,7-tetrahydrocamptothecin

N,20-O-diacetyl-1,2,6,7-tetrahydrocamptothecin

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96.3 percent / H2SO4, conc. aq. HNO3 / 1 h
2: 82.3 percent / 20percent aq. H2SO4 / 2 h / Heating
3: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 2 h / Heating
4: 96.2 percent / H2 / PtO2 / ethanol; dioxane / 2 h / 760 Torr
5: 1.) 20percent aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h
View Scheme
Acetic acid (4R,5bS,11aS)-4-acetoxy-4-ethyl-9-nitro-3,13-dioxo-3,4,5b,11a,12,13-hexahydro-1H,11H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-6-yl ester

Acetic acid (4R,5bS,11aS)-4-acetoxy-4-ethyl-9-nitro-3,13-dioxo-3,4,5b,11a,12,13-hexahydro-1H,11H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-6-yl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82.3 percent / 20percent aq. H2SO4 / 2 h / Heating
2: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 2 h / Heating
3: 96.2 percent / H2 / PtO2 / ethanol; dioxane / 2 h / 760 Torr
4: 1.) 20percent aq. H2SO4, aq. NaNO2, 2.) H2O / 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h
View Scheme
(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione
174092-80-9

(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation
2: 82 percent / aq. HBr / 72 h / 110 °C
View Scheme

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 45 percent / ICl / CCl4; CH2Cl2 / 48 h / Ambient temperature
2: 73 percent / Me3SiCl, NaI / acetonitrile; H2O / 5 h / 65 °C
3: 78 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide / 1.) 0 deg C, 10 min; r.t., 15 min, 2.) toluene, 70 deg C, 20 h
4: 51 percent / Me6Sn2 / benzene / 5 h / 70 °C / Irradiation
5: 82 percent / aq. HBr / 72 h / 110 °C
View Scheme
2-methoxy-6-(trimethylsilyl)pyridine
170453-55-1

2-methoxy-6-(trimethylsilyl)pyridine

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: tBuLi
2: nBuLi, I2
3: 63 percent / Et3SiH / trifluoroacetic acid
4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2
5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3
6: 47 percent / ICl
7: 72 percent / aq. HI
8: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
9: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
2-Methoxy-6-trimethylsilanyl-pyridine-3-carbaldehyde
453518-21-3

2-Methoxy-6-trimethylsilanyl-pyridine-3-carbaldehyde

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: nBuLi, I2
2: 63 percent / Et3SiH / trifluoroacetic acid
3: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2
4: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3
5: 47 percent / ICl
6: 72 percent / aq. HI
7: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
8: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde
174092-75-2

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 63 percent / Et3SiH / trifluoroacetic acid
2: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2
3: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3
4: 47 percent / ICl
5: 72 percent / aq. HI
6: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
7: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
3-[((E)-But-2-enyl)oxymethyl]-4-iodo-2-methoxy-6-trimethylsilanyl-pyridine

3-[((E)-But-2-enyl)oxymethyl]-4-iodo-2-methoxy-6-trimethylsilanyl-pyridine

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2
2: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3
3: 47 percent / ICl
4: 72 percent / aq. HI
5: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
6: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione
174092-80-9

(S)-4-ethyl-4-hydroxy-6-iodo-7-(prop-2-yn-1-yl)-1,7-dihydro-3H-pyrano[3,4-c]pyridino-3,8(4H)-dione

4-isocyanophenol
162471-15-0

4-isocyanophenol

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
With hexamethyldistannane In benzene at 70℃; Irradiation;
Camptothecin 1-oxide
86639-48-7

Camptothecin 1-oxide

acetic acid
64-19-7

acetic acid

A

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

B

(S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
19685-11-1

(S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

Conditions
ConditionsYield
With sulfuric acid In 1,4-dioxane for 0.5h; Irradiation;A 25%
B 30.5%
7-Methoxy-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid methyl ester
161681-89-6

