Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product Description Product Name 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl] benzenesulfonamide CAS No. 119018-29-0 Appearance White crystalline powder Assay ≥99

3-Ethyl-4-methyl-3-pyrrolin-2-one4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Cas 119018-29-0 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Almost whi

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Glimepiride sulfonamide

Cas:119018-29-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Basic information Product Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide 119018-29-0

Cas:119018-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 119018-29-0 with competitive price

Cas:119018-29-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrroline)carboxamido]ethyl]benzene sulfonamide

Cas:119018-29-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Our Adwantage: 1.We have stock so we can delivery quickly at the very day when receive the payment. 2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order. 3.High quality gua

Pharmaceutical Glimepiride Intermediate CAS 119018-29-0 Glimepiride Sulfonamide

Cas:119018-29-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Factory supply Glimepiride Intermediate CAS 119018-29-0 99%purity bottom price

Cas:119018-29-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Pyrrole-1-carboxamide,N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo- 119018-29-0

Cas:119018-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide CAS: 119018-29-0 MF: C16H21N3O4S MW: 351.42 EINECS: 411-850-0 Mol File: 119018-29-0.mol 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-y

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Kilogram

FOB Price: $270.0 / 285.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide CAS:119018-29-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of ch

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide CAS:119018-29-0

Cas:119018-29-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Pyrrole-1-carboxamide,N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-

Cas:119018-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Hangzhou Think Chemical Co. Ltd

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide CAS:119018-29-0 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten year

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrrole-1-carboxamide,N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-

Cas:119018-29-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-[2-[(3-Ethyl-4-Methyl-2-Oxo-3-Pyrrolin-1-Yl)Carboxamido]Ethyl]Benzenesulfonamide

Cas:119018-29-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 119018-29-0 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-[2-[(3-ETHYL-4-METHYL-2-OXO-3-PYRROLIN-1-YL)CARBOXAMIDO]ETHYL]BENZENESULFONAMIDE

Cas:119018-29-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

N-[2-[4-(Aminosulfonyl)phenyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo]-1H-pyrrole-1-carboxamide

Cas:119018-29-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Product Name: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide Synonyms: 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

Cas:119018-29-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benzenesulfonyl chloride
119043-16-2

4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benzenesulfonyl chloride

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
With ammonia In water at 80℃; for 1.5h;97.8%
With ammonia In water at 60℃; for 4h;
With ammonia at 70℃; for 3 - 4h;
With ammonium hydroxide In methanol at 20 - 30℃; for 2h; Industrial scale;8.47 kg
With ammonium hydroxide at 20℃; for 16h;
C24H30N4O6S

C24H30N4O6S

4-(2-aminoethyl)benzenesulfonamide
35303-76-5

4-(2-aminoethyl)benzenesulfonamide

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
With propionic acid In isopropyl alcohol for 7.5h; Reagent/catalyst; Reflux;93.6%
4-{2-[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl)amino]ethyl}benzene-1-sulfonic acid

4-{2-[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carbonyl)amino]ethyl}benzene-1-sulfonic acid

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
With ammonia In 1,4-dioxane at 35℃; Temperature;90.28%
With ammonia In 1,4-dioxane at 35℃; Temperature;90.28%
phenyl 3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

phenyl 3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

4-(2-aminoethyl)benzenesulfonamide
35303-76-5

4-(2-aminoethyl)benzenesulfonamide

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;85%
In isopropyl alcohol for 6h; Reflux;85.5%
3-ethyl-4-methyl-3-pyrrolin-2-one
766-36-9

3-ethyl-4-methyl-3-pyrrolin-2-one

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / toluene / Heating
2: ClSO3H / 10 °C
3: NH3 / H2O / 4 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h
1.2: 5 h / 20 °C
2.1: tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: toluene / 2 h / 120 - 130 °C / Industrial scale
2: chlorosulfonic acid / dichloromethane / -5 - 30 °C
3: ammonium hydroxide / methanol / 2 h / 20 - 30 °C / Industrial scale
View Scheme
Multi-step reaction with 3 steps
1: toluene / 4 h / Molecular sieve; Reflux; Inert atmosphere
2: chlorosulfonic acid / dichloromethane / 5.5 h / 30 - 35 °C / Inert atmosphere
3: ammonium hydroxide / 16 h / 20 °C
View Scheme
1-acetyl-3-ethyl-4-methyl-1,5-dihydro-pyrrol-2-one
61892-80-6