7-Methoxy-1,3-dihydro-pyrrolo[3,4-b]quinoline-2-carboxylic acid methyl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 30percent HBr/HOAc / 12 h / 20 °C
2: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
3: TFA / H2O; toluene
4: DDQ
5: diisobutylaluminum hydride (DIBAH) / CH2Cl2
6: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
7: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 7 steps
1: 30percent HBr/HOAc / 12 h / 20 °C
2: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
3: TFA / H2O; toluene
4: DDQ
5: diisobutylaluminum hydride (DIBAH) / CH2Cl2
6: NaBH4 / methanol
7: 72 percent / 48percent HBr
View Scheme
2-(Methoxycarbonyl-prop-2-ynyl-amino)-N-(4-methoxy-phenyl)-acetimidic acid methyl ester

2-(Methoxycarbonyl-prop-2-ynyl-amino)-N-(4-methoxy-phenyl)-acetimidic acid methyl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: acetonitrile / 50 °C
2: 30percent HBr/HOAc / 12 h / 20 °C
3: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
4: TFA / H2O; toluene
5: DDQ
6: diisobutylaluminum hydride (DIBAH) / CH2Cl2
7: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
8: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 8 steps
1: acetonitrile / 50 °C
2: 30percent HBr/HOAc / 12 h / 20 °C
3: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
4: TFA / H2O; toluene
5: DDQ
6: diisobutylaluminum hydride (DIBAH) / CH2Cl2
7: NaBH4 / methanol
8: 72 percent / 48percent HBr
View Scheme
2-[1-((2R,4S)-2-tert-Butyl-4-ethyl-5-oxo-[1,3]dioxolan-4-yl)-2,2-dimethoxy-ethyl]-malonic acid monomethyl ester

2-[1-((2R,4S)-2-tert-Butyl-4-ethyl-5-oxo-[1,3]dioxolan-4-yl)-2,2-dimethoxy-ethyl]-malonic acid monomethyl ester

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
2: TFA / H2O; toluene
3: DDQ
4: diisobutylaluminum hydride (DIBAH) / CH2Cl2
5: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
6: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 6 steps
1: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
2: TFA / H2O; toluene
3: DDQ
4: diisobutylaluminum hydride (DIBAH) / CH2Cl2
5: NaBH4 / methanol
6: 72 percent / 48percent HBr
View Scheme
7-Methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline; hydrobromide

7-Methoxy-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline; hydrobromide

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
2: TFA / H2O; toluene
3: DDQ
4: diisobutylaluminum hydride (DIBAH) / CH2Cl2
5: 1.) NaBH4; 2.) aq. NaOH / 1.) MeOH
6: 72 percent / 48percent HBr
View Scheme
Multi-step reaction with 6 steps
1: 89 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, 1-hydroxybenzotriazole (HOBT), Et3N / tetrahydrofuran
2: TFA / H2O; toluene
3: DDQ
4: diisobutylaluminum hydride (DIBAH) / CH2Cl2
5: NaBH4 / methanol
6: 72 percent / 48percent HBr
View Scheme
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

10-methoxycamptothecin
19685-10-0

10-methoxycamptothecin

Conditions
ConditionsYield
In 1,4-dioxane; methanol at 20℃; for 2h;100%
88%
In 1,4-dioxane; methanol; diethyl ether for 1h; Ambient temperature;87.5%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

4-piperidinopiperidine-1-carbonyl chloride
103816-19-9

4-piperidinopiperidine-1-carbonyl chloride

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin
103816-16-6

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 4h;100%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

9-bromo-10-hydroxycamptothecin
1097323-11-9

9-bromo-10-hydroxycamptothecin

Conditions
ConditionsYield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 2h;98%
With N-Bromosuccinimide In N,N-dimethyl-formamide95%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