1-acetyl-3-ethyl-4-methyl-1,5-dihydro-pyrrol-2-one

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / Na2CO3; H2O / Heating
2: 65 percent / toluene / Heating
3: ClSO3H / 10 °C
4: NH3 / H2O / 4 h / 60 °C
View Scheme
ethyl-α-ethylacetoacetate cyanohydrin
247098-17-5

ethyl-α-ethylacetoacetate cyanohydrin

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 15 percent / H2; Ac2O / Ra-Ni / 40 °C / 3800 Torr
2: 90 percent / Na2CO3; H2O / Heating
3: 65 percent / toluene / Heating
4: ClSO3H / 10 °C
5: NH3 / H2O / 4 h / 60 °C
View Scheme
ethyl 2-ethyl-3-oxobutanoate
607-97-6

ethyl 2-ethyl-3-oxobutanoate

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 80 percent / dimethylformamide / 0 - 5 °C
2: 15 percent / H2; Ac2O / Ra-Ni / 40 °C / 3800 Torr
3: 90 percent / Na2CO3; H2O / Heating
4: 65 percent / toluene / Heating
5: ClSO3H / 10 °C
6: NH3 / H2O / 4 h / 60 °C
View Scheme
3-ethyl-4-methyl-2-oxo-N-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide
247098-18-6

3-ethyl-4-methyl-2-oxo-N-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ClSO3H / 10 °C
2: NH3 / H2O / 4 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / tetrahydrofuran / 20 °C
2: ammonia / 1,4-dioxane / 35 °C
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / dichloromethane / -5 - 30 °C
2: ammonium hydroxide / methanol / 2 h / 20 - 30 °C / Industrial scale
View Scheme
Multi-step reaction with 2 steps
1: chlorosulfonic acid / dichloromethane / 5.5 h / 30 - 35 °C / Inert atmosphere
2: ammonium hydroxide / 16 h / 20 °C
View Scheme
3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamide

3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamide

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; copper(l) iodide / Petroleum ether / 9 h / 85 °C
2: chlorosulfonic acid / tetrahydrofuran / 20 °C
3: ammonia / 1,4-dioxane / 35 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; sodium hydroxide / Petroleum ether / 9 h / 85 °C
2: chlorosulfonic acid / tetrahydrofuran / 20 °C
3: ammonia / 1,4-dioxane / 35 °C
View Scheme
2-phenylethyl chloride
622-24-2

2-phenylethyl chloride

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide; copper(l) iodide / Petroleum ether / 9 h / 85 °C
2: chlorosulfonic acid / tetrahydrofuran / 20 °C
3: ammonia / 1,4-dioxane / 35 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; sodium hydroxide / Petroleum ether / 9 h / 85 °C
2: chlorosulfonic acid / tetrahydrofuran / 20 °C
3: ammonia / 1,4-dioxane / 35 °C
View Scheme
phenethyl isocyanate
1943-82-4

phenethyl isocyanate

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene / 2 h / 120 - 130 °C / Industrial scale
2: chlorosulfonic acid / dichloromethane / -5 - 30 °C
3: ammonium hydroxide / methanol / 2 h / 20 - 30 °C / Industrial scale
View Scheme
Multi-step reaction with 3 steps
1: toluene / 4 h / Molecular sieve; Reflux; Inert atmosphere
2: chlorosulfonic acid / dichloromethane / 5.5 h / 30 - 35 °C / Inert atmosphere
3: ammonium hydroxide / 16 h / 20 °C
View Scheme
(1R,4R)-1-isocyanato-4-methylcyclohexane
32175-00-1