10-hydroxy-(20S)-camptothecin trifluoromethanesulfonate
123949-09-7

10-hydroxy-(20S)-camptothecin trifluoromethanesulfonate

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 23 - 50℃; Inert atmosphere;97%
With triethylamine In N,N-dimethyl-formamide at 23 - 50℃;97%
With triethylamine In N,N-dimethyl-formamide at 20℃;96.7%
With triethylamine In N,N-dimethyl-formamide at 50℃; for 3h;
With triethylamine In N,N-dimethyl-formamide at 50℃;
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

9-iodine-10-hydroxycamptothecin
1256544-04-3

9-iodine-10-hydroxycamptothecin

Conditions
ConditionsYield
With N-iodo-succinimide In N,N-dimethyl-formamide at 0 - 20℃; for 2h;97%
With N-iodo-succinimide In N,N-dimethyl-formamide at 0 - 20℃; for 2h;95%
1-chlorocarbonyl-4-piperidinopiperidine hydrochloride

1-chlorocarbonyl-4-piperidinopiperidine hydrochloride

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride

10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin hydrochloride

Conditions
ConditionsYield
With potassium carbonate; triethylamine In acetonitrile at 60℃; for 6h;97%
glutaric anhydride,
108-55-4

glutaric anhydride,

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C25H22N2O8

C25H22N2O8

Conditions
ConditionsYield
With pyridine at 25℃; for 72h;97%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

2-Methylpropionic anhydride
97-72-3

2-Methylpropionic anhydride

camptothecin 10,20-di-O-isobutyrate

camptothecin 10,20-di-O-isobutyrate

Conditions
ConditionsYield
sulfuric acid at 20 - 100℃; for 16h;96%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

10-hydroxy-mappicine ketone

10-hydroxy-mappicine ketone

Conditions
ConditionsYield
In various solvent(s) at 200℃; for 9h;95%
triethylsilyl chloride
994-30-9

triethylsilyl chloride

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

20(S)-O-triethylsilylcampothecin
1004265-03-5

20(S)-O-triethylsilylcampothecin

Conditions
ConditionsYield
Stage #1: (S)-10-hydroxycamptothecin With 1H-imidazole In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere;
Stage #2: triethylsilyl chloride With dmap In N,N-dimethyl-formamide
94%
Stage #1: (S)-10-hydroxycamptothecin With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: triethylsilyl chloride With dmap In N,N-dimethyl-formamide at 20℃; for 60h; Inert atmosphere;
94%
With 1H-imidazole; dmap In N,N-dimethyl-formamide for 24.1667h;94%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

10-tert-butoxycarbonyloxycamptothecin
362496-88-6

10-tert-butoxycarbonyloxycamptothecin

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide at 20℃;94%
With pyridine In N,N-dimethyl-formamide at 20℃;
With pyridine In N,N-dimethyl-formamide at 20℃;2.1 g
With pyridine In dichloromethane
In pyridine; N,N-dimethyl-formamide at 20℃; Inert atmosphere;
glutaric anhydride,
108-55-4

glutaric anhydride,

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C25H22N2O8
1353778-70-7

C25H22N2O8

Conditions
ConditionsYield
With pyridine at 20℃; for 48h;94%
With pyridine at 20℃;59.22%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

4-nitrophenyl camptothecin-10-yl carbonate
656233-42-0

4-nitrophenyl camptothecin-10-yl carbonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 1h; Schlenk technique;93%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h;93%
With triethylamine at 20℃; for 1h;91%

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C39H50N4O12
945867-58-3

C39H50N4O12

Conditions
ConditionsYield
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;92%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Cyclohexanecarboxylic acid

Cyclohexanecarboxylic acid

(S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl cyclohexanecarboxylate

(S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl cyclohexanecarboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;92%