(1R,4R)-1-isocyanato-4-methylcyclohexane

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

glimepiride
93479-97-1

glimepiride

Conditions
ConditionsYield
In tert-butyl methyl ether; cyclohexanone at 30℃; for 10h; Temperature;94.5%
Stage #1: N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With potassium carbonate In acetone; butanone for 0.5h; Inert atmosphere; Reflux;
Stage #2: (1R,4R)-1-isocyanato-4-methylcyclohexane In acetone; butanone Inert atmosphere; Reflux;
90%
Stage #1: N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With potassium carbonate at 55 - 60℃; for 1h; Heating / reflux;
Stage #2: (1R,4R)-1-isocyanato-4-methylcyclohexane In toluene for 12h; Heating / reflux;
86.3%
trans-4-methylcyclohexylamine

trans-4-methylcyclohexylamine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

glimepiride

glimepiride

Conditions
ConditionsYield
Stage #1: 1,1'-carbonyldiimidazole; N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With N,N,N,N,N,N-hexamethylphosphoric triamide; 1,8-diazabicyclo[5.4.0]undec-7-ene at 80℃; for 3h; Inert atmosphere; Heating;
Stage #2: trans-4-methylcyclohexylamine Concentration; Temperature; Reagent/catalyst;
85.1%
phenyl ((1r,4r)-4-methylcyclohexyl)carbamate

phenyl ((1r,4r)-4-methylcyclohexyl)carbamate

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

glimepiride
93479-97-1

glimepiride

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile for 5h; Reflux;85%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

C19H25N3O6S

C19H25N3O6S

Conditions
ConditionsYield
With triethylamine In dichloromethane at 5 - 30℃;83%
With triethylamine In dichloromethane at 0 - 30℃; for 2h;83%
1-(4-isocyanato-cyclohexylmethoxymethyl)-4-methoxy-benzene
599174-27-3

1-(4-isocyanato-cyclohexylmethoxymethyl)-4-methoxy-benzene

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

C32H42N4O7S
599174-28-4

C32H42N4O7S

Conditions
ConditionsYield
With potassium carbonate In acetone for 8h; Heating;80%
trans-4-methyl cyclohexyl isocyanate

trans-4-methyl cyclohexyl isocyanate

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

amaryl
93479-97-1

amaryl

Conditions
ConditionsYield
Stage #1: N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With potassium carbonate In tetrahydrofuran at 50 - 55℃; for 6h; Heating / reflux;
Stage #2: trans-4-methyl cyclohexyl isocyanate In toluene for 6h; Heating / reflux;
50%
4-isocyanato-1,2,3,5,6, 7-hexahydro-s-indacene
210827-31-9

4-isocyanato-1,2,3,5,6, 7-hexahydro-s-indacene

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

3-ethyl-N-(4-(N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)sulfamoyl)phenethyl)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

3-ethyl-N-(4-(N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)sulfamoyl)phenethyl)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

Conditions
ConditionsYield
Stage #1: N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With sodium hydride In tetrahydrofuran; mineral oil
Stage #2: 4-isocyanato-1,2,3,5,6, 7-hexahydro-s-indacene In tetrahydrofuran; mineral oil at 20℃; for 15h; Inert atmosphere;
50%
N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

trans-hydroxyglimepiride

trans-hydroxyglimepiride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / K2CO3 / acetone / 8 h / Heating
2: BF3*OEt2 / CH2Cl2 / 0 °C
View Scheme
N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

cis-hydroxyglimepiride

cis-hydroxyglimepiride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / K2CO3 / acetone / 8 h / Heating
2: BF3*OEt2 / CH2Cl2 / 0 °C
View Scheme
(1R,4R)-1-isocyanato-4-methylcyclohexane
32175-00-1

(1R,4R)-1-isocyanato-4-methylcyclohexane

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
119018-29-0

N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

glimepiride
93479-97-1

glimepiride

Conditions
ConditionsYield
Stage #1: (1R,4R)-1-isocyanato-4-methylcyclohexane; N-{2-[4-(aminosulfonyl)phenyl]ethyl}-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide With potassium carbonate In acetonitrile at 50 - 60℃; for 6h;
Stage #2: With water at 70 - 75℃; for 4h;

Downstream Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View