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

Topotecan hydrochloride
119413-54-6, 123949-07-5

Topotecan hydrochloride

Conditions
ConditionsYield
In propan-1-ol; dichloromethane91%
formaldehyd
50-00-0

formaldehyd

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

(S)-1-Pyrrolidin-2-yl-methanol

(S)-1-Pyrrolidin-2-yl-methanol

10-hydroxyl-9-L-prolinol (+)methylcamptothecin
1439356-77-0

10-hydroxyl-9-L-prolinol (+)methylcamptothecin

Conditions
ConditionsYield
In acetic acid at 40 - 90℃; Mannich Aminomethylation;90.2%
methanol
67-56-1

methanol

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

7-hydroxymethyl-10-hydroxycamptothecin
86639-61-4

7-hydroxymethyl-10-hydroxycamptothecin

Conditions
ConditionsYield
With sulfuric acid; dihydrogen peroxide; iron(II) sulfate at 20℃; for 96h; hydroxymethylation;90%
2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione
118-29-6

2-(hydroxymethyl)-1H-isoindole-1,3(2H)-dione

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C29H21N3O7
1352172-54-3

C29H21N3O7

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 12h;90%
N-hydroxymethyl-3,4,5,6-tetrahydrophthalimide
4887-42-7

N-hydroxymethyl-3,4,5,6-tetrahydrophthalimide

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C29H25N3O7
1352172-55-4

C29H25N3O7

Conditions
ConditionsYield
With sulfuric acid at 0 - 20℃; for 12h;90%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

prenyl bromide
870-63-3

prenyl bromide

(S)-4-ethyl-4-hydroxy-9-((3-methylbut-2-en-1-yl)oxy)-1,12-dihydro-14H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

(S)-4-ethyl-4-hydroxy-9-((3-methylbut-2-en-1-yl)oxy)-1,12-dihydro-14H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Conditions
ConditionsYield
With potassium carbonate In acetone for 3h; Reflux;90%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

carbonic acid 4-ethoxycarbonyloxy-4-ethyl-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester ethyl ester

carbonic acid 4-ethoxycarbonyloxy-4-ethyl-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester ethyl ester

Conditions
ConditionsYield
With pyridine In 1,2-dichloro-ethane89.2%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

poly(ethylene glycol)-O-glycolic acid ether

poly(ethylene glycol)-O-glycolic acid ether

10-camptothecin-[poly(ethylene glycol)-O-glycolic acid ether] ester, Mw=40000

10-camptothecin-[poly(ethylene glycol)-O-glycolic acid ether] ester, Mw=40000

Conditions
ConditionsYield
With pyridine; O-phenyl phosphorodichloridate In chloroform at 20℃; for 18h;89%
C21H38N2O8
945867-57-2

C21H38N2O8

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C41H54N4O13
945867-59-4

C41H54N4O13

Conditions
ConditionsYield
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h;89%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

camptothecin 10,20-di-O-butyrate

camptothecin 10,20-di-O-butyrate

Conditions
ConditionsYield
sulfuric acid at 20 - 100℃;89%
1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C28H32N2O9

C28H32N2O9

Conditions
ConditionsYield
Stage #1: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide; (S)-10-hydroxycamptothecin With potassium carbonate In N,N-dimethyl-formamide at 40℃;
Stage #2: With sulfuric acid In tetrahydrofuran; water for 3h; Reflux;
89%
(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

allyl bromide
106-95-6

allyl bromide

10-allyloxycamptothecin
185425-24-5

10-allyloxycamptothecin

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;88.2%
With potassium carbonate In N,N-dimethyl-formamide
C10H20O8S

C10H20O8S

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C30H36N2O10

C30H36N2O10

Conditions
ConditionsYield
Stage #1: C10H20O8S; (S)-10-hydroxycamptothecin With potassium carbonate In N,N-dimethyl-formamide at 40℃;
Stage #2: With sulfuric acid In tetrahydrofuran; water for 3h; Reflux;
88%
C18H36O12S

C18H36O12S

(S)-10-hydroxycamptothecin
19685-09-7

(S)-10-hydroxycamptothecin

C38H52N2O14

C38H52N2O14

Conditions
ConditionsYield
Stage #1: C18H36O12S; (S)-10-hydroxycamptothecin With potassium carbonate In N,N-dimethyl-formamide at 40℃;
Stage #2: With sulfuric acid In tetrahydrofuran; water for 3h; Reflux;
88%

